Food and Chemical Toxicology

Mon, 01/27/2020 - 03:22
Author(s): Han Zhongzh, Deng LimiaoAbstractAflatoxin is a highly toxic and carcinogenic substance with fluorescence characteristic. To explore the feasibility of detection the degree of aflatoxin contamination using hyperspectral imaging technology, we proposed a machine learning detection method based on support vector machine (SVM) combining band index and narrow band. First, five...
Fri, 01/24/2020 - 03:20
Author(s): Shuhua Yang, Lin Li, Lihui Yu, Lin Sun, Kang Li, Cui Tong, Weixiang Xu, Gengyuan Cui, Miao Long, Peng LiAbstractWe investigated the protective effect and mechanism of selenium-enriched yeast (SY) on caecal injury induced by ochratoxin A (OTA) in broilers. Eighty broiler chickens of 1-day-old with similar weight were randomly assigned to Control group, OTA group, SY group and OTA + SY...
Thu, 01/16/2020 - 03:20
Author(s): Elize Aparecida Santos Musachio, Stífani Machado Araujo, Vandreza Cardoso Bortolotto, Shanda de Freitas Couto, Mustafa Munir Mustafa Dahleh, Marcia Rósula Poetini, Eliana Fernandes Jardim, Luana Barreto Meichtry, Bruna Piaia Ramborger, Rafael Roehrs, Gustavo Petri Guerra, Marina PrigolAbstractThe pathogenesis of Parkinson's disease has not been fully clarified yet but its cause is...
Wed, 01/15/2020 - 03:20
Author(s): Ning Xu, Miao Li, Wei-Chun Chou, Zhoumeng LinAbstractThe extensive use of doxycycline in aquaculture results in drug residue violations that negatively impact human food safety. This study aimed to develop a physiologically based pharmacokinetic (PBPK) model for doxycycline to predict drug residues and withdrawal times (WTs) in grass carp (Ctenopharyngodon idella) after daily oral...
Wed, 01/15/2020 - 03:20
Author(s): Manon Pruvost-Couvreur, Bruno Le Bizec, Camille Béchaux, Gilles RivièreAbstractUsually health risk related to food contaminants is assessed based on consumption data collected on a few days. Consequently, this approach considers neither the evolution of exposures over time nor the potential accumulation of the substance.The aim of the present study was to develop a method to assess...
Sun, 01/12/2020 - 03:20
Author(s): Joon-Goo Lee, Youngjin Jeong, Dongsul Kim, Gil-Jin Kang, Youngwon KangAbstractTetrabromobisphenol A (TBBPA) and Hexabromocyclododecanes (HBCDs) are two of the most used BFRs and they have cumulated in the environment. TBBPA and HBCDs in food were determined and their risks were assessed. The analytical method used was validated in different food categories, and the performance...
Sun, 01/12/2020 - 03:20
Author(s): Francesca Cavaliere, Stefano Lorenzetti, Pietro CozziniAbstractBisphenol A (BPA), a synthetic compound widely used as a building block for polycarbonate plastics, has been declared in the European Union (EU) as a substance of very high concern (SVHC). A series of BPA alternatives and derivatives (bisphenols/BPs) with similar physical-chemical properties have been produced and used by...
Sun, 01/12/2020 - 03:20
Author(s): Katarzyna Czaja, Paweł Struciński, Wojciech Korcz, Maria Minorczyk, Agnieszka Hernik, Bożena WiadrowskaAbstractConsumers are constantly exposed to trace levels of residues present in food commodities, arising from the use of pesticides. For this reason, assessing the risk caused by pesticide residues present in food requires not only identification and toxicological properties...
Sun, 01/05/2020 - 03:21
Author(s): Haihua Wang, Wei Huang, Ying Gong, Chienmin Chen, Tengyun Zhang, Xiaoping DiaoAbstractThe levels of 16 PAHs were determined in the adductor, gills, gonads, hepatopancreas and mantles of the pearl oyster (Pinctada martensii) and the mussel (Perna viridis) collected from coasts of Li'an and Xincun Bays. The levels of ΣPAHs ranged from 597.1 to 2332 ng g−1 d w in the various tissues of...
