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Infectivity and Abnormal Prion Protein (PrP) in Tissues from Sheep Exposed to Atypical Scrapie

Institutions
Environment Agency - ENVT UK
Start date
2007
End date
2013
Objective
This project will establish distribution of abnormal PrP using various tools including Immunohistochemistry, and infectivity (using transgenic mice model) in sheep tissues such as blood, muscle, central nervous system(CNS) and milk. The research will give consideration to the fact that atypical cases could be either a spontaneous affection from CNS origin or an acquired infectious disease resulting from an oral contamination.
More information
Background:
Recently identified atypical scrapie cases in sheep represent an emerging TSE of which little is known. Incidence in EU countries seems to vary between 3 and 11 per 10,000 tested animals. However, because there is probably a lack of sensitivity in screening tests towards this particular TSE, this value is likely to be an underestimation. There is no consistent information concerning the abnormal PrP or infectivity distribution in peripheral tissues of atypical cases. This absence of data, combined with the involvement of ARR/ARR (genotype most resistant to BSE) animals that were believed to be resistant to TSE, represent a major concern with regards to the efficiency of the current food protection policy against TSE.

Find more about this project and other FSA food safety-related projects at the Food Standards Agency Research webpage.

Funding Source
Food Standards Agency
Project source
View this project
Project number
FS231050 (M03058)
Categories
Bacterial Pathogens
Commodities
Meat, Poultry, Game