Allergy

Fri, 12/11/2020 - 22:04
In addition to known allergens, other proteins in pollen can aid the development of an immune response in allergic individuals. The contribution of the “unknown” protein allergens is apparent in phylogenetically related species where, despite of high homology of the lead allergens, the degree of allergenic potential can vary greatly. The aim of this study was to identify other potentially...
Sat, 11/28/2020 - 22:08
Cephalosporins are, after penicillins, the most important β‐lactam inductors of immediate allergic reactions. Their antigenic determinants are not completely identified due to difficulties for studying the structure of cephalosporin‐protein conjugates, hampering the existence of in vitro tests with enough sensitivity to detect cephalosporin allergy.1 Therefore, the only diagnostic standardised...
Fri, 11/20/2020 - 22:07
Peanut allergy (PA) currently affects approximately 2% of the general population of Western nations and may be increasing in prevalence. Patients with PA and their families/caregivers bear a considerable burden of self‐management to avoid accidental peanut exposure and to administer emergency medication (adrenaline) if needed. Compared with other food allergies, PA is associated with higher rates...
Thu, 11/05/2020 - 22:09
Background Atabecestat is an orally administered BACE inhibitor developed to treat Alzheimer’s disease. Elevations in hepatic enzymes were detected in a number of in trial patients, which resulted in termination of the drug development programme. Immunohistochemical characterization of liver tissue from an index case of atabecestat‐mediated liver injury revealed an infiltration of T‐lymphocytes...
Sun, 11/01/2020 - 22:09
In past ten years, microRNAs (miRNAs) have gained scientific attention due to their importance in the pathophysiology of allergic diseases and theirpotential as biomarkersin liquid biopsies. They act as master post‐transcriptional regulators that control most cellular processes. As one miRNA can target several mRNAs, often within the same pathway, dysregulated expression of miRNAs may alter...
Wed, 10/21/2020 - 22:09
Background Heat‐and pepsin‐sensitive plant food allergens (PR‐10 and profilin) sometimes cause systemic reaction. Objective To detect the risk factors for systemic reactions induced by labile food allergens. Methods A retrospective multicenter study was performed on patients with a documented history of systemic allergic reaction to labile plant food allergens and on age‐matched controls with a...
Tue, 09/22/2020 - 22:10
Coronavirus disease‐19 (COVID‐19) is a new disease caused by SARS‐CoV‐2. Since the beginning of 2020, it has become one of the main challenges of our times, causing a high incidence of severe pneumonia, acute respiratory distress syndrome (ARDS), multiorgan failure and death1. At the root of COVID‐19 lies the sudden development of ‘cytokine storms’, hyper‐inflammatory responses involving the...
Tue, 09/08/2020 - 22:10
Modern healthcare requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping and the development and application of reliable biomarkers. A detailed clinical history and...
Mon, 08/24/2020 - 21:26
Large differences in COVID‐19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage were associated with low death rates in...
Sun, 06/07/2020 - 22:08
Background Childhood asthma is a multifactorial inflammatory condition of the airways, associated with specific changes in respiratory microbiome and circulating metabolome. Methods To explore the functional capacity of asthmatic microbiome and its intricate connection with the host, we performed shotgun sequencing of airway microbiome and untargeted metabolomics profiling of serum samples in a...
Mon, 04/06/2020 - 03:16
Background Betalactam (BL) antibiotics are the most common cause of drug hypersensitivity. Amoxicillin (AX), which is often prescribed alongside clavulanic acid (Clav), is the most common elicitor. The aim of this study was to determine whether AX and Clav‐responsive T‐cells are detectable in patients with immediate hypersensitivity to AX‐Clav, to assess whether these T‐cells display the same...
Sun, 02/09/2020 - 03:17
IgE mediated food allergy remains a significant and growing problem across the globe. Of the various treatment modalities, oral immunotherapy (OIT) and epicutaneous immunotherapy (EPIT) have been the best studied. Across various studies of OIT for egg, milk and peanut allergy, strong levels of desensitization have been shown. With egg and peanut OIT, a limited remission, or sustained...
Thu, 11/28/2019 - 03:28
Since the introduction of allergen immunotherapy (AIT) over 100 years ago, focus has been on standardization of allergen extracts, with reliable molecular composition of allergens receiving the highest attention. While adjuvants play a major role in European AIT, they have been less well studied. In this Position Paper we summarize current unmet needs of adjuvants in AIT citing current evidence....
Thu, 10/10/2019 - 03:20
The achievement of long lasting, safe treatments for food allergy is dependent on the understanding of the immunological basis of food allergy. Accurate diagnosis is essential for management. In recent years, data from oral food challenges have revealed that routine allergy testing is poor at predicting clinical allergy for tree nuts, almonds in particular. More advanced antigen‐based tests...
Sun, 10/06/2019 - 03:19
Introduction Hypersensitivity to non‐steroidal anti‐inflammatory drugs (NSAIDs) are of great concern because they are frequently encountered in daily clinical practice. Drug provocation tests (DPT) are particularly needed for NSAIDs. Methods The aim of this retrospective study was to detect eliciting dose thresholds during NSAIDs DPT in order to suggest optimal step doses, using the survival...