During infection, bacterial pathogens successfully sense, respond and adapt to a myriad of harsh environments presented by the mammalian host. This exquisite level of adaptation requires a robust modulation of their physiological and metabolic features. Additionally, virulence determinants, which include host invasion, colonization and survival despite the host's immune responses and...
Treated wastewater from reclaimed facilities (WWTP) has become a reusable source for a variety of applications, such as agricultural irrigation. However, it is also a potential reservoir of clinically-relevant multidrug resistant (MDR) pathogens, including ESKAPE (Enterococcus faecium and Streptococcus surrogates, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas...
While antibiotic-resistant bacteria have been detected in extreme environments, including Antarctica, to date there are no reports of Acinetobacter species isolated from this region. Here, we characterized by whole-genome sequencing (WGS) the genetic content of a single antibiotic-resistant Acinetobacter spp. isolate (A154) collected in Antarctica. The isolate was recovered in 2013 from soil...
Pet and EspC are toxins secreted by enteroaggregative (EAEC) and enteropathogenic (EPEC) diarrheagenic Escherichia coli pathotypes, respectively. Both toxins are members of the Serine Protease Autotransporters of Enterobacteriaceae (SPATEs) family. Pet and EspC are important virulence factors that produce cytotoxic and enterotoxic effects on enterocytes. Here, we evaluated the effect of curcumin...
Atypical enteropathogenic E. coli (aEPEC) is a group of diarrhoeagenic Escherichia coli with high diversity of serogroups, which lack the bundle-forming pili (BFP) and genes encoding for shiga toxins. The aim of this study was to isolate, identify and determine virulence and antibiotic resistance profiles of aEPEC O177 strains from cattle feces. A total of 780 samples were collected from beef and...
This study aimed to determine the antimicrobial activity of thymoquinone (TQ) against L. monocytogenes, and to examine its inhibitory effects on biofilm formation, motility, hemolysin production, and attachment-invasion of host cells. The minimum inhibitory concentrations (MICs) of TQ against eight different L. monocytogenes strains ranged from 6.25–12.50 μg/mL. Crystal violet staining showed...
Heat-labile toxin (LT) is a well-characterized powerful enterotoxin produced by enterotoxigenic Escherichia coli (ETEC). This toxin is known to contribute to diarrhea in young children in developing countries, international travelers, as well as many different species of young animals. Interestingly, it has also been revealed that LT is involved in other activities in addition to its role in...
Giardia lamblia, a single-celled eukaryote, colonizes and thrives in the small intestine of humans. Because of its compact and reduced genome, Giardia has adapted a “minimalistic” life style, as it becomes dependent on available resources of the small intestine. Because Giardia expresses fewer sphingolipid (SL) genes—and glycosphingolipids are critical for encystation—we investigated the SL...
Salmonella enterica serotype Typhimurium is a major global food-borne pathogen and causes life-threatening infections. Although the resistance mechanisms to fluoroquinolones in S. Typhimurium had been well defined, tolerance to fluoroquinolones and the associated mechanism for this are obscure. In the current work， we investigated an oqxAB-positive plasmid pHXY0908 and analyzed its role in S....
The lifecycle of the causative agent of the severe secretory diarrheal disease cholera, Vibrio cholerae, is characterized by the transition between two dissimilar habitats, i.e. as a natural inhabitant of aquatic ecosystems and as a pathogen in the human gastrointestinal tract. V. cholerae faces diverse stressors along its lifecycle, which require effective adaptation mechanisms to facilitate the...
Campylobacter jejuni outer membrane vesicles (OMVs) contain numerous virulence-associated proteins including the cytolethal distending toxin and three serine proteases. As C. jejuni lacks the classical virulence-associated secretion systems of other enteric pathogens that deliver effectors directly into target cells, OMVs may have a particularly important role in virulence. C. jejuni OMV...
