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Public Health Surveillance for Foodborne Infections: Design of Epidemiological Studies and Applying Seroepidemiology to Validate the Surveillance Pyramid

Institutions
Statens Serum Institut (SSI)
Start date
2007
Objective
  • To establish antibody decay profiles of immunoglobulin (Ig) A, IgG and IgM for persons with a stool culture-confirmed infection with S. Enteritidis (SE) or S. Typhimurium (ST) using a mixed salmonella ELISA (decay profiles for antibodies against campylobacter (CA) have already been established)
  • To measure antibodies against SE/ST and CA in ~5000 population-representative serum samples from several European countries
  • To estimate the incidence of SE/ST and CA infections in the population by using a mathematical back-calculation model
  • To calculate "multipliers" (i.e. the ratio between the number of infections in the population divided by the number of notified cases), which allow to 'calibrate' the surveillance systems of different countries
  • To develop a standard protocol for the application of the method beyond the scope of WP32
  • To make recommendations for additional studies, eg. to explore the protective effect of antibodies to foodborne pathogens and what implications this has for case-control studies of risk factors for foodborne pathogens and to compare the incidence of exposures leading to an antibody response in humans with quantitative risk assessment approaches
Funding Source
European Union
Project number
MVN-WP32
Categories
Bacterial Pathogens
Risk Assessment, Management, and Communication