Food and Chemical Toxicology

Sun, 04/04/2021 - 06:05
Author(s): María Izco, Ariane Vettorazzi, Raquel Forcen, Javier Blesa, Maria de Toro, Natalia Alvarez-Herrera, J Mark Cooper, Elena Gonzalez-Peñas, Adela Lopez de Cerain, Lydia Alvarez-Erviti Some epidemiological studies with different levels of evidence have pointed to a higher risk of Parkinson’s disease (PD) after exposure to environmental toxicants. A practically unexplored potential...
Sun, 04/04/2021 - 06:05
Author(s): Firouzeh Hassani Moghadam, Mohammad A. Taher, Hassan Karimi-Maleh A sensitive and fast approach has been introduced for the voltammetric sensing of bisphenol A based on modification of a paste electrode with Pt-SWCNTs and 1-ethyl-3-methylimidazolium n-butylsulfate as a highly conductive binder. The new sensor was used to determine the concentration of bisphenol A in food products in I-...
Sun, 03/28/2021 - 06:05
Author(s): Zhuang Hong, Wang Minghua, Nan Bo, Yang Chaoyue, Yan Haiyang, Ye Haiqing, Xi Chunyu, Zhang Yan, Yuan Yuan Acrylamide (AA) is a common endogenous contaminant in food, with a complex toxicity mechanism. The study on liver damage to experimental animals caused by AA has aroused a great attention. Rosmarinic acid (RosA) as a natural antioxidant shows excellent protective effects against AA...
Wed, 03/17/2021 - 06:05
Author(s): Ha Ngo-Thanh, Trang Dam Thuy, Kazutomo Suzue, Wataru Kamitani, Hideaki Yokoo, Koji Isoda, Chikako Shimokawa, Hajime Hisaeda, Takashi Imai The consumption of dietary acrylamide (ACR), a carcinogen, results in the dysfunction of various organs and the immune system. However, the impact of ACR exposure on the progression of infectious diseases is unknown. This study investigated the...
Sun, 03/14/2021 - 06:05
Author(s): Xiaotong Li, Zhiming Lv, Jia Chen, Eugenie Nepovimova, Miao Long, Wenda Wu, Kamil Kuca Aflatoxin B1 (AFB1) is a mycotoxin often found in food and livestock feed. It can affect human and animal health and is especially damaging to the liver. This study aims to evaluate whether Bacillus amyloliquefaciens (hereafter referred to as B. amyloliquefaciens) B10 can alleviate the toxic effects...
Sun, 03/14/2021 - 06:05
Author(s): Wei Wei, Chong Liu, Ping Ke, Xiaoyun Chen, Ting Zhou, Junfeng Xu, Yu Zhou Ochratoxin A (OTA), a potent mycotoxin, is a common contaminant of agro-products, which seriously threatens food safety. The OTA regulatory limits vary from different countries/regions. However, little is known about the toxicological effects of successive exposure to regulatory levels of OTA. In this study,...
Sun, 03/14/2021 - 06:05
Author(s): Bozidar Udovicki, Nikola Tomic, Bojana Spirovic Trifunovic, Sasa Despotovic, Jelena Jovanovic, Liesbeth Jacxsens, Andreja Rajkovic Classified as Group 1 carcinogens aflatoxins (AFs) are of major concern for food safety and public health. Within the AFs group, aflatoxin B1 (AFB1) occurs at the highest levels in different food products and is considered as the most potent representative...
Sat, 03/13/2021 - 06:08
Author(s): Marjan Koushkestani, Samira Abbasi-Moayed, Forough Ghasemi, Vahideh Mahdavi, M. Reza Hormozi-Nezhad In this work, a colorimetric sensor array has been designed for the identification and discrimination of thiometon (TM) and phosalone (PS) as organophosphate pesticides and prothioconazole (PC) as a triazole pesticide. For this purpose, two different plasmonic nanoparticles including...
