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MENTORING IN PREVENTION OF HOSPITAL-ACQUIRED INFECTIONS AND ANTIBIOTIC RESISTANCE

Investigators
Milstone, Aaron M
Institutions
Johns Hopkins University
Start date
2018
End date
2023
Objective
Despite technological advances and improved care delivery, antibiotic resistance and healthcare associatedinfections continue to plague our health system. The applicant, Dr. Aaron Milstone, is a Pediatric InfectiousDiseases Physician and Epidemiologist who had focused his career on the prevention of antibiotic resistanceand healthcare-associated infections. This K24 application builds on his career goals of translating laboratoryand epidemiologic observations into patient- and population-level interventions and will prepare him and histrainees to identify, develop, and test new strategies to prevent infections and antibiotic resistance. Thespecific research aims are to: 1) identify risk factors for and develop a predictive model of carbapenem-resistant organism colonization and transmission in hospitalized patients, 2) identify bacterial communities,bacterial genes, and patient clinical characteristics associated with resistance to S. aureus nasal colonizationin hospitalized neonates at risk for S. aureus acquisition from parents with known S. aureus colonization, and3) determine whether bacterial culture stewardship reduces antibiotic use and resistance. The proposedprojects will build on existing funded projects and collaborations in microbiome, genomics, and implementationscience, expand the Dr. Milstone's knowledge in these areas, and make him a more effective PI and patientoriented research mentor.
Funding Source
Nat'l. Inst. of Allergy and Infectious Diseases
Project source
View this project
Project number
1K24AI141580-01
Categories
Antimicrobial Resistance
Education and Training