Food and Chemical Toxicology

The Research Publications track research that is published across national and international peer-reviewed journals. The most recent articles are available ahead of print and searchable by Journal Title, Subject, USDA Grant Funding Agencies or FDA Grant Funding Agencies. The research publications are tracked across five subject areas: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, and Viruses.

Thu, 08/06/2020 - 06:13
Author(s): Qian Bu, Yan Huang, Meng Li, Yanping Dai, Xin Fang, Ke Chen, Qian Liu, Aiqin Xue, Kai Zhong, Yina Huang, Hong Gao, Xiaobo Cen Acrylamide (ACR) is a common food contaminant with neurotoxic effects that are formed in the Maillard browning reaction during the heat processing of food. Importantly, pregnant women are also exposed to ACR in food during pregnancy and thus, the fetus is likely...
Wed, 08/05/2020 - 06:08
Author(s): Boris A. Katsnelson, Svetlana V. Klinova, Oksana P. Gerzen, Alexander A. Balakin, Oleg N. Lookin, Ruslan V. Lisin, Salavat R. Nabiev, Larisa I. Privalova, Ilzira A. Minigalieva, Vladimir G. Panov, Leonid B. Katsnelson, Larisa V. Nikitina, Daniil A. Kuznetsov, Yuri L. Protsenko This investigation continues our study of the effects of Pb-Cd poisoning on the heart, extending the enquiry...
Sat, 08/01/2020 - 06:12
Author(s): Rili Hao, Xinyu Song, Feng Li, Xintong Tan, Dongxiao Sun-Waterhouse, Dapeng Li Exposure to nonbiodegradable cadmium (Cd) causes many health problems including the damage to the nervous system. This study aimed to increase knowledge about its neurotoxic effects and the neuroprotective potential of caffeic acid phenethyl ester (CAPE, a polyphenol abundant in honeybee propolis). In mice,...
Wed, 07/22/2020 - 06:07
Author(s): Gengfu Wang, Yingpei Li, Yun Li, Jiaxiang Zhang, Chengfan Zhou, Changhao Wu, Qixing Zhu, Tong Shen Bisphenol A (BPA) exposure can increase the risk of immune-related diseases in later life. Vitamin D3 (Vit D3) has been shown to have multiple immunomodulatory actions and has been used to treat immune diseases. However, the potential beneficial effects of Vit D3 on BPA-induced adverse...
Sat, 07/11/2020 - 06:08
Author(s): D. Karlstetter, A. Mally Furan is a liver toxicant and carcinogen that occurs in heat-processed foods. Due to its volatility, analysis of furan in food does not provide reliable estimates of exposure. Biomarker-based approaches offer the opportunity to more accurately assess human exposure, but a correlation between concentrations of potential biomarkers of furan exposure and external...
Wed, 07/08/2020 - 06:07
Author(s): Maqusood Ahamed, Mohd Javed Akhtar, M.A. Majeed Khan, Hisham A. Alhadlaq Numerous applications of reduced graphene oxide (RGO) and pervasive cadmium (Cd) have led concern about their co-exposure to the environment and human. We studied the combined effects of RGO and Cd in human liver (HepG2) cells. Initially, we found that RGO (up to 50 μg/ml) did not harm to HepG2 cells while Cd...
Tue, 07/07/2020 - 06:09
Author(s): Katarina Baralić, Katarina Živančević, Dragana Javorac, Aleksandra Buha Djordjevic, Milena Anđelković, Dragica Jorgovanović, Evica Antonijević Miljaković, Marijana Ćurčić, Zorica Bulat, Biljana Antonijević, Danijela Đukić-Ćosić Phthalates and bisphenol A, to which people are mainly exposed through food, interfere with the body's endocrine system, along with various other toxic effects...
Sun, 07/05/2020 - 06:06
Author(s): Andrew D. Younger, Anna Neish, David I. Walker, Kaitlyn L. Jenkins, James A. Lowther, Tina A. Stapleton, Mickael Teixeira Alves Depuration of oysters can effectively reduce levels of E. coli, however, may not be effective in safeguarding against viral contamination (EFSA, 2012). These trials assess the removal of Norovirus Genogroups I and II (NoV GI and GII) and F + RNA bacteriophage...
