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MOLECULAR MECHANISMS OF POTATO VIRUS Y PATHOSYSTEMS UNDER NATURAL AND ENGINEERED RESISTANCE

Investigators
Fondong, V.
Institutions
Delaware State University
Start date
2020
End date
2024
Objective
The goals of this project are to uncover the molecular basis of PVY strain pathosystems in natural resistance conferred by R and N genes, respectively, as well as through trans-acting siRNA (tasiRNA)-engineered resistance. This will be achieved through tthree objectives, which are to:Determine key factors regulating plant-virus interactions in the establishment of PVY strain-specific pathosystems in potato using deep sequencing and data analysis capabilities;Characterize the nature of tasiRNA-mediated resistance by identifying and molecularly characterizing regulators of this resistance in N. tobacum and in potato. We will also compare efficiencies of TAS1 and TAS3 pathways in generating tasiRNA-mediated resistance.Identify and determine the role of key regulators found to be involved in PVY infectivity and resistance using virus-induced gene silencing (VIGS), short tandem target mimic (STTM) and/or molecular sponges (SPs).We will also train undergraduate and graduate students, as well as postdoctoral scientists.
Funding Source
Nat'l. Inst. of Food and Agriculture
Project source
View this project
Project number
DELX2019-07003
Accession number
1020967
Categories
Bacterial Pathogens
Prevention and Control
Commodities
Produce