Food and Chemical Toxicology

Sun, 07/25/2021 - 06:06
Author(s): Jia Chen, Zhiming Lv, Ziyang Cheng, Tiancheng Wang, Peng Li, Aibo Wu, Eugenie Nepovimova, Miao Long, Wenda Wu, Kamil Kuca Aflatoxin B1 is a mycotoxin that widely exists in feed and has a great impact on human and animal health. This study aimed to examine whether Bacillus amyloliquefaciens B10 protected against aflatoxin B1-induced cecal inflammation in mice. It was found that Bacillus...
Fri, 07/23/2021 - 16:01
Author(s): Ana M. Molina, Nieves Abril, Antonio J. Lora, Paula V. Huertas-Abril, Nahum Ayala, Carmen Blanco, M.Rosario Moyano Abstract Human exposure to bisphenol-A (BPA) is largely unavoidable because BPA is an environmental contaminant found in soil, water, food and indoor dust. The safety of authorized BPA amounts in consumer products is under question because new studies have reported...
Wed, 07/21/2021 - 06:06
Author(s): Ying Deng, Qinghua Wu, Wenda Wu, Kamil Kuca The special issue "Mycotoxins in Food: New Determination Methods, Toxic Mechanisms, and Control Strategies" in Food and Chemical Toxicology contains 28 articles on current hot topics in mycotoxins, including deoxynivalenol, T-2 toxin, and fumonisins. Intestinal toxicity, immune toxicity, and oxidative stress are especially concerned by...
Wed, 07/07/2021 - 06:05
Author(s): Linlin Ni, Yanfeng Wei, Jingjing Pan, Xiaoyang Li, Bin Xu, Yu Deng, Tianyao Yang, Wei Liu Methylmercury (MeHg) is a environmental contaminant, which can induce neurotoxic effects. So far, the exact molecular mechanisms of autophagy and its effect on apoptosis in MeHg-induced neurotoxicity have not been elucidated. Here, rats were exposed to MeHg (4, 8, or 12 μmol/kg) for 4 weeks to...
Mon, 06/28/2021 - 06:06
Author(s): Kim Lara Gützkow, Johanna Ebmeyer, Nina Kröncke, Nadja Kampschulte, Linda Böhmert, Cindy Schöne, Nils Helge Schebb, Rainer Benning, Albert Braeuning, Ronald Maul The use of insects as food and feed is gaining more attention for ecological and ethical reasons. Despite the high tolerance of edible yellow mealworm (Tenebrio molitor) larvae to aflatoxin B1 (AFB1), the metabolic fate of the...
Fri, 06/11/2021 - 06:06
Author(s): Shao-Shuai Bi, Hai-Yao Jin, Milton Talukder, Jing Ge, Cong Zhang, Mei-Wei Lv, Mamoon Ali Yaqoob Ismail, Jin-Long Li Cadmium (Cd) is one of the toxic environmental heavy metals that poses health hazard to animal due to its toxicity. Nano-Selenium (Nano-Se) is a Nano-composite form of Se, which has emerged as promising therapeutic agent for its protective roles against heavy metals-...
Fri, 06/11/2021 - 06:06
Author(s): Serena Santonicola, Stefania Albrizio, Maria Carmela Ferrante, Mercogliano Raffaelina The occurrence of analogues of bisphenol A (BPA), including bisphenol F(BPF) in milk is still not well known. BPF may enter the milk chain at the farm and during milk processing at the dairy company. This study identified the main BPF contamination pathways using a monitoring model based on the...
Thu, 06/10/2021 - 06:12
Author(s): Online Supporting Material, Ling Zhao, Yue Feng, Zi-Jian Xu, Ni-Ya Zhang, Wan-Po Zhang, Mahmoud Mohamed Khalil, Lv-Hui Sun The aim of the present study was to explore the underlying mechanism of selenium (Se)-mediated detoxification of aflatoxin B1 (AFB1)-induced cardiotoxicity in chicks. A Se-deficient, corn-soybean meal-basal diet (36 μg Se/kg, BD) and three test diets (BD+1.0 mg...