Wed, 07/01/2020 - 06:07
Author(s): Guannan Le, Xin Yuan, Lili Hou, Lei Ge, Shuiping Liu, Muhmood Azhar, Kai Liu, Ziman Lin, Dandan Liu, Fang Gan, Suquan Song, Cuilin Pan, Xingxiang Chen, Kehe Huang Ochratoxin A (OTA) was reported to induce proximal tubules nephrotoxicity in humans and animals. However, the toxicity of OTA on glomeruli has rarely been studied. We investigated OTA-induced glomerular injury and the...
Fri, 06/05/2020 - 03:32
Author(s): Omolola A. Adesanoye, Amos O. Abolaji, Tolulope R. Faloye, Hannah O. Olaoye, Adeola O. Adedara Bisphenol A (BPA) is an industrial chemical used in the production of various plastic materials. It is associated with reproductive, immunological and neurological disorders. Luteolin, a flavonoid found in fruits and vegetables, possesses anti-oxidative, anti-inflammatory and free radical...
Sat, 05/30/2020 - 03:35
Author(s): Shirin Hooshfar, Roya Khosrokhavar, Hassan Yazdanpanah, Samira Eslamizad, Farzad Kobarfard, Firuzeh Nazari, Venetia Kokaraki, Manolis Kokkinakis, Marina Goumenou, Christina Tsitsimpikou, Aristides Tsatsakis In this study, two accurate, precise, selective and sensitive methods were developed for determining aflatoxin M1 (AFM1) in infant formula milk using immunoaffinity column clean-up...
Wed, 05/20/2020 - 03:30
Author(s): Man Liu, Chao Cheng, Xuezhi Li, Sihan Zhou, Jiali Hua, Jie Huang, Yongxin Li, Kunlong Yang, Peng Zhang, Yan Zhang, Jun Tian Ochratoxin A (OTA) is a ubiquitous food contaminant and a critical food safety concern due to its nephron toxic effects, which impacts all parts of the world. Luteolin (LUT) had gained increasing interest as a health-promoting food antioxidant component. However,...
Thu, 05/14/2020 - 03:30
Author(s): Neus González, Josep Calderón, Antoni Rúbies, Jaume Bosch, Isabel Timoner, Victòria Castell, Montse Marquès, Martí Nadal, José L. Domingo Diet is the major route of exposure to arsenic (As), with rice and rice products as food groups with relatively highest As concentrations. This study was aimed at determining the concentrations of total arsenic (total As) and inorganic arsenic (InAs...
Sat, 05/09/2020 - 03:30
Author(s): Mosaad A. Abdel-Wahhab, Aziza A. El-Nekeety, Amal S. Hathout, Asmaa S. Salman, Sekena H. Abdel-Aziem, Nabila S. Hassan, Mohamed S. Abdel-Aziz This study aimed to determine the bioactive compounds of Bacillus sp. MERNA97 extract and to evaluate their efficacy against the oxidative damage, genotoxicity, chromosomal aberration and DNA fragmentation in rats treated with AFB1. Sixty male...
Sat, 05/09/2020 - 03:30
Author(s): Mingyang Wang, Shuhua Yang, Jing Cai, Rong Yan, Lingqi Meng, Miao Long, Yi Zhang Zearalenone (ZEA) is a mycotoxin that contaminates crops worldwide and is toxic to the reproductive systems of mammals, however, the toxicological mechanism by which ZEA affects germ cells is not fully understood. In this study, proteomic analysis using iTRAQ technology was adopted to determine the...
