International Journal of Antimicrobial Agents

Mon, 12/02/2019 - 03:23
Author(s): Ivana Kubašová, Dzung B. Diep, Kirill V. Ovchinnikov, Andrea Lauková, Viola StrompfováAbstractOne of the relatively widespread properties of many enterococcal strains is the production of bacteriocins, which could be useful as natural food preservatives inhibiting pathogenic and spoilage microorganisms. However, knowledge of the distribution and spectrum of bacteriocin activity as well...
Mon, 11/25/2019 - 03:23
Author(s): Satoshi Nishida, Yasuo OnoAbstractBackground: Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae has expanded rapidly and is associated with severe nosocomial infections. Last-line antibiotics such as colistin and tigecycline remain the only treatment option. Here, we describe the genetic background of a novel pan-resistant KPC-producing K. pneumoniae isolate...
Mon, 11/25/2019 - 03:23
Author(s): Pramod Kumar, Priti Yadav, K.V. Ingole, Rishi Jaiswal, N.S. Khalid, Durgesh G. Deshmukh, A.K. Goel, P.K. YadavaAbstractIt is evident from previous cholera epidemic/outbreaks in India, Africa and America that seventh pandemic ElTor (7PET) with Haitian genotype (7PET-HCT) were associated with increased mortality. Present study highlights emergence of 7PET-HCT isolates causing two cholera...
Thu, 11/07/2019 - 03:23
Author(s): James A. Karlowsky, Sibylle H. Lob, Krystyna M. Kazmierczak, Katherine Young, Mary R. Motyl, Daniel F. SahmAbstractβ-lactam- and multidrug-resistant (MDR) Gram-negative bacilli frequently cause lower respiratory tract infections (LRTIs) in patients housed in intensive care units (ICUs). Relebactam, a novel diazabicyclooctane inhibitor of Ambler class A and C β-lactamases, in...
Tue, 10/29/2019 - 03:24
Author(s): Nader S. Abutaleb, Mohamed N. SeleemAbstractVancomycin-resistant enterococci (VRE) are a leading cause of nosocomial infections due to the limited number of effective therapeutic options. In an effort to repurpose FDA-approved drugs against antibiotic-resistant bacteria, we identified auranofin as a potent drug against VRE. The present study determined that auranofin's antibacterial...
Sun, 10/20/2019 - 03:28
Author(s): Gaurav Kumar, Bagre Issa, Sarmistha Biswal, Diamond Jain, Amitabha Bhattacharjee, Anindya S. GhoshAbstractNew Delhi Metallo beta-lactamase (NDM) is of significant public health concern due to its enormous potential to hydrolyse all the major beta-lactams including carbapenems. Previous reports indicate that the amino acid substitutions affect NDM activity despite being located outside...
Wed, 10/16/2019 - 03:28
Author(s): Armand Van Deun, Tom Decroo, Sabira Tahseen, Arnaud Trébucq, Valérie Schwoebel, Nimer Ortuno-Gutierrez, Bouke C. de Jong, Hans L. Rieder, Alberto Piubello, Chen-Yuan ChiangAbstractThe 2018 World Health Organization (WHO) treatment guidelines for multidrug-/rifampicin-resistant tuberculosis (MDR/RR-TB) give preference to all-oral long regimens for 18-20 months. The document strongly...
Thu, 10/10/2019 - 03:27
Author(s): Yen Ee Tan, Jocelyn Qi-Min Teo, Nurdyana Binte Abdul Rahman, Oon Tek Ng, Marimuthu Kalisvar, Ai Ling Tan, Tse Hsien Koh, Rick Twee Hee OngAbstractCandida auris has emerged as a multidrug-resistant pathogen worldwide. While it is known that there are 4 geographic clades, little is known about its genomic epidemiology in the Southeast Asian region. Laboratory identification can be...
Thu, 10/10/2019 - 03:27
Author(s): Stefan EBMEYER, Erik KRISTIANSSON, D.G. Joakim LARSSONAbstractObjectiveUnderstanding the origins of antibiotic resistance genes is important to assess and manage risks associated with the emergence of novel resistance genes. The chromosomal ampC gene (CAV-1) of Aeromonas caviae has been reported as the origin of mobile FOX cephalosporinases. The recent identification of A. caviae as...