Enteroaggregative Escherichia coli (EAEC) infections are one of the most frequent causes of persistent diarrhea in children, immunocompromised patients and travelers worldwide. The most prominent colonization factors of EAEC are aggregative adherence fimbriae (AAF). EAEC prototypical strain 042 harbors the AAF/II fimbriae variant, which mediates adhesion to intestinal epithelial cells and...
Integrative Analyses of Long Non-coding RNA and mRNA Involved in Piglet Ileum Immune Response to Clostridium perfringens Type C Infection
Xiaoyu Huang1, Wenyang Sun1, Zunqiang Yan1, Hairen Shi1, Qiaoli Yang1, Pengfei Wang1, Shenggui Li1, Lixia Liu2, Shengguo Zhao1 and Shuangbao Gun1,3*
1College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China
Anna-Maria Schmidt, Ulrike Escher, Soraya Mousavi, Manja Boehm, Steffen Backert, Stefan Bereswill, Markus M. Heimesaat
Shijun Li, Ying Liu, Yue Wang, Ming Wang, Chunting Liu, Yi Wang
Jussa-Pekka Virtanen, Riikka Keto-Timonen, Kaisa Jaakkola, Noora Salin, Hannu Korkeala
Shama Mujawar, Derek Gatherer, Chandrajit Lahiri
M. Soledad Hielpos, Andrea G. Fernández, Juliana Falivene, Iván M. Alonso Paiva, Florencia Muñoz González, Mariana C. Ferrero, Priscila C. Campos, Angelica T. Vieira, Sergio Costa Oliveira, Pablo C. Baldi
Garima Arora, Deepika Chaudhary, Saqib Kidwai, Deepak Sharma, Ramandeep Singh
Zujie Yao, Lina Sun, Yuqian Wang, Ling Lin, Zhuang Guo, Dong Li, Wenxiong Lin, Xiangmin Lin
Sumit Kumar, Trpta Bains, Ashley Sae Won Kim, Christina Tam, Jong Kim, Luisa W. Cheng, Kirkwood M. Land, Anjan Debnath, Vipan Kumar
Betina Hebbelstrup Jensen, Camilla Adler Sørensen, Stig Hebbelstrup Rye Rasmussen, Dorthe Rejkjær Holm, Alice Friis-Møller, Jørgen Engberg, Hengameh C. Mirsepasi-Lauridsen, Carsten Struve, Anette M. Hammerum, Lone Jannok Porsbo, Randi Føns Petersen, Andreas Munk Petersen, Karen Angeliki Krogfelt
Samuel Lebourgeois, Audrey Fraisse, Catherine Hennechart-Collette, Laurent Guillier, Sylvie Perelle, Sandra Martin-Latil
Karolina Jaworska, Marta Nieckarz, Marta Ludwiczak, Adrianna Raczkowska, Katarzyna Brzostek
Jeffrey K. Schachterle, Ryan M. Stewart, M. Brett Schachterle, Joshua T. Calder, Huan Kang, John T. Prince, David L. Erickson
Xingchen Zhao, Xudong Tang, Na Guo, Yanan An, Xiangrong Chen, Ce Shi, Chao Wang, Yan Li, Shulin Li, Hongyue Xu, Mingyuan Liu, Yang Wang, Lu Yu
Yiquan Zhang, Lingfei Hu, George Osei-Adjei, Ying Zhang, Wenhui Yang, Zhe Yin, Renyun Lu, Xiumei Sheng, Ruifu Yang, Xinxiang Huang, Dongsheng Zhou
Emanuela Marini, Gloria Magi, Gianna Ferretti, Tiziana Bacchetti, Angelica Giuliani, Armanda Pugnaloni, Maria Rita Rippo, Bruna Facinelli