Mon, 03/01/2021 - 06:05
Author(s): Jin Liu, Jinglan Liao, Chenyun Zhang, Lingfeng Zeng, Chaowei Zong, Yake Lv, Jingwen Li, Wenchang Zhang Cadmium (Cd) is known to affect ovarian granulosa cells (GCs), but no information on the transgenerational effects of Cd on GCs. In this study, pregnant Sprague-Dawley (SD) rats were orally dosed with Cd from gestation day 1 until birth. F1 or F2 female rats were mated with untreated...
Sat, 02/20/2021 - 06:13
Author(s): Jose Alejandro Romero Herrera, Sofie Theresa Thomsen, Lea Jakobsen, Sisse Fagt, Karina Banasik, Jose MG. Izarzugaza, Søren Brunak, Sara M. Pires Lifestyle and sociodemographics are likely to influence dietary patterns, and, as a result, human exposure to chemical contaminants in foods and their associated health impact. We aimed to characterize subgroups of the Danish population based...
Tue, 02/16/2021 - 06:13
Author(s): Yuanyuan Fang, Lili Lu, Yuan Liang, Dongjie Peng, Michael Aschner, Yueming Jiang Lead is a heavy metal pollutant that is widely present in the environment. It affects every organ system, yet the nervous system appears to be the most sensitive and primary target. Although many countries have made significant strides in controlling Pb pollution, Pb poisoning continuous to be a major...
Sat, 02/13/2021 - 06:13
Author(s): Chaoyue Yang, Bo Nan, Haiqing Ye, Haiyang Yan, Minghua Wang, Yuan Yuan Acrylamide (AA), an important by-product of the Maillard reaction, has been reported to be genotoxic and carcinogenic. The present study employed miRNAs to investigate the toxic mechanism of AA and their role against AA toxicity. Deep sequencing of small RNA libraries was performed and miR-193b-5p was applied for...
Sat, 02/13/2021 - 06:13
Author(s): Yumi Abiko, Yusuke Katayama, Masahiro Akiyama, Yoshito Kumagai Garlic (Allium sativum L.) contains numerous sulfur compounds. We have previously found that reactive sulfur species such as glutathione persulfide, glutathione polysulfide, protein-bound persulfides, and hydrogen sulfide can bind to methylmercury to give bismethylmercury sulfide, which is less toxic than methylmercury. It...
Thu, 02/11/2021 - 06:13
Author(s): Jiahui Han, Chengni Jin, Yujie Zhong, Jiachang Zhu, Qi Liu, Dianjun Sun, Jiayu Feng, Xiaodong Xia, Xiaoli Peng Patulin (PAT) is a kind of mycotoxins that commonly found in decayed fruits and their products. Our previous studies have shown that PAT induced cell apoptosis and the overproduction of reactive oxygen species (ROS) in human embryonic kidney (HEK293) cells. The present study...
Fri, 02/05/2021 - 06:06
Author(s): Alireza Khataee, Hessamaddin Sohrabi, Omid Arbabzadeh, Pegah Khaaki, Mir Reza Majidi Highly sensitive and rapid methods for the Ochratoxin A (OTA) detection as a main class of Ochratoxins (OT) in various food samples is significant. In the present review, novel OTA detection techniques based on electrochemical and conventional methods have been extensively explained, and also compared...
Wed, 02/03/2021 - 06:05
Author(s): Huiwen Zhang, Yushen Liu, Shuo Yao, Mingyu Shang, Chao Zhao, Juan Li, Juan Wang Food safety problems attributed to foodborne pathogenic bacteria seriously endanger human health and cause substantial economic losses. Novel assays for rapid and sensitive identification of foodborne pathogenic bacteria are highly desired. In this study, a multicolor sensing system has been established for...
Fri, 01/29/2021 - 06:06
Author(s): Ivana Mirkov, Aleksandra Popov Aleksandrov, Marina Ninkov, Dina Tucovic, Jelena Kulas, Milica Zeljkovic, Dusanka Popovic, Milena Kataranovski Cadmium (Cd) has been listed as one of the most toxic substances affecting numerous tissues/organs, including the immune system. Due to variations in studies examining Cd effects on the immune system (exposure regime, experimental systems, immune...
