Food and Chemical Toxicology

Fri, 11/27/2020 - 06:08
Author(s): Lisa Goedtke, Andrea John, Alfonso Lampen, Albrecht Seidel, Albert Braeuning, Stefanie Hessel-Pras Carcinogenic benzo[a]pyrene (BP) and other non-carcinogenic polycyclic aromatic hydrocarbons (PAH) like fluoranthene (FA) and pyrene (PYR) occur as food contaminants. Molecular effects of BP, FA and PYR in human liver cells were investigated using mixtures occurring in grilled meat....
Sat, 11/21/2020 - 06:13
Author(s): Katharina Vejdovszky, Daniela Mihats, Antonia Griesbacher, Josef Wolf, Johann Steinwider, Johannes Lueckl, Bernhard Jank, Ian Kopacka, Elke Rauscher-Gabernig Through our daily diet, we are exposed to a variety of food contaminants. Yet, assessing the cumulative health risk of chemical mixtures remains a challenge. Using a recently developed method, the modified Reference Point Index (...
Thu, 11/19/2020 - 06:14
Author(s): Marta Mesias, Cristina Delgado-Andrade, Francisca Holgado, Lucía González-Mulero, Francisco J. Morales Variability in home-cooking practices affects dietary exposure to acrylamide, limiting risk evaluation. Two observational tests (controlled and randomized) involving 127 volunteers was designed to investigate the influence of consumer decisions on acrylamide formation during the...
Thu, 11/19/2020 - 06:14
Author(s): Qian Chu, Shaopeng Wang, Liping Jiang, Yuhang Jiao, Xiance Sun, Jing Li, Ling Yang, Yunfeng Hou, Ningning Wang, Xiaofeng Yao, Xiaofang Liu, Cong Zhang, Guang Yang Patulin (PAT), a kind of mycotoxin, is produced by many common fungi in fruit and vegetable-based products. It has been shown to cause hepatotoxicity. However, the possible mechanisms are not completely elucidated. The...
Fri, 11/06/2020 - 06:09
Author(s): Süreyya Oğuz Tümay, Vildan Şanko, Erhan Demirbas, Ahmet Şenocak Cadmium is one of the most toxic metal that accumulates in the human body via food chain, industrial/agricultural activies. It also has negative effects in organs such as the brain, liver and central nervous system. Therefore, International Agency for Research on Cancer is classified cadmium as “carcinogenic to humans” (...
Fri, 11/06/2020 - 06:09
Author(s): Promy Virk, Nourah Abdual Rahman Al-mukhaizeem, Sara Hamad Bin Morebah, Dalia Fouad, Mai Elobeid Contamination of cereal crops with zearalenone (ZEA), a mycotoxin produced by Fusarium fungi, is a worldwide health concern. The study assessed the ameliorative potential of resveratrol (RSV), a potent antioxidant against ZEA induced toxicity in adult male Wistar rats. Rats (n = 40), with...
Thu, 11/05/2020 - 06:17
Author(s): Yun Li, JiaSheng Wang, JinJuan Li, XiuLan Sun Previous studies on the risk assessment of chemicals with respect to human health have focused mainly on the safety of individual substances. Recently, public health policy emphasizes the combined effects of mixtures. An overall risk probability (ORP)-based method long with the combined toxicity factor (cuv) can be used to evaluate the...
Thu, 11/05/2020 - 06:17
Author(s): Pu Cui, Hangbin Yan, Daniel Granato, Chi-Tang Ho, Ziling Ye, Yong Wang, Liang Zhang, Yu Zhou Recently, mycotoxins safety in Chinese post-fermented teas has attracted much attention because it is still controversial whether environmental fungi in the teas are able to produce aflatoxins. In this study, a rapid and selective analytical method based on immunoaffinity column (IAC) cleaning...
