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Phage Encoded Transfer of Antibiotic Resistance in Salmonella

Investigators
LeJeune, Jeffrey
Institutions
Ohio State University
Start date
2006
End date
2007
Objective
1. Determine the prevalence of generalized transducing phages among multi drugresistant Salmonella of bovine-origin.

2. Determine the susceptibility of bovine-origin Salmonella to transducing phages isolated from multi drug-resistant Salmonella. 3. Determine the frequency of antibiotic resistance gene transduction among different serovars of bovine-origin Salmonella.

More information
Findings: Wild-type phage is common among Salmonella of bovine origin. Many phages have broad host ranges and are able to multiply in various serovars of Salmonella, which may facilitate the genetic exchange among Salmonella in the environment. β-lactam resistance and tetracycline resistance can be transduced from S. Heidelberg to S. Typhimurium via wild-type phage transduction. Phage-mediated antibiotic resistance transfer may contribute to the emergence and dissemination of antibiotic-resistant Salmonella in the food production environment.
Funding Source
Nat'l. Cattlemen's Beef Assoc.
Project number
BC-2006-16
Categories
Bacterial Pathogens
Antimicrobial Resistance