An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Identification of Fusarium Mycotoxin Responsible for DNA Adducts in Human Esophageal Tissue

Investigators
Howard, Paul
Institutions
DHHS/FDA - National Center for Toxicological Research
Objective
The goals of this project are
  1. To isolate and identify the DNA adduct.
  2. To identify the mycotoxin responsible for adduct formation.
  3. To determine the extent of the presence of this mycotoxin in foods and the DNA adduct in esophageal tissue samples.<?OL
More information
A unique DNA adduct has been detected in esophageal tumor tissue taken from SouthAfrican patients suffering from terminal esophageal cancer. This same adduct can beformed in vitro by incubating methanolic extracts of Fusarium fungi with DNA.

The fact that the presence of the fungi in food is epidemiologically associated with esophageal cancer suggests the adduct may be involved in cancer formation, or at the least, as a biomarker of exposure.

FY 2001 Plans:

  1. Prepare protocol.
  2. Initiate the studies on DNA adduct identification.
Funding Source
Nat'l. Center For Toxicological Research
Project number
X10024
Categories
Mycotoxins
Natural Toxins