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Identification of Immune Subsets that Contribute to IFNgamma- Dependent Protection against S. Typhimurium In Vivo

Institute for Animal Health
Start date
End date
The aim of this work is to identify the cell subsets that contribute to IFNg-dependent immunity to Salmonella typhimurium infection during primary and subsequent rechallenge infections. There are three main objectives addressed by this proposal.
  1. Determination of the anti- Salmonella mechanism(s) mediated by natural killer (NK) cells
  2. The minimal requirement for T cell subsets and the IFNg- mediated anti-Salmonella response
  3. The interaction between different T cell subsets and the IFNg-mediated anti- Salmonella response.
Funding Source
Biotechnology and Biological Sciences Research Council
Project number
Bacterial Pathogens