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MECHANISMS OF VIRULENCE GENE REGULATION IN S. AUREUS

Investigators
Hurlburt B K
Institutions
USDA - Agricultural Research Service
Start date
2001
End date
2005
Objective
The current proposal is focused on the interaction of two globally-acting regulators of virulence gene expression in Staphylococcus aureus: sar and agr. Specific aims of proposed research are: 1)define cis regulatory elements responsible for activation of agr genes by SarA; 2)define domains of SarA required for activation of agr transcription; 3)define interaction of SarA with agr regulatory elements at atomic level; 4)develop anti-staphylococcal inhibitors that target global regulatory factors.
Funding Source
Agricultural Research Service
Project source
View this project
Project number
6435-43440-041-01R
Accession number
404778
Categories
Staphylococcus
Viruses and Prions
Bacterial Pathogens