International Journal of Medical Microbiology

Thu, 11/07/2019 - 03:25
Author(s): Ding-qian Liu, Jun-li Zhang, Zhi-fen Pan, Jun-tao Mai, Heng-jun Mei, Yue Dai, Lu Zhang, Qing-zhong WangAbstractMycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), can persist in the host for decades without causing TB symptoms and can cause a latent infection, which is an intricate challenge of current TB control. The DosR regulon, which contains approximately...
Wed, 10/23/2019 - 03:33
Author(s): Mali Salmon-Divon, David KornspanAbstractBrucella melitensis Rev.1 is the live attenuated Elberg-originated vaccine strain of the facultative intracellular Brucella species, and is widely used to control brucellosis in small ruminants. However, Rev.1 may cause abortions in small ruminants that have been vaccinated during the last trimester of gestation, it is pathogenic to humans, and...
Tue, 10/22/2019 - 03:27
Author(s): Soojin Shim, Sang Hee Soh, Young Bin Im, Hyun-Eui Park, Chong-Su Cho, Suk Kim, Han Sang YooAbstractsBrucella spp. is the causative agent of brucellosis, one of the worldwide diseases. The pathogen infects humans and animals mainly through the digestive or respiratory tract. Therefore, induction of mucosal immunity is required as the first line of defense. In this study, three Brucella...
Sun, 09/22/2019 - 03:21
Author(s): Farina E. Lennartz, Bianca Schwartbeck, Angelika Dübbers, Jörg Große-Onnebrink, Christina Kessler, Peter Küster, Holger Schültingkemper, Georg Peters, Barbara C. KahlAbstractBackground: Staphylococcus aureus is one of the most frequently isolated pathogens in the respiratory tract of CF patients. Recently, we characterized peculiar mucoid S. aureus isolates, which are excessive biofilm...
Sun, 09/22/2019 - 03:21
Author(s): Sandra Unsleber, Wolfgang Wohlleben, Evi StegmannAbstractPeptidoglycan (PG) is a bacteria specific cell surface layer that ensures the bacterial shape and integrity. The two actinomycetes Amycolatopsis balhimycina and Microbispora sp. PTA-5024 are producers of PG targeting antibiotics. To prevent the binding of their secreted product to their own PG, they developed specific self-...
Sun, 09/22/2019 - 03:21
Author(s): Jangsup Moon, Narae Kim, Tae-Joon Kim, Jin-Sun Jun, Han Sang Lee, Hye-Rim Shin, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, Manho Kim, Sang Kun Lee, Kon ChuAbstractEarly administration of antibiotics is crucial in the management of bacterial meningitis. Rapid pathogen identification helps to make a definite diagnosis of bacterial meningitis and enables tailored...
Sun, 09/22/2019 - 03:21
Author(s): Regina Selb, Vidmante Fuchs, Barbara Graf, Axel Hamprecht, Michael Hogardt, Ludwig Sedlacek, Roman Schwarz, Evgeny A. Idelevich, Sören L. Becker, Jürgen Held, Claus P. Küpper-Tetzel, Ilka McCormick-Smith, Daniela Heckmann, Jasmin Gerkrath, Chang-Ok Han, Dunja Wilmes, Volker RickertsAbstractCryptococcosis is a fungal infection of the central nervous system predominantly caused by...
Wed, 08/14/2019 - 01:05
Available online 12 August 2019 Author(s): Yaxin Guo, Ying Xu, Xilong Kang, Dan Gu, Yang Jiao, Chuang Meng, Peipei Tang, Xiaohai Wang, Cuiying Huang, Shizhong Geng, Xinan Jiao, Zhiming PanAbstractSalmonella Enteritidis (SE) is a highly adapted pathogen causing severe economic losses in the poultry industry worldwide. Chickens infected by SE are a major source of human food poisoning. Vaccination...