Huynh T. Hop, Lauren T. Arayan, Tran X. N. Huy, Alisha W. B. Reyes, Son H. Vu, WonGi Min, Hu J. Lee, Man H. Rhee, Hong H. Chang, Suk Kim
Muhammad A. B. Shabbir, Yanping Tang, Zihui Xu, Mingyue Lin, Guyue Cheng, Menghong Dai, Xu Wang, Zhengli Liu, Zonghui Yuan, Haihong Hao
Sylvie M. Roche, Sébastien Holbert, Jérôme Trotereau, Samantha Schaeffer, Sonia Georgeault, Isabelle Virlogeux-Payant, Philippe Velge
Grith M. Maigaard Hermansen, Anders Boysen, Thøger J. Krogh, Arkadiusz Nawrocki, Lars Jelsbak, Jakob Møller-Jensen
Fang Liu, Rena Ma, Yiming Wang, Li Zhang
Haitao Yu, Xiuliang Ding, Lijun Shang, Xiangfang Zeng, Hongbin Liu, Ning Li, Shuo Huang, Yuming Wang, Gang Wang, Shuang Cai, Meixia Chen, Crystal L. Levesque, Lee J. Johnston, Shiyan Qiao
Mengjiao Guo, Rong Li, Qianqian Xiao, Xiuxiu Fan, Ning Li, Yingli Shang, Liangmeng Wei, Tongjie Chai
María C. Miraglia, Ana M. Rodriguez, Paula Barrionuevo, Julia Rodriguez, Kwang S. Kim, Vida A. Dennis, M. Victoria Delpino, Guillermo H. Giambartolomei
Tao Wang, Yonghui Yu, Xiaofei Liang, Shengdong Luo, Zemin He, Zhihui Sun, Yongqiang Jiang, Anders Omsland, Pei Zhou, Lihua Song
Jun Yuan, Zhong Chen, Zhiqiang Guo, Ding Li, Feng Zhang, Jiaojiao Shen, Yi Zhang, Shihua Wang, Zhenhong Zhuang
Hélène Bierne, Eliane Milohanic, Mounia Kortebi
Rui Cruz, Isabel Pereira-Castro, Maria T. Almeida, Alexandra Moreira, Didier Cabanes, Sandra Sousa
Saba Imdad, Akhilesh Kumar Chaurasia, Kyeong Kyu Kim
Guang Yang, Yule Hu, Opemipo E. Fasoyin, Yuewei Yue, Lijie Chen, Yue Qiu, Xiuna Wang, Zhenhong Zhuang, Shihua Wang
Michael P. Hays, Diane Houben, Yang Yang, Joen Luirink, Philip R. Hardwidge
Aseem Pandey, Furong Lin, Ana L. Cabello, Luciana F. da Costa, Xuehuan Feng, Hui-Qiang Feng, Ming-Zhe Zhang, Takao Iwawaki, Allison Rice-Ficht, Thomas A. Ficht, Paul de Figueiredo, Qing-Ming Qin
Jyoti M. Gurung, Ayad A. A. Amer, Monika K. Francis, Tiago R. D. Costa, Shiyun Chen, Anton V. Zavialov, Matthew S. Francis
Rui Hong Guo, Ju Young Lim, Duong Nu Tra My, Se Jin Jo, Jung Up Park, Joon Haeng Rhee, Young Ran Kim
Jin Liu, Yuhao Dong, Nannan Wang, Shougang Li, Yuanyuan Yang, Yao Wang, Furqan Awan, Chengping Lu, Yongjie Liu
Kirill V. Korneev, Anna N. Kondakova, Ekaterina N. Sviriaeva, Nikita A. Mitkin, Angelo Palmigiano, Andrey A. Kruglov, Georgy B. Telegin, Marina S. Drutskaya, Luisa Sturiale, Domenico Garozzo, Sergei A. Nedospasov, Yuriy A. Knirel, Dmitry V. Kuprash
Leah Schwiesow, Erin Mettert, Yahan Wei, Halie K. Miller, Natalia G. Herrera, David Balderas, Patricia J. Kiley, Victoria Auerbuch
Andrés E. Marcoleta, Macarena A. Varas, Javiera Ortiz-Severín, Leonardo Vásquez, Camilo Berríos-Pastén, Andrea V. Sabag, Francisco P. Chávez, Miguel L. Allende, Carlos A. Santiviago, Octavio Monasterio, Rosalba Lagos