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Integrative Functional and Physiological Genomics of Poultry

Zhou, Huaijun
Texas A&M University
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To determine the functional mechanisms of genetic changes as a result of selection and gene introgression.
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NON-TECHNICAL SUMMARY: Campylobacter is commensal bacteria in chickens. It can cause diarrhea in human. Genetically resistant birds using associated genes can be selected to improve resistance to bacterial infection in chickens. Functional genomics tools can be used to detect resistant genes or signal pathway related to bacterial infection. Eventually, the expected results can be used to improve food safety.

APPROACH: Birds will be challenged with Campylobacter jejuni. Tissues will be collected to isolate RNA for microarray analysis. Differentially expressed genes will be detected using bioinformatic and statistical methods. The outcome of this study are expected to genetically improve resistance to bacterial infection in chickens.

Funding Source
Nat'l. Inst. of Food and Agriculture
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Bacterial Pathogens
Natural Toxins
Viruses and Prions
Chemical Contaminants
Meat, Poultry, Game