Thu, 06/06/2019 - 01:11
Available online 4 June 2019 Author(s): Erwin Bohn, Michael Sonnabend, Kristina Klein, Ingo B. AutenriethAbstractType III secretion systems (T3SS) play a crucial role for virulence in many Gram-negative bacteria. After tight bacterial contact to host cells, the T3SS injects effector proteins into the host cells, which leads to cell invasion, tissue destruction and/or immune evasion. Over the last...
Mon, 06/03/2019 - 01:12
Available online 1 June 2019 Author(s): Karolin Leibiger, Jonas Malte Schweers, Monika SchützAbstractBacteria often express numerous virulence factors. These virulence factors make them successful pathogens, by e.g. mediating attachment to host cells and thereby facilitating persistence or invasion, or by contributing to the evasion of the host immune system to allow proliferation and spread...
Tue, 04/30/2019 - 01:14
Available online 28 April 2019 Author(s): G. Douglas Inglis, Valerie F. Boras, Andrew L. Webb, Vivien V. Suttorp, Pamela Hodgkinson, Eduardo N. TaboadaAbstractInfections by pathogenic Campylobacter species were determined in diarrheic (n = 2,217) and non-diarrheic control (n = 104) people in Southwestern Alberta (SWA) over a 1-year period using specialized and conventional isolation, and direct...
Sun, 04/21/2019 - 01:12
Available online 19 April 2019 Author(s): Yufei Wang, Yuehua Ke, Cuijuan Duan, Xueping Ma, Qinfang Hao, Lijie Song, Xiaojin Guo, Tao Sun, Wei Zhang, Jing Zhang, Yiwen Zhao, Zhijun Zhong, Xiaoli Yang, Zeliang ChenAbstractBrucella species are the causative agents of brucellosis, a worldwide zoonotic disease that affects a broad range of mammals and causes great economic losses. Small regulatory...
Sun, 03/31/2019 - 01:09
Available online 28 March 2019 Author(s): Raman Karthikeyan, Pratapa Gayathri, Paramasamy Gunasekaran, Medicharla V. Jagannadham, Jeyaprakash RajendhranAbstractMembrane vesicles (MVs) are produced by various Gram positive and Gram negative pathogenic bacteria and play an important role in virulence. In this study, the membrane vesicles (MVs) of L. monocytogenes were isolated from the culture...
Mon, 02/04/2019 - 01:10
Available online 31 January 2019 Author(s): Mariana Bona, Pedro Henrique Medeiros, Ana Karolina Santos, Thiago Freitas, Mara Prata, Herlice Veras, Marília Amaral, Daniel Oliveira, Alexandre Havt, Aldo Ângelo LimaABSTRACTShigella/Enteroinvasive Escherichia coli (EIEC) pathotype is a major enteropathogen associated with diarrhea and malnutrition in children from developing countries. This study...
Fri, 01/18/2019 - 01:12
Available online 16 January 2019 Author(s): Xiumei Sheng, Weiwei Wang, Long Chen, Hong Zhang, Ying Zhang, Shungao Xu, Huaxi Xu, Xinxiang HuangAbstractMig-14 is essential for Salmonella enterica serovar Typhimurium (S. Typhimurium) resistance to antimicrobial peptides, including polymyxin B (PB). However, the molecular mechanism is as yet unknown. In this study, we demonstrated that mig-14 also...
Wed, 01/02/2019 - 01:10
Available online 30 December 2018 Author(s): Atsushi Hinenoya, Hidetoshi Ichimura, Sharda Prasad Awasthi, Noritomo Yasuda, Jun Yatsuyanagi, Shinji YamasakiAbstractEscherichia albertii is an emerging gastrointestinal pathogen, related to Escherichia coli, which can be misidentified as enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC), due to the presence of the eae gene in E....
Thu, 12/13/2018 - 01:11
Available online 11 December 2018 Author(s): G. Bruna Garcia, S. Felipe Castro, A.M. Mônica Vieira, M. Dennys Girão, T. Lucas Uenishi, C. Maria Cergole-Novella, F. Luis Dos Santos, M.F. Roxane Piazza, T. Rodrigo Hernandes, A.T. Tânia GomesAbstractTypical enteropathogenic Escherichia coli strains (tEPEC) cause attaching/effacing lesions in eukaryotic cells and produce the bundle-forming pilus (BFP...