Sat, 01/04/2020 - 03:22
Author(s): M. Alonso-Garrido, P. Tedeschi, A. Maietti, G. Font, N. Marchetti, L. ManyesAbstractC. maxima (var. Delica), a variety of pumpkin, is well known for its high concentration on carotenoids, possessing dietary benefits and antioxidant properties. Aflatoxins and enniatins are common mycotoxins present in food and feed with an extended toxicity profile in humans and animals. Both types of...
Sat, 12/28/2019 - 03:21
Author(s): Liliana J.G. Silva, Luciana Macedo, André M.P.T. Pereira, Sofia Duarte, Celeste M. Lino, Angelina PenaAbstractOchratoxin A (OTA) is a mycotoxin detected worldwide. Urine biomonitoring is a more realistic and non-invasive way to assess exposure when compared to traditional methods based on food occurrence and consumption data. Few studies have investigated children's exposure to OTA,...
Sat, 12/28/2019 - 03:21
Author(s): Yuanyuan Huang, Jianlin Zhu, Hong Li, Wenxiang Wang, Yuchen Li, Xiao Yang, Nahong Zheng, Qiumei Liu, Qunwei Zhang, Wenchang Zhang, Jin LiuAbstractThe mechanisms of prenatal cadmium (Cd) exposure cause adverse effect transmission to future generations that remain unclear. In this study, pregnant SD rats were orally dosed with Cd (0, 0.5, 2.0, and 8.0 mg/kg/day) from gestation day 1...
Sat, 12/28/2019 - 03:21
Author(s): Yanwen Xue, Fang Huang, Rongxue Tang, Qingsheng Fan, Bing Zhang, Zhenjiang Xu, Xiaoming Sun, Zheng Ruan
Fri, 12/27/2019 - 03:22
Author(s): Mustafa Oguzhan Caglayan, Zafer ÜstündağAbstractMycotoxins are toxic compounds produced by the metabolism of certain fungi that threaten the food and agricultural industry. Over hundreds of mycotoxins, one of the most common toxins, zearalenone (ZEN), has toxic effects on human and animal health due to its mutagenicity, treatogenicity, carcinogenicity, nephrotoxicity, immunotoxicity,...
Thu, 12/26/2019 - 03:21
Author(s): Hua Chen, Chunlei Zhu, Feng Chen, Jingjing Xu, Xiuting Jiang, Zeyu Wu, Xiaowei Ding, Gao-Chao Fan, Yizhong Shen, Yingwang YeAbstractFluoroquinolone antibiotics (FQs), a new class of pollutants that seriously threaten human health through environmental and food residues, have aroused wide public concern. However, little attention has been paid to the potential toxicity of FQs' metal...
Sat, 12/21/2019 - 03:35
Author(s): Ana Carolina Justino de Araújo, Priscilla Ramos Freitas, Cristina Rodrigues dos Santos Barbosa, Débora Feitosa Muniz, Janaína Esmeraldo Rocha, Ana Cristina Albuquerque da Silva, Cícera Datiane de Morais Oliveira-Tintino, Jaime Ribeiro-Filho, Luiz Everson da Silva, Camila Confortin, Wanderlei do Amaral, Cícero Deschamps, José Maria Barbosa-Filho, Natanael Teles Ramos de Lima, Saulo...
Sun, 12/08/2019 - 03:37
Author(s): Roman Pavela, Filippo Maggi, Riccardo Petrelli, Loredana Cappellacci, Michela Buccioni, Alessandro Palmieri, Angelo Canale, Giovanni BenelliAbstractCarlina acaulis (Compositae) is traditionally used for food and medicinal purposes in central and southern Europe. Its root essential oil (EO), mainly composed of carlina oxide, is included in the BELFRIT botanical list of food supplements...
