Fish & Shellfish Immunology

The Research Publications track research that is published across national and international peer-reviewed journals. The most recent articles are available ahead of print and searchable by Journal Title, Subject, USDA Grant Funding Agencies or FDA Grant Funding Agencies. The research publications are tracked across five subject areas: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, and Viruses.

Tue, 05/12/2020 - 03:31
Author(s): Qingqing Liu, Wei Wang, Yiming Zhang, Yuan Cui, Shiwen Xu, Shu Li Bisphenol A (BPA) is an industrial raw material widely used in water bottles, medical devices and food packaging, and is now ubiquitous in the environment. However, the effects of BPA on the toxicity of fish lymphocytes and the roles of microRNA (miRNA) in this process remain poorly understood. To explore the mechanism,...
Sat, 05/02/2020 - 03:30
Author(s): Heqian Zhang, Wenzhi Cheng, Libing Zheng, Panpan Wang, Qinghui Liu, Zhen Li, Tianjiao Li, Yiming Wei, Yong Mao, Xiangyong Yu Anti-lipopolysaccharide factor (ALF), which belongs to the antimicrobial peptide (AMP) family, has become a relatively new weapon to combat severe infections and has been demonstrated to be active against bacteria, fungi and some viruses. In the present study, a...
Thu, 04/30/2020 - 03:33
Author(s): Xuhui Zhang, Zhiyuan Sun, Jinfeng Cai, Jiahong Wang, Guibin Wang, Zunling Zhu, Fuliang Cao This study was aimed to evaluate the effects of partial replacement of fish meal by fermented moringa leaves (FMLs) on growth performance, serum biochemistry, antioxidant status, nonspecific immunity, and resistance against Aeromonas hydrophila in juvenile gibel carp (Carassius auratus gibelio...
Thu, 04/16/2020 - 03:23
Author(s): Long Zhang, Ruixue Shi, Haofeng Ouyang, Yanhe Li Carbohydrate sulfotransferases 11 (chst11) is one of the enzymes that synthesize chondroitin sulfate (CS), which has extensive immune functions in vitro and plays a critical role in mediating the infection of host by pathogenic microorganisms. However, whether it has immune functions in crayfish is still poorly understood. In our...
Wed, 04/08/2020 - 03:27
Author(s): Shulin Liu, Aiguo Zhou, Shaolin Xie, Di Sun, Yue Zhang, Zhuolin Sun, Yanfeng Chen, Jixing Zou The great Gambusia affinis (G. affins) is considered as a important animal model to study the endocrine disruption, ecological behavior, and environmental pollutant. The present study aims to build a new promising infection model with A. hydrophila in aquaculture. The mRNA expression of Rac1,...
Tue, 04/07/2020 - 03:40
Author(s): Waode Munaeni, Widanarni, Munti Yuhana, Mia Setiawati, Aris Tri Wahyudi This study investigated the influence of Eleutherine bulbosa (Mill.) Urb. on the immune responses, bacterial population in the intestines, and resistance of white shrimp, Litopenaeus vannamei, against infection with Vibrio parahaemolyticus. Shrimp were fed with three dosages of powder, at 6.25 g kg–1 (P6.25), 12.5 ...
Fri, 04/03/2020 - 03:22
Author(s): Thais Heloisa Vaz Farias, Salvador Arijo, Alberto Medina, Gabriela Pala, Ed Jonny da Rosa Prado, Hélio José Montassier, Fabiana Pilarski, Marco Antonio de Andrade Belo Aeromonas hydrophila is responsible for outbreaks of a severe infectious disease in fish farms around the world and is one of the major causes of economic losses to the neotropical fish farmers. This study assessed the...
Mon, 03/30/2020 - 03:22
Author(s): Jorge Silva-Jara, Carlos Angulo, María Esther Macias, Carlos Velazquez, Crystal Guluarte, Martha Reyes-Becerril In México, the infusion of Jatropha vernicosa stem bark has been used in folk medicine for many clinical situations, but no reports were available about this particular species of Jatropha in fish of mammals. In this first screening report, the phytochemical, antioxidant...