Mon, 10/07/2019 - 03:26
Author(s): Logan Meurer, William Payne, J. Stephen GuffeyAbstractCampylobacter jejuni is a gram negative, microaerophilic bacteria that is the leading cause of food-borne illnesses in the United States, frequently producing severe diarrhea. Campylobacter jejuni has recently demonstrated antibiotic resistance. Alternative methods for treating these infections must be investigated. Visible light...
Sun, 09/22/2019 - 03:20
Author(s): Carlos Hernán Rodriguez, German Traglia, Nadya Bastias, Cecilia Pandolfo, Geni Bruni, Marcela Nastro, Ruben Barrios, Eleonora M. Bavastro, Mariana Carol Rey, Isabel A. Marques, Facundo Heger, Carlos Vay, Jennifer S. Fernandez, María Soledad Ramirez, Angela FamigliettiAbstractThe increasing use of polymyxins as last-resort drugs for managing infections by Acinetobacter baumannii has led...
Sun, 09/22/2019 - 03:20
Author(s): Ricardo Sobhie Diaz, Iart Luca Shytaj, Leila B. Giron, Benedikt Obermaier, Ermelindo della Libera, Juliana Galinskas, Danilo Dias, James Hunter, Mario Janini, Gisele Gosuen, Paulo Abrão Ferreira, Maria Cecilia Sucupira, Juliana Maricato, Oliver Fackler, Marina Lusic, Andrea Savarino, SPARC Working GroupABSTRACTAntiretroviral therapy (ART) is typically composed of a combination of three...
Sun, 09/22/2019 - 03:20
Author(s): Dishon Muloi, John Kiiru, Melissa J. Ward, James M. Hassell, Judy M. Bettridge, Timothy P. Robinson, Bram A.D. van Bunnik, Margo Chase-Topping, Gail Robertson, Amy B Pedersen, Eric M. Fèvre, Mark E.J. Woolhouse, Erastus K. Kang'ethe, Samuel KariukiAbstractThere are substantial limitations in our understanding of the distribution of antibiotic resistance (AMR) in humans and livestock in...
Sun, 09/22/2019 - 03:20
Author(s): D. Fonseca e Silva, A. Silva-Dias, R. Gomes, I. Martins-Oliveira, M.H. Ramos, A.G. Rodrigues, R. Cantón, C. Pina-VazAbstractObjectivesThe accurate assessment of antimicrobial susceptibility of colistin is crucial with the increasing number of multi-drug resistant Gram-negative bacteria and simultaneous increasing of colistin resistance. Both EUCAST and CLSI recommend broth...
Sun, 09/22/2019 - 03:20
Author(s): Luís G.A. Longo, Viviane S. de Sousa, Gabriela B. Kraychete, Lívia H. Justo-da-Silva, Jaqueline A. Rocha, Silvana V. Superti, Raquel R. Bonelli, Ianick S. Martins, Beatriz M. MoreiraAbstractKlebsiella pneumoniae is an important human pathogen, able to accumulate and disseminate a variety of antimicrobial resistance genes. Resistance to colistin, one of the last therapeutic options for...
Sun, 09/22/2019 - 03:20
Author(s): Yu-Lin Lee, Min-Chi Lu, Pei-Lan Shao, Po-Liang Lu, Yen-Hsu Chen, Shu-Hsing Cheng, Wen-Chien Ko, Chi-Ying Lin, Ting-Shu Wu, Muh-Yong Yen, Lih-Shinn Wang, Chang-Pan Liu, Wen-Sen Lee, Zhi-Yuan Shi, Yao-Shen Chen, Fu-Der Wang, Shu-Hui Tseng, Chao-Nan Lin, Yu-Hui Chen, Wang-Huei ShengABSTRACTMulticentre surveillance of antimicrobial susceptibility of clinically important Gram-negative...
Sun, 09/22/2019 - 03:20
Author(s): Olivier Barraud, Céline Ravry, Bruno François, Thomas Daix, Marie-Cécile Ploy, Philippe VignonAbstractIn sepsis, early and appropriate antibiotic therapy is key but frequently challenging due to increasing incidence of multidrug-resistant bacteria. Shotgun metagenomics (SM) feasibility has been scarcely assessed in urinary tract infections (UTI). We evaluated the feasibility of SM to...
