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Identification of Regulatory Genes in A. Flavus And A. Nidulans that are Involved In Mycotoxin Production, Morphogenesis, and Virulence

Investigators
Cary, J. W.
Institutions
Northern Illinois University
Start date
2014
End date
2019
Objective

Identify key genes involved in regulation of oxidative stress, nitric oxide production, and nitrogen metabolism in Aspergillus (A.) nidulans and A. flavus whose expression are dependent on the presence of regulatory genes such as veA. Determine role of these genes in regulation of biological activities such as fungal toxin production, morphogenesis, and virulence.

More information

Data acquired from Aspergillus (A.) flavus whole genome microarray/two-hybrid studies will be used to identify key genetic components of signaling pathways that control aflatoxin production and fungal morphogenesis. Using both A. flavus and the model fungus, A. nidulans, gene inactivation studies will determine the role of novel as well as previously characterized genes involved in fungal response to oxidative stress on toxin production and morphogenesis. The role of VeA and other regulatory proteins on production of hydrolytic enzymes involved in fungal pathogenesis of crop plants will be determined using molecular and biochemical techniques.

Funding Source
Agricultural Research Service
ARS (NP108)
Project source
View this project
Project number
6054-42000-021-21
Accession number
426639
Categories
Mycotoxins
Natural Toxins