Thu, 12/06/2018 - 01:10
Publication date: October 2018 , Volume 308, Issue 7Author(s): Michael Berger, Petya Berger, Erick Denamur, Alexander Mellmann, Ulrich DobrindtAbstractThe highly virulent Escherichia coli O104:H4 isolate that caused a large outbreak in 2011 carries three plasmids. Out of these, only one, the IncI plasmid pO104_90 that encodes two extended spectrum beta-lactamases, can transfer itself by...
Thu, 12/06/2018 - 01:10
Publication date: October 2018 , Volume 308, Issue 7Author(s): Gerald B. Koudelka, Jason W. Arnold, Dolonchapa ChakrabortyAbstractShiga toxin-producing Escherichia coli (STEC) are a diverse group of strains that are implicated in over 270,000 cases of human illness annually in the United States alone. Shiga toxin (Stx), encoded by a resident temperate lambdoid bacteriophage, is the main STEC...
Thu, 12/06/2018 - 01:10
Publication date: October 2018 , Volume 308, Issue 7Author(s): Valeria Michelacci, Antonella Maugliani, Rosangela Tozzoli, Giulia Corteselli, Paola Chiani, Fabio Minelli, Federica Gigliucci, Silvia Arancia, Gabriella Conedera, Chiara Targhetta, Alessandro Pierasco, Lucia Collini, Antonio Parisi, Gaia Scavia, Stefano MorabitoAbstractIn February 2017 a case of Hemolytic-Uremic Syndrome (HUS) was...
Thu, 12/06/2018 - 01:10
Publication date: October 2018 , Volume 308, Issue 7Author(s): Fan Yang, Lei Yang, Zhanhe Chang, Lianxia Chang, Bin YangAbstractEnteropathogenic Escherichia coli colonizes the human small intestine and causes severe diarrhea. Short-chain fatty acids are abundant in the intestine owing to the metabolic activity of the microflora and are important for intestinal health. Here, we found that acetate...
Thu, 12/06/2018 - 01:10
Available online 16 November 2018 Author(s): Marc Schulte, Torsten Sterzenbach, Katarzyna Miskiewicz, Laura Elpers, Michael Hensel, Nicole HansmeierAbstractThe expression of bacterial virulence factors is controlled in response to host or environmental factors and most virulence genes are not expressed under laboratory conditions. Investigations of molecular structures and cellular functions of...
Thu, 12/06/2018 - 01:10
Publication date: December 2018 , Volume 308, Issue 8Author(s): S. Feuerbaum, N. Saile, G. Pohlentz, J. Müthing, H. SchmidtAbstractEnterohemorrhagic Escherichia coli (EHEC) O157:H7 strain EDL933 encodes the single chromosomal 9-O-acetylesterase NanS, and several copies of prophage-encoded 9-O-acetylesterases (NanS-p). These enzymes have recently been shown to cleave 5-N-acetyl-9-O-acetyl...
Thu, 12/06/2018 - 01:10
Publication date: December 2018 , Volume 308, Issue 8Author(s): Anni Bommer, Olga Böhler, Eva Johannsen, Ulrich Dobrindt, Thorsten KucziusAbstractThe worldwide spread of toxin-producing and multi-drug resistant bacteria in water, food and the environment is considered a major threat to human health. Drinking water quality is controlled by inspection of fecal indicators presence whereby viable...
Thu, 12/06/2018 - 01:10
Publication date: December 2018 , Volume 308, Issue 8Author(s): Alipio Pinto, Clara Berdasco, David Arenas-Mosquera, Adriana Cangelosi, Patricia A. Geoghegan, Myriam C. Nuñez, Jorge GoldsteinAbstractInfections by Enterohemorrhagic Escherichia coli may cause in addition to hemolytic uremic syndrome neurological disorders which may lead to fatal outcomes in patients. The brain striatum is usually...
