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Toxicants in Human Placentae and Reproductive Outcomes in Ukraine

Investigators
Little, Ruth
Institutions
DHHS/NIH - National Institute of Environmental Health Sciences
Start date
2000
End date
2000
Objective
We have collected data on over 3,000 pregnant women in two urban areas of Ukraine, a former Soviet republic, where pollution is reputedly high; we took placentas and breast milk from 2,200 of them during delivery and hospitalization. We have been analyzing these data and have now published findings on all the pollutants that were studied.
More information
In general, the toxicants appear at such low levels in this sample, in spite of reports of high pollution, that the effect on reproductive outcomes cannot be addressed. However, we have described the outcome of pregnancy in this population. Sixty percent of all pregnancies were terminated. The rate of preterm birth in our sample is remarkably low, but this is ascribed to the high fetal death rate at low gestational ages, and the high prevalence of prematurity (the preterm rate is computed on live births only). Risk factors for preterm birth have been addressed in the two urban areas, and will continue with an examination of the rate of low birth weight.
Funding Source
Nat'l. Inst. of Environmental Health Sciences
Project number
1Z01ES049010-07
Categories
Sanitation and Quality Standards
Bacterial Pathogens