An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

The interrelationships of calcium and vitamin A and D intakes on bone in a swine model

Investigators
Tanumihardjo, Sherry
Institutions
University of Wisconsin - Madison
Start date
2020
End date
2024
Objective
Hypotheses: We hypothesize that excessive vitamin A, especially in combination with vitamin D deficiency will lead to bone abnormalities, and these effects will be rescued by providing excess dietary calcium.Supporting Objectives-The proposed studies have two overarching objectives that will use innovative methods to assess:1) The interactions of non-optimal (deficient or excessive) vitamin A and D statuses on growth and bone development in young growing pigs.We will measure bone turnover biomarkers, growth, and quality by dual-energy X-ray absorptiometry (DXA) and clinical-computed tomography (CT) of pigs fed combinations of deficient or excessive levels of vitamins A and D.We will determine how vitamin D deficiency and hypervitaminosis interact with excessive levels of vitamin A to worsen or mitigate its impact on bone metabolism.2) The effect of suboptimal (deficient or excessive) dietary vitamin A on a background of adequate and excessive calcium intake.We will modulate dietary vitamin A and calcium to determine changes in detrimental or protective clinical outcomes in growing pigs. Adequate vitamin D will be provided.These studies could prove to be relevant in animals due to the tendency of commercial swine feed manufacturers to add nutrients at levels far above NRC recommendations, and in humans where overlapping interventions for vitamin A deficiency and excessive intake of preformed retinol due to supplements and fortification can lead to hypervitaminosis A. Balancing vitamins A and D and calcium are important food safety consideration.
Funding Source
Nat'l. Inst. of Food and Agriculture
Project source
View this project
Project number
WIS03078
Accession number
1022808
Categories
Sanitation and Quality Standards
Parasites
Natural Toxins
Viruses and Prions
Bacterial Pathogens
Chemical Contaminants