Tue, 05/05/2020 - 03:31
Author(s): Ana G. Cabado, Jorge Lago, Virginia González, Lucía Blanco, Beatriz Paz, Jorge Diogène, Laura Ferreres, Maria Rambla-Alegre
Thu, 04/30/2020 - 03:32
Author(s): A.M. Api, F. Belmonte, D. Belsito, S. Biserta, D. Botelho, M. Bruze, G.A. Burton, J. Buschmann, M.A. Cancellieri, M.L. Dagli, M. Date, W. Dekant, C. Deodhar, A.D. Fryer, S. Gadhia, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, D.C. Liebler This safety assessment is based on the RIFM Criteria Document (Api et al., 2015), which should be referred to for clarifications. Each endpoint...
Wed, 04/29/2020 - 03:30
Author(s): Si Chen, Shuhua Yang, Mingyang Wang, Jia Chen, Sheng Huang, Zhen Wei, Ziyang Cheng, Hanli Wang, Miao Long, Peng Li The toxic effect of zearalenone (ZEA) is not fully understood and there is an urgent need for the development of effective agents to protect against the toxic effects of ZEA. In this study, we detected whether curcumin (CUR) can reduce Leydig cells apoptosis induced by ZEA...
Thu, 04/23/2020 - 03:27
Author(s): Ogouyôm Herbert Iko Afé, Caroline Douny, Yénoukounmè Euloge Kpoclou, Ahmed Igout, Jacques Mahillon, Victor Anihouvi, Djidjoho Joseph Hounhouigan, Marie-Louise Scippo This paper presents methods of reduction of polycyclic aromatic hydrocarbons (PAHs) in grilled or smoked meat and fishery products. Using keywords such as “smoking”, “grilling”, “processing”, “roasting”, “barbecue”, “...
Mon, 04/06/2020 - 03:20
Author(s): Mònica Campàs, Jaume Reverté, Maria Rambla-Alegre, Katrina Campbell, Arjen Gerssen, Jorge Diogène Tetrodotoxin (TTX) is a potent neurotoxin responsible for many food poisoning incidents and some fatalities. Although mainly associated with the consumption of pufferfish, in recent years, TTX has been found in shellfish, particularly in Europe. In this work, a magnetic bead (MB)-based...
Wed, 04/01/2020 - 03:21
Author(s): Kailun Yu, Xiuli Zhang, Xuemei Tan, Mengmeng Ji, Yao Chen, Zhongxiao Wan, Zengli Yu 2,3,7,8-Tetrachlorobenzo-p-dioxin (TCDD), one of the key endocrine disruptors, has been shown to cause reproductive and developmental disorders. Our previous studies have primarily focused on TCDD induced impairment of ovarian follicular development in female F1 rats. It is unknown whether TCDD exposure...
Thu, 03/26/2020 - 03:21
Author(s): M.Á. Martínez, J. Blanco, J. Rovira, V. Kumar, J.L. Domingo, M. Schuhmacher This study was aimed at comparing the toxicity effects on cell viability and the obesogenic activity of Bisphenol A (BPA) and its analogues, Bisphenol S (BPS) and Bisphenol F (BPF), by in vitro assays with a preadipocytic 3T3-L1 cell line. To compare the toxic potential and select the concentrations of each...
Mon, 03/23/2020 - 03:23
Author(s): Marion Hulin, Véronique Sirot, Paule Vasseur, Aurelie Mahe, Jean-Charles Leblanc, Julien Jean, Philippe Marchand, Anaïs Venisseau, Bruno LE. Bizec, Gilles Riviere A total diet study (TDS) was conducted between 2010 and 2016 to characterize the health risk related to chemical residues in food of French not breastfed children under three years of age (infant TDS). Among the targeted...
Sun, 03/22/2020 - 03:20
Author(s): Emily J. Werder, Juliane I. Beier, Dale P. Sandler, Keith C. Falkner, Tyler Gripshover, Banrida Wahlang, Lawrence S. Engel, Matthew C. Cave Exposures to volatile organic compounds and metals have previously been associated with liver diseases including steatohepatitis, although more data are needed. Benzene, toluene, ethylbenzene, xylenes, styrene (BTEXS) and metals were measured in...
