Fish & Shellfish Immunology

Fri, 01/24/2020 - 03:22
Author(s): Junjie Nie, Zhixue Yu, Defu Yao, Fan Wang, Chunhua Zhu, Kaihui Sun, Jude Juventus Aweya, Yueling ZhangAbstractThe histone deacetylase, sirtuin 6 (SIRT6), plays an essential role in the regulation of oxidative stress, mitochondrial function and inflammation in mammals. However, the specific role of SIRT6 in invertebrate immunity has not been reported. Here, we characterized for the...
Thu, 01/16/2020 - 03:22
Author(s): Lang Lang, Minnan Bao, Weixin Jing, Wei Chen, Lan WangAbstractToll is essential in innate immune system which is important for defense against bacterial, fungal and viral infections in invertebrates. Our previous study showed that cadmium (Cd) could change the expression pattern of ShToll3 in the epithelium (gills and midgut from the freshwater crab Sinopotamon henanense) infected by...
Wed, 01/15/2020 - 03:22
Author(s): A. Panigrahi, R.R. Das, M.R. Sivakumar, A. Saravanan, C. Saranya, N.S. Sudheer, K.P. Kumaraguru Vasagam, P. Mahalakshmi, S. Kannappan, G. GopikrishnaAbstractEffect of bio-augmentation of Bacillus spp in biofloc on growth, survival and immunity in Indian white shrimp Penaeus indicus was evaluated. Nine Bacillus strains were isolated and screened individually as well as in the form of a...
Thu, 01/09/2020 - 03:39
Author(s): Hourong Liu, Chengwen Song, Junhao Ning, Yuan Liu, Zhaoxia CuiAbstractVariable lymphocyte receptors (VLRs) play an important role via their antigen-special reorganization in jawless vertebrates (agnathans) adaptive immune response. In the present study, the open reading frame (ORF) of Eriocheir sinensis VLRA (designated as EsVLRA) was identified. EsVLRA comprised a 799-amino-acid...
Wed, 01/08/2020 - 03:25
Author(s): Xifeng Qiao, Pingchao Li, Jianan He, Zeshu Yu, Jiaxing Chen, Liangge He, Xue Yu, Haoran Lin, Danqi Lu, Yong ZhangAbstractScavenger receptors play a central role in defending against infectious diseases in mammals. However, the function of SRECII remains unknown in teleost fish. In this study, type F scavenger receptor expressed by endothelial cells-II (SRECII) cDNA sequence was first...
Sun, 01/05/2020 - 03:23
Author(s): Zhuojun Han, Yi Zhou, Xiaojin Zhang, Jinpeng Yan, Jun Xiao, Yongju Luo, Huifang Zheng, Huan ZhongAbstractGhrelin is a peptide hormone secreted by gastrointestinal tract which regulates multiple physiological processes such as appetite, metabolism, growth and gonad development in fish. In the present study, the effects of ghrelin on hybrid tilapia infected with Aeromonas hydrophila are...
Sat, 01/04/2020 - 03:24
Author(s): Lei Liu, Yunfei DangAbstractMannose-binding lectin (MBL) is a crucial pattern recognition receptor in the host innate immune system. Previously, we reported the biological function of Ctenopharyngodon idella MBL (CiMBL) in initiating the lectin pathway of the complement system. In the present study, we further explored its biological function including the agglutinating ability,...
Sat, 01/04/2020 - 03:24
Author(s): Xiaoling Dai, Xin Huang, Zhuoxing Zhang, Ruidong Zhang, Xueying Cao, Chao Zhang, Kaiqiang Wang, Qian RenAbstractInnate immunity is the primary defense of crustaceans against pathogens. Crustins, as antimicrobial peptides, are important to crustacean innate immunity. In this study, two kinds of Gly-rich crustin genes were cloned from Macrobrachium nipponense and were referred to as Mn-...
