Research Publications (Food Safety)

Background The effect of systemic treatment of ventilator-associated pneumonia (VAP) with telavancin, a semisynthetic lipoglycopeptide with good penetration in vitro biofilms, has not been tested in vivo during mechanical ventilation.

Background: Daptomycin (DAP) is indicated for difficult-to-treat Gram-positive infections, especially those caused by methicillin-resistant S. aureus (MRSA). Exposure of S.

Background The anti-biofilm efficacy of dalbavancin has been evaluated in static models. Using an in vitro pharmacokinetic/pharmacodynamic model, we evaluated the comparative activity of dalbavancin alone and with rifampicin against biofilm-embedded methicillin-resistant S. aureus (MRSA). Methods Two MRSA strains (HUB-4/HUB-5) were evaluated with the Calgary Device System and the dynamic CDC-Biofilm Reactor over 144 h.

Background: Few studies have evaluated the use of ceftriaxone (CRO) in the treatment of methicillin-sensitive Staphylococcus aureus (MSSA) infections. The purpose of this study was to compare the safety and efficacy of CRO versus cefazolin (CFZ) for patients with MSSA bacteremia. Methods: This was a multi-center, single health-system retrospective study.

Respective activities of ceftaroline and ceftobiprole were reported against staphylococci isolated in 2008, 2013, 2017, 2018 from bacteraemia and lower respiratory tract infections in England and Ireland.1 Methicillin-susceptible staphylococci were susceptible to both molecules. The behavior of methicillin-resistant staphylococci was dependent on the bacterial species. Only 1/424 (0.23%) methicillin-resistant S.

Complex (CC) 398 livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) has been reported worldwide in a variety of food-animal species.

Multinational surveillance programmes for methicillin-resistant Staphylococcus aureus (MRSA) are dependent on national structures for data collection. This study aimed to capture the diversity of national MRSA surveillance programmes and propose a framework for harmonisation of MRSA surveillance.

The antibiotic susceptibility patterns were correlated with particular spa types, and this correlation would help physicians select appropriate antibiotics for treatment of invasive MRSA infections. The aim of this research was to investigate invasive methicillin-resistant Staphylococcus aureus (MRSA) through delineatingthe molecular typing results and correlating them with antibiotic susceptibility.

Toxoplasmosis is a major health issue worldwide especially for immune-deficient individuals and the offspring of newly infected mothers. It is caused by a unicellular intracellular parasite called Toxoplasma gondii. Although the drugs commonly used to treat toxoplasmosis are efficient, they present serious side effects and adverse events are common. Therefore, there is a need for the discovery of new compounds with potent anti-T. gondii activity.

Author(s): Jing Wang, Yue Jiang, Ruo-Yun Ji, Zhen-Yu Wang, Meng-Jun Lu, Han Wu, Cai-Yue Mei, Qiu-Chun Li, Xinan Jiao Colistin and tigecycline are regarded as the last-resort antibiotics for the treatment of serious clinical infections caused by enxtensively drug-resistant Gram-negative organisms, particularly carbapenemase-producing Enterobacteriaceae and Acinetobacter isolates, but the emergence and spread of plasmid-mediated colistin (mcr) or tigecycline [tet(X) and tmexCD1-toprJ1] res

Author(s): Patrick McKernan, Benjamin Cassidy, Alexis Woodward, James Battiste, Douglas Drevets, Roger Harrison

Author(s): Albert Moreno-Mingorance, Paula Espinal, Virginia Rodriguez, Lidia Goterris, Anna Fàbrega, Judit Serra-Pladevall, M. Jesús Barberà, M. Alberny, Héctor Martín-González, Thais Cornejo-Sánchez, Mayuli Armas, Alba Mir-Cros, Alex Raventós, Belén Viñado, T. Pumarola, M.N. Larrosa, Juan José González-López

Author(s): Xiaoming Wang, Zhuoren Ling, Naiyan Sun, Yongshi Liu, Jinhu Huang, Liping Wang

Author(s): Patrick McKernan, Benjamin Cassidy, Alexis Woodward, James Battiste, Douglas Drevets, Roger Harrison

Author(s): Lekshmi Narendrakumar, Sivakumar Krishnankutty Chandrika, Sabu Thomas

Author(s): Emre Kara, Kutay Demirkan, Serhat Unal

Author(s): Raymond Chang, Tzi Bun Ng, Wei-Zen Sun

Author(s): Ashish Yashwantrao Pawar

Author(s): Yang Song, Min Zhang, Ling Yin, Kunkun Wang, Yiyi Zhou, Mi Zhou, Yun Lu

Author(s): Arianna Pani, Marinella Lauriola, Alessandra Romandini, Francesco Scaglione