Thu, 03/19/2020 - 03:21
Author(s): Vladimir Ostry, Marcela Dofkova, Jitka Blahova, Frantisek Malir, Radek Kavrik, Irena Rehurkova, Jiri Ruprich A dietary exposure assessment to sum of deoxynivalenol (DON) forms, sum of T-2/HT-2 toxins (T2/HT2) and zearalenone (ZEA) was conducted for Czech children 4–6 years and Czech men and women 18–59 years. Retail foods (25 different commodities, n = 336) were assessed by LC-MS/MS...
Sun, 03/15/2020 - 03:36
Author(s): Venkatanaidu Karri, Marta Schuhmacher, Vikas Kumar Conventional toxicological risk assessment methods mainly working on single chemicals that fail to adequately address the simultaneous exposure and their potential toxicity in humans. We herein investigated the toxic heavy metals lead (Pb), arsenic (As), and methylmercury (MeHg) and their binary mixtures role in neurodegenerative...
Wed, 03/11/2020 - 03:21
Author(s): Ana Juan-García, Saverio Carbone, Maissa Ben-Mahmoud, Gianni Sagratini, Jordi Mañes The co-presence of more than one mycotoxin in food is being evidenced in last food surveys as reported in the literature. Beauvericin (BEA) is a non-legislated emergent mycotoxin while Ochratoxin A (OTA) has been widely studied and legislated. Concentration range individually studied was from 2.5 to 0.3...
Mon, 03/09/2020 - 03:37
Author(s): Chanchal Sharma, Sun Chul Kang The presence of acrylamide (ACR) in food results in evident cognitive decline, accumulation of misfolded proteins, neurotoxicity, neuroinflammation, and neuronal apoptosis leading to progressive neurodegeneration. Here, we used 4 dpf zebrafish larvae exposed to ACR (1mM/3days) as our model, and neuronal proteins were analyzed. Next, we tested the effect...
Thu, 03/05/2020 - 03:23
Author(s): Ikuko Miyazaki, Ryo Kikuoka, Nami Isooka, Mika Takeshima, Kanau Sonobe, Rei Arai, Hidemaru Funakoshi, Kyle E. Quin, Jonathan Smart, Kazumasa Zensho, Masato Asanuma Bisphenol A diglycidyl ether (BADGE) is an epoxy resin used for the inner coating of canned food and beverages. BADGE can easily migrate from the containers and become a contaminant. In this study, we examined the effects of...
Tue, 02/18/2020 - 03:21
Author(s): Mohaddeseh Abouhosseini Tabari, Arash Rostami, Aref Khodashenas, Filippo Maggi, Riccardo Petrelli, Cristiano Giordani, Léon Azefack Tapondjou, Fabrizio Papa, Yanting Zuo, Kevin Cianfaglione, Mohammad Reza YoussefiAbstractIn this work, the essential oils (EOs) from Litchi chinensis, Clausena anisata, Heracleum sphondylium, Pimpinella anisum, Lippia alba, Crithmum maritimum and Syzygium...
Sun, 02/16/2020 - 03:35
Author(s): Fatih Mehmet Kandemir, Serkan Yıldırım, Sefa Kucukler, Cuneyt Caglayan, Ekrem Darendelioğlu, Muhammet Bahaeddin DortbudakAbstractAcrylamide (ACR) is a heat-induced carcinogen substance that is found in some foods due to cooking or other thermal processes. The aim of present study was to assess the probable protective effects of morin against ACR-induced hepatorenal toxicity in rats....
Thu, 02/06/2020 - 03:23
Author(s): Fatemeh Ahmadian, Arash Chaichi Nosrati, Ali Shahriyari, Faezi-Ghasemi Mohammad, Soheil Shokri-FashtaliAbstractAflatoxins are carcinogenic metabolites produced by Aspergillus and Penicillium spp. Aflatoxin contamination of food is a serious health hazard. Some metal ions (such as Zn2+) affect Aspergillus growth and aflatoxin biosynthesis. Presence of zinc in the growth medium incites...