Mon, 03/30/2020 - 03:21
Author(s): Tengfei Liu, Yongjie Wu, Yawen Han, Qingyang Liu, Shulin Chen, Huiying Zhao Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of crucial signaling molecules that mediate the signal transduction of various immune signaling pathways. Extensive studies have demonstrated that TRAFs play vital roles in regulating cellular immune responses. However, the biological...
Sat, 03/07/2020 - 03:21
Author(s): Shuai Liu, Chenyuan Pan, Yi Tang, Fangyi Chen, Ming Yang, Ke-Jian Wang Bisphenol A (BPA), a well-known environmental endocrine-disrupting chemical (EDC), could pose a great toxicity risk to aquatic organisms. The present study aimed to evaluate the underlying role of long non-coding RNAs (lncRNAs) in BPA-induced immunotoxicity in head kidney (HK) macrophages of the red common carp (...
Fri, 03/06/2020 - 03:40
Author(s): Sukanta Kumar Nayak Infectious diseases are adversely affecting aquaculture practices throughout world and Asian countries are no exception. Indian aquaculture practices are facing serious setback due to a variety of infectious agent's which are responsible for severe mortality and morbidity of all the cultured freshwater fish species leading to severe economic losses. The emergence of...
Thu, 02/20/2020 - 03:25
Author(s): Xiao-bo Yan, Xiao-hui Dong, Bei-ping Tan, Shuang Zhang, Shu-yan Chi, Qi-huiYang, Hong-yu Liu, Yuan-zhi YangAbstractThe aim of this study was to investigate the effects of feeding alternative dietary oils to hybrid grouper fish (♀Epinephelus fuscoguttatus × ♂E. lanceolatu) on their growth, histological morphology of hepatocytes, disease resistance, immune response, and expression of...
Sat, 02/15/2020 - 03:23
Author(s): Ryunkyoung Oh, Min Jeong Lee, Young-Ok Kim, Bo-Hye Nam, Hee Jeong Kong, Ju-Won Kim, Jung-yeon Park, Jung-Kil Seo, Dong-Gyun KimAbstractWe isolated and purified an antimicrobial peptide (AMP) from the mantle of the hard-shelled mussel, Mytilus coruscus. The peptide was purified through C18 reversed-phase high-performance liquid chromatography, and displayed antibacterial activity. Total...
Fri, 02/14/2020 - 03:23
Author(s): Pan Wu, Liying Xie, Yanling Wang, Yubo Cui, Zhaobo Chen, Xuejun Zou, Hui Ge, Chengjiang Ruan, Ying Zhang, Hua JinAbstractApplication of traditional bait in aquaculture caused environment pollution and disease frequent occurrence. Residual papaya could be re-utilized to culture Tilapia mossambica as dietary supplement. Therefore, a novel integrated system of the improvement of yield,...
Wed, 02/12/2020 - 10:48
Author(s): Sun Jiaxin, Wang Shengchen, Cao Yirong, Wang Shuting, Li ShuAbstractCadmium (Cd) is a bioaccumulative toxic heavy metal element that has been shown to cause irreversible damage to the immune system once contaminated with water, thereby jeopardizing the health of fish and other aquatic organisms. Neutrophils react against multiple invading pathogens through different mechanisms. The...
Wed, 02/12/2020 - 03:22
Author(s): Keqiang Wei, Yue Wei, Changxia SongAbstractThere has been extensive research on local and systemic oxidative stress and immunosuppression in cadmium exposed crustaceans, but the underlying mechanisms remain to be elucidated. Because of multiple functions of epithelial cells, such as storing and detoxifying heavy metals, producing and secreting immune-related molecules (i.e. hemocyanin...
Sat, 02/08/2020 - 03:23
Author(s): Andre P. Van, Neila Alvarez de Haro, James E. Bron, Andrew P. DesboisAbstractNeutrophils release nuclear chromatin decorated with antimicrobial proteins into the extracellular milieu as an innate immune defence mechanism to counter invading microbes. These chromatin structures, called extracellular traps (ETs) and released by a process called NETosis, have been detected in mammals,...
