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Nutraceutical Safety and Efficacy

Investigators
Lachance, Paul
Institutions
Rutgers University
Start date
2002
End date
2007
Objective
  1. Selection, cultivation, propagation of standardized phytoceutical plants
  2. Phytochemical/genomic composition (DNA and chemical fingerprinting of plant(s)
  3. Inhibitory effect of selected fractions exposed to whole cell-line(s) and metabolism
  4. Safety valuations with the development of rapid immunoassay
  5. Studies of bioavailability
  6. Studies of efficacy (in-vitro, whole animal, human)
More information
NON-TECHNICAL SUMMARY: The Dietary Supplement Health and Education Act of 1994 permits the sale of vitamins, minerals, amino acids and herbs (individually or naturally occurring) but these can lack thorough safety and efficacy data. The assurance of safety and efficacy resides in identifying nutraceutical products chemically and biologically at their origin by global positioning, and throughout their bar-coded existence and monitored under the principles of Hazard Analysis Critical Control Point (protects against bioterrorism)

APPROACH: 1. Collection and identification (DNA sequence) of medicinal plants unique to the New Jersey Pine Barrens (NI labs at NJ EcoComplex) 2. Preparative bioassay directed fractionation chemistry HPLC/MS equipment in New Brunswick (CAFT), NJ EcoComplex (NI) 3. Comparative efficacy (DNA sequence) studies of human cancer cell lines (Coriell Institute, Camden) 4. Developoment of standardized nutraceutical products and human efficacy studies (Cooper Health Systems, Camden) 5. Application of Intelligent Product Delivery System for safety assurance 6. Conduct of herbal medicine and nutraceutical education courses for professionals (Cook OCPE)

Funding Source
Nat'l. Inst. of Food and Agriculture
Project source
View this project
Project number
NJ10146
Accession number
194715
Categories
Chemical Contaminants
Food Defense and Integrity
Risk Assessment, Management, and Communication