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Sexual Dimorphism in the Inflammatory Response to Biomaterials

Investigators
Chen, James
Institutions
DHHS/FDA - National Center for Toxicological Research
Objective
Determine if a sex difference in the in vitro response of human monocytes and mouse peritoneal macrophages to various biomaterials can be demonstrated. Based on existing literature, we hypothesize that there will be a significant sex difference in the synthesis and release of inflammatory mediators that could influence the biocompatibility of the material.
Funding Source
Nat'l. Center For Toxicological Research
Project number
E0696301