Sat, 02/08/2020 - 03:23
Author(s): Anying Zhang, Xiaoyu Jian, Dan Wang, Jingqi Ren, Xinyan Wang, Hong ZhouAbstractIn mammals, interleukin 21 (IL-21) is a broad pleiotropic cytokine that plays critical roles in the development of several inflammatory and autoimmune diseases. In fish, functional information of Il-21 is limited, and its role in immune response is largely unknown. In the present study, we cloned a coding...
Fri, 02/07/2020 - 03:44
Author(s): Zhuoxing Zhang, Chao Zhang, Xiaoling Dai, Ruidong Zhang, Xueying Cao, Kaiqiang Wang, Xin Huang, Qian RenAbstractNuclear factor κB (NF-κB) plays a key role in the innate immunity of invertebrates. Relish belongs to the NF-κB family. In insects, alternative splicing induces the sequence diversity of the Relish gene. However, information on the roles of various relish isoforms in...
Fri, 02/07/2020 - 03:44
Author(s): Le Fei Jiao, Tian Meng Dai, Sun Qian Zhong, Min Jin, Peng Sun, Qi Cun ZhouAbstractThe intestine is the primary target of pathogenic microbes during invasion. However, the interaction of Vibrio parahaemolyticus (V. parahaemolyticus) with intestinal epithelial cells and its effects on the intestinal function of Litopenaeus vannamei (L. vannamei) are poorly studied. Therefore, the aim of...
Thu, 02/06/2020 - 03:25
Author(s): Sheng-Wei Luo, Zi-Ye Luo, Teng Yan, Kai-Kun Luo, Ping-Hui Feng, Shao-Jun LiuAbstractHepcidin, a multifunctional hormone oligopeptide, not only exhibits a regulatory role in iron metabolism, but also participates in the regulation of teleostean immunity. In this study, ORF sequence of WR-hepcidin was 258 bp and encoded 85 amino acid residues. Tissue-specific analysis revealed that the...
Wed, 02/05/2020 - 03:24
Author(s): Xing-Wei Liu, Lin Feng, Wei-Dan Jiang, Pei Wu, De-Min Yang, Ling Tang, Sheng-Yao Kuang, He-Qun Shi, Xiao-Qiu Zhou, Yang LiuAbstractThe present study evaluated the effects of (2-Carboxyethyl)dimethylsulfonium Bromide (Br-DMPT) supplementation on the intestinal immune function and potential mechanisms of on-growing grass carp (Ctenopharyngodon idella) by feeding fish (initial weight 216....
Mon, 02/03/2020 - 03:23
Author(s): Yan-li Su, Guang-hua Wang, Jing-jing Wang, Bing Xie, Qin-qin Gu, Dong-fang Hao, Hong-mei Liu, Min ZhangAbstractAt present, several reports have indicated that the C-terminal peptides of tissue factor pathway inhibitor 1 (TFPI-1) were active antibacterial peptides. However, the functions of TFPI-1 C-terminal peptides in teleost are still very limited. In this study, a C-terminal peptide...
Wed, 01/29/2020 - 03:40
Author(s): Junchang Feng, Zhongliang Cai, Yongyan Chen, Haoyong Zhu, Xulu Chang, Xianfeng Wang, Zhen Liu, Jianxin Zhang, Guoxing NieAbstractMicrobial exopolysaccharides (EPS) from Lactococcus have been found to have an important role in the probiotic activity of this bacterium; however, the immunomodulatory and antioxidant activities have not been fully explored in aquaculture. In the present...
Fri, 01/24/2020 - 03:22
Author(s): Junjie Nie, Zhixue Yu, Defu Yao, Fan Wang, Chunhua Zhu, Kaihui Sun, Jude Juventus Aweya, Yueling ZhangAbstractThe histone deacetylase, sirtuin 6 (SIRT6), plays an essential role in the regulation of oxidative stress, mitochondrial function and inflammation in mammals. However, the specific role of SIRT6 in invertebrate immunity has not been reported. Here, we characterized for the...
