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Pro-Inflammatory Response to Campylobacter and Heat-Stable Campylobacter Products

Institutions
University of Nottingham
Start date
2003
End date
2006
Objective
Human colonic epithelial cells respond to Campylobacter jejuni by activation of the transcription factor NF-kB to induce innate immunity and switch on pro-inflammatory cytokines. C. jejuni cell components stable to heat treatment constitute a potent activator of NF-kB leading to the efficient induction of cytokines/chemokines including interleukin-8.

We propose to characterise the bioactive components of Campylobacters and examine human gut epithelial cell responses to these products.

Funding Source
Biotechnology and Biological Sciences Research Council
Project number
D20452
Categories
Campylobacter