Wed, 02/05/2020 - 03:22
Author(s): Liang Gao, Youdan Dong, Ren Lin, Yuan Meng, Fengjuan Wu, Lihong JiaAbstractBisphenol A (BPA) can inhibit the differentiation and function of regulatory T cells (Treg), and affect the balance of helper T cell (Th) 1/Th2, therefore, the immunotoxicity of BPA has attracted widespread attention in recent years, but its mechanism is not clear. The main aim of this study was to explore the...
Sun, 02/02/2020 - 03:21
Author(s): A. Cimbalo, M. Alonso-Garrido, G. Font, L. ManyesAbstractMycotoxins are considered to be a major risk factor affecting human and animal health as they are one of the most dangerous contaminants of food and feed. This review aims to compile the research developed up to date on the toxicological effects that mycotoxins can induce on human health, through the examination of a selected...
Thu, 01/30/2020 - 03:22
Author(s): Wim Schelstraete, Mathias Devreese, Siska CroubelsAbstractMycotoxins frequently contaminate food and feed materials, posing a threat to human and animal health. Fusarium species produce important mycotoxins with regard to their occurrence and toxicity, especially deoxynivalenol (DON), fumonisin B1 (FB1), zearalenone (ZEN) and T-2 toxin (T-2). The susceptibility of an animal species...
Wed, 01/29/2020 - 03:37
Author(s): Noelia Pallarés, Laura Righetti, Silvia Generotti, Daniele Cavanna, Emilia Ferrer, Chiara Dall’Asta, Michele SumanAbstractEnniatin B is an emerging mycotoxin known to present biological activity because of its ionophoric characteristics. This compound has demonstrated strong in vitro cytotoxicity against different cancer cells, also at low molecular concentrations. Its natural...
Mon, 01/27/2020 - 03:22
Author(s): Han Zhongzh, Deng LimiaoAbstractAflatoxin is a highly toxic and carcinogenic substance with fluorescence characteristic. To explore the feasibility of detection the degree of aflatoxin contamination using hyperspectral imaging technology, we proposed a machine learning detection method based on support vector machine (SVM) combining band index and narrow band. First, five...
Fri, 01/24/2020 - 03:20
Author(s): Shuhua Yang, Lin Li, Lihui Yu, Lin Sun, Kang Li, Cui Tong, Weixiang Xu, Gengyuan Cui, Miao Long, Peng LiAbstractWe investigated the protective effect and mechanism of selenium-enriched yeast (SY) on caecal injury induced by ochratoxin A (OTA) in broilers. Eighty broiler chickens of 1-day-old with similar weight were randomly assigned to Control group, OTA group, SY group and OTA + SY...
Thu, 01/16/2020 - 03:20
Author(s): Elize Aparecida Santos Musachio, Stífani Machado Araujo, Vandreza Cardoso Bortolotto, Shanda de Freitas Couto, Mustafa Munir Mustafa Dahleh, Marcia Rósula Poetini, Eliana Fernandes Jardim, Luana Barreto Meichtry, Bruna Piaia Ramborger, Rafael Roehrs, Gustavo Petri Guerra, Marina PrigolAbstractThe pathogenesis of Parkinson's disease has not been fully clarified yet but its cause is...
Wed, 01/15/2020 - 03:20
Author(s): Ning Xu, Miao Li, Wei-Chun Chou, Zhoumeng LinAbstractThe extensive use of doxycycline in aquaculture results in drug residue violations that negatively impact human food safety. This study aimed to develop a physiologically based pharmacokinetic (PBPK) model for doxycycline to predict drug residues and withdrawal times (WTs) in grass carp (Ctenopharyngodon idella) after daily oral...
Wed, 01/15/2020 - 03:20
Author(s): Manon Pruvost-Couvreur, Bruno Le Bizec, Camille Béchaux, Gilles RivièreAbstractUsually health risk related to food contaminants is assessed based on consumption data collected on a few days. Consequently, this approach considers neither the evolution of exposures over time nor the potential accumulation of the substance.The aim of the present study was to develop a method to assess...
