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(P)Ppgpp-Mediated Antibiotic Tolerance In The Gram-Positive Bacterium Bacillus Subtilis

Wang, JA
University of Wisconsin System
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The major goal of this project is to understand how Gram-positive bacteria tolerate antibiotic treatments. Understanding this basic mechanism will provide new directions in antagonizing pathogenic Gram-positive bacteria by reducing their tolerance.
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We will use genetic, cell biological and biochemical approaches to conduct the research. For example, we engineer mutants of bacteria that are more sensitive to antibiotic stress, and then trying to treat wild type cells in a way that would mimic the mutations. By doing so, we develop effective strategies that potentiate antibiotic efficacy.
Evaluation: We hope to publish major data papers and reviews on peer reviewed journals.
Funding Source
Nat'l. Inst. of Food and Agriculture
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Antimicrobial Resistance