Thu, 12/06/2018 - 01:10
Publication date: December 2018 , Volume 308, Issue 8Author(s): Jacob R. Elder, Narayan C. Paul, Raquel Burin, Jean Guard, Devendra H. ShahAbstractSalmonella pathogenicity island 13 (SPI-13) contributes to the virulence of Salmonella. The majority of the SPI-13 genes encode proteins putatively involved in bacterial metabolism, however, their functions largely remain uncharacterized. It is...
Thu, 12/06/2018 - 01:10
Publication date: December 2018 , Volume 308, Issue 8Author(s): Mohamed A. KarmaliAbstractThe appearance of highly pathogenic strains of Shiga toxin (Stx)-producingEscherichia. coli (STEC) has owed largely to the acquisition of Stx-encoding prophages by strains of E. coli that have pre-existing potential as enteric pathogens, such as atypical enteropathogenic E. coli (aEPEC) and enteroaggregative...
Thu, 12/06/2018 - 01:10
Publication date: December 2018 , Volume 308, Issue 8Author(s): Nadine Legros, Gottfried Pohlentz, Daniel Steil, Johannes MüthingAbstractShiga toxin (Stx)-mediated injury of the kidneys and the brain represent the major extraintestinal complications in humans upon infection by enterohemorrhagic Escherichia coli (EHEC). Damage of renal and cerebral endothelial cells is the key event in the...
Thu, 12/06/2018 - 01:10
Publication date: December 2018 , Volume 308, Issue 8Author(s): Inga Eichhorn, Torsten Semmler, Alexander Mellmann, Derek Pickard, Muna F. Anjum, Angelika Fruth, Helge Karch, Lothar H. WielerAbstractEnterohemorrhagic Escherichia coli (EHEC) are a cause of bloody diarrhea, hemorrhagic colitis (HC) and the potentially fatal hemolytic uremic syndrome (HUS). While O157:H7 is the dominant EHEC...
Thu, 12/06/2018 - 01:10
Publication date: December 2018 , Volume 308, Issue 8Author(s): Gillian A.M. Tarr, Hanna N. Oltean, Amanda I. Phipps, Peter Rabinowitz, Phillip I. TarrAbstractBackgroundMultiple case definitions for post-diarrheal hemolytic uremic syndrome (D+ HUS) associated with Shiga toxin-producing Escherichia coli (STEC) are used across public health, research, and clinical practice.MethodsTo identify a...
Wed, 06/27/2018 - 05:22
Publication date: Available online 26 June 2018 Author(s): Gillian A.M. Tarr, Hanna N. Oltean, Amanda I. Phipps, Peter Rabinowitz, Phillip I. Tarr Background The veracity of the association between antibiotic use and hemolytic uremic syndrome (HUS) caused by Escherichia coli O157:H7 has been a topic of debate. We postulated that criteria used to define HUS affect this association...
Wed, 06/20/2018 - 01:13
Publication date: Available online 19 June 2018 Author(s): Martina Bielaszewska, Monika Marejková, Andreas Bauwens, Lisa Kunsmann-Prokscha, Alexander Mellmann, Helge Karch Proinflammatory cytokines play important roles in the pathogenesis of diseases caused by enterohemorrhagic Escherichia coli (EHEC) O157, but the spectrum of bacterial components involved in the proinflammatory...
Wed, 06/20/2018 - 01:13
Publication date: Available online 19 June 2018 Author(s): Nadja Haarmann, Michael Berger, Ivan U. Kouzel, Alexander Mellmann, Petya Berger Escherichia coli O104:H4 (E. coli O104:H4), which caused in 2011 a massive foodborne outbreak in Germany, is characterized by an unusual combination of virulence traits. E. coli O104:H4 contains a prophage-encoded Shiga toxin (Stx) gene, which...