Sat, 01/04/2020 - 03:24
Author(s): Chao Zhang, Xueying Cao, Kaiqiang Wang, Xiaoling Dai, Ruidong Zhang, Zhuoxing Zhang, Xin Huang, Qian RenAbstractTranscription factor activator protein 1 (AP1) plays an irreplaceable role in the response to a variety of external stimulants, such as cellar stress, bacterial and viral infections, and inflammatory cytokines. In this study, we identified a novel AP1 gene from Macrobrachium...
Mon, 12/30/2019 - 03:24
Author(s): Limei Qiu, Hao Chen, Zhi Zhou, Huan Zhang, Rui Liu, Qilin Yi, Chuanyan Yang, Lei Gao, Lingling WangAbstractOyster Crassostrea gigas, is considered as a useful environmental indicator since it is widely distributed along the intertidal zone whereby it tends to accumulate cadmium and is always exposed to various pathogen agents. However, its molecular responses to both cadmium and...
Mon, 12/30/2019 - 03:24
Author(s): Chunling Wang, Xiaodan Wang, Shusheng Xiao, Xianyong Bu, Zhideng Lin, Changle Qi, Jian G. Qin, Liqiao ChenAbstractThe T-2 toxin is a trichothecene mycotoxin and is highly toxic to aquatic animals, but little is known on its toxic effect in crustaceans. In the present study, the crab juveniles were fed with diets containing four levels of T-2 toxin: 0 (control), 0.6 (T1), 2.5 (T2) and 5...
Thu, 12/26/2019 - 03:23
Author(s): Jianhua Ming, Jinyun Ye, Yixiang Zhang, Qiyou Xu, Xia Yang, Xianping Shao, Jun Qiang, Pao XuAbstractThis study investigated the effects of dietary curcumin on growth performance, non-specific immunity, antioxidant capacity and related genes expression of NF-κB and Nrf2 signaling pathways in grass carp (Ctenopharyngodon idella). A total of 525 juvenile grass carps with mean initial body...
Thu, 12/26/2019 - 03:23
Author(s): Yuan Fang, Xiao-yan Xu, Yubang Shen, Jiale LiAbstractCtenopharyngodon idella growth arrest and DNA damage-inducible 45 ab (CiGadd45ab) is a subtype of the Gadd45a gene of the Gadd45 family in grass carp. There is increasing evidence that microRNAs (miRNAs) are involved in the regulation of inflammatory and apoptotic responses. However, little is known about the regulatory effects of...
Wed, 12/25/2019 - 03:22
Author(s): Wenjie Xu, Hongyan Li, Liyun Wu, Junyan Jin, Xiaoming Zhu, Dong Han, Haokun Liu, Yunxia Yang, Xudong Xu, Shouqi XieAbstractThis study was conducted to investigate the effect of dietary Scenedesmus ovalternus on the growth and disease resistance of gibel carp (Carassius gibelio) during overwintering. Gibel carp (initial body weight: 90.39 ± 0.33 g) were fed with diets containing 0% or 4...
Wed, 12/25/2019 - 03:22
Author(s): Zhongyu Zhang, Gaoyang Liu, Rui Ma, Xiaozhou Qi, Gaoxue Wang, Bin Zhu, Fei LingAbstractAeromonas hydrophila is a strong gram-negative bacterium that can cause a mass death of grass carp, and result in the huge economic loss. Development of practical vaccines is the best way to control the outbreak of this bacterial disease. In this study, a whole-cell inactivated vaccine was obtained...
Sun, 12/22/2019 - 03:22
Author(s): Xue Kong, Yanan Li, Haibin ZhangAbstractHydrothermal vents and cold seep zones are two special habitats in the deep sea. These habitats are always dark, and have extreme temperatures (low or high), heavy metals and toxic substances (sulfide, methane). Vesicomyidae clams, which maintain endosymbionts in their gills, are common species in these two special zones and are thought to...
Sun, 12/22/2019 - 03:22
Author(s): Yue Wang, Xue-Peng Wang, Bin Zhang, Zhi-Min Li, Li-Guo Yang, Xin-Cang Li, Hongyu MaAbstractLysin motif (LysM)-containing proteins function as pattern-recognition receptors in plants to recognize different N-acetylglucosamine-containing ligands, thereby triggering specific defense responses against pathogens. However, the biological functions of these proteins in animals remain unclear...