Wed, 11/04/2020 - 06:09
Author(s): Valentin Năstăsescu, Magdalena Mititelu, Marina Goumenou, Anca Oana Docea, Elisavet Renieri, Denisa Ioana Udeanu, Eliza Oprea, Andreea Letitia Arsene, Cristina Elena Dinu-Pîrvu, Manuela Ghica Cattle milk’s health benefits can be compromised by the presence of contaminants. The levels of cadmium, copper, lead and zinc, and residues of dichlorodiphenyldichloroethylene (DDE),...
Tue, 11/03/2020 - 06:17
Author(s): Jian-Ri Li, Yen-Chuan Ou, Chih-Cheng Wu, Jiaan-Der Wang, Shih-Yi Lin, Ya-Yu Wang, Wen-Ying Chen, Su-Lan Liao, Chun-Jung Chen Excessive accumulation of cadmium is known to cause nephrotoxicity by targeting renal proximal tubular epithelial cells. Studies showed an essential role of autophagy in cadmium-induced nephrotoxicity; however, its underlying mechanisms accompanied by autophagy...
Mon, 11/02/2020 - 06:08
Author(s): Fojan Agahi, Cristina Juan, Guillermina Font, Ana Juan-García Zearalenone (ZEA), α-zearalenol (α-ZEL) and β-zearalenol (β-ZEL) (ZEA's metabolites) are co/present in cereals, fruits or their products. All three with other compounds, constitute a cocktail-mixture that consumers (and also animals) are exposed and never entirely evaluated, nor in vitro nor in vivo. Effect of ZEA has been...
Wed, 10/14/2020 - 06:09
Author(s): Masatake Fujimura, Fusako Usuki, Takamitsu Unoki The main target organ for MeHg is the nervous system, and its neurological dysfunction remains irreversible. Therefore, predictive biomarkers associated with individual susceptibility to MeHg and future clinical severity are needed to protect against the progression of MeHg toxicity. In this study, we demonstrated that plasma thiol...
Wed, 10/07/2020 - 06:09
Author(s): Chaozhi Wei, Leilei Yu, Nanzhen Qiao, Shumin Wang, Fengwei Tian, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wei Chen Patulin (PAT) is a widespread mycotoxin that harms the health of both humans and animals. In this study, among the 17 tested Lactobacillus plantarum strains, L. plantarum 13M5, isolated from traditional Chinese fermented foods, showed the highest PAT degradation rate of up to...
Tue, 10/06/2020 - 06:14
Author(s): Marta Oliveira, Carolina De Gasperi Portella, Maria João Ramalhosa, Cristina Delerue-Matos, L.S. Sant’Ana, Simone Morais This work assessed the concentrations of 18 polycyclic aromatic hydrocarbons (PAHs) in edible tissues of whitemouth croaker (Micropogonias furnieri) and meagre (Argyrosomus regius) captured in different Atlantic Ocean fishing areas and available to Brazilian and...
Sat, 10/03/2020 - 06:15
Author(s): Peter Cressey, Geoff Miles, Darren Saunders, Andrew J. Pearson Fish (n = 281) of six species, caught in New Zealand waters, were analysed for total mercury (t-Hg), methylmercury (MeHg) and the long-chain polyunsaturated fatty acids, eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA). Mean t-Hg and MeHg concentrations for the six species were in the range 0.06-0.53 mg/kg and 0.06...
Fri, 10/02/2020 - 06:09
Author(s): Luciana Guimarães Eiró, Maria Karolina Martins Ferreira, Leonardo Oliveira Bittencourt, Walessa Alana Bragança Aragão, Michel Platini Caldas de Souza, Marcia Cristina Freitas da Silva, Aline Dionizio, Marília Afonso Rabelo Buzalaf, Maria Elena Crespo-López, Rafael Rodrigues Lima Methylmercury (MeHg) is considered by the World Health Organization (WHO) as one of the chemicals of...
Fri, 10/02/2020 - 06:08
Author(s): Sabine Guth, Angelika Roth, Barbara Engeli, Dirk W. Lachenmeier, Alexander T. Cartus, Stephanie Hüser, Matthias Baum, Patrick Diel, Gerhard Eisenbrand, Jan G. Hengstler, Hans-Ulrich Humpf, Hans-Georg Joost, Alfonso Lampen, Marcel Leist, Doris Marko, Pablo Steinberg, Angela Mally, Jürg Zarn In the past, it was generally accepted as a default assumption that No-Observed-Adverse-Effect...