Sat, 12/07/2019 - 03:22
Author(s): Xiaoxing Liang, Nuoya Yin, Shengxian Liang, Renjun Yang, Shuyu Liu, Yuanping Lu, Linshu Jiang, Qunfang Zhou, Guibin Jiang, Francesco FaiolaAbstractBisphenol A (BPA) and its derivatives, including bisphenols S (BPS), F (BPF), E (BPE), B (BPB), Z (BPZ), and AF (BPAF), are widely used in consumer products. Moreover, they are typically detected in the environment, food, and humans....
Thu, 11/28/2019 - 03:36
Author(s): Salma Ouhibi, Arnau Vidal, Carla Martins, Ridha Gali, Abderrazzek Hedhili, Sarah De Saeger, Marthe De BoevreAbstractBiomarker-driven research has been proposed as a successful method to assess the exposure of individuals to xenobiotics, including mycotoxins, through estimation of their metabolites in biological fluids. A methodology to determine patulin (PAT) and citrinin (CIT) in...
Sat, 11/23/2019 - 03:22
Author(s): Neus González, Sara C. Cunha, Ricardo Ferreira, José O. Fernandes, Montse Marquès, Martí Nadal, José L. DomingoAbstractThe present study was aimed at assessing the exposure of an adult population to nine BPs analogues (BPA, BPS, BPF, BPB, BPAF, BPZ, BPE, BPAP and BPP) through a duplicate diet study. Up to 40 canned and non-canned food samples were purchased from Tarragona (Catalonia,...
Fri, 11/22/2019 - 03:22
Author(s): L. Heras-González, J.A. Latorre, M. Martinez-Bebia, D. Espino, F. Olea-Serrano, M. Mariscal-ArcasAbstractPhytoestrogens are natural components of plants, including numerous foods that form part of the habitual diet of humans and animals. They have similar estrogenic effects to those of synthetic endocrine disrupters such as monomers of plastic materials, e.g., polycarbonates and epoxy...
Wed, 11/20/2019 - 03:37
Author(s): R. Bevan, P.T.C. Harrison, B. Jeffery, D. MitchellAbstractKey issues around the evaluation of risks to humans from mineral oils in food and feedstuffs are discussed. MOHs (MOAH and MOSH) occur in food due to their intended use, contamination from environmental sources and during transport/processing, or through migration from food contact materials. Problems in setting and enforcing...
Wed, 11/20/2019 - 03:37
Author(s): Svetlana V. Klinova, Ilzira A. Minigalieva, Larisa I. Privalova, Irene E. Valamina, Oleg H. Makeyev, Eugene A. Shuman, Artem A. Korotkov, Vladimir G. Panov, Marina P. Sutunkova, Julia V. Ryabova, Tatiana V. Bushueva, Tatiana N. Shtin, Vladimir B. Gurvich, Boris A. KatsnelsonAbstractOutbred male rats were repeatedly injected intraperitoneally two-level sub-lethal doses of lead acetate...
Tue, 11/19/2019 - 03:22
Author(s): Isa Marmelo, Vera Barbosa, Ana Luísa Maulvault, Maria Paula Duarte, António MarquesAbstractDespite the bioaccessibility of nutrients and contaminants present in individual seafood products has been thoroughly studied, information is extremely limited in what concerns complete seafood-based meals, where interactions between ingredients may occur. Hence, this study aimed to evaluate the...
Sun, 11/17/2019 - 03:21
Author(s): Qinghua Wu, Wenda Wu, Kamil KucaAbstractThis October, the Nobel Prize in Physiology or Medicine 2019 was jointly awarded to William G. Kaelin Jr., Sir Peter J. Ratcliffe, and Gregg L. Semenza for their discoveries of “how cells sense and adapt to oxygen availability.” Importantly, the protein named hypoxia-inducible factors (HIF) were revealed in the molecular machinery that how cells...