Sat, 12/21/2019 - 03:39
Author(s): Le He, LiQun Wu, YiJun Tang, Peng Lin, ShaoWei Zhai, YiQun Xiao, SongLin GuoAbstractIn cultivated European eels, Aeromonas hydrophila, Edwardsiella anguillarum and Vibrio vulnificus are three important bacterial pathogens. In this study, an expressed recombinant Outer membrane proteinⅡ (rOmpⅡ) from A. hydrophila was intraperitoneally injected into European eels (Angullia angullia). All...
Fri, 12/20/2019 - 03:24
Author(s): Yunkun Li, Puzhen Xia, Jiayu Wu, Anqi Huang, Guixian Bu, Fengyan Meng, Fanli Kong, Xiaohan Cao, Xingfa Han, Guozhi Yu, Xiaofu Pan, Shiyong Yang, Xianyin Zeng, Xiaogang DuAbstractLipopolysaccharide (LPS) is a classical pathogen-associated molecular pattern that can trigger strong inflammatory response mainly by TLR4-mediated signaling pathway in mammals, but the molecular mechanism of...
Thu, 12/19/2019 - 03:25
Author(s): Peng He, Wei-Dan Jiang, Xiang-An Liu, Lin Feng, Pei Wu, Yang Liu, Jun Jiang, Bei-Ping Tan, Qi-Hui Yang, Sheng-Yao Kuang, Ling Tang, Xiao-Qiu ZhouAbstractThe aim of this study was to investigate the effects of dietary biotin deficiency on the growth performance and immune function of the head kidney, spleen and skin in on-growing grass carp (Ctenopharyngodon idella). A total of 540 on-...
Tue, 12/17/2019 - 03:24
Author(s): Shuyan Miao, Bei Han, Chenze Zhao, Juntao Hu, Jinyu Zhu, Xin Zhang, Longsheng SunAbstractOne Pediococcus acidilactici strain, named PA-GY2 was isolated from the gut of cultured Macrobrachium rosenbergii. In order to better examine the potential scope and applicability of this strain in M. rosenbergii culture, based on the control diet, four experimental diets containing single or...
Mon, 12/16/2019 - 03:22
Author(s): Songlin Guo, Le He, Liqun Wu, Yiqun Xiao, Shaowei Zhai, Qinpi YanAbstractIn cultivated European eels, Aeromonas hydrophila, Edwardsiella anguillarum and Vibrio vulnificus are three important bacterial pathogens. In this study, European eels (Anguilla anguilla) were immunized by the bivalent expression products of the outer membrane protein (Omp) gene from A. hydrophila (OmpⅡ) and E....
Sun, 12/15/2019 - 03:23
Author(s): Yuying Sun, Congcong Yan, Mengfei Liu, Yujie Liu, Wenzheng Wang, Wei Cheng, Fusheng Yang, Jiquan ZhangAbstractDuring the immune defense reaction of invertebrate, a plenty of reactive oxygen species (ROS) could be induced to product. Though ROS can kill foreign invaders, the accumulation of these reactive molecules in animals will cause serious cell damage. Carotenoids could function as...
Sun, 12/15/2019 - 03:23
Author(s): Nan Wu, Xuan Xu, Biao Wang, Xian-Mei Li, Ying-Yin Cheng, Ming Li, Xiao-Qin Xia, Yong-An ZhangAbstractFoodborne enteritis has become a limiting factor in aquaculture. Plant protein sources have already caused enteritic inflammation and inhibition in growth performance. Attempts have been made to find an effective solution to foodborne enteritis. Based on the previously suggested fish...
Sun, 12/15/2019 - 03:23
Author(s): Lu Qin, Jinhua Xiang, Fan Xiong, Guitang Wang, Hong Zou, Wenxiang Li, Ming Li, Shangong WuAbstractTo study the effect of dietary supplementation of Bacillus licheniformis FA6 on the growth, survival and intestinal health of grass carp, we assessed the antioxidant capacity, intestinal barrier, expression levels of immune genes, and the resistance to Aeromonas hydrophila AH-1 infection....