Wed, 06/09/2021 - 06:05
Author(s): Marta Mesias, Cristina Delgado-Andrade, Francisca Holgado, Lucía González-Mulero, Francisco J. Morales Two observational tests were designed to investigate the influence of consumer decisions during the preparation of French fries from fresh potatoes on acrylamide formation. In both tests, color was of paramount importance to volunteers with regards to the decision to stop the frying...
Sun, 06/06/2021 - 06:05
Author(s): Katarina Baralić, Katarina Živančević, Dragica Jorgovanović, Dragana Javorac, Jelena Radovanović, Tamara Gojković, Aleksandra Buha Djordjevic, Marijana Ćurčić, Zoran Mandinić, Zorica Bulat, Biljana Antonijević, Danijela Đukić-Ćosić Linkage between bis(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA) co-exposure and type 2 diabetes mellitus (T2DM), as well...
Wed, 06/02/2021 - 06:05
Author(s): Benyang Wu, Xiaoyan Chai, Aiming He, Zhen Huang, Sheng Chen, Pingfan Rao, Lijing Ke, Leiwen Xiang Acrylamide has a variety of toxicities, including carcinogenicity, and can be present in food via the Maillard reaction in processing of certain foods. Previous studies have demonstrated that co-existing Maillard reaction products (MRPs) ameliorated acrylamide-induced abnormal...
Sun, 05/30/2021 - 06:05
Author(s): Dan Wu, Hezuo Liu, Yang Liu, Wei Wei, Qi Sun, Deliang Wen, Lihong Jia The adverse effects of bisphenol A (BPA) on learning and memory may be related with oxidative stress, but the mechanisms are unclear. This study aimed to investigate the mechanism of damaged learning and memory caused by BPA through inducing oxidative stress, as well as to explore whether alpha-lipoic acid (ALA) show...
Sun, 05/30/2021 - 06:05
Author(s): Srednicka Paulina, Juszczuk-Kubiak Edyta, Wojcicki Michał, Akimowicz Monika, Roszko Lukasz Marek Nowadays, people are exposed to diverse environmental and chemical pollutants produced by industry and agriculture. Food contaminations such as persistent organic pollutants (POPs), heavy metals, and mycotoxins are a serious concern for global food safety with economic and public health...
Fri, 05/21/2021 - 06:06
Author(s): Julia Baudry, Pauline Rebouillat, Benjamin Allès, Jean-Pierre Cravedi, Mathilde Touvier, Serge Hercberg, Denis Lairon, Rodolphe Vidal, Emmanuelle Kesse-Guyot Purpose To examine dietary exposure to 25 pesticide residues in several diet groups including omnivores, pesco-vegetarians, vegetarians and vegans while accounting for the farming system (organic or conventional) of plant-based...
Tue, 05/18/2021 - 06:13
Author(s): Letícia.A. Apolinário, Leandra.N.Z. Ramalho, Motahareh Hashemi Moosavi, Alessandra.V. Jager, Marlei.J. Augusto, Maurício.R. Trotta, Tânia Petta, Amin Mousavi Khaneghah, Carlos.A.F. Oliveira, Fernando.S. Ramalho In this study, the changes in oncogenic and tumor suppressor signaling pathways in liver and their association with serum and urinary biomarkers of aflatoxin exposure were...
Wed, 05/12/2021 - 06:06
Author(s): Clémence Budin, Hai-Yen Man, Carine Al-Ayoubi, Sylvie Puel, Barbara M.A. van Vugt-Lussenburg, Abraham Brouwer, Isabelle P. Oswald, Bart van der Burg, Laura Soler Aflatoxins are a group of mycotoxins that have major adverse effects on human health. Aflatoxin B1 (AFB1) is the most important aflatoxin and a potent carcinogen once converted into a DNA-reactive form by cytochrome P450...