Thu, 11/14/2019 - 03:21
Author(s): Tom Jansen, Liesbeth Claassen, Irene van Kamp, Daniëlle R.M. TimmermansAbstractIn toxicological health risk assessment, epistemic uncertainties (e.g. about an agent's intrinsic properties or toxicity) often remain, preventing definitive statements about whether a chemical carries a risk. In this study, we analyzed public appraisals of uncertain risks of food additives and contaminants...
Wed, 11/13/2019 - 03:21
Author(s): Jana Tulinska, Vlasta Masanova, Aurelia Liskova, Miroslava Lehotska Mikusova, Eva Rollerova, Zora Krivosikova, Kornelia Stefikova, Iveta Uhnakova, Monika Ursinyova, Janka Babickova, Andrea Babelova, Milena Busova, Lubomira Tothova, Ladislava Wsolova, Maria Dusinska, Martin Sojka, Mira Horvathova, Radka Alacova, Zbynek Vecera, Pavel MikuskaAbstractDue to the growing number of...
Wed, 11/13/2019 - 03:21
Author(s): Lei Wang, Hyun Soo Kim, Jae Young Oh, Jun Geon Je, You-Jin Jeon, BoMi RyuAbstractExcessive exposure to ultraviolet (UV) irradiation from the sun is the primary environmental factor that causes aging of the skin. Most skin diseases caused by UV are attributed to UVB (280–320 nm). The purpose of this study is to investigate the protective effect of diphlorethohydroxycarmalol (DPHC),...
Wed, 11/13/2019 - 03:21
Author(s): Katharina Schultrich, Colin J. Henderson, Albert Braeuning, Thorsten BuhrkeAbstract3-Chloro-1,2-propanediol (3-MCPD) is a food contaminant which has been classified as a non-genotoxic carcinogen (category 2B). Previous studies suggested that oxidative stress might play a role in 3-MCPD toxicity. To elucidate the impact of 3-MCPD-mediated organ toxicity in more detail, transgenic...
Tue, 11/05/2019 - 03:23
Author(s): Anja Kavčič, Bojan Budič, Katarina Vogel-MikušAbstractThe effects of foliar Se biofortification (Se+) of the lettuce on the transfer and toxicity of Hg from soil contaminated with HgCl2 (H) and soil collected near the former Hg smelter in Idrija (I), to terrestrial food chain are explored, with Spanish slug as a primary consumer. Foliar application of Se significantly increased Se...
Wed, 10/30/2019 - 03:22
Author(s): Lan Gao, Lukas Rutz, Dieter SchrenkAbstractContamination of food, feed and herbal medicines with plants containing pyrrolizidine alkaloids (PA) leads to measurable amounts of PA in many products. Since a number of PA are hepatotoxic in humans and animals and hepato-carcinogenic in animal experiments, the assessment of the relative toxic potencies of widely occurring PA contaminants...
Wed, 10/23/2019 - 03:30
Author(s): Zonghao Yue, Yanjuan Chen, Yujuan Song, Jie Zhang, Xingdong Yang, Jian Wang, Lili Li, Zhongke SunAbstractAcrylamide (AA), a food contaminant, caused islet remodeling and increased hepatic glycogen content in male rats, but the effect of AA on glucose homeostasis in female rats remains unclear. In this study, female SD rats were orally treated with 0, 15, or 30 mg/kg·bw AA for 3 weeks....
Fri, 10/18/2019 - 03:27
Author(s): Annette Petersen, Bodil Hamborg Jensen, Nathalie Michelle Löbl, Elsa Nielsen, Lea Bredsdorff, Sisse Fagt, Tue Christensen, Julie BobergAbstractThis study shows that dietary habits have an impact on contaminant exposures. A tool was developed to calculate chemical exposures for different Danish population groups. First, the tool divided the individuals into quartiles using a previously...
Sat, 10/05/2019 - 03:24
Author(s): Ina Geburek, Angelika Preiss-Weigert, Monika Lahrssen-Wiederholt, Dieter Schrenk, Anja TheseAbstractPyrrolizidine alkaloid (PA) forming plants are found worldwide and may contaminate food products at levels being of concern for human health. Due to the high biodiversity of PA producing plants many different types of PA structures are formed. PAs themselves are not toxic but require...