Sun, 12/15/2019 - 03:23
Author(s): Felix K.A. Kuebutornye, Zhiwen Wang, Yishan Lu, Emmanuel Delwin Abarike, Michael Essien Sakyi, Yuan Li, Cai Xia Xie, Vivian HlordziAbstractSkin and intestinal mucosa lymphoid tissues are known to be the fish's first line of defence since they serve as the first point of contact for pathogens. Only few studies have investigated the influence of host-associated Bacillus on mucosal...
Thu, 12/12/2019 - 03:26
Author(s): Saekil Yun, Seung-Jun Lee, Sib Sankar Giri, Hyoun Joong Kim, Sang Geun Kim, Sang Wha Kim, Se Jin Han, Jun Kwon, Woo Taek Oh, Se Chang ParkAbstractThe aim of this study was to develop and evaluate a novel route of administration for vaccinating fish against Aeromonas hydrophila infection using a dissolving microneedles (MNs) patch. The A. hydrophila JUNAH strain was inactivated with...
Tue, 12/10/2019 - 03:26
Author(s): Qingchao Wang, Wei Ji, Zhen XuAbstractIn the past decades, the aquaculture industry made great progress in China, which contributes more than 70% yield of the world's farmed fish. Along with the rapid growth of fish production, increased emergence and outbreak of numbers of diseases pose harm to the aquaculture industry and food safety. From the efficient, safe, environmental and...
Wed, 12/04/2019 - 03:24
Author(s): Wilson Gómez Manrique, Mayra Araguaia Pereira Figueiredo, Ives Charlie-Silva, Marco Antonio de Andrade Belo, Cristina Corsi DibAbstractIn order to understand the pathophysiology of melanomcrophage centers (MMCs) formation during the tilapia defense response to bacterial infections, the present study evaluated the response, in terms of area, number and pigment constitution, of splenic...
Wed, 12/04/2019 - 03:24
Author(s): Bing-Chang Lee, Chun-Wei Hung, Cheng-Yung Lin, Chen-Han Shih, Huai-Jen TsaiAbstractTo develop an alternative to conventional antibiotics used in the aquaculture and livestock industries, we employed Bacillus subtilis, considered a biosafe microorganism, to express the degradable antimicrobial peptide lactoferricin. An expression plasmid pP43-6LFBII-GFP, in which reporter GFP cDNA was...
Wed, 12/04/2019 - 03:24
Author(s): Lang Xie, Yixi Tao, Ronghua Wu, Qin Ye, Hao Xu, Yun LiAbstractIt is documented that tlx1, an orphan homeobox gene, plays critical roles in the regulation of early spleen developmental in mammalian species. However, there is no direct evidence supporting the functions of tlx1 in non-mammalian species, especially in fish. In this study, we demonstrated that tlx1 is expressed in the...
Wed, 12/04/2019 - 03:24
Author(s): Xiaolin Meng, Wenpan Hu, Shengkui Wu, Zhenxiang Zhu, Ronghua Lu, Guokun Yang, Chaobin Qin, Liping Yang, Guoxing NieAbstractThe Chinese yam peel (CYP) is a by-product of yam processing that is rich in various nutrients and a good source for feed additives. This study investigated the effects of CYP on the intestinal microbiota and gut defence barrier of the common carp (Cyprinus carpio...
Wed, 12/04/2019 - 03:24
Author(s): Fengyu Yuan, Zilan Yang, Ting Tang, Song Xie, Fengsong LiuAbstractSmall heat shock proteins (sHSPs) are ATP-independent chaperones and involved into various physiological and stress processes. In the present study, a 28.6-kD sHSP coding gene, MnHSP28.6, was cloned and characterized from the oriental river prawn Macrobrachium nipponense. Tissue distribution analysis via qPCR and western...