Thu, 01/16/2020 - 03:22
Author(s): Lang Lang, Minnan Bao, Weixin Jing, Wei Chen, Lan WangAbstractToll is essential in innate immune system which is important for defense against bacterial, fungal and viral infections in invertebrates. Our previous study showed that cadmium (Cd) could change the expression pattern of ShToll3 in the epithelium (gills and midgut from the freshwater crab Sinopotamon henanense) infected by...
Wed, 01/15/2020 - 03:22
Author(s): A. Panigrahi, R.R. Das, M.R. Sivakumar, A. Saravanan, C. Saranya, N.S. Sudheer, K.P. Kumaraguru Vasagam, P. Mahalakshmi, S. Kannappan, G. GopikrishnaAbstractEffect of bio-augmentation of Bacillus spp in biofloc on growth, survival and immunity in Indian white shrimp Penaeus indicus was evaluated. Nine Bacillus strains were isolated and screened individually as well as in the form of a...
Thu, 01/09/2020 - 03:39
Author(s): Hourong Liu, Chengwen Song, Junhao Ning, Yuan Liu, Zhaoxia CuiAbstractVariable lymphocyte receptors (VLRs) play an important role via their antigen-special reorganization in jawless vertebrates (agnathans) adaptive immune response. In the present study, the open reading frame (ORF) of Eriocheir sinensis VLRA (designated as EsVLRA) was identified. EsVLRA comprised a 799-amino-acid...
Wed, 01/08/2020 - 03:25
Author(s): Xifeng Qiao, Pingchao Li, Jianan He, Zeshu Yu, Jiaxing Chen, Liangge He, Xue Yu, Haoran Lin, Danqi Lu, Yong ZhangAbstractScavenger receptors play a central role in defending against infectious diseases in mammals. However, the function of SRECII remains unknown in teleost fish. In this study, type F scavenger receptor expressed by endothelial cells-II (SRECII) cDNA sequence was first...
Sun, 01/05/2020 - 03:23
Author(s): Zhuojun Han, Yi Zhou, Xiaojin Zhang, Jinpeng Yan, Jun Xiao, Yongju Luo, Huifang Zheng, Huan ZhongAbstractGhrelin is a peptide hormone secreted by gastrointestinal tract which regulates multiple physiological processes such as appetite, metabolism, growth and gonad development in fish. In the present study, the effects of ghrelin on hybrid tilapia infected with Aeromonas hydrophila are...
Sat, 01/04/2020 - 03:24
Author(s): Lei Liu, Yunfei DangAbstractMannose-binding lectin (MBL) is a crucial pattern recognition receptor in the host innate immune system. Previously, we reported the biological function of Ctenopharyngodon idella MBL (CiMBL) in initiating the lectin pathway of the complement system. In the present study, we further explored its biological function including the agglutinating ability,...
Sat, 01/04/2020 - 03:24
Author(s): Xiaoling Dai, Xin Huang, Zhuoxing Zhang, Ruidong Zhang, Xueying Cao, Chao Zhang, Kaiqiang Wang, Qian RenAbstractInnate immunity is the primary defense of crustaceans against pathogens. Crustins, as antimicrobial peptides, are important to crustacean innate immunity. In this study, two kinds of Gly-rich crustin genes were cloned from Macrobrachium nipponense and were referred to as Mn-...
Sat, 01/04/2020 - 03:24
Author(s): Chao Zhang, Xueying Cao, Kaiqiang Wang, Xiaoling Dai, Ruidong Zhang, Zhuoxing Zhang, Xin Huang, Qian RenAbstractTranscription factor activator protein 1 (AP1) plays an irreplaceable role in the response to a variety of external stimulants, such as cellar stress, bacterial and viral infections, and inflammatory cytokines. In this study, we identified a novel AP1 gene from Macrobrachium...
Mon, 12/30/2019 - 03:24
Author(s): Limei Qiu, Hao Chen, Zhi Zhou, Huan Zhang, Rui Liu, Qilin Yi, Chuanyan Yang, Lei Gao, Lingling WangAbstractOyster Crassostrea gigas, is considered as a useful environmental indicator since it is widely distributed along the intertidal zone whereby it tends to accumulate cadmium and is always exposed to various pathogen agents. However, its molecular responses to both cadmium and...
