Annals of the New York Academy of Sciences

The Research Publications track research that is published across national and international peer-reviewed journals. The most recent articles are available ahead of print and searchable by Journal Title, Subject, USDA Grant Funding Agencies or FDA Grant Funding Agencies. The research publications are tracked across five subject areas: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, and Viruses.

Mon, 07/27/2020 - 22:11
Achalasia is a primary motility disorder of the esophagus, and while there are several treatment options, there is no consensus regarding them. When therapeutic intervention for achalasia fails, a careful evaluation of the cause of the persistent or recurrent symptoms using upper endoscopy, esophageal manometry, and contrast radiologic studies is required to understand the cause of therapy...
Mon, 07/06/2020 - 22:12
In this review, we highlight new and emerging metrics and tools in esophageal function testing and the clinical manifestations and management of esophageal involvement in connective tissue disorders. Abstract This work summarizes new and emerging metrics and tools in esophageal function testing and their potential clinical impact. Because the diagnostic sensitivity and reliability of conventional...
Fri, 06/05/2020 - 22:11
In this review and synthesis, we explore how global change can cause populations to become maladapted and how populations, in turn, exhibit adaptive or maladaptive responses to global change. We use the metaphor of a “double‐edged sword” to explore these evolutionary responses to global change. As the double‐edged sword has both beneficial and detrimental effects, evolutionary responses to global...
Tue, 12/03/2019 - 03:34
Our review provides a comprehensive treatise on the progress in understanding teixobactin chemistry, structure−activity relationships, and mechanisms of antibacterial activity. Teixobactin represents an exciting starting point for the development of new antibiotics that can be used to combat multidrug‐resistant bacterial (“superbug”) infections. Abstract The discovery of antibiotics has led to...
Thu, 11/07/2019 - 03:19
Neuropeptides function as neuromodulators in the brain, whereby they are released in a paracrine manner and activate G protein–coupled receptors in adjacent cells. Because neuropeptides are made in, and secreted from, cancer cells, then bind to cell surface receptors, they function in an autocrine manner. Bombesin (BB)‐like peptides synthesized by neuroendocrine tumor small cell lung cancer bind...
Tue, 10/08/2019 - 03:22
In this review, we focus on how full‐length chromogranin A and its peptides, including PST, vasostatin‐1, CST, and serpinin, as important modulators of cardiovascular functions, immunometabolism, and cancer. Abstract Chromogranin A (CgA)—the index member of the chromogranin/secretogranin secretory protein family—is ubiquitously distributed in endocrine, neuroendocrine, and immune cells. Elevated...
Wed, 09/25/2019 - 03:21
Whole‐genome sequence analysis was performed on a multidrug‐resistant Providencia rettgeri PR002 clinical strain isolated from the urine of a hospitalized patient in Pretoria, South Africa, in 2013. The array, multiplicity, and diversity of resistance and virulence genes in this strain are concerning, necessitating stringent infection control, antibiotic stewardship and periodic resistance...
Sun, 09/22/2019 - 03:18
We performed a literature search for English research papers, published between 2013 and 2018, reporting on plasmid‐mediated carbapenem resistance. A rise in both carbapenemase types and associated plasmid replicon groups was seen, with China, Canada, and the United States recording a higher increase than other countries. Most reported plasmids were conjugative but not present in multiple...