Sat, 09/28/2019 - 03:19
Author(s): Fang Du, Ting Zhao, Hong-Chen Ji, Ying-Biao Luo, Fen Wang, Guang-Hua Mao, Wei-Wei Feng, Yao Chen, Xiang-Yang Wu, Liu-Qing YangAbstractPolychlorinated biphenyls (PCBs) would do serious damage to multiple systems, while coplanar polychlorinated biphenyls, the most toxic member of the family, has been widely taken into consideration. In this study, ICR mice were fed with different doses...
Sat, 09/28/2019 - 03:19
Author(s): Subrata Banik, Mahmuda Akter, Serene Ezra Corpus Bondad, Takeshi Saito, Toshiyuki Hosokawa, Masaaki KurasakiAbstractCarvacrol is a monoterpenic phenol found in essential oils, is considered a safe food additive, and possesses various therapeutic properties. Numerous studies have also deciphered the protective role of carvacrol on various cytotoxicities. We clarify the effects of...
Tue, 09/24/2019 - 03:24
Author(s): Daniela Enescu, Miguel A. Cerqueira, Pablo Fucinos, Lorenzo M. PastranaAbstractNanotechnology applied to food and beverage packaging has created enormous interest in recent years, but in the same time there are many controversial issues surrounding nanotechnology and food. The benefits of engineered nanoparticles (ENPs) in food-contact applications are accompanied by safety concerns...
Tue, 09/24/2019 - 03:24
Author(s): Alexandra E. Turley, Kristin K. Isaacs, Barbara A. Wetmore, Agnes L. Karmaus, Michelle R. Embry, Mansi KrishanAbstractPrograms including the ToxCast project have generated large amounts of in vitro high‒throughput screening (HTS) data, and best approaches for the interpretation and use of HTS data, including for chemical safety assessment, remain to be evaluated. To fill this gap, we...
Tue, 09/24/2019 - 03:24
Author(s): Nathan C. Twaddle, Frederick A. Beland, Daniel R. DoergeAbstractArsenic is a common toxic contaminant in food and drinking water. Metabolic activation of arsenic species produces reactive trivalent intermediates that can disrupt cellular regulatory systems by covalent binding to thiol groups. Arsenic exposures have been associated with human diseases including cancer, diabetes, lung...
Tue, 09/24/2019 - 03:24
Author(s): Keuri Eleutério Rodrigues, Fábio Rodrigues de Oliveira, Benilson Ramos Cassunde Barbosa, Ricardo S. Oliveira Paraense, Cahy Manoel Bannwart, Bruno Gonçalves Pinheiro, Anderson de Santana Botelho, Nilton Akio Muto, Cristine Bastos do Amarante, Moises Hamoy, Barbarella de Matos Macchi, Cristiane do Socorro Ferraz Maia, Alejandro Ferraz do Prado, José Luiz Martins do...
Tue, 09/24/2019 - 03:24
Author(s): Guowei Chen, Gang Wang, Cuijuan Zhu, Xinwei Jiang, Jianxia Sun, Lingmin Tian, Weibin BaiAbstractGastrointestinal studies suggested that balanced gut microbial community contribute to a healthy gut. Our previous studies have suggested that cyanidin-3-O-glucoside (C3G) can alleviate food contaminant 3-Chloro-1,2-propanediol (3-MCPD) induced testis injury and improve the spermatogenesis...
Tue, 09/24/2019 - 03:24
Author(s): Shahrzad Tafazoli, Trung D. Vo, Ashley Roberts, Chester Rodriguez, René Viñas, Michael E. Madonna, Yi-Hsuan Chiang, Juliana W. Noronha, Jonathon C. Holguin, Jason A. Ryder, Alan PerlsteinAbstractMiraculin is a glycoprotein with the ability to make sour substances taste sweet. The safety of miraculin has been evaluated using an approach proposed by the Food and Agriculture Organization...
