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Systemic Spread of Listeria Monocytogenes After Oral Infection

Investigators
D'Orazio, Sarah
Institutions
University of Kentucky
Start date
2011
End date
2012
Objective
No abstract available.
More information
Public Health Relevance: Listeria monocytogenes (Lm) infections occur following the ingestion of contaminated ¿ready-to-eat¿ food products such as unpasteurized cheeses and deli meats and have a high mortality rate, particularly for some pregnant women/neonates and people over the age of 60. In this study, we are testing the idea that Lm elicits a strong protective immune response in most individuals that will limit the infection to a mild gastroenteritis. We predict that in susceptible individuals who lack the ability to mount this innate immune response, unrestricted growth of Lm will result in systemic spread and invasion of the central nervous system.
Funding Source
Nat'l. Inst. of Allergy and Infectious Diseases
Project source
View this project
Project number
1R56AI091918-01A1
Categories
Bacterial Pathogens
Listeria
Commodities
Meat, Poultry, Game
Dairy