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Molecular Mechanisms of the Inflammatory Response Induced by Shigella Flexneri

Investigators
McCormick, Beth
Institutions
University of Massachusetts Medical School - Worcester
Start date
2010
End date
2011
Objective
Despite the understanding gained by our long-standing interest in studying Shigella, shigellosis continues to pose worldwide medical concerns and remains a cause of food-borne diseases even in developed countries. The identification of host cellular targets of Shigella virulence proteins will aid clinical therapeutic drug designs and treatment of multidrug-resistant bacteria.

Results from this study will not only broaden our understanding of Shigella pathogenesis but will also provide vital insights into basic host cell biology.

Funding Source
Nat'l. Inst. of Diabetes and Digestive and Kidney Diseases
Project number
1R56DK084984-01A1
Categories
Shigella
Bacterial Pathogens