Sun, 09/22/2019 - 03:20
Author(s): Rafael Ortega-Huedo, Marina Cuesta, Andreas Hoefer, Bruno Gonzalez-ZornAbstractBackgroundInfectious pathogens harboring cephalosporin or fluoroquinolones resistance constitute a serious hazard to human health.ObjectivesThe aim of this study is to set up a methodology based on econometric analysis and largest European Union (EU) resistance database (EARS-Net) to model EU nosocomial...
Sun, 09/22/2019 - 03:20
Author(s): Yangqun Liu, Changlin Han, Zhiyao Chen, Dan Guo, Xiaohua YeAbstractBackgroundAlthough previous studies have suggested an association between livestock exposure and the risk of methicillin-resistant Staphylococcus aureus (MRSA) carriage in humans, it remains unclear whether there is a dose-response relationship.ObjectiveThe aim of this study was to evaluate the relationship between...
Sun, 09/22/2019 - 03:20
Author(s): F. Lagi, G. Baldin, M. Colafigli, A. Capetti, G. Madeddu, S. Tekle Kiros è un, S. Di Giambenedetto, G. SterrantinoAbstractObjectivesThe aim of this study was to compare the tolerability and viro-immunological efficacy of dolutegravir-based regimens (DTG group) with regimens based on EVG, RAL, PI or NNRTI (NODTG group) in patients with acute HIV-1 infections (AHI).MethodsAll patients...
Sun, 09/22/2019 - 03:20
Author(s): Rixt A. Wijma, Angela Huttner, Sven van Dun, Wendy Kloezen, Iain J. Abbott, Anouk E. Muller, Birgit C.P. Koch, Johan W. MoutonABSTRACTGiven emerging uropathogen resistance to more recent antibiotics, old antibiotics used for uncomplicated urinary tract infection (UTI) warrant re-examination. In this study, the urinary antibacterial activities of fosfomycin and nitrofurantoin were...
Sun, 09/22/2019 - 03:20
Author(s): Thuy Nguyen, Constance Delaugerre, Marc-Antoine Valantin, Corinne Amiel, Emmanuelle Netzer, Thomas L'Yavanc, Michel Ohayon, Gérard Israel, Nadia Valin, Nesrine Day, Georges Kreplak, Gilles Pialoux, Vincent Calvez, Jean-Michel Molina, Anne-Geneviève Marcelin, Eve TodescoABSTRACTIntroductionMixed hepatitis C virus (HCV) genotype (GT) infections are clinically important as different...
Fri, 09/13/2019 - 01:03
Available online 11 September 2019 Author(s): Claudine Fournier, Marta Aires-de-Sousa, Patrice Nordmann, Laurent PoirelAbstractBackgroundOur study aimed to prospectively analyze the occurrence of colistin-resistant and extended-spectrum ß-lactamase (ESBL)-producing Enterobacterales colonizing pigs in two farms in Portugal, and to evaluate the putative correlations with different antibiotic usages...
Mon, 09/02/2019 - 01:03
Available online 31 August 2019 Author(s): Jin-Lei Wang, Hany M. Elsheikha, Ting-Ting Li, Jun-Jun He, Meng-Jie Bai, Qin-Li Liang, Xing-Quan Zhu, Wei CongABSTRACTThe obligate intracellular parasite Toxoplasma gondii can infect nearly all warm-blooded animals including humans. Although infection with this parasite is generally benign, severe illness may occur in the infected individuals if their...
Fri, 08/02/2019 - 01:03
Available online 30 July 2019 Author(s): Imad Al Kassaa, Rayane Rafei, Mirna Moukhtar, Mazen Zaylaa, Adem Gharsallaoui, Abdeslam Asehraou, Khaled El Omari, Ahmad Shahin, Monzer Hamze, Nour-Eddine ChihibAbstractAlthough bacteriocins from lactic acid bacteria (LAB) are successfully applied as natural alternatives to food preservation as well as to antibiotics, they are scattered through literature...
