An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Studies to Reduce Transmission of H5N1 HPAI Virus, and Assess Infectivity and Transmissibility of H5N1 HPAI Viruses for Pigs

Investigators
Swayne, David
Institutions
USDA - Agricultural Research Service
Start date
2008
End date
2010
Objective
  1. Investigate modified simple slaughter methods to reduce aerosol generation during home slaughter process and determine the impact of such improvements on reducing virus transmission.
  2. Improved methods of evaluating vaccine efficacy in poultry AI vaccines.
  3. Determining infectivity, transmissibility, and pathogenicity of 5 isolates of H5N1 highly pathogenic avian influenza virus (HPAIV) for pigs.
More information
APPROACH: Aerosol generation and virus levels will be measured in rooms conducting simulated home processing of asymptomatic H5N1 HPAI virus infected chickens. A simple, plastic-bag method for processing will be evaluated for reducing aerosol and virus generation and reducing transmission to chicken and ferret models. Develop attenuated H5 AI viruses that will be used to produce reference antibodies from chickens for testing cross neutralization of H5 HPAI viruses in a chicken egg neutralizing test as a means to assess vaccines seed strain efficacy against drift variant field viruses. Five H5N1 HPAI viruses will be intrabronchally inoculated into pigs and examined for contact transmission. Pigs will be examined for infection by serology, virus isolation, and RRT-PCR assays.
Funding Source
Agricultural Research Service
Project number
6612-32000-048-26R
Accession number
414328
Categories
Viruses and Prions
Bacterial Pathogens
Commodities
Eggs
Meat, Poultry, Game