Journal of Food Biochemistry

Wed, 05/26/2021 - 22:07
Journal of Food Biochemistry, EarlyView. Lead nitrate (LN) and cadmium chloride (CdCl2), regarded as environmental contaminants, are toxic heavy metals. Sesamol is a dietary phytochemical found in sesame oil. We aimed to analyze the hepatotoxic and nephrotoxic effects of LN and CdCl2 and to evaluate the possible protective effect of sesamol. LN (90 mg/kg bw per day), CdCl2 (3 mg/kg bw per day),...
Mon, 05/03/2021 - 22:07
Journal of Food Biochemistry, EarlyView. Bisphenol A (BPA) is used as a plasticizer in polycarbonate plastics. It has been used in consumer products and epoxy resins for decades as protective coatings and linings for food and beverage bottles. This can trigger human reactions to BPA which interferes with estrogen receptors. Our study explored the ameliorative effects of selenium (Se) in male rats...
Mon, 05/03/2021 - 22:07
Journal of Food Biochemistry, EarlyView. 3‐Monochloropropane‐1,2‐diol (3‐MCPD) as a byproduct of food processing and a carcinogenic agent has attracted much attention in the last decades. Kidney is the main target organ that is sensitive to the toxicity of 3‐MCPD. Due to limited evidence about possible 3‐MCPD toxicity, we design an investigation to determine the role of mitochondrial biogenesis...
Mon, 12/28/2020 - 22:08
Scheme summarizing the protective properties of Chrysin against testicular toxicity caused by lead acetate in rats. Abstract In the present study, the protective effects of chrysin (CHR) against testicular damage caused by lead acetate (PbAc) were examined. In this way, 30 min after rats were given 25 and 50 mg/kg/b.w CHR orally for seven consecutive days, 30 mg/kg/b.w PbAc was administered...
Sat, 12/19/2020 - 22:08
The multi‐target activity of curcumin makes it a promising pharmacological lead for structural modifications focused on the preparation of new therapeutics with improved bioavailability. A possible modification is to “decompose” the parent curcumin structure into constituent units and to build up curcumin analogues with biphenyl structural moiety. Their antioxidant compositions with DL‐α‐...
Fri, 12/11/2020 - 22:05
Moringa oleifera Lam. extract (MOE) led to the activation of the detoxifying enzyme systems in the Pb (II)‐intoxicated rodents. Administration of MOE offers protection against PbAc‐intoxicated rodents’ brain tissues by inhibiting oxidative stress, apoptosis and inflammation, via attenuating NF‐κB signaling pathways. Abstract In this study, we investigate the potential protective effect of Moringa...
Sun, 11/29/2020 - 22:09
Natural phytoconstituents such as eugenol, cinnamaldehyde, alpha terpinyl acetate, piperine and cuminaldehyde have multi‐target‐directed ligand potential and can have disease modifying effects. Abstract Alzheimer's disease (AD) is a neurodegenerative disorder, and multiple factors are involved in disease progression. This is why there is an urgent need to develop novel molecules with multi‐target...
Mon, 11/16/2020 - 22:11
Screening of terpenoids from Azadirachta indica against the Akt showed they are potent inhibitors of the protein. The screening revealed lupeol, a triterpenoid as the lead compound. Lupeol demonstrate surpassing inhibitory potential on Akt 2 than ipatasertib in in‐silico studies Terpenoids extract downregulate Akt mRNA and demonstrated anti‐Akt downstream signaling effects; anti‐inflammatory,...
Tue, 11/10/2020 - 22:11
Shanghai smoked fish (SSF) was first prepared in this work. Volatile flavor compounds of SSF were identified via Maillard reaction. Pyrazines and furans could modify the flavor of SSF. Glucose is beneficial to enhance the aroma of SSF. Abstract In this work, the effects of substrates on volatile flavor compounds of Shanghai smoked fish (SSF) from grass carp was investigated by head space‐solid‐...
Fri, 11/06/2020 - 22:11
Cationic (GCP1) and anionic (GCP2) peroxidases were purified from day‐6 sprouts of garden cress. Broad substrate specificity of natural plant phenolic compounds was demonstrated for the purified peroxidases. GCP2 showed a high affinity toward sinapyl and coniferyl alcohols, which contributed in lignin synthesis. GCP2 could be used for removal of phenol and p‐chlorophenol from polluted soil as...
Wed, 10/28/2020 - 22:10
Carotenoid isolated from the leaves of Spondias mombim; astaxanthin, β‐carotene‐15,15ʹ‐epoxide, and 7,7ʹ,8,8ʹ‐tetrahydro‐β‐β‐carotene demonstrate selective inhibition of XIAP by hydrophobic interactions within the domains of BIR2 and BIR3. The carotenoid isolates downregulate the expression of XIAP, Bcl‐2, COX‐2, and TNF‐α mRNAs, increase the activities of catalase, LDH, ALP, ALT enzymes, and...
