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TRANSLATING A DISCOVERY INTO IMPROVING FOOD SAFETY: A NOVEL POULTRY SALMONELLA VACCINE AND DIAGNOSTIC METHODOLOGY TO CONTROL FOODBORNE SALMONELLOSIS

Investigators
Kariyawasam, Subhashinie
Institutions
University of Florida
Start date
2021
End date
2023
Objective
Long-term goal. The long-term goal of this proposal is to reduce foodborne outbreakscaused bynontyphoidal Salmonella associated with poultry meat, eggs, and poultry products by minimizing Salmonella colonization of chickens and contamination of shell eggs by developing an effective vaccine, which can provide protectionagainst multiple Salmonella serovars and a high throughput rapid diagnostic tool for the detection of Salmonella in shell eggs.The specific objectives of the proposal are to:i. Assess the immmunogenicty and efficcay of InvG protein of Salmonella Enteritidis against a challenge of S. Enteritidis in chickens.ii. Determine if antibodies against InvG can transfer passively from vaccinated hens to progeny chickens, thus providing protection against homologous and heterologous Salmonella.iii. Construct an E. coli-vectored vaccine expressing InvG to minimize colonization of chicken intestines and ovaries by nontyphoidal Salmonella.iv. Establish a proof of concept, high throughput, rapid test for targeting InvG on the surface of Salmonella found in shell eggs.
Funding Source
Nat'l. Inst. of Food and Agriculture
Project source
View this project
Project number
FLA-VME-005992
Accession number
1023994
Categories
Salmonella
Parasites
Natural Toxins
Viruses and Prions
Bacterial Pathogens
Chemical Contaminants
Commodities
Meat, Poultry, Game