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Novel Technologies and Techniques for the Detection of Residues, Toxins, and Other Chemicals in Foods

Schneider, Marilyn; Medina, Marjorie; Lehotay, Steven; Chen, Guoying
USDA - Agricultural Research Service
Start date
End date
  1. To develop laboratory-based multiclass, multiresidue analytical methods for veterinary drugs in animal-derived foods, feeds, and marker matrices (e.g., tissues, blood, urine);
  2. To develop field-based instruments and methods for analytical screening of chemicals of food safety/security concern (or nutritional interest) in foods;
  3. To develop field-portable and laboratory-based analytical methods for the screening and reliable identification of biotoxins and phytochemicals in foods;
  4. Devise a scientifically defensible and practical system to evaluate qualitative identification of chemical residues in complex matrices; and
  5. Employ and adapt progressive analytical concepts previously developed for pesticides (QuEChERS and related approaches) to meet other food safety and security applications (e.g. dioxins).
More information
Approach: The project involves the application and evaluation of rapid and sensitive lab-based approaches to dependably detect mutliple veterinary drug classes in animal-derived foods predominantly using atmospheric pressure ionization/tandem mass spectrometry. Similarly, for multiple chemical residues and toxins in meats, poultry, eggs, fruits, vegetables, and grains, the approach involves the development and evaluation of rapid lab-based quantitative and confirmatory analytical approaches predominatly using as chromatography/tandem mass spectrometry. Furthermore, field-based screening techniques for chemical contaminants in foods at tolerance levels will be developed. The results obtained by these novel methods will be compared to those obtained by traditional techniques currently in use.
Funding Source
Agricultural Research Service
Project number
Accession number
Chemical Contaminants
Natural Toxins
Bacterial Pathogens
Meat, Poultry, Game