Current Opinion in Microbiology

Tue, 08/11/2020 - 06:16
Author(s): Hiroshi Ashida, Toshihiko Suzuki, Chihiro Sasakawa In response to bacterial infection, epithelial cells undergo several types of cell death, including apoptosis, necrosis, pyroptosis, and necroptosis, which serve to expel the infected cells and activate the innate and acquired immune responses. Shigella initially invades macrophages and subsequently surrounding enterocytes; the...
Sat, 02/15/2020 - 03:24
Author(s): Lalita RamakrishnanThirty years ago Stanley Falkow formulated molecular Koch’s postulates as a framework to help dissect the contribution of microbial genes to their pathogenicity (Box 1). Three years later, his advice led me to develop Mycobacterium marinum, a close genetic relative of Mycobacterium tuberculosis, as a model for tuberculosis pathogenesis. Here, I discuss insights into...
Thu, 02/13/2020 - 03:38
Author(s): Antonio Serapio-Palacios, Barton Brett FinlayEnteropathogenic Escherichia coli (EPEC) is an important cause of infant diarrhea and mortality worldwide. The locus of enterocyte effacement (LEE) pathogenicity island in the EPEC genome encodes a type 3 secretion system (T3SS). This nanomachine directly injects a sophisticated arsenal of effectors into host cells, which is critical for...
Sun, 02/09/2020 - 03:23
Author(s): Ila Anand, Wonyoung Choi, Ralph R IsbergIntravacuolar bacterial pathogens establish intracellular niches by constructing membrane-encompassed compartments. The vacuoles surrounding the bacteria are remarkably stable, facilitating microbial replication and preventing exposure to host cytoplasmically localized innate immune sensing mechanisms. To maintain integrity of the membrane...
Sat, 02/08/2020 - 03:23
Author(s): Corrella S DetweilerBacterial pathogens must resist host innate immunity to cause disease. While Gram-negative bacteria have a protective outer membrane, this membrane is subject to host-induced damage that makes these pathogens vulnerable. We developed a high content screening platform that identifies compounds that cause the killing of the bacterial pathogen Salmonella enterica in...
Thu, 12/06/2018 - 01:11
Publication date: February 2019Source: , Volume 47Author(s): Victoria KorolikCampylobacter jejuni is a ubiquitous gastrointestinal pathogen, transmitted to humans from birds and animals, where C. jejuni is part of normal intestinal flora. In C. jejuni, similar to other motile bacteria, chemotaxis pathway and the array of chemosensors sense and respond to external stimuli with unique precision and...
Thu, 12/06/2018 - 01:11
Publication date: February 2019Source: , Volume 47Author(s): Brittany R Ruhland, Michelle L ReniereListeria monocytogenes (Lm) is a Gram-positive bacterium that thrives in nature as a saprophyte and in the mammalian host as an intracellular pathogen. Both environments pose potential danger in the form of redox stress. In addition, endogenous reactive oxygen species (ROS) are continuously...