Tue, 10/13/2020 - 22:11
In this study, CTS and β‐CD were cross‐linked to synthesize a biomass membrane for adsorbing Zn2+ to reduce the Zn2+ content in wastewater via adsorption. The results show that the CTS/β‐CDP composite membrane was placed into the wastewater for effective adsorption Zn2+,which could achieve high adsorption efficiency. Abstract In this study, a β‐cyclodextrin polymer (β‐CDP) was synthesized by...
Tue, 10/13/2020 - 22:11
Cadmium chloride evoked oxidative stress‐mediated inflammation and cell death in testis of rats. Ferulic acid acts as an antioxidant protector against CdCl2‐induced reproductive toxicity via enhancing Nrf2/ARE signaling pathway in rats. Abstract Here, we examined the protective effect of ferulic acid (FA) on cadmium chloride (CdCl2)‐mediated reproductive toxicity in male rats. Animals were...
Mon, 10/05/2020 - 22:11
Lentil peptides fractions demonstrated antiglycation, antioxidant and antiproliferative activity. After HPLC‐MSMS sequencing, 28 novel peptides were identified. Abstract Bioactive peptides produced from natural sources are considered as strategic target for drug discovery. Hyperglycemia caused protein glycation alters the structure of many tissues that impairs their functions and lead...
Thu, 10/01/2020 - 22:11
The categories, properties, and applications of extremophilic enzymes in food processing and food waste valorisation are covered in this review. These enzymes' ability to maintain catalytic activities under extreme conditions opens up a broad range of applications in the food industry, including starch liquefaction/saccharification, keratin degradation, production of structured lipids,...
Wed, 09/16/2020 - 22:13
First prepare oyster peptide samples, analyze the oyster peptides by amino acid composition analysis, high‐performance liquid chromatography detection, etc. Then the oyster peptides are gavage to rats, and then analyze the rat serum indexes, related genes and protein expression, antioxidant detection, and HE staining used to study the characteristics of oyster peptides. Abstract This study aimed...
Thu, 09/03/2020 - 22:12
In this paper, the HepG2 cells were induced by high insulin to develop a insulin resistance cell model, then the function of four peptides, VLP, LLP, VA and LL, derived from pea evaluated based on this model. The results showed that pea peptides can alleviate insulin resistance by enhancing insulin signaling pathway (IRS‐1/PI3K/AKT) and reducing intracellular oxidative stress. Abstract This study...
Mon, 08/24/2020 - 21:28
The effects of thiols were examined to inhibit the enzymatic browning of fresh‐cut potato during 48 hr of storage. Polyphenol oxidase (PPO) activity, residual thiol contents, ascorbic acid and antioxidant activities of treated samples were determined after 1, 24 and 48 hr. NAC (2.0%) and CYS (1.0%, 2.0%) solutions totally inhibited the activity of PPO and increased the thiol contents, ascorbic...
Mon, 08/24/2020 - 21:28
CH and RH reduced browning severity of fresh‐cut taros; CH and RH reduced browning of fresh‐cut taros by regulating PAL, POD and PPO activity; Terpenoids contained in hydrosol extracts might play roles in regulating the activity of PAL, POD and PPO. Abstract Hydrosols are byproducts produced by steam distillation of aromatic plant materials. Previous studies reported hydrosols owned effectively...
Fri, 08/14/2020 - 22:11
A dietary supplement composed of lactoferrin hydrolysate (LfH), whey protein hydrolysate (WPH) and vanillin showed antibacterial activity against E.coli and S.aureus in vitro. The studied supplement also exhibited significant antioxidant properties in the model system and anti‐oxidative stress activity in mice exposed to paclitaxel. This supplement has a potential for use in the food matrix to...
Wed, 08/12/2020 - 22:11
About 19 hydrolyzable tannins were computed against 3CLpro enzyme of 2019‐nCoV. It was found that pedunculagin, tercatain, and castalin interacted with Cys145 and His41 of 2019‐nCoV‐3CLpro. Likewise, pedunculagin‐2019‐nCoV‐3CLpro remain stable, with no obvious fluctuations. We predicted that the understandings obtained in the current study may evidence valued for discovering and unindustrialized...
Tue, 08/04/2020 - 22:11
Chitosan‐stabilized selenium nanoparticles (Ch‐SeNPs) displayed high radical‐scavenging activity and reducing power that were not significantly changed during storage. Ch‐SeNPs displayed more protection against ACR‐induced damages comparing to Na2SeO3, where more than 90% of the glutathione pool in the brain tissue was in reduced form. Correlation coefficient analysis demonstrated the attenuating...
Thu, 07/30/2020 - 22:11
The FTIR explored various functional groups and HPLC analysis indicated the presence of kaempferol and quercetin in the methanol extract of Moringa oleifera leaf. In vitro cytotoxicity assay revealed that IC50 of the plant extract was more than 1,000 µg/ml. The plant extract might be safe up to 2,000 mg/kg single dose. Long term use of the plant extract was mostly devoid of major system...