Tue, 12/03/2019 - 03:42
Author(s): Renjiao Gao, Li Chen, Wei Zhang, Shuo Zhang, Jie Rao, Jun HuAbstractThis study aims to investigate the effects of replacing different proportions of fishmeal with Antarctic krill (AK) on the growth performance, body composition and nonspecific immunity index of red swamp crayfish Procambarus clarkia. AK was used to replace 0 (control), 25%, 50% and 100% of the fishmeal in the basic...
Mon, 12/02/2019 - 03:24
Author(s): Gaoyang Wang, Yutong Lei, Ting Kang, Zhi Li, Hui Fei, Shun Yang, Peng Zhou, Chunsheng Wang, Zhengbing Lv, Mengmeng Huang, Xuewei XuAbstractC-type lectins are Ca2+-dependent carbohydrate-binding proteins containing one or more carbohydrate-recognition domains (CRDs). C-type lectins play crucial roles in innate immunity, including nonself-recognition and pathogen elimination. In the...
Sat, 11/30/2019 - 03:25
Author(s): Sushmita Sadangi, Arpita Mohanty, Mahismita Paichha, Suchismita Gouda, Ashis Saha, Surajit Das, Mrinal SamantaAbstractInterleukin-1 receptor associated kinase (IRAK1) is one of the crucial signal transduction mediators in TLR/IL-1R signaling pathways in host immune system. To investigate about it in rohu (Labeo rohita), one of the economically important freshwater fish species in the...
Fri, 11/29/2019 - 03:19
Author(s): Dan Tang, Xueling Shi, Huayun Guo, Yuze Bai, Chenchen Shen, Yiping Zhang, Zhengfei WangAbstractThe red-swamp crayfish (Procambarus clarkii) is the most important economic shrimp species in China, and is an important model crustacean organism in many fields of research. In crustaceans, gills interface directly with the ambient environment and thus play a vital role in the toxicology. In...
Thu, 11/28/2019 - 03:40
Author(s): Ronghua Wu, Junyu Shen, Xinlian Lai, Tao He, Yun LiAbstractThe disease outbreak caused by viral infection and bacterial pathogens has hampered the sustainable development of the gibel carp (Carassius auratus gibelio) industry, lack of monoclonal antibodies against serum immunoglobulin (Ig) of gibel carp has impeded the development of nonfatal immunoassays in detection of pathogen...
Mon, 11/25/2019 - 03:24
Author(s): Yuanqing Kan, Lu Meng, Lingling Xie, Lixia Liu, Wenyue Dong, Jintao Feng, Yuchen Yan, Chao Zhao, Gang Peng, Decheng Wang, Mingfang Lu, Chen Yang, Chen NiuAbstractMacrophages are the first-line host defense that the invading Mycobacterium tuberculosis (Mtb) encounters. It has been recently reported that host aerobic glycolysis was elevated post the infection by a couple of virulent...
Sat, 11/23/2019 - 03:24
Author(s): Hongzao Lv, Tao Zhou, Chuanju Dong, Shengnan Kong, Lin Chen, Fei Pu, Xuejun Li, Peng XuAbstractComplement is a complex component of innate immune system, playing an important role in defense against pathogens and host homeostasis. The complement system has been comprehensively studied in mammals, however less is known about complement in teleost, especially in tetraploid common carp (...
Wed, 11/20/2019 - 03:41
Author(s): Qingying Liu, Minglei Xu, Zhenzhu Sun, Huaqun Ye, Kangsen Mai, Xiaohong Tan, Cuiyun Zou, Shu Chen, Ningning Su, Yuanyuan Zhou, Leling Chen, Chaoxia YeAbstractThe purpose of the present study was to explore the impaired anti-bacteria ability in immune organs and immune systems of obscure puffer induced by chronic dietary phosphorus (P) deficiency. Fish were fed diets supplemented with 6...
Mon, 11/18/2019 - 03:24
Author(s): Gao Xiaolong, Ke Caihuan, Wu Fucun, Li Xian, Liu YingAbstractTo study the effects of Bacillus lincheniformis feeding frequency on the survival and growth of Haliotis discus hannai abalone, we measured the expression levels of nonspecific immune genes and monitored the anti-Vibrio parahaemolyticus immune reaction. H. discus hannai (shell length: 32.75 ± 2.63 mm, body weight: 4.91 ± 0.34...