Wed, 06/20/2018 - 01:13
Publication date: Available online 19 June 2018 Author(s): S. Stalb, S.A. Barth, K. Sobotta, E. Liebler-Tenorio, L. Geue, C. Menge In 2011, Germany was struck by the largest outbreak of hemolytic uremic syndrome. The highly virulent E. coli outbreak strain LB226692 possesses a blended virulence profile combining genetic patterns of human adapted enteroaggregative E. coli (EAEC),...
Wed, 06/20/2018 - 01:13
Publication date: Available online 19 June 2018 Author(s): Inga Eichhorn, Katrin Heidemanns, Rainer G. Ulrich, Herbert Schmidt, Torsten Semmler, Angelika Fruth, Astrid Bethe, David Goulding, Derek Pickard, Helge Karch, Lothar H. Wieler Bacteriophages play an important role in the evolution of bacterial pathogens. A phage-mediated transfer of stx-genes to atypical...
Fri, 06/08/2018 - 22:49
Publication date: Available online 8 June 2018 Author(s): Qiong Liu, Kuang Tan, Jianhui Yuan, Kuangyu Song, Rong Li, Xiaotian Huang, Qing Liu Salmonella enteric serovar infections result in high morbidity and mortality worldwide. Cross-protective vaccines are an effective strategy in controlling salmonellosis caused by multiple serotypes. In our previous study, outer membrane...
Tue, 05/29/2018 - 19:31
Publication date: Available online 29 May 2018 Author(s): Maren Mylius, Johannes Dreesman, Matthias Pulz, Gerhard Pallasch, Konrad Beyrer, Katja Claußen, Franz Allerberger, Angelika Fruth, Christina Lang, Rita Prager, Antje Flieger, Sabine Schlager, Daniela Kalhöfer, Elke Mertens Following a school ski-trip to Austria from 10-18/02/2017, nine of 25 participants of...
Thu, 05/03/2018 - 10:24
Publication date: Available online 2 May 2018 Author(s): Adriana Calderaro, Monica Martinelli, Mirko Buttrini, Sara Montecchini, Silvia Covan, Sabina Rossi, Francesca Ferraglia, Paolo Montagna, Federica Pinardi, Sandra Larini, Maria Cristina Arcangeletti, Maria Cristina Medici, Carlo Chezzi, Flora De Conto This study represents a 2-year picture of the epidemiology...
Mon, 03/26/2018 - 19:16
Publication date: Available online 26 March 2018 Author(s): Nadja Saile, Lisa Schwarz, Kristina Eißenberger, Jochen Klumpp, Florian W. Fricke, Herbert Schmidt Enterohemorrhagic E. coli (EHEC) are serious bacterial pathogens which are able to cause a hemorrhagic colitis or the life-threatening hemolytic-uremic syndrome (HUS) in humans. EHEC strains can carry different numbers of...
Fri, 03/23/2018 - 18:07
Publication date: Available online 23 March 2018 Author(s): Sirirat Luk-in, Tanittha Chatsuwan, Chaiwat Pulsrikarn, Aroon Bangtrakulnonth, Ubolrat Rirerm, Wanla Kulwichit S. Choleraesuis is a highly invasive zoonotic pathogen that causes a serious systemic infection in humans. The emergence and increase of resistance to ceftriaxone and ciprofloxacin among S. Choleraesuis has...
Tue, 03/13/2018 - 12:21
Publication date: Available online 12 March 2018 Author(s): Doreen Baumann, Helen Salia, Lilo Greune, Stephanie Norkowski, Britta Körner, Zina M. Uckeley, Gad Frankel, Marianne Guenot, Christian Rüter, M. Alexander Schmidt Enteropathogenic Escherichia coli (EPEC) subvert host cell signaling pathways by injecting effector proteins via a Type 3 Secretion System (T3SS). The...