Tue, 07/16/2019 - 01:05
Available online 7 June 2019 Author(s): Maya L. Nadimpalli, Agathe de Lauzanne, Thong Phe, Laurence Borand, Jan Jacobs, Laetitia Fabre, Thierry Naas, Simon Le Hello, Marc SteggerABSTRACTEscherichia coli ST410 (Ec-ST410) is an emerging, multidrug-resistant clone. Recent investigations of its global epidemiology and evolution have been based almost exclusively on isolates from Europe and North...
Tue, 07/16/2019 - 01:05
Available online 13 July 2019 Author(s): Yuan Lin, Hongjuan Zhang, Weibao Song, Shuyi Si, Yanxing Han, Jiandong JiangAbstractThe current outbreak of Zika virus (ZIKV) is the impetus for novel, safe and efficacious anti-ZIKV agents. ZIKV non-structural protein 5 (NS5) RNA-dependent RNA polymerase (RdRp) is essential for viral replication and is logically regarded as an attractive drug target. In...
Sun, 06/16/2019 - 01:12
Available online 14 June 2019 Author(s): Yu-Lin Lee, Min-Chi Lu, Pei-Lan Shao, Po-Liang Lu, Yen-Hsu Chen, Shu-Hsing Cheng, Wen-Chien Ko, Chi-Ying Lin, Ting-Shu Wu, Muh-Yong Yen, Lih-Shinn Wang, Chang-Pan Liu, Wen-Sen Lee, Zhi-Yuan Shi, Yao-Shen Chen, Fu-Der Wang, Shu-Hui Tseng, Chao-Nan Lin, Yu-Hui Chen, Wang-Huei ShengAbstractWe performed multicentre surveillance of the antimicrobial...
Thu, 06/13/2019 - 01:17
Available online 11 June 2019 Author(s): Qingqing Xu, Jianping Jiang, Zhenhan Zhu, Teng Xu, Zi-Ke Sheng, Meiping Ye, Xiaogang Xu, Minggui WangAbstractKlebsiella pneumoniae is one of the common pathogens causing urinary tract infections (UTIs). Nitrofurantoin (NIT), with high therapeutic concentrations in urine, is recommended as first-line drug for both empiric treatment and chemoprophylaxis of...
Sun, 04/28/2019 - 01:13
Available online 26 April 2019 Author(s): Bao-Tao Liu, Xuyong Li, Qidi Zhang, Hu Shan, Ming Zou, Feng-Jing SongAbstractThe presence of mobilized colistin resistance (mcr) genes is a global concern. However, data concerning mcr in fresh vegetables, a reservoir for antibiotic resistance genes, is still rare. In this study, mcr genes were analyzed among 528 vegetable samples from 53 supermarkets or...
Sun, 04/07/2019 - 01:13
Available online 6 April 2019 Author(s): Chengtao Sun, Baoli Chen, Anette Hulth, Stefan Schwarz, Xing Ji, Lennart E. Nilsson, Shizhen Ma, Qiang Sun, Zhenwang Bi, Yang Wang, Zhenqiang Bi, Congming Wu, Stefan BörjessonAbstractLivestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is an increasingly important public health concern worldwide; however, data on LA-MRSA from Asian...
Mon, 03/18/2019 - 01:12
Available online 16 March 2019 Author(s): Aimee K. Murray, Lihong Zhang, Jason Snape, William H. GazeAbstractBacterial communities are exposed to a cocktail of antimicrobial agents, including antibiotics, heavy metals and biocidal antimicrobials such as quaternary ammonium compounds (QACs). The extent to which these compounds may select or co-select for antimicrobial resistance (AMR) is not fully...
Sat, 03/16/2019 - 01:14
Available online 14 March 2019 Author(s): Gang Zhang, Kaiwen Sun, Guomin Ai, Jianjuan Li, Na Tang, Yuqin Song, Chao Wang, Jie FengAbstractIntrinsic resistance of bacteria to antibiotics plays an increasingly significant role in antibiotic resistance. However, the breadth of intrinsic resistance has not been fully elucidated. Here we identified a novel class of chloramphenicol acetyltransferase (...
