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Treatment for GBS Colonization in Pregnant Women

Investigators
Norbury, Kenneth
Institutions
Biomedical Development Corporation
Start date
1997
End date
2003
Objective
The goal of this project is to further develop Iocide, a novel iodine-based antimicrobial technology, for use as a topical bacteriocide for group B streptococci (GBS) in the vaginal tract of pregnant women during the intrapartum period.
More information
GBS is the leading cause of neonatal bacterial disease and death, and most frequently occurs in neonates as sepsis, meningitis, and pneumonia. Despite clinical advances to date, GBS continues to be a major cause of illness and death among newborns. Due to the limitations of current clinical strategies, a need exists for alternate approaches to prevent GBS-related neonatal disease.

The following specific aims have been designed to achieve this goal:

  1. To optimize the formulation of the Iocide vaginal gel,
  2. to determine the effective range of Iocide in vitro,
  3. to demonstrate safety and efficacy to the Iocide in animals, and
  4. to determine safety and efficacy of Iocide in human clinical trials.
Funding Source
Nat'l. Inst. of Child Health and Human Devel.
Project number
2R44HD034990-02