Thu, 05/06/2021 - 06:10
Author(s): Liye Zhu, Jieyu Yuhan, Kunlun Huang, Xiaoyun He, Zhihong Liang, Wentao Xu Mycotoxins contaminate all types of food and feed, threatening human and animal health through food chain accumulation, producing various toxic effects. Increasing attention is being focused on the molecular mechanism of mycotoxin-induced toxicity in all kinds of in vivo and in vitro models. Epigenetic...
Tue, 05/04/2021 - 06:10
Author(s): G.S. Bondy, I.H.C. Curran, L.C. Coady, C. Armstrong, C. Bourque, S. Bugiel, D. Caldwell, K. Kwong, D.E. Lefebvre, C. Maurice, F. Marchetti, P.P. Pantazopoulos, N. Ross, A.M. Gannon Ochratoxin A (OTA) is a mycotoxin produced by Aspergillus and Penicillium molds. Grain-based foods account for most human dietary exposures to OTA. OTA is a teratogen, but its reproductive and developmental...
Thu, 04/29/2021 - 12:02
Author(s): Fan Zhao, Huan Liu, Zhanghuan Li, Pengfei Lin, Aihua Wang, Yaping Jin, Yanglei Yi The nonsteroidal estrogenic compound bisphenol A (BPA) is widely present in several industrial and medical products including plastic food containers and sealants in dentistry. There are growing concerns on the toxic effects of this compounds since BPA is known to have reproductive toxicity. This study...
Wed, 04/21/2021 - 06:05
Author(s): Neelam Yadav, Surender Singh Yadav, Anil Kumar Chhilar, Jogender Singh Rana Aflatoxin B1 (AFB1) is one of the most potent mycotoxin contaminating several foods and feeds. It suppresses immunity and consequently increases mutagenicity, carcinogenicity, teratogenicity, hepatotoxicity, embryonic toxicity and increasing morbidity and mortality. Continuous exposure of AFB1 causes liver...
Sun, 04/04/2021 - 06:05
Author(s): María Izco, Ariane Vettorazzi, Raquel Forcen, Javier Blesa, Maria de Toro, Natalia Alvarez-Herrera, J Mark Cooper, Elena Gonzalez-Peñas, Adela Lopez de Cerain, Lydia Alvarez-Erviti Some epidemiological studies with different levels of evidence have pointed to a higher risk of Parkinson’s disease (PD) after exposure to environmental toxicants. A practically unexplored potential...
Sun, 04/04/2021 - 06:05
Author(s): Firouzeh Hassani Moghadam, Mohammad A. Taher, Hassan Karimi-Maleh A sensitive and fast approach has been introduced for the voltammetric sensing of bisphenol A based on modification of a paste electrode with Pt-SWCNTs and 1-ethyl-3-methylimidazolium n-butylsulfate as a highly conductive binder. The new sensor was used to determine the concentration of bisphenol A in food products in I-...
Sun, 03/28/2021 - 06:05
Author(s): Zhuang Hong, Wang Minghua, Nan Bo, Yang Chaoyue, Yan Haiyang, Ye Haiqing, Xi Chunyu, Zhang Yan, Yuan Yuan Acrylamide (AA) is a common endogenous contaminant in food, with a complex toxicity mechanism. The study on liver damage to experimental animals caused by AA has aroused a great attention. Rosmarinic acid (RosA) as a natural antioxidant shows excellent protective effects against AA...
Wed, 03/17/2021 - 06:05
Author(s): Ha Ngo-Thanh, Trang Dam Thuy, Kazutomo Suzue, Wataru Kamitani, Hideaki Yokoo, Koji Isoda, Chikako Shimokawa, Hajime Hisaeda, Takashi Imai The consumption of dietary acrylamide (ACR), a carcinogen, results in the dysfunction of various organs and the immune system. However, the impact of ACR exposure on the progression of infectious diseases is unknown. This study investigated the...
Sun, 03/14/2021 - 06:05
Author(s): Xiaotong Li, Zhiming Lv, Jia Chen, Eugenie Nepovimova, Miao Long, Wenda Wu, Kamil Kuca Aflatoxin B1 (AFB1) is a mycotoxin often found in food and livestock feed. It can affect human and animal health and is especially damaging to the liver. This study aims to evaluate whether Bacillus amyloliquefaciens (hereafter referred to as B. amyloliquefaciens) B10 can alleviate the toxic effects...
