Research Projects Database Search | National Agricultural Library

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National Agricultural Library

U.S. Department of Agriculture

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Displaying projects 1 - 25 of 96

to stimulate the development of a new therapeutic for cryptosporidium

Funding Source

Bill and Melinda Gates Fndn.

Start date

2016

End date

2018
to establish a national surveillance system for enteric fever in India

Funding Source

Bill and Melinda Gates Fndn.

Start date

2017

End date

2019
to estimate the burden and severity of invasive Salmonella infections in Moshi, Tanzania

Funding Source

Bill and Melinda Gates Fndn.

Start date

2016

End date

2018
to support late preclinical and early clinical development of a novel treatment for cryptosporidiosis

Funding Source

Bill and Melinda Gates Fndn.

Start date

2016

End date

2018
to evaluate effectiveness and impact of typhoid conjugate vaccine introduction program in Navi Mumbai, India

Funding Source

Bill and Melinda Gates Fndn.

Start date

2017

End date

2019
to identify natural compounds in human milk that protect infants from environmental enteric disease and diarrhea

Funding Source

Bill and Melinda Gates Fndn.

Start date

2017

End date

2019
to identify the transmission patterns of Cryptosporidium, a leading cause of diarrhea in young children, in Bangladesh

Funding Source

Bill and Melinda Gates Fndn.

Start date

2015

End date

2017
to compare the virulence of wild type S. Typhi with that of a toxin-defective mutant in a human volunteer model of S. Typhi infection

Funding Source

Bill and Melinda Gates Fndn.

Start date

2015

End date

2017
to evaluate the performance of typhoid diagnostics in a confined population, during an outbreak of typhoid in Zomba and Malosa, Malawi.

Funding Source

Bill and Melinda Gates Fndn.

Start date

2016

End date

2018
to determine if an approved drug product for another indication will demonstrate efficacy in humans to treat diarrhea caused by Cryptospordidium

Funding Source

Bill and Melinda Gates Fndn.

Start date

2017

End date

2019
to understand typhoid transmission dynamics in a highly endemic setting in Kenya, thereby informing effective prevention strategies, including vaccination

Funding Source

Bill and Melinda Gates Fndn.

Start date

2016

End date

2018
to determine the prevalence of cryptosporidium infection among adults with HIV infection using a rapid diagnostic stool test in order to design a therapeutic intervention study

Funding Source

Bill and Melinda Gates Fndn.

Start date

2016

End date

2018
to complete a study and publication on the evidence for the currently used definition of diarrhea, as well as systematic reviews related to dehydration and Shigella indications

Funding Source

Bill and Melinda Gates Fndn.

Start date

2015

End date

2017
to develop methods to identify environmental reservoirs of S. Typhi, and use these findings to inform targeted intervention strategies for typhoid fever through spatial modeling

Funding Source

Bill and Melinda Gates Fndn.

Start date

2016

End date

2018
to engineer a live vaccine delivery platform that can be given by oral administration to reduce the global diarrheal burden in young children due to infections by enteric pathogens

Funding Source

Bill and Melinda Gates Fndn.

Start date

2016

End date

2018
to determine if vaccination can reduce Campylobacter infection and environmental enteric dysfunction (EED), thereby improving gut health while increasing infant growth trajectories

Funding Source

Bill and Melinda Gates Fndn.

Start date

2016

End date

2018
to determine critical environmental transmission pathways of typhoid in low-income urban areas and design environmental surveillance strategies to monitor typhoid in the environment

Funding Source

Bill and Melinda Gates Fndn.

Start date

2016

End date

2018
to apply highly sensitive quantitative molecular diagnostics for pathogens to understand the etiology of community diarrhea and the relationship and effects of enteropathogens on healthy growth

Funding Source

Bill and Melinda Gates Fndn.

Start date

2015

End date

2017
to develop human experimental challenge models in which adult volunteers will be given the protozoan pathogen Cryptosporidium hominis in order to lay a rational foundation for vaccine development

Funding Source

Bill and Melinda Gates Fndn.

Start date

2015

End date

2017
to characterize population genetics of Cryptosporidium in children with acute diarrhea and their accompanying caregivers and use molecular techniques to characterize caregiver to child transmission

Funding Source

Bill and Melinda Gates Fndn.

Start date

2014

End date

2016
to understand what drives sustained low-level typhoid transmission in Santiago, Chile, where typhoid was once highly endemic, and to use these lessons to assess the feasibility of typhoid elimination

Funding Source

Bill and Melinda Gates Fndn.

Start date

2017

End date

2019
to reduce cholera's disease burden in both epidemic and endemic settings through use of evidence-based practices, increased stakeholder collaboration and implementation of renewed strategies for cholera control

Funding Source

Bill and Melinda Gates Fndn.

Start date

2017

End date

2019
to systematically compare and analyze a broad range of genomic and transcriptomic datasets to establish up-to-date reference genome sequences and functional annotation for human-infecting Cryptosporidium species

Funding Source

Bill and Melinda Gates Fndn.

Start date

2016

End date

2018
to understand what the reservoirs and transmission routes of Non-typhoidal Salmonellae are in sub-Saharan Africa; and how asymptomatic infection of children by Non-typhoidal Salmonellae affects serodiagnostic tests

Funding Source

Bill and Melinda Gates Fndn.

Start date

2015

End date

2017
to describe the proportion of hospitalizations from enteric pathogens among hospitalized patients with diarrhea and febrile illness in each of the seven divisions of Bangladesh in order to design wider country wide program

Funding Source

Bill and Melinda Gates Fndn.

Start date

2015

End date

2017