Fri, 01/29/2021 - 06:06
Author(s): Anand Kumar Chaudhari, Vipin Kumar Singh, Somenath Das, Nawal Kishore Dubey Spoilage of food by mycotoxigenic fungi poses a serious risk to food security throughout the world. In view of the negative effects of synthetic preservatives, essential oils (EOs) and their bioactive constituents are gaining momentum as suitable substitute to ensure food safety by controlling mycotoxins....
Sat, 01/23/2021 - 06:11
Author(s): Irmela Sarvan, Anna Elena Kolbaum, Ulrike Pabel, Thorsten Buhrke, Matthias Greiner, Oliver Lindtner The BfR MEAL Study is the first German total diet study and will establish a representative and comprehensive database for dietary exposure assessment in Germany. The present study reports first results of the BfR MEAL Study regarding methylmercury in fish, seafood and mushrooms. In...
Sat, 01/09/2021 - 06:09
Author(s): Shabir Ahmad Mir, B.N. Dar, Manzoor Ahamd Shah, Sajad Ahmad Sofi, Afshan Mumtaz Hamdani, Carlos A.F. Oliveira, Motahareh Hashemi Moosavi, Amin Mousavi Khaneghah, Anderson S. Sant'Ana Emerging decontamination technologies have been attracted considerable attention to address the consumers' demand for high quality and safe food products. As one of the important foods in the human diet,...
Sat, 01/09/2021 - 06:09
Author(s): D. Tardieu, A. Travel, C. Le Bourhis, J.-P. Metayer, A. Mika, D. Cleva, C. Boissieu, P. Guerre Previous studies using zearalenone (ZEN) and fumonisins (FB) revealed alpha-zearalanol (α-ZOL) and FB1 in the liver of turkeys and chickens with no sign of toxicity. The aim of the present study was to determine whether contamination persists after distribution of a mycotoxin-free diet for...
Fri, 01/08/2021 - 06:05
Author(s): Wanyue Huang, Menglin Liu, Bonan Xiao, Jian Zhang, Miao Song, Yanfei Li, Zheng Cao Aflatoxin B1 (AFB1) is an unavoidable food and environmental contaminant, which can lead to disorders in spermatogenesis and its mechanism remains unclear. The blood-testis barrier (BTB) is responsible for ensuring normal spermatogenesis in testes. Therefore, we hypothesized that disruption of the BTB...
Thu, 01/07/2021 - 06:09
Author(s): Na Ling, Xin Wang, Dengyu Liu, Yizhong Shen, Danfeng Zhang, Dexin Ou, Hongying Fan, Juan Wang, Yu Ding, Jumei Zhang, Qingping Wu, Yingwang Ye Cronobacter malonaticus is one of the important foodborne pathogens causing infections mainly in adults. Biofilm formation, adhesion, and motility in Cronobacter have been documented, but the implying molecular mechanism has received little...
Wed, 01/06/2021 - 06:04
Author(s): Ru Jia, Faizan Ahmed Sadiq, Wenbin Liu, Lirong Cao, Zhuoyu Shen Deoxynivalenol (DON) poses a serious health threat to animals and humans consuming DON-contaminated food and feed. Biological means of detoxification of DON are considered as one of the effective strategies. The aim of the work was to study ameliorative effects of Bacillus subtilis ASAG 216 on DON-induced toxicosis in...
Fri, 01/01/2021 - 06:04
Author(s): Bo Song, Guiya Xiong, Huan Luo, Zhenzi Zuo, Zhijun Zhou, Xiuli Chang Cadmium (Cd) is a toxic heavy metal and widely exists in the environment. Extensive studies have revealed that Cd exposure can elicit neurotoxicity and potentially interfere with neurogenesis. However, underlying mechanisms by which Cd exposure affects neurogenesis remain unclear. In this study, we performed single-...