Sun, 03/14/2021 - 06:05
Author(s): Wei Wei, Chong Liu, Ping Ke, Xiaoyun Chen, Ting Zhou, Junfeng Xu, Yu Zhou Ochratoxin A (OTA), a potent mycotoxin, is a common contaminant of agro-products, which seriously threatens food safety. The OTA regulatory limits vary from different countries/regions. However, little is known about the toxicological effects of successive exposure to regulatory levels of OTA. In this study,...
Sun, 03/14/2021 - 06:05
Author(s): Bozidar Udovicki, Nikola Tomic, Bojana Spirovic Trifunovic, Sasa Despotovic, Jelena Jovanovic, Liesbeth Jacxsens, Andreja Rajkovic Classified as Group 1 carcinogens aflatoxins (AFs) are of major concern for food safety and public health. Within the AFs group, aflatoxin B1 (AFB1) occurs at the highest levels in different food products and is considered as the most potent representative...
Sat, 03/13/2021 - 06:08
Author(s): Marjan Koushkestani, Samira Abbasi-Moayed, Forough Ghasemi, Vahideh Mahdavi, M. Reza Hormozi-Nezhad In this work, a colorimetric sensor array has been designed for the identification and discrimination of thiometon (TM) and phosalone (PS) as organophosphate pesticides and prothioconazole (PC) as a triazole pesticide. For this purpose, two different plasmonic nanoparticles including...
Mon, 03/01/2021 - 06:05
Author(s): Jin Liu, Jinglan Liao, Chenyun Zhang, Lingfeng Zeng, Chaowei Zong, Yake Lv, Jingwen Li, Wenchang Zhang Cadmium (Cd) is known to affect ovarian granulosa cells (GCs), but no information on the transgenerational effects of Cd on GCs. In this study, pregnant Sprague-Dawley (SD) rats were orally dosed with Cd from gestation day 1 until birth. F1 or F2 female rats were mated with untreated...
Sat, 02/20/2021 - 06:13
Author(s): Jose Alejandro Romero Herrera, Sofie Theresa Thomsen, Lea Jakobsen, Sisse Fagt, Karina Banasik, Jose MG. Izarzugaza, Søren Brunak, Sara M. Pires Lifestyle and sociodemographics are likely to influence dietary patterns, and, as a result, human exposure to chemical contaminants in foods and their associated health impact. We aimed to characterize subgroups of the Danish population based...
Tue, 02/16/2021 - 06:13
Author(s): Yuanyuan Fang, Lili Lu, Yuan Liang, Dongjie Peng, Michael Aschner, Yueming Jiang Lead is a heavy metal pollutant that is widely present in the environment. It affects every organ system, yet the nervous system appears to be the most sensitive and primary target. Although many countries have made significant strides in controlling Pb pollution, Pb poisoning continuous to be a major...
Sat, 02/13/2021 - 06:13
Author(s): Chaoyue Yang, Bo Nan, Haiqing Ye, Haiyang Yan, Minghua Wang, Yuan Yuan Acrylamide (AA), an important by-product of the Maillard reaction, has been reported to be genotoxic and carcinogenic. The present study employed miRNAs to investigate the toxic mechanism of AA and their role against AA toxicity. Deep sequencing of small RNA libraries was performed and miR-193b-5p was applied for...
Sat, 02/13/2021 - 06:13
Author(s): Yumi Abiko, Yusuke Katayama, Masahiro Akiyama, Yoshito Kumagai Garlic (Allium sativum L.) contains numerous sulfur compounds. We have previously found that reactive sulfur species such as glutathione persulfide, glutathione polysulfide, protein-bound persulfides, and hydrogen sulfide can bind to methylmercury to give bismethylmercury sulfide, which is less toxic than methylmercury. It...