Sun, 02/03/2019 - 01:12
Available online 1 February 2019 Author(s): Dee Shortridge, Leonard R. Duncan, Michael A. Pfaller, Robert K. FlammAbstractCeftolozane-tazobactam (C-T) is a combination of an antipseudomonal cephalosporin and a β-lactamase inhibitor. C-T was approved by the US Food and Drug Administration in 2014 and by the European Medicine Agency in 2015 for use in adults to treat complicated urinary tract...
Mon, 12/31/2018 - 01:11
Available online 29 December 2018 Author(s): Philip G. Drennan, Evan J. Begg, Sharon J. Gardiner, Carl M.J. Kirkpatrick, Steve T. ChambersAbstractWe have evaluated the literature to review optimal dosing and monitoring of intravenous vancomycin in adults, in response to evolving understanding of targets associated with efficacy and toxicity. The area under the total concentration-time curve (0 -...
Sun, 11/04/2018 - 01:10
Available online 3 November 2018 Author(s): Agnès B. Jousset, Sandrine Bernabeu, Remy A. Bonnin, Elodie Creton, Garance Cotellon, Aimie Sauvadet, Thierry Naas, Laurent DortetAbstractPlasmid-mediated colistin resistance is increasingly described worldwide in Enterobacteriaceae from animal and from human isolates. Diffusion of these resistance traits among carbapenem-resistant enterobacterial...
Fri, 10/12/2018 - 01:12
Available online 10 October 2018 Author(s): Bruce C. Koppen, Patrick P.G. Mulder, Leonie de Boer, Martijn Riool, Jan W. Drijfhout, Sebastian A.J. ZaatABSTRACTAntibiotic resistance and biofilm formation are the major reasons for failure in treatment of bacterial infections. We therefore aimed to identify synergistic combinations of conventional antibiotics and novel Synthetic Antimicrobial and...
Fri, 10/05/2018 - 01:12
Available online 2 October 2018 Author(s): Shuaiyin Chen, Huiying Liu, Wenjuan Liang, Lijuan Hong, Bing Zhang, Lu Huang, Xiangjiao Guo, Guangcai DuanAbstractMultidrug resistances Shigella is an enormous threat of public health. The resistance genes always located in plasmids, phages and integrons, which get into bacteria cells by horizontal gene transfer (HGT). CRISPR-Cas systems are adaptive...
Sun, 09/02/2018 - 01:11
Available online 31 August 2018 Author(s): Karolina A. Lis, Corinna Kehrenberg, Annika Boulaaba, Maren von Köckritz-Blickwede, Sylvia Binder, Yangfang Li, Julia L. Zimmermann, Yvonne Pfeifer, Birte AhlfeldAbstractObjectiveTo investigate the impact of cold atmospheric pressure plasma (CAP) produced by a Surface-Micro-Discharge (SMD) plasma source as a new strategy to combat the transmission of...
Sat, 08/25/2018 - 01:08
Available online 24 August 2018 Author(s): Chih-Cheng Lai, Yi-Tsung Lin, Yu-Tzu Lin, Min-Chi Lu, Zhi-Yuan Shi, Yao-Shen Chen, Lih-Shinn Wang, Shu-Hui Tseng, Chao-Nan Lin, Yen-Hsu Chen, Wen-Chien Ko, Fu-Der Wang, Po-Ren Hsueh, Infection Control Society of TaiwanABSTRACTIn 2017, this nationwide surveillance was conducted to investigate the prevalence and clinical characteristics of patients with...
Sat, 08/04/2018 - 01:13
Available online 3 August 2018 Author(s): Amira Klibi, Abderrazek Maaroufi, Carmen Torres, Ahlem JouiniAbstractThe prevalence of methicillin-resistant (MR) and methicillin-susceptible (MS) coagulase-negative staphylococci (CNS) and the implicated mechanisms of resistance and virulence were investigated in milk of mastitis cows. In addition the presence of SCCmec type is analyzed in MR...
Sat, 08/04/2018 - 01:13
Available online 3 August 2018 Author(s): Losasso Carmen, Di Cesare Andrea, Mastrorilli Eleonora, Patuzzi Ilaria, Cibin Veronica, Eckert Ester M, Fontaneto Diego, Vanzo Angiola, Ricci Antonia, Corno GianlucaAbstractThe massive use of antimicrobials in animal farming is considered as the greatest contributor to the phenomenon of antimicrobial resistant bacteria (ARB) presence in food of animal...