Fri, 09/04/2020 - 06:08
Author(s): Cetewayo S. Rashid, Amita Bansal, Clementina Mesaros, Marisa S. Bartolomei, Rebecca A. Simmons Humans are ubiquitously exposed bisphenol A (BPA), and epidemiological studies show a positive association between BPA exposure and diabetes risk, but the impact of parental exposure on offspring diabetes risk in humans is unknown. Our previous studies in mice show disruption of metabolic...
Mon, 08/31/2020 - 06:08
Author(s): Tangni Emmanuel K, Van Pamel Els, Huybrechts Bart, Delezie Evelyne, Van Hoeck Els, Daeseleire Els Fusarium mycotoxins are fungal contaminants found in different crops intended for human and animal consumption. Due to the co-occurrence of several of mycotoxins, the present study aimed at examining the transfer of these toxins into tissues of broiler chickens and eggs of laying hens fed...
Thu, 08/27/2020 - 06:12
Author(s): Peipei Pan, Yingfen Ying, Feifei Ma, Cheng Zou, Yige Yu, Yang Li, Zengqiang Li, Yinghui Fang, Tongliang Huang, Ren-Shan Ge, Yiyan Wang Zearalenone is an estrogenic mycotoxin produced by a variety of Fusarium fungi. There is evidence that exposure to zearalenone can cause intrauterine growth restriction, but little is known about the mechanism in the rat placenta caused by zearalenone....
Wed, 08/26/2020 - 06:08
Author(s): Wajid Ali Khan, Muhammad Balal Arain, Mustafa Soylak In the last few years, nanomaterials are widely used sorbents for the extraction of heavy metals in food samples. The nanomaterials have a larger surface area and show high selectivity, fast adsorption capability, and high efficiency for food contaminants (heavy metals). Carbon nanomaterials (CNMs), magnetic nanoparticles (MNPs),...
Mon, 08/17/2020 - 06:08
Author(s): Amaia Ereño Artabe, Hugo Cunha-Silva, Alejandro Barranco Halogenated organic compounds are a particular group of contaminants consisting of a large number of substances, and of great concern due to their persistence in the environment, potential for bioaccumulation and toxicity. Some of these compounds have been classified as persistent organic pollutants (POPs) under The Stockholm...
Sun, 08/16/2020 - 06:08
Author(s): Amaia Lasagabaster, Elisa Jiménez, Tatiana Lehnherr, Katherine Miranda-Cadena, Hansjörg Lehnherr Listeria monocytogenes is a well-known pathogen responsible for the severe foodborne disease listeriosis. The control of L. monocytogenes occurrence in seafood products and seafood processing environments is an important challenge for the seafood industry and the public health sector....
Sun, 08/16/2020 - 06:08
Author(s): Nan Bo, Hong Yilin, Yang Chaoyue, Li Lu, Yuan Yuan Acrylamide (AA) is one of the important products of the Maillard reaction. AA hepatotoxicity is related to inflammation, which can be indicated by the activation of NLRP3 inflammasome. In this study, AA activated NLRP3 inflammasome and released a large number of inflammatory factors in HepG2 cells. AA induced oxidative stress (OS) and...
Thu, 08/06/2020 - 06:13
Author(s): Qian Bu, Yan Huang, Meng Li, Yanping Dai, Xin Fang, Ke Chen, Qian Liu, Aiqin Xue, Kai Zhong, Yina Huang, Hong Gao, Xiaobo Cen Acrylamide (ACR) is a common food contaminant with neurotoxic effects that are formed in the Maillard browning reaction during the heat processing of food. Importantly, pregnant women are also exposed to ACR in food during pregnancy and thus, the fetus is likely...