Wed, 12/30/2020 - 06:04
Author(s): Xusheng Li, Haiwei Li, Dongbao Cai, Ping Li, Jietian Jin, Xinwei Jiang, Zhenhua Li, Lingmin Tian, Guobing Chen, Jianxia Sun, Weibin Bai Cadmium (Cd) is a potentially toxic trace element frequently existed in foods, water, and air, threatening liver function from its continuous bioaccumulation and induction of oxidative stress and inflammation. However, the hepatotoxicity of Cd during...
Sat, 12/26/2020 - 06:08
Author(s): Jesús Herrera-Bravo, Jorge F. Beltrán-Lissabet, Kathleen Saavedra, Nicolás Saavedra, Monserrat Hevia, Marysol Alvear, Fernando Lanas, Luis A. Salazar Polycyclic Aromatic Hydrocarbons (PAHs) are pollutants found in the air generated mainly by the combustion of coal or biomass burning. Exposure to Polycyclic Aromatic Hydrocarbons is positively correlated with cardiovascular diseases....
Sat, 12/26/2020 - 06:08
Author(s): Nan Bo, Yang Chaoyue, Li Lu, Ye Haiqing, Yan Haiyang, Wang Minghua, Yuan Yuan Acrylamide (AA) in heat-processed food leads to widespread concerns due to its hepatotoxicity. Allicin, a plant-derived antioxidant, possesses a significant protective effect on AA-induced hepatotoxicity, but the mechanism is still unclear. Herein, we investigated the mechanism in Kupffer cells and SD rats...
Thu, 12/17/2020 - 06:09
Author(s): Beatriz Ferrer, Lisa M. Prince, Alexey A. Tinkov, Abel Santamaria, Marcelo Farina, João Batista Rocha, Aaron B. Bowman, Michael Aschner Several studies have demonstrated that heavy metals disrupt energy homeostasis. Leptin inhibits food intake and decreases body weight through activation of its receptor in the hypothalamus. The impact of heavy metals on leptin signaling in the...
Sat, 12/12/2020 - 06:04
Author(s): Amanda Caroline Trassi Conteçotto, Giseli Cristina Pante, Juliana Cristina Castro, Aline Amenecia de Souza, Renata Sano Lini, Jéssica Cristina Zoratto Romoli, Benício Alves de Abreu Filho, Jane Martha Graton Mikcha, Simone Aparecida Galerani Mossini, Miguel Machinski Junior This study aimed to evaluate the risk concerning child population’s health because of the occurrence of AFM1 in...
Fri, 12/11/2020 - 06:03
Author(s): Hongyan Guo, Jian Ji, Kaimin Wei, Jiadi Sun, Yinzhi Zhang, Xiulan Sun Deoxynivalenol (DON) and cadmium (Cd) not only share target organs, but also share certain upstream and downstream toxic pathways. DON and Cd may accumulate in the food chain, increasing the risk of joint exposure. Therefore, there is a significant need to characterize the joint toxicity of these two compounds. The...
Thu, 12/10/2020 - 06:04
Author(s): Celine Meerpoel, Arnau Vidal, Mirjana Andjelkovic, Marthe De Boevre, Emmanuel K. Tangni, Bart Huybrechts, Mathias Devreese, Siska Croubels, Sarah De Saeger Exposure to mycotoxins is a worldwide problem. To ensure public health, it is imperative to characterize the risks related to these toxins. The present study aims to conduct a dietary exposure assessment of citrinin (CIT) and...
Wed, 12/09/2020 - 06:06
Author(s): Beatriz Ferrer, Lisa M. Prince, Alexey A. Tinkov, Abel Santamaria, Aaron B. Bowman, Michael Aschner Methylmercury (MeHg) is a neurotoxic pollutant widely present in the environment. Initial symptoms of MeHg may include loss of body weight. However, the mechanisms by which MeHg induces body weight changes have yet to be fully elucidated. Body weight is regulated by multiple mechanisms....
