An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Identification of Immune Subsets that Contribute to IFNgamma-Dependent Protection against S. Typhimurium In Vivo

Institutions
Institute for Animal Health
Start date
2001
End date
2004
Objective
Salmonellosis is a food-borne zoonosis with important medical and veterinary implications. Continued reduction of antibiotic usage in livestock is a priority and the development of more efficacious vaccines is an appropriate and sustainable method of control. Rational vaccine design requires a thorough understanding of the immune cell types and immune mechanisms that operate against Salmonella infection in vivo. Interferon gamma is important in the anti-salmonella response but the cellular source(s) of effective IFNgamma remain unknown.

This proposal will identify the relative contribution of different cell types to the IFNgamma- dependent effector response that operate at different phases of primary and challenge infections.

Funding Source
Biotechnology and Biological Sciences Research Council
Project number
D14755
Categories
Bacterial Pathogens
Prevention and Control
Salmonella