An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Modulation of Dosing Regimes to Prevent Development of Fluoroquinolone Resistance in Bacteria (Mainly Salmonella and E. Coli) in Chicken

Institutions
Veterinary Laboratories Agency, UK
Start date
2004
End date
2006
Objective
  • Investigate different dosing regimes of enrofloxacin and possibly difloxacin in chickens on the development of resistance in Salmonella and E. coli in the first instance and possibly in Campylobacter and Mycoplasma.
  • Determine fluoroquinolone concentrations in poultry serum and tissues during dosing and relate this to a mutant prevention concentration
  • Investigate quinolone concentrations and resistance in faecal flora from treated animals and analyse any resulting mutants.
  • Use evidence from 1 to 3 to provide advice on strategies to minimise the development of resistance in poultry dosed with quinolones.
Funding Source
Dept. for Environment, Food and Rural Affairs
Project number
VM02201
Categories
Campylobacter
Escherichia coli
Salmonella
Commodities
Meat, Poultry, Game