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Interindividuality in Cytochrome P450 and Paraoxonase Mediated Metabolism of Mixtures of Pesticides

Institutions
CXR Biosciences
Start date
2005
End date
2008
Objective
This research project will investigate the influence of genetic variability in enzyme activity on the toxicity of mixtures of pesticides.

The project will investigate the role of cytochromes P450 and paraoxonase in variability in response to individual pesticides and mixtures.

Metabolism of selected pesticides will be characterised. In vitro techniques will be used to investigate interactions of the pesticides in mixtures at low individual concentrations in human tissues.

The data obtained will provide a framework for future development of mathematical models to predict the effects of individual variability on the metabolism, and hence toxicity, of complex pesticide mixtures.

More information
In its report on Risk Assessment of Mixtures of Pesticides and Similar Substances, the Committee on Toxicity of Chemicals in Food Consumer Products and the Environment (COT) highlighted the need for characterisation of possible variability in human responses to mixtures of residues, including genetic susceptibility.

This project will adopt an enzymological approach to investigate the role of polymorphic drug metabolising enzymes in the toxicity of mixtures of pesticides.

Find more about this project and other FSA food safety-related projects at the Food Standards Agency Research webpage.

Funding Source
Food Standards Agency
Project number
T10011
Categories
Pesticide Residues
Predictive Microbiology