Wed, 12/02/2020 - 06:07
Author(s): Manar Al Ayoubi, Michele Solfrizzo, Lucia Gambacorta, Ian Watson, Nada El Darra Spices are susceptible to mycotoxin contamination which can cause gastrointestinal and adverse central nervous symptoms in humans, which highlights the importance of assessing the risk of their consumption on a daily basis. The aim of this study was to assess the risk of mycotoxin intake from spices in...
Fri, 11/27/2020 - 06:08
Author(s): Lisa Goedtke, Andrea John, Alfonso Lampen, Albrecht Seidel, Albert Braeuning, Stefanie Hessel-Pras Carcinogenic benzo[a]pyrene (BP) and other non-carcinogenic polycyclic aromatic hydrocarbons (PAH) like fluoranthene (FA) and pyrene (PYR) occur as food contaminants. Molecular effects of BP, FA and PYR in human liver cells were investigated using mixtures occurring in grilled meat....
Sat, 11/21/2020 - 06:13
Author(s): Katharina Vejdovszky, Daniela Mihats, Antonia Griesbacher, Josef Wolf, Johann Steinwider, Johannes Lueckl, Bernhard Jank, Ian Kopacka, Elke Rauscher-Gabernig Through our daily diet, we are exposed to a variety of food contaminants. Yet, assessing the cumulative health risk of chemical mixtures remains a challenge. Using a recently developed method, the modified Reference Point Index (...
Thu, 11/19/2020 - 06:14
Author(s): Marta Mesias, Cristina Delgado-Andrade, Francisca Holgado, Lucía González-Mulero, Francisco J. Morales Variability in home-cooking practices affects dietary exposure to acrylamide, limiting risk evaluation. Two observational tests (controlled and randomized) involving 127 volunteers was designed to investigate the influence of consumer decisions on acrylamide formation during the...
Thu, 11/19/2020 - 06:14
Author(s): Qian Chu, Shaopeng Wang, Liping Jiang, Yuhang Jiao, Xiance Sun, Jing Li, Ling Yang, Yunfeng Hou, Ningning Wang, Xiaofeng Yao, Xiaofang Liu, Cong Zhang, Guang Yang Patulin (PAT), a kind of mycotoxin, is produced by many common fungi in fruit and vegetable-based products. It has been shown to cause hepatotoxicity. However, the possible mechanisms are not completely elucidated. The...
Fri, 11/06/2020 - 06:09
Author(s): Süreyya Oğuz Tümay, Vildan Şanko, Erhan Demirbas, Ahmet Şenocak Cadmium is one of the most toxic metal that accumulates in the human body via food chain, industrial/agricultural activies. It also has negative effects in organs such as the brain, liver and central nervous system. Therefore, International Agency for Research on Cancer is classified cadmium as “carcinogenic to humans” (...
Fri, 11/06/2020 - 06:09
Author(s): Promy Virk, Nourah Abdual Rahman Al-mukhaizeem, Sara Hamad Bin Morebah, Dalia Fouad, Mai Elobeid Contamination of cereal crops with zearalenone (ZEA), a mycotoxin produced by Fusarium fungi, is a worldwide health concern. The study assessed the ameliorative potential of resveratrol (RSV), a potent antioxidant against ZEA induced toxicity in adult male Wistar rats. Rats (n = 40), with...
Thu, 11/05/2020 - 06:17
Author(s): Yun Li, JiaSheng Wang, JinJuan Li, XiuLan Sun Previous studies on the risk assessment of chemicals with respect to human health have focused mainly on the safety of individual substances. Recently, public health policy emphasizes the combined effects of mixtures. An overall risk probability (ORP)-based method long with the combined toxicity factor (cuv) can be used to evaluate the...
Thu, 11/05/2020 - 06:17
Author(s): Pu Cui, Hangbin Yan, Daniel Granato, Chi-Tang Ho, Ziling Ye, Yong Wang, Liang Zhang, Yu Zhou Recently, mycotoxins safety in Chinese post-fermented teas has attracted much attention because it is still controversial whether environmental fungi in the teas are able to produce aflatoxins. In this study, a rapid and selective analytical method based on immunoaffinity column (IAC) cleaning...
