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Human Pharmacokinetics of Bisphenol A

Investigators
Doerge, Daniel
Institutions
DHHS/FDA - National Center for Toxicological Research
Objective

  1. Measure deuterated BPA from blood and urine samples from adult humans after a single oral dose of 100 µg/kg bw in order to resolve uncertainty regarding human metabolism, pharmacokinetics (PK), and mass balance of BPA.
  2. Integrate these new human PK and mass-balance data with the PK data from experimental animal models (e.g., mouse, rat, and monkey) along with human urinary biomonitoring data to refine a physiologically based pharmacokinetic (PBPK) model for BPA.
More information
Responsible Division: Biochemical Toxicology
Funding Source
Nat'l. Center For Toxicological Research
Project source
View this project
Project number
E0750001
Categories
Sanitation and Quality Standards