Thu, 03/08/2018 - 08:28
Publication date: March 2018 , Volume 308, Issue 2 Author(s): Pedro Henrique N. Panzenhagen, Narayan C. Paul, Carlos A. Conte, Renata G. Costa, Dália P. Rodrigues, Devendra H. Shah In sub-Saharan Africa, two genetically distinct lineages of multi-drug resistant non-typhoidal Salmonella (NTS) serovar Typhimurium sequence type 313 (ST313) are known to cause invasive disease among...
Thu, 03/08/2018 - 08:28
Publication date: Available online 6 March 2018 Author(s): Dao-Feng Zhang, Xin-Yi Yang, Jing Zhang, Xiaojie Qin, Xiaozhen Huang, Yan Cui, Min Zhou, Chunlei Shi, Nigel P. French, Xianming Shi Staphylococcal superantigens play a very important role in infections and food poisoning caused by Staphylococcus aureus. Recently, S. argenteus and S. schweitzeri were recognized as...
Wed, 09/20/2017 - 13:59
Publication date: Available online 14 September 2017 Author(s): Julian Pechstein, Jan Schulze-Luehrmann, Anja Lührmann Coxiella burnetii is an obligate intracellular and airborne pathogen which can cause the zoonotic disease Q fever. After inhalation of contaminated aerosols alveolar macrophages are taking up C. burnetii into a phagosome. This phagosome matures to a very large vacuole...
Sat, 09/09/2017 - 12:07
Publication date: Available online 8 September 2017 Author(s): Mahsa Namakchian, Kristin Kassler, Heinrich Sticht, Michael Hensel, Jörg Deiwick The facultative intracellular pathogen Salmonella enterica survives and replicates inside the Salmonella-containing vacuole (SCV) of mammalian host cells. SifA is a key effector protein translocated by a type III secretion system and...
Wed, 09/06/2017 - 10:05
Publication date: Available online 5 September 2017 Author(s): Roman G. Gerlach, Steffi Walter, Michael McClelland, Christiane Schmidt, Matthias Steglich, Rita Prager, Jennifer K. Bender, Stephan Fuchs, Christoph Schoerner, Wolfgang Rabsch, Werner Lang, Jonathan Jantsch Infections of very young children or immunocompromised people with Salmonella of higher subspecies...
Wed, 09/06/2017 - 10:05
Publication date: Available online 5 September 2017 Author(s): Jung-Chi Chen, Chuan-Fu Chang, Duen-Wei Hsu, Jwu-Ching Shu, Hong-Yi Chen, Chien-Yen Chen, Chi-Yu Lu, Chien-Cheng Chen The alternative transcription factor σB in Bacillus cereus governs the transcription of a number of genes that confer protection against general stress. This transcription factor is regulated by...
Thu, 08/31/2017 - 08:30
Publication date: Available online 30 August 2017 Author(s): Atsushi Hinenoya, Noritomo Yasuda, Natsuko Mukaizawa, Sikander Sheikh, Yuko Niwa, Sharda Prasad Awasthi, Masahiro Asakura, Teizo Tsukamoto, Akira Nagita, M. John Albert, Shinji Yamasaki Cytolethal distending toxin (CDT)-producing Escherichia coli have been isolated from patients with diarrhea, sepsis and...
Thu, 08/17/2017 - 01:17
Publication date: Available online 16 August 2017 Author(s): Nicolas Cabanel, Marc Galimand, Christiane Bouchier, Margarita Chesnokova, Valery Klimov, Elisabeth Carniel The enteropathogen Yersinia pseudotuberculosis causes gastrointestinal infections in humans. Although this species is usually susceptible to antibiotics active against Gram-negative bacteria, we identified three...
Mon, 04/03/2017 - 21:43
Publication date: Available online 3 April 2017 Author(s): C.P.A. Skarp, O. Akinrinade, R. Kaden, C. Johansson, H. Rautelin Campylobacter jejuni is an important foodborne pathogen and the most commonly reported bacterial cause of gastroenteritis. C. jejuni is occasionally found in blood, although mechanisms important for invasiveness have remained unclear. C. jejuni is divided...

Pages