Thu, 07/23/2020 - 22:10
In this study, we assessed the protective effect of berberine (BBR) against mercuric chloride (HgCl2)‐induced reproductive impairment. Twenty‐eight adult male Wistar rats were placed into four groups: control, BBR, HgCl2 and BBR + HgCl2. HgCl2 intoxication caused a marked decrease in testosterone accompanied by a pro‐oxidant/antioxidant imbalance. In addition, histological deformations and...
Mon, 07/06/2020 - 22:10
High levels of p‐Coumaric acid was first isolated and identified from Spirulina. Inhibitory kinetics and mechanism of p‐Coumaric acid on two enzymes were studied. Molecular modeling revealed the Spirulina p‐Coumaric acid binding mode. Abstract Spirulina species are edible with high nutritional as well as potential therapeutic values. In this work, we show that phenolic extracts from Spirulina (p‐...
Wed, 07/01/2020 - 22:10
Black tea (BTE) or curcumin (CMN) ameliorated hepatorenal changes induced by aflatoxin‐B1 (AFB1) with high improvement when combined BTE/CMN was used. Forty eight adult male rats were used into 8 groups: G1; control, G2, G3, and G4 were; olive oil, BTE and CMN, respectively, G5 was; olive oil‐dissolved AFB1. G6, G7 and G8 were; AFB1 along with BTE, CMN and BTE plus CMN, respectively. Liver/kidney...
Sun, 06/28/2020 - 22:09
PC12 cells were treated with acrylamide (AA) in the absence or presence of P‐CS, and cell apoptosis was analyzed. Interestingly, P‐CS pretreatment of the cells could significantly prevent AA‐induced cell death, glutathione (GSH) contents decrease, and ROS overproduction. Further investigation of the molecular mechanism underlying the effect of P‐CS on cell apoptosis revealed that P‐CS was able to...
Fri, 06/26/2020 - 22:09
Allergic diseases are known as an IgE‐mediated immune response to an innocuous environmental antigen. Especially, FcεRI expressing on the cell surface of mast cells and basophils is considered as a key trigger of acute allergic responses. Recently, numerous bioactive agents derived from natural products have been revealed to inhibit the expression of FcεRI subunits as well as block FcεRI...
Thu, 06/25/2020 - 22:10
Antioxidant and anti‐proliferative activities of M. laevigeta leaf and bark extract were determined against EAC cells in the peritoneum fluid of Swiss albino mice. Morphological alteration of the treated EAC cells on florescence microscope and DNA degradation in gel electrophoresis confirmed the apoptosis induction. The Expression pattern of the Bax, Bcl‐2 and PARP‐1 in comparison to control...
Wed, 06/17/2020 - 22:10
The best harvesting periods to obtain high level of bioactive compounds were assessed in minimally processed orange‐ and cream‐flesh sweet potatoes. Cream‐flesh showed browning, while orange‐flesh presented whitening after minimally process. Best visual quality was obtained by delaying the harvest for 30 and 60 days. Orange sweet potatoes presented β‐carotene as the major carotenoid (up to 99%)...
Mon, 06/15/2020 - 22:10
Soybean peptides on the inhibition of lipopolysaccharide‐induced RAW264.7 cell inflammation, which impeded the increase of toll‐like receptor 4 activity by restricting LY96, while also inhibiting the mitogen‐activated protein kinase (MAPK)‐c‐Jun N‐terminal kinase (JNK) pathway in cells, as well as LPS‐induced NF‐κB activation caused by the degradation of nuclear factor of kappa light polypeptide...
Tue, 06/09/2020 - 22:10
Praying mantis egg case powder inhibits the accumulation of Cd concentration in catfish bone and muscle tissues and increases its dietary protein content. It also up‐regulated serum NO level in catfish to initiate vasodilatation of bones and muscles for proper blood flow. Finally, it augments the dwindling of myeloperoxidase activity caused by Cd exposure, which has the potential to kills...
Tue, 06/09/2020 - 22:10
Zingerone restored anti‐oxidant enzyme activity (CAT, SOD, GPx, and GR), normalized lipid profile, improved organ function, and prevented tissue injury in kidney and liver. Abstract Among the heavy metal poisonings, lead is considered as a major toxic metal causing hematological, neurological, immunological, hepatic, and renal dysfunctions. Lead causes inhibition of ALAD leading to the ALA...
Fri, 06/05/2020 - 03:27
The adverse effect of Aflatoxin B1 (AFB1) and the beneficial effects of gallic Acid (GA) against AFB1 induced toxicity in vitro have been published. Here we present in vivo findings on AFB1 and GA on hepatorenal function in rats, exposed to AFB1 only or co‐treated with GA for 28 successive days. AFB1 significantly increased pro‐inflammatory biomarkers, suppressed IL