Mon, 07/30/2018 - 01:13
Available online 29 July 2018 Author(s): Bojana Beović, Céline Pulcini, Catherine Dumartin, Guillaume Béraud, Barbara Nerat, Cristina Maurel, May Doušak, Milan Čižman, the LEASH Study Group on behalf of ESCMID Study Group for Antimicrobial StewardshiP (ESGAP)AbstractAntimicrobial stewardship (AMS) is the cornerstone activity in the combat against antimicrobial resistance. In order to ensure...
Fri, 07/06/2018 - 01:14
Available online 16 May 2018 Author(s): Ignacio Gutiérrez-del-Río, Javier Fernández, Felipe LombóAbstractSynthetic food additives generate a negative perception in consumers. Therefore, food manufacturers search for safer natural alternatives as those involving phytochemicals and plant essential oils. These bioactives have antimicrobial activities widely proved in in vitro tests. Foodborne...
Fri, 07/06/2018 - 01:14
Available online 23 May 2018 Author(s): Su-Chen Lim, Grace O. Androga, Daniel R. Knight, Peter Moono, Niki F. Foster, Thomas V. RileyAbstractWe recently reported a high prevalence of Clostridium difficile in retail vegetables, compost and lawn in Western Australia (WA). The objective of this study was to investigate the antimicrobial susceptibility of previously isolated food and environmental C...
Fri, 07/06/2018 - 01:14
Available online 30 May 2018 Author(s): Abdullah Ibn Mafiz, Liyanage Nirasha Perera, Yingshu He, Wei Zhang, Shujie Xiao, Weilong Hao, Shi Sun, Kequan Zhou, Yifan ZhangABSTRACTUrban agricultural soils can be an important reservoir of antibiotic resistance, and have great food safety and public health indications. This study investigated antibiotic-resistant bacteria and antibiotic resistance genes...
Fri, 07/06/2018 - 01:14
Publication date: June 2018 , Volume 51, Issue 6Author(s): Carla Andrea Alonso, Gerardo Cortés-Cortés, Elaa Maamar, Mariana Massó, Rosa del Carmen Rocha-Gracia, Carmen Torres, Daniela Centrón, María Paula QuirogaAbstractIntegrons are genetic platforms able to excise, integrate and express antibiotic resistance gene cassettes (GCs). Here we investigated the complete genetic organisation, genetic...
Fri, 07/06/2018 - 01:14
Publication date: June 2018 , Volume 51, Issue 6Author(s): Delfino Vubil, Clara Balleste-Delpierre, Rita Mabunda, Sozinho Acácio, Marcelino Garrine, Tacilta Nhampossa, Pedro Alonso, Inacio Mandomando, Jordi VilaAbstractThe objective of this study was to assess antibiotic resistance and the molecular epidemiology of shigella isolates from a case–control study of diarrhoea, conducted from 2007 to...
Fri, 07/06/2018 - 01:14
Publication date: July 2018 , Volume 52, Issue 1Author(s): Qiuxia Ma, Yong Huang, Jian Wang, Xuebin Xu, Jane Hawkey, Chaojie Yang, Beibei Liang, Xiaofeng Hu, Fuli Wu, Xiaoxia Yang, Jinyan Wang, Rongrui Li, Peng Li, Jing Xie, Leili Jia, Ligui Wang, Rongzhang Hao, Yigang Tong, Kathryn E. Holt, Shaofu QiuAbstractSince the plasmid-mediated polymyxin resistance gene mcr-1 was first reported in...
Fri, 07/06/2018 - 01:14
Publication date: July 2018 , Volume 52, Issue 1Author(s): Manjulika Shukla, Isha Soni, Karen Matsuyama, Tran Tran, Mary Tanga, Leyi Gong, Sidharth ChopraAbstractMultidrug-resistant Acinetobacter baumannii (MDR-Ab) is one of the most significant nosocomial pathogens that is being increasingly isolated in healthcare settings worldwide. Owing to its inherent drug-resistant nature, coupled with its...

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