Wed, 11/04/2020 - 06:09
Author(s): Valentin Năstăsescu, Magdalena Mititelu, Marina Goumenou, Anca Oana Docea, Elisavet Renieri, Denisa Ioana Udeanu, Eliza Oprea, Andreea Letitia Arsene, Cristina Elena Dinu-Pîrvu, Manuela Ghica Cattle milk’s health benefits can be compromised by the presence of contaminants. The levels of cadmium, copper, lead and zinc, and residues of dichlorodiphenyldichloroethylene (DDE),...
Tue, 11/03/2020 - 06:17
Author(s): Jian-Ri Li, Yen-Chuan Ou, Chih-Cheng Wu, Jiaan-Der Wang, Shih-Yi Lin, Ya-Yu Wang, Wen-Ying Chen, Su-Lan Liao, Chun-Jung Chen Excessive accumulation of cadmium is known to cause nephrotoxicity by targeting renal proximal tubular epithelial cells. Studies showed an essential role of autophagy in cadmium-induced nephrotoxicity; however, its underlying mechanisms accompanied by autophagy...
Mon, 11/02/2020 - 06:08
Author(s): Fojan Agahi, Cristina Juan, Guillermina Font, Ana Juan-García Zearalenone (ZEA), α-zearalenol (α-ZEL) and β-zearalenol (β-ZEL) (ZEA's metabolites) are co/present in cereals, fruits or their products. All three with other compounds, constitute a cocktail-mixture that consumers (and also animals) are exposed and never entirely evaluated, nor in vitro nor in vivo. Effect of ZEA has been...
Wed, 10/14/2020 - 06:09
Author(s): Masatake Fujimura, Fusako Usuki, Takamitsu Unoki The main target organ for MeHg is the nervous system, and its neurological dysfunction remains irreversible. Therefore, predictive biomarkers associated with individual susceptibility to MeHg and future clinical severity are needed to protect against the progression of MeHg toxicity. In this study, we demonstrated that plasma thiol...
Wed, 10/07/2020 - 06:09
Author(s): Chaozhi Wei, Leilei Yu, Nanzhen Qiao, Shumin Wang, Fengwei Tian, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wei Chen Patulin (PAT) is a widespread mycotoxin that harms the health of both humans and animals. In this study, among the 17 tested Lactobacillus plantarum strains, L. plantarum 13M5, isolated from traditional Chinese fermented foods, showed the highest PAT degradation rate of up to...
Tue, 10/06/2020 - 06:14
Author(s): Marta Oliveira, Carolina De Gasperi Portella, Maria João Ramalhosa, Cristina Delerue-Matos, L.S. Sant’Ana, Simone Morais This work assessed the concentrations of 18 polycyclic aromatic hydrocarbons (PAHs) in edible tissues of whitemouth croaker (Micropogonias furnieri) and meagre (Argyrosomus regius) captured in different Atlantic Ocean fishing areas and available to Brazilian and...
Sat, 10/03/2020 - 06:15
Author(s): Peter Cressey, Geoff Miles, Darren Saunders, Andrew J. Pearson Fish (n = 281) of six species, caught in New Zealand waters, were analysed for total mercury (t-Hg), methylmercury (MeHg) and the long-chain polyunsaturated fatty acids, eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA). Mean t-Hg and MeHg concentrations for the six species were in the range 0.06-0.53 mg/kg and 0.06...
Fri, 10/02/2020 - 06:09
Author(s): Luciana Guimarães Eiró, Maria Karolina Martins Ferreira, Leonardo Oliveira Bittencourt, Walessa Alana Bragança Aragão, Michel Platini Caldas de Souza, Marcia Cristina Freitas da Silva, Aline Dionizio, Marília Afonso Rabelo Buzalaf, Maria Elena Crespo-López, Rafael Rodrigues Lima Methylmercury (MeHg) is considered by the World Health Organization (WHO) as one of the chemicals of...

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