Wed, 08/05/2020 - 06:08
Author(s): Boris A. Katsnelson, Svetlana V. Klinova, Oksana P. Gerzen, Alexander A. Balakin, Oleg N. Lookin, Ruslan V. Lisin, Salavat R. Nabiev, Larisa I. Privalova, Ilzira A. Minigalieva, Vladimir G. Panov, Leonid B. Katsnelson, Larisa V. Nikitina, Daniil A. Kuznetsov, Yuri L. Protsenko This investigation continues our study of the effects of Pb-Cd poisoning on the heart, extending the enquiry...
Sat, 08/01/2020 - 06:12
Author(s): Rili Hao, Xinyu Song, Feng Li, Xintong Tan, Dongxiao Sun-Waterhouse, Dapeng Li Exposure to nonbiodegradable cadmium (Cd) causes many health problems including the damage to the nervous system. This study aimed to increase knowledge about its neurotoxic effects and the neuroprotective potential of caffeic acid phenethyl ester (CAPE, a polyphenol abundant in honeybee propolis). In mice,...
Wed, 07/22/2020 - 06:07
Author(s): Gengfu Wang, Yingpei Li, Yun Li, Jiaxiang Zhang, Chengfan Zhou, Changhao Wu, Qixing Zhu, Tong Shen Bisphenol A (BPA) exposure can increase the risk of immune-related diseases in later life. Vitamin D3 (Vit D3) has been shown to have multiple immunomodulatory actions and has been used to treat immune diseases. However, the potential beneficial effects of Vit D3 on BPA-induced adverse...
Sat, 07/11/2020 - 06:08
Author(s): D. Karlstetter, A. Mally Furan is a liver toxicant and carcinogen that occurs in heat-processed foods. Due to its volatility, analysis of furan in food does not provide reliable estimates of exposure. Biomarker-based approaches offer the opportunity to more accurately assess human exposure, but a correlation between concentrations of potential biomarkers of furan exposure and external...
Wed, 07/08/2020 - 06:07
Author(s): Maqusood Ahamed, Mohd Javed Akhtar, M.A. Majeed Khan, Hisham A. Alhadlaq Numerous applications of reduced graphene oxide (RGO) and pervasive cadmium (Cd) have led concern about their co-exposure to the environment and human. We studied the combined effects of RGO and Cd in human liver (HepG2) cells. Initially, we found that RGO (up to 50 μg/ml) did not harm to HepG2 cells while Cd...
Tue, 07/07/2020 - 06:09
Author(s): Katarina Baralić, Katarina Živančević, Dragana Javorac, Aleksandra Buha Djordjevic, Milena Anđelković, Dragica Jorgovanović, Evica Antonijević Miljaković, Marijana Ćurčić, Zorica Bulat, Biljana Antonijević, Danijela Đukić-Ćosić Phthalates and bisphenol A, to which people are mainly exposed through food, interfere with the body's endocrine system, along with various other toxic effects...
Sun, 07/05/2020 - 06:06
Author(s): Andrew D. Younger, Anna Neish, David I. Walker, Kaitlyn L. Jenkins, James A. Lowther, Tina A. Stapleton, Mickael Teixeira Alves Depuration of oysters can effectively reduce levels of E. coli, however, may not be effective in safeguarding against viral contamination (EFSA, 2012). These trials assess the removal of Norovirus Genogroups I and II (NoV GI and GII) and F + RNA bacteriophage...
Wed, 07/01/2020 - 06:07
Author(s): Guannan Le, Xin Yuan, Lili Hou, Lei Ge, Shuiping Liu, Muhmood Azhar, Kai Liu, Ziman Lin, Dandan Liu, Fang Gan, Suquan Song, Cuilin Pan, Xingxiang Chen, Kehe Huang Ochratoxin A (OTA) was reported to induce proximal tubules nephrotoxicity in humans and animals. However, the toxicity of OTA on glomeruli has rarely been studied. We investigated OTA-induced glomerular injury and the...