Sun, 01/12/2020 - 03:20
Author(s): Joon-Goo Lee, Youngjin Jeong, Dongsul Kim, Gil-Jin Kang, Youngwon KangAbstractTetrabromobisphenol A (TBBPA) and Hexabromocyclododecanes (HBCDs) are two of the most used BFRs and they have cumulated in the environment. TBBPA and HBCDs in food were determined and their risks were assessed. The analytical method used was validated in different food categories, and the performance...
Sun, 01/12/2020 - 03:20
Author(s): Francesca Cavaliere, Stefano Lorenzetti, Pietro CozziniAbstractBisphenol A (BPA), a synthetic compound widely used as a building block for polycarbonate plastics, has been declared in the European Union (EU) as a substance of very high concern (SVHC). A series of BPA alternatives and derivatives (bisphenols/BPs) with similar physical-chemical properties have been produced and used by...
Sun, 01/12/2020 - 03:20
Author(s): Katarzyna Czaja, Paweł Struciński, Wojciech Korcz, Maria Minorczyk, Agnieszka Hernik, Bożena WiadrowskaAbstractConsumers are constantly exposed to trace levels of residues present in food commodities, arising from the use of pesticides. For this reason, assessing the risk caused by pesticide residues present in food requires not only identification and toxicological properties...
Sun, 01/05/2020 - 03:21
Author(s): Haihua Wang, Wei Huang, Ying Gong, Chienmin Chen, Tengyun Zhang, Xiaoping DiaoAbstractThe levels of 16 PAHs were determined in the adductor, gills, gonads, hepatopancreas and mantles of the pearl oyster (Pinctada martensii) and the mussel (Perna viridis) collected from coasts of Li'an and Xincun Bays. The levels of ΣPAHs ranged from 597.1 to 2332 ng g−1 d w in the various tissues of...
Sat, 01/04/2020 - 03:22
Author(s): M. Alonso-Garrido, P. Tedeschi, A. Maietti, G. Font, N. Marchetti, L. ManyesAbstractC. maxima (var. Delica), a variety of pumpkin, is well known for its high concentration on carotenoids, possessing dietary benefits and antioxidant properties. Aflatoxins and enniatins are common mycotoxins present in food and feed with an extended toxicity profile in humans and animals. Both types of...
Sat, 12/28/2019 - 03:21
Author(s): Liliana J.G. Silva, Luciana Macedo, André M.P.T. Pereira, Sofia Duarte, Celeste M. Lino, Angelina PenaAbstractOchratoxin A (OTA) is a mycotoxin detected worldwide. Urine biomonitoring is a more realistic and non-invasive way to assess exposure when compared to traditional methods based on food occurrence and consumption data. Few studies have investigated children's exposure to OTA,...
Sat, 12/28/2019 - 03:21
Author(s): Yuanyuan Huang, Jianlin Zhu, Hong Li, Wenxiang Wang, Yuchen Li, Xiao Yang, Nahong Zheng, Qiumei Liu, Qunwei Zhang, Wenchang Zhang, Jin LiuAbstractThe mechanisms of prenatal cadmium (Cd) exposure cause adverse effect transmission to future generations that remain unclear. In this study, pregnant SD rats were orally dosed with Cd (0, 0.5, 2.0, and 8.0 mg/kg/day) from gestation day 1...
Fri, 12/27/2019 - 03:22
Author(s): Mustafa Oguzhan Caglayan, Zafer ÜstündağAbstractMycotoxins are toxic compounds produced by the metabolism of certain fungi that threaten the food and agricultural industry. Over hundreds of mycotoxins, one of the most common toxins, zearalenone (ZEN), has toxic effects on human and animal health due to its mutagenicity, treatogenicity, carcinogenicity, nephrotoxicity, immunotoxicity,...
Thu, 12/26/2019 - 03:21
Author(s): Hua Chen, Chunlei Zhu, Feng Chen, Jingjing Xu, Xiuting Jiang, Zeyu Wu, Xiaowei Ding, Gao-Chao Fan, Yizhong Shen, Yingwang YeAbstractFluoroquinolone antibiotics (FQs), a new class of pollutants that seriously threaten human health through environmental and food residues, have aroused wide public concern. However, little attention has been paid to the potential toxicity of FQs' metal...

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