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SALMONELLA PATHOGENICITY ISLAND 2 EFFECTOR PROTEINS

Investigators
Miller, Samuel
Institutions
University of Washington
Start date
2001
End date
2017
Objective
Salmonella are facultative intracellular pathogens which cause significant diseases in humans and animals. These organisms cause several disease syndromes, including enteric (typhoid) fever, gastroenteritis, bacteremias and focal infections. Typhoid fever is a severe systemic illness which is mostly a problem in the developing world and in travelers. Non-typhoidal salmonella infections are increasing in the USA and are largely associated with contaminated food. Salmonellae infections are most severe in infants, the elderly, and in immunosuppressed individuals. This application proposes to study a set of virulence genes, termed Salmonella translocated effectors, that are translocated across the phagosome membrane into the eucaryotic cell cytoplasm by a type III secretion system encoded on Salmonella pathogenicity island II will be studied. This application proposes to further define these proteins, and to study in molecular detail their role in bacterial virulence.
Funding Source
Nat'l. Inst. of Allergy and Infectious Diseases
Project source
View this project
Project number
5R01AI048683-15
Categories
Salmonella
Bacterial Pathogens
Viruses and Prions