Fri, 06/05/2020 - 03:32
Author(s): Omolola A. Adesanoye, Amos O. Abolaji, Tolulope R. Faloye, Hannah O. Olaoye, Adeola O. Adedara Bisphenol A (BPA) is an industrial chemical used in the production of various plastic materials. It is associated with reproductive, immunological and neurological disorders. Luteolin, a flavonoid found in fruits and vegetables, possesses anti-oxidative, anti-inflammatory and free radical...
Sat, 05/30/2020 - 03:35
Author(s): Shirin Hooshfar, Roya Khosrokhavar, Hassan Yazdanpanah, Samira Eslamizad, Farzad Kobarfard, Firuzeh Nazari, Venetia Kokaraki, Manolis Kokkinakis, Marina Goumenou, Christina Tsitsimpikou, Aristides Tsatsakis In this study, two accurate, precise, selective and sensitive methods were developed for determining aflatoxin M1 (AFM1) in infant formula milk using immunoaffinity column clean-up...
Wed, 05/20/2020 - 03:30
Author(s): Man Liu, Chao Cheng, Xuezhi Li, Sihan Zhou, Jiali Hua, Jie Huang, Yongxin Li, Kunlong Yang, Peng Zhang, Yan Zhang, Jun Tian Ochratoxin A (OTA) is a ubiquitous food contaminant and a critical food safety concern due to its nephron toxic effects, which impacts all parts of the world. Luteolin (LUT) had gained increasing interest as a health-promoting food antioxidant component. However,...
Thu, 05/14/2020 - 03:30
Author(s): Neus González, Josep Calderón, Antoni Rúbies, Jaume Bosch, Isabel Timoner, Victòria Castell, Montse Marquès, Martí Nadal, José L. Domingo Diet is the major route of exposure to arsenic (As), with rice and rice products as food groups with relatively highest As concentrations. This study was aimed at determining the concentrations of total arsenic (total As) and inorganic arsenic (InAs...
Sat, 05/09/2020 - 03:30
Author(s): Mosaad A. Abdel-Wahhab, Aziza A. El-Nekeety, Amal S. Hathout, Asmaa S. Salman, Sekena H. Abdel-Aziem, Nabila S. Hassan, Mohamed S. Abdel-Aziz This study aimed to determine the bioactive compounds of Bacillus sp. MERNA97 extract and to evaluate their efficacy against the oxidative damage, genotoxicity, chromosomal aberration and DNA fragmentation in rats treated with AFB1. Sixty male...
Sat, 05/09/2020 - 03:30
Author(s): Mingyang Wang, Shuhua Yang, Jing Cai, Rong Yan, Lingqi Meng, Miao Long, Yi Zhang Zearalenone (ZEA) is a mycotoxin that contaminates crops worldwide and is toxic to the reproductive systems of mammals, however, the toxicological mechanism by which ZEA affects germ cells is not fully understood. In this study, proteomic analysis using iTRAQ technology was adopted to determine the...
Tue, 05/05/2020 - 03:31
Author(s): Ana G. Cabado, Jorge Lago, Virginia González, Lucía Blanco, Beatriz Paz, Jorge Diogène, Laura Ferreres, Maria Rambla-Alegre
Thu, 04/30/2020 - 03:32
Author(s): A.M. Api, F. Belmonte, D. Belsito, S. Biserta, D. Botelho, M. Bruze, G.A. Burton, J. Buschmann, M.A. Cancellieri, M.L. Dagli, M. Date, W. Dekant, C. Deodhar, A.D. Fryer, S. Gadhia, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, D.C. Liebler This safety assessment is based on the RIFM Criteria Document (Api et al., 2015), which should be referred to for clarifications. Each endpoint...
Wed, 04/29/2020 - 03:30
Author(s): Si Chen, Shuhua Yang, Mingyang Wang, Jia Chen, Sheng Huang, Zhen Wei, Ziyang Cheng, Hanli Wang, Miao Long, Peng Li The toxic effect of zearalenone (ZEA) is not fully understood and there is an urgent need for the development of effective agents to protect against the toxic effects of ZEA. In this study, we detected whether curcumin (CUR) can reduce Leydig cells apoptosis induced by ZEA...