Thu, 02/11/2021 - 06:13
Author(s): Jiahui Han, Chengni Jin, Yujie Zhong, Jiachang Zhu, Qi Liu, Dianjun Sun, Jiayu Feng, Xiaodong Xia, Xiaoli Peng Patulin (PAT) is a kind of mycotoxins that commonly found in decayed fruits and their products. Our previous studies have shown that PAT induced cell apoptosis and the overproduction of reactive oxygen species (ROS) in human embryonic kidney (HEK293) cells. The present study...
Fri, 02/05/2021 - 06:06
Author(s): Alireza Khataee, Hessamaddin Sohrabi, Omid Arbabzadeh, Pegah Khaaki, Mir Reza Majidi Highly sensitive and rapid methods for the Ochratoxin A (OTA) detection as a main class of Ochratoxins (OT) in various food samples is significant. In the present review, novel OTA detection techniques based on electrochemical and conventional methods have been extensively explained, and also compared...
Wed, 02/03/2021 - 06:05
Author(s): Huiwen Zhang, Yushen Liu, Shuo Yao, Mingyu Shang, Chao Zhao, Juan Li, Juan Wang Food safety problems attributed to foodborne pathogenic bacteria seriously endanger human health and cause substantial economic losses. Novel assays for rapid and sensitive identification of foodborne pathogenic bacteria are highly desired. In this study, a multicolor sensing system has been established for...
Fri, 01/29/2021 - 06:06
Author(s): Ivana Mirkov, Aleksandra Popov Aleksandrov, Marina Ninkov, Dina Tucovic, Jelena Kulas, Milica Zeljkovic, Dusanka Popovic, Milena Kataranovski Cadmium (Cd) has been listed as one of the most toxic substances affecting numerous tissues/organs, including the immune system. Due to variations in studies examining Cd effects on the immune system (exposure regime, experimental systems, immune...
Fri, 01/29/2021 - 06:06
Author(s): Anand Kumar Chaudhari, Vipin Kumar Singh, Somenath Das, Nawal Kishore Dubey Spoilage of food by mycotoxigenic fungi poses a serious risk to food security throughout the world. In view of the negative effects of synthetic preservatives, essential oils (EOs) and their bioactive constituents are gaining momentum as suitable substitute to ensure food safety by controlling mycotoxins....
Sat, 01/23/2021 - 06:11
Author(s): Irmela Sarvan, Anna Elena Kolbaum, Ulrike Pabel, Thorsten Buhrke, Matthias Greiner, Oliver Lindtner The BfR MEAL Study is the first German total diet study and will establish a representative and comprehensive database for dietary exposure assessment in Germany. The present study reports first results of the BfR MEAL Study regarding methylmercury in fish, seafood and mushrooms. In...
Sat, 01/09/2021 - 06:09
Author(s): Shabir Ahmad Mir, B.N. Dar, Manzoor Ahamd Shah, Sajad Ahmad Sofi, Afshan Mumtaz Hamdani, Carlos A.F. Oliveira, Motahareh Hashemi Moosavi, Amin Mousavi Khaneghah, Anderson S. Sant'Ana Emerging decontamination technologies have been attracted considerable attention to address the consumers' demand for high quality and safe food products. As one of the important foods in the human diet,...
Sat, 01/09/2021 - 06:09
Author(s): D. Tardieu, A. Travel, C. Le Bourhis, J.-P. Metayer, A. Mika, D. Cleva, C. Boissieu, P. Guerre Previous studies using zearalenone (ZEN) and fumonisins (FB) revealed alpha-zearalanol (α-ZOL) and FB1 in the liver of turkeys and chickens with no sign of toxicity. The aim of the present study was to determine whether contamination persists after distribution of a mycotoxin-free diet for...
Fri, 01/08/2021 - 06:05
Author(s): Wanyue Huang, Menglin Liu, Bonan Xiao, Jian Zhang, Miao Song, Yanfei Li, Zheng Cao Aflatoxin B1 (AFB1) is an unavoidable food and environmental contaminant, which can lead to disorders in spermatogenesis and its mechanism remains unclear. The blood-testis barrier (BTB) is responsible for ensuring normal spermatogenesis in testes. Therefore, we hypothesized that disruption of the BTB...
