Annals of the New York Academy of Sciences

Tue, 12/03/2019 - 03:34
Our review provides a comprehensive treatise on the progress in understanding teixobactin chemistry, structure−activity relationships, and mechanisms of antibacterial activity. Teixobactin represents an exciting starting point for the development of new antibiotics that can be used to combat multidrug‐resistant bacterial (“superbug”) infections. Abstract The discovery of antibiotics has led to...
Thu, 11/07/2019 - 03:19
Neuropeptides function as neuromodulators in the brain, whereby they are released in a paracrine manner and activate G protein–coupled receptors in adjacent cells. Because neuropeptides are made in, and secreted from, cancer cells, then bind to cell surface receptors, they function in an autocrine manner. Bombesin (BB)‐like peptides synthesized by neuroendocrine tumor small cell lung cancer bind...
Tue, 10/08/2019 - 03:22
In this review, we focus on how full‐length chromogranin A and its peptides, including PST, vasostatin‐1, CST, and serpinin, as important modulators of cardiovascular functions, immunometabolism, and cancer. Abstract Chromogranin A (CgA)—the index member of the chromogranin/secretogranin secretory protein family—is ubiquitously distributed in endocrine, neuroendocrine, and immune cells. Elevated...
Wed, 09/25/2019 - 03:21
Whole‐genome sequence analysis was performed on a multidrug‐resistant Providencia rettgeri PR002 clinical strain isolated from the urine of a hospitalized patient in Pretoria, South Africa, in 2013. The array, multiplicity, and diversity of resistance and virulence genes in this strain are concerning, necessitating stringent infection control, antibiotic stewardship and periodic resistance...
Sun, 09/22/2019 - 03:18
We performed a literature search for English research papers, published between 2013 and 2018, reporting on plasmid‐mediated carbapenem resistance. A rise in both carbapenemase types and associated plasmid replicon groups was seen, with China, Canada, and the United States recording a higher increase than other countries. Most reported plasmids were conjugative but not present in multiple...