Mon, 12/30/2019 - 03:24
Author(s): Chunling Wang, Xiaodan Wang, Shusheng Xiao, Xianyong Bu, Zhideng Lin, Changle Qi, Jian G. Qin, Liqiao ChenAbstractThe T-2 toxin is a trichothecene mycotoxin and is highly toxic to aquatic animals, but little is known on its toxic effect in crustaceans. In the present study, the crab juveniles were fed with diets containing four levels of T-2 toxin: 0 (control), 0.6 (T1), 2.5 (T2) and 5...
Thu, 12/26/2019 - 03:23
Author(s): Jianhua Ming, Jinyun Ye, Yixiang Zhang, Qiyou Xu, Xia Yang, Xianping Shao, Jun Qiang, Pao XuAbstractThis study investigated the effects of dietary curcumin on growth performance, non-specific immunity, antioxidant capacity and related genes expression of NF-κB and Nrf2 signaling pathways in grass carp (Ctenopharyngodon idella). A total of 525 juvenile grass carps with mean initial body...
Thu, 12/26/2019 - 03:23
Author(s): Yuan Fang, Xiao-yan Xu, Yubang Shen, Jiale LiAbstractCtenopharyngodon idella growth arrest and DNA damage-inducible 45 ab (CiGadd45ab) is a subtype of the Gadd45a gene of the Gadd45 family in grass carp. There is increasing evidence that microRNAs (miRNAs) are involved in the regulation of inflammatory and apoptotic responses. However, little is known about the regulatory effects of...
Wed, 12/25/2019 - 03:22
Author(s): Wenjie Xu, Hongyan Li, Liyun Wu, Junyan Jin, Xiaoming Zhu, Dong Han, Haokun Liu, Yunxia Yang, Xudong Xu, Shouqi XieAbstractThis study was conducted to investigate the effect of dietary Scenedesmus ovalternus on the growth and disease resistance of gibel carp (Carassius gibelio) during overwintering. Gibel carp (initial body weight: 90.39 ± 0.33 g) were fed with diets containing 0% or 4...
Wed, 12/25/2019 - 03:22
Author(s): Zhongyu Zhang, Gaoyang Liu, Rui Ma, Xiaozhou Qi, Gaoxue Wang, Bin Zhu, Fei LingAbstractAeromonas hydrophila is a strong gram-negative bacterium that can cause a mass death of grass carp, and result in the huge economic loss. Development of practical vaccines is the best way to control the outbreak of this bacterial disease. In this study, a whole-cell inactivated vaccine was obtained...
Sun, 12/22/2019 - 03:22
Author(s): Xue Kong, Yanan Li, Haibin ZhangAbstractHydrothermal vents and cold seep zones are two special habitats in the deep sea. These habitats are always dark, and have extreme temperatures (low or high), heavy metals and toxic substances (sulfide, methane). Vesicomyidae clams, which maintain endosymbionts in their gills, are common species in these two special zones and are thought to...
Sun, 12/22/2019 - 03:22
Author(s): Yue Wang, Xue-Peng Wang, Bin Zhang, Zhi-Min Li, Li-Guo Yang, Xin-Cang Li, Hongyu MaAbstractLysin motif (LysM)-containing proteins function as pattern-recognition receptors in plants to recognize different N-acetylglucosamine-containing ligands, thereby triggering specific defense responses against pathogens. However, the biological functions of these proteins in animals remain unclear...
Sat, 12/21/2019 - 03:39
Author(s): Le He, LiQun Wu, YiJun Tang, Peng Lin, ShaoWei Zhai, YiQun Xiao, SongLin GuoAbstractIn cultivated European eels, Aeromonas hydrophila, Edwardsiella anguillarum and Vibrio vulnificus are three important bacterial pathogens. In this study, an expressed recombinant Outer membrane proteinⅡ (rOmpⅡ) from A. hydrophila was intraperitoneally injected into European eels (Angullia angullia). All...
