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Identification of Immune Subsets that Contribute to IFNgamma- Dependent Protection against S. Typhimurium In Vivo

Institutions
Institute for Animal Health
Start date
2001
End date
2003
Objective
The aim of this work is to identify the cell subsets that contribute to IFNg-dependent immunity to Salmonella typhimurium infection during primary and subsequent rechallenge infections. There are three main objectives addressed by this proposal.
  1. Determination of the anti- Salmonella mechanism(s) mediated by natural killer (NK) cells
  2. The minimal requirement for T cell subsets and the IFNg- mediated anti-Salmonella response
  3. The interaction between different T cell subsets and the IFNg-mediated anti- Salmonella response.
Funding Source
Biotechnology and Biological Sciences Research Council
Project number
856
Categories
Salmonella
Bacterial Pathogens