An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

IMPACT OF THE DIET-DERIVED ANTIOXIDANT ERGOTHIONEINE ON BIOLOGICAL AGING AND CELLULAR SENESCENCE

Investigators
Pazdro, Ro, .
Institutions
University of Georgia
Start date
2021
End date
2026
Objective
The proposed project will determine the effects of the diet-derived antioxidant, ergothioneine, which is abundant in mushrooms, on biological aging. Thatoverarching purposewill be achieved via the following major goals:1) To define the impact of ergothioneine deficiency on the mammalian lifespan;2) To evaluate the efficacy of ergothioneine as a therapeutic against age-related cellular senescence and histological changes; and3) To determine the effects of ergothioneine on cellular antioxidant defenses and canonical longevity pathways.
Funding Source
Nat'l. Inst. of Food and Agriculture
Project source
View this project
Project number
GEO00904
Accession number
1025784
Categories
Chemical Contaminants