Tue, 09/24/2019 - 03:24
Author(s): Ana Juan-García, Domenico Montesano, Jordi Mañes, Cristina JuanAbstractIn this work, the cytotoxicity of Beauvericin (BEA), lutein (LUT), zeaxanthin (ZEAX) and goji berries extract (GBE) rich in carotenoids, was investigated, as well as cytoprotective effects of these carotenoids against BEA induced-cytotoxicity on Caco-2 cells. Cytotoxicity was carried out using MTT and protein...
Tue, 09/24/2019 - 03:24
Author(s): L. Mantecón, R. Moyano, A.M. Cameán, A. JosAbstractTetraSOD® is a powder of the lyophilized biomass of Tetraselmis chuii strain CCFM03, a marine microalga with a history of use as feed in the aquaculture industry. Recently, algae including T. chuii have been investigated for their potential use in human food. However, published toxicology studies addressing the safety of T. chuii as a...
Tue, 09/24/2019 - 03:24
Author(s): Caroline Silveira Martinez, Janaina Trindade Piagette, Alyne Gourlart Escobar, Ángela Martín, Roberto Palacios, Franck Maciel Peçanha, Dalton Valentim Vassallo, Christopher Exley, María Jesús Alonso, Mercedes Salaices, Marta Miguel, Giulia Alessandra WiggersAbstractAluminum (Al) is toxic for humans and animals. Here, we have tested the potential for Egg White Hydrolysate (EWH) to...
Thu, 09/19/2019 - 14:29
Publication date: Available online 17 September 2019 Food and Chemical ToxicologyAuthor(s): Wei Yang, Zhi-Kai Tian, Hui-Xin Yang, Zhao-Jun Feng, Jian-Mei Sun, Hong Jiang, Chao Cheng, Qing-Lei Ming, Chan-Min LiuAbstractFisetin, a natural flavonoid found in plants, fruits and vegetables, exerts anti-cancer, anti-oxidant, anti-inflammatory and anti-mitotic effects. The current study instigates the...
Thu, 09/19/2019 - 14:29
Publication date: Available online 19 September 2019 Food and Chemical ToxicologyAuthor(s): Luka Žnideršič, Anita Mlakar, Helena ProsenAbstractThe development and validation of a simple, low-cost, and sensitive method for the determination of nine compounds expected in beverages and vinegar as a result of migration from food contact material (parabens, phenolic antioxidants, sulfonamide...
Tue, 09/17/2019 - 01:03
Publication date: Available online 15 September 2019 Food and Chemical ToxicologyAuthor(s): J. Pitt, M. Chan, C. Gibson, O. Hasselwander, A. Lim, P. Mukerji, R. Mukherjea, A. Myhre, P. Sarela, P. Tenning, M.W. Himmelstein, J.M. RoperAbstract3-Fucosyllactose (3-FL), a highly abundant complex carbohydrate in human breast milk, functions as a prebiotic promoting early microbial colonization of the...
Sun, 09/15/2019 - 01:03
Publication date: Available online 7 September 2019 Food and Chemical ToxicologyAuthor(s): Katharina Vejdovszky, Daniela Mihats, Antonia Griesbacher, Josef Wolf, Johann Steinwider, Johannes Lueckl, Bernhard Jank, Ian Kopacka, Elke Rauscher-GabernigAbstractRisk assessment of chemical mixtures remains a challenging task in all areas of food and consumer safety. So far, no general method has been...
Mon, 09/02/2019 - 01:03
Publication date: Available online 31 August 2019 Food and Chemical ToxicologyAuthor(s): Yancho Zarev, Tania Naessens, Mart Theunis, Esameldin Elgorashi, Sandra Apers, Iliana Ionkova, Luc Verschaeve, Luc Pieters, Nina Hermans, Kenn FoubertAbstractStem bark of Erythrina latissima E. Mey (Leguminosae) contains a wide range of prenylated flavonoids able to counteract the genotoxic properties of...

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