Mon, 11/18/2019 - 03:24
Author(s): Di Wang, Shujing Zhang, Baozhong LiuAbstractTAF5L is a component of the P300/CBP-associated factor (PCAF) histone acetylase complex, which serves as a coactivator and takes part in basal transcription such as promoter recognition, complex assembly and transcription initiation. In our study, the full-length sequence of MpTAF5L was identified and characterized in the clam M. petechialis...
Thu, 11/14/2019 - 03:23
Author(s): Miao Li, Fang-Chao Hu, Fang Qiao, Zhen-Yu Du, Mei-Ling ZhangAbstractWith the development of aquaculture industry, high-carbohydrate diet is used to stimulate protein-sparing effect and reduce feed cost. However, fish utilize carbohydrates poorly in general, and instead, high level of carbohydrates in the diet influence the growth condition of fish. How to alleviate the side effects of...
Wed, 11/13/2019 - 03:23
Author(s): Zhouyi Zhang, Weijia Zhang, Changkao Mu, Ronghua Li, Weiwei Song, Yangfang Ye, Ce Shi, Lei Liu, Huan Wang, Chunlin WangAbstractGalectins are a family of β-galactoside-binding lectins that play key roles in the invertebrate innate immunity system, but no galectin genes have been identified in the mud crab (Scylla paramamosain) so far. The present study is the first to clone a galectin...
Wed, 11/13/2019 - 03:23
Author(s): Limin Wu, Yongjing Li, Yufeng Xu, Lei Wang, Xiao Ma, Chuanju Dong, Xianliang Zhao, Xue Tian, Xuejun Li, Xianghui KongAbstractMyostatin, through type I receptor (kinase 4, 5, ALK4/5), functions to participate in the immune system and negatively regulate muscle growth in mammals. However, the role of myostatin (mstn) in the immune system of teleosts is largely unknown. In a previous...
Thu, 11/07/2019 - 03:24
Author(s): Hui Yang, Haoran Xiong, Kaihang Mi, Yingying Zhang, Xiaojun Zhang, Guohong ChenAbstractDue to the aquatic animal pathogens are numerous and specific, the pathogen invasion mechanisms are more complicated. The cell surface receptors play vital roles to understand these mechanisms. Syndecan is a cell surface protein and could function as a receptor involved bacteria and virus infections...
Wed, 11/06/2019 - 03:24
Author(s): Zhuoxing Zhang, Keke Han, Xiaoling Dai, Ruidong Zhang, Xueying Cao, Chao Zhang, Kaiqiang Wang, Xin Huang, Qian RenAbstractTwo lipopolysaccharides (LPS) and β-1, 3-glucan binding protein (LGBP), designated as PcLGBP isoform1 and PcLGBP isoform2, respectively, were identified from Procambarus clarkii in this study. The full-length cDNA of PcLGBP isoform1 was 1308 bp containing an open...
Tue, 11/05/2019 - 03:25
Author(s): Hui Li, Guilan Di, Yi Zhang, Rongrong Xue, Jing Zhang, Junping LiangAbstractCadmium (Cd) is a nonessential metal that is a contaminant in aquatic ecosystems. Cd can accumulate in aquatic animals, leading to detrimental effects in tissues, and Cd exposure can induce immunotoxicity in fish. MicroRNAs (miRNAs) play critical roles in immune responses, yet the participation of miRNAs in Cd-...
Sun, 11/03/2019 - 02:24
Author(s): Ying Huang, Qian RenAbstractKruppel-like factors (KLFs) belong to a family of zinc finger-containing transcription factors that are widely present in eukaryotes. In the present study, a novel KLF from the giant river prawn Macrobrachium rosenbergii (designated as MrKLF) was successfully cloned and characterized. The full-length cDNA of MrKLF was 1799 bp with an open reading frame of...

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