Thu, 01/07/2021 - 06:09
Author(s): Na Ling, Xin Wang, Dengyu Liu, Yizhong Shen, Danfeng Zhang, Dexin Ou, Hongying Fan, Juan Wang, Yu Ding, Jumei Zhang, Qingping Wu, Yingwang Ye Cronobacter malonaticus is one of the important foodborne pathogens causing infections mainly in adults. Biofilm formation, adhesion, and motility in Cronobacter have been documented, but the implying molecular mechanism has received little...
Wed, 01/06/2021 - 06:04
Author(s): Ru Jia, Faizan Ahmed Sadiq, Wenbin Liu, Lirong Cao, Zhuoyu Shen Deoxynivalenol (DON) poses a serious health threat to animals and humans consuming DON-contaminated food and feed. Biological means of detoxification of DON are considered as one of the effective strategies. The aim of the work was to study ameliorative effects of Bacillus subtilis ASAG 216 on DON-induced toxicosis in...
Fri, 01/01/2021 - 06:04
Author(s): Bo Song, Guiya Xiong, Huan Luo, Zhenzi Zuo, Zhijun Zhou, Xiuli Chang Cadmium (Cd) is a toxic heavy metal and widely exists in the environment. Extensive studies have revealed that Cd exposure can elicit neurotoxicity and potentially interfere with neurogenesis. However, underlying mechanisms by which Cd exposure affects neurogenesis remain unclear. In this study, we performed single-...
Wed, 12/30/2020 - 06:04
Author(s): Xusheng Li, Haiwei Li, Dongbao Cai, Ping Li, Jietian Jin, Xinwei Jiang, Zhenhua Li, Lingmin Tian, Guobing Chen, Jianxia Sun, Weibin Bai Cadmium (Cd) is a potentially toxic trace element frequently existed in foods, water, and air, threatening liver function from its continuous bioaccumulation and induction of oxidative stress and inflammation. However, the hepatotoxicity of Cd during...
Sat, 12/26/2020 - 06:08
Author(s): Jesús Herrera-Bravo, Jorge F. Beltrán-Lissabet, Kathleen Saavedra, Nicolás Saavedra, Monserrat Hevia, Marysol Alvear, Fernando Lanas, Luis A. Salazar Polycyclic Aromatic Hydrocarbons (PAHs) are pollutants found in the air generated mainly by the combustion of coal or biomass burning. Exposure to Polycyclic Aromatic Hydrocarbons is positively correlated with cardiovascular diseases....
Sat, 12/26/2020 - 06:08
Author(s): Nan Bo, Yang Chaoyue, Li Lu, Ye Haiqing, Yan Haiyang, Wang Minghua, Yuan Yuan Acrylamide (AA) in heat-processed food leads to widespread concerns due to its hepatotoxicity. Allicin, a plant-derived antioxidant, possesses a significant protective effect on AA-induced hepatotoxicity, but the mechanism is still unclear. Herein, we investigated the mechanism in Kupffer cells and SD rats...
Thu, 12/17/2020 - 06:09
Author(s): Beatriz Ferrer, Lisa M. Prince, Alexey A. Tinkov, Abel Santamaria, Marcelo Farina, João Batista Rocha, Aaron B. Bowman, Michael Aschner Several studies have demonstrated that heavy metals disrupt energy homeostasis. Leptin inhibits food intake and decreases body weight through activation of its receptor in the hypothalamus. The impact of heavy metals on leptin signaling in the...
Sat, 12/12/2020 - 06:04
Author(s): Amanda Caroline Trassi Conteçotto, Giseli Cristina Pante, Juliana Cristina Castro, Aline Amenecia de Souza, Renata Sano Lini, Jéssica Cristina Zoratto Romoli, Benício Alves de Abreu Filho, Jane Martha Graton Mikcha, Simone Aparecida Galerani Mossini, Miguel Machinski Junior This study aimed to evaluate the risk concerning child population’s health because of the occurrence of AFM1 in...

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