Thu, 04/23/2020 - 03:27
Author(s): Ogouyôm Herbert Iko Afé, Caroline Douny, Yénoukounmè Euloge Kpoclou, Ahmed Igout, Jacques Mahillon, Victor Anihouvi, Djidjoho Joseph Hounhouigan, Marie-Louise Scippo This paper presents methods of reduction of polycyclic aromatic hydrocarbons (PAHs) in grilled or smoked meat and fishery products. Using keywords such as “smoking”, “grilling”, “processing”, “roasting”, “barbecue”, “...
Mon, 04/06/2020 - 03:20
Author(s): Mònica Campàs, Jaume Reverté, Maria Rambla-Alegre, Katrina Campbell, Arjen Gerssen, Jorge Diogène Tetrodotoxin (TTX) is a potent neurotoxin responsible for many food poisoning incidents and some fatalities. Although mainly associated with the consumption of pufferfish, in recent years, TTX has been found in shellfish, particularly in Europe. In this work, a magnetic bead (MB)-based...
Wed, 04/01/2020 - 03:21
Author(s): Kailun Yu, Xiuli Zhang, Xuemei Tan, Mengmeng Ji, Yao Chen, Zhongxiao Wan, Zengli Yu 2,3,7,8-Tetrachlorobenzo-p-dioxin (TCDD), one of the key endocrine disruptors, has been shown to cause reproductive and developmental disorders. Our previous studies have primarily focused on TCDD induced impairment of ovarian follicular development in female F1 rats. It is unknown whether TCDD exposure...
Thu, 03/26/2020 - 03:21
Author(s): M.Á. Martínez, J. Blanco, J. Rovira, V. Kumar, J.L. Domingo, M. Schuhmacher This study was aimed at comparing the toxicity effects on cell viability and the obesogenic activity of Bisphenol A (BPA) and its analogues, Bisphenol S (BPS) and Bisphenol F (BPF), by in vitro assays with a preadipocytic 3T3-L1 cell line. To compare the toxic potential and select the concentrations of each...
Mon, 03/23/2020 - 03:23
Author(s): Marion Hulin, Véronique Sirot, Paule Vasseur, Aurelie Mahe, Jean-Charles Leblanc, Julien Jean, Philippe Marchand, Anaïs Venisseau, Bruno LE. Bizec, Gilles Riviere A total diet study (TDS) was conducted between 2010 and 2016 to characterize the health risk related to chemical residues in food of French not breastfed children under three years of age (infant TDS). Among the targeted...
Sun, 03/22/2020 - 03:20
Author(s): Emily J. Werder, Juliane I. Beier, Dale P. Sandler, Keith C. Falkner, Tyler Gripshover, Banrida Wahlang, Lawrence S. Engel, Matthew C. Cave Exposures to volatile organic compounds and metals have previously been associated with liver diseases including steatohepatitis, although more data are needed. Benzene, toluene, ethylbenzene, xylenes, styrene (BTEXS) and metals were measured in...
Thu, 03/19/2020 - 03:21
Author(s): Vladimir Ostry, Marcela Dofkova, Jitka Blahova, Frantisek Malir, Radek Kavrik, Irena Rehurkova, Jiri Ruprich A dietary exposure assessment to sum of deoxynivalenol (DON) forms, sum of T-2/HT-2 toxins (T2/HT2) and zearalenone (ZEA) was conducted for Czech children 4–6 years and Czech men and women 18–59 years. Retail foods (25 different commodities, n = 336) were assessed by LC-MS/MS...
Sun, 03/15/2020 - 03:36
Author(s): Venkatanaidu Karri, Marta Schuhmacher, Vikas Kumar Conventional toxicological risk assessment methods mainly working on single chemicals that fail to adequately address the simultaneous exposure and their potential toxicity in humans. We herein investigated the toxic heavy metals lead (Pb), arsenic (As), and methylmercury (MeHg) and their binary mixtures role in neurodegenerative...

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