Fri, 12/20/2019 - 03:24
Author(s): Yunkun Li, Puzhen Xia, Jiayu Wu, Anqi Huang, Guixian Bu, Fengyan Meng, Fanli Kong, Xiaohan Cao, Xingfa Han, Guozhi Yu, Xiaofu Pan, Shiyong Yang, Xianyin Zeng, Xiaogang DuAbstractLipopolysaccharide (LPS) is a classical pathogen-associated molecular pattern that can trigger strong inflammatory response mainly by TLR4-mediated signaling pathway in mammals, but the molecular mechanism of...
Thu, 12/19/2019 - 03:25
Author(s): Peng He, Wei-Dan Jiang, Xiang-An Liu, Lin Feng, Pei Wu, Yang Liu, Jun Jiang, Bei-Ping Tan, Qi-Hui Yang, Sheng-Yao Kuang, Ling Tang, Xiao-Qiu ZhouAbstractThe aim of this study was to investigate the effects of dietary biotin deficiency on the growth performance and immune function of the head kidney, spleen and skin in on-growing grass carp (Ctenopharyngodon idella). A total of 540 on-...
Tue, 12/17/2019 - 03:24
Author(s): Shuyan Miao, Bei Han, Chenze Zhao, Juntao Hu, Jinyu Zhu, Xin Zhang, Longsheng SunAbstractOne Pediococcus acidilactici strain, named PA-GY2 was isolated from the gut of cultured Macrobrachium rosenbergii. In order to better examine the potential scope and applicability of this strain in M. rosenbergii culture, based on the control diet, four experimental diets containing single or...
Mon, 12/16/2019 - 03:22
Author(s): Songlin Guo, Le He, Liqun Wu, Yiqun Xiao, Shaowei Zhai, Qinpi YanAbstractIn cultivated European eels, Aeromonas hydrophila, Edwardsiella anguillarum and Vibrio vulnificus are three important bacterial pathogens. In this study, European eels (Anguilla anguilla) were immunized by the bivalent expression products of the outer membrane protein (Omp) gene from A. hydrophila (OmpⅡ) and E....
Sun, 12/15/2019 - 03:23
Author(s): Yuying Sun, Congcong Yan, Mengfei Liu, Yujie Liu, Wenzheng Wang, Wei Cheng, Fusheng Yang, Jiquan ZhangAbstractDuring the immune defense reaction of invertebrate, a plenty of reactive oxygen species (ROS) could be induced to product. Though ROS can kill foreign invaders, the accumulation of these reactive molecules in animals will cause serious cell damage. Carotenoids could function as...
Sun, 12/15/2019 - 03:23
Author(s): Nan Wu, Xuan Xu, Biao Wang, Xian-Mei Li, Ying-Yin Cheng, Ming Li, Xiao-Qin Xia, Yong-An ZhangAbstractFoodborne enteritis has become a limiting factor in aquaculture. Plant protein sources have already caused enteritic inflammation and inhibition in growth performance. Attempts have been made to find an effective solution to foodborne enteritis. Based on the previously suggested fish...
Sun, 12/15/2019 - 03:23
Author(s): Lu Qin, Jinhua Xiang, Fan Xiong, Guitang Wang, Hong Zou, Wenxiang Li, Ming Li, Shangong WuAbstractTo study the effect of dietary supplementation of Bacillus licheniformis FA6 on the growth, survival and intestinal health of grass carp, we assessed the antioxidant capacity, intestinal barrier, expression levels of immune genes, and the resistance to Aeromonas hydrophila AH-1 infection....
Sun, 12/15/2019 - 03:23
Author(s): Felix K.A. Kuebutornye, Zhiwen Wang, Yishan Lu, Emmanuel Delwin Abarike, Michael Essien Sakyi, Yuan Li, Cai Xia Xie, Vivian HlordziAbstractSkin and intestinal mucosa lymphoid tissues are known to be the fish's first line of defence since they serve as the first point of contact for pathogens. Only few studies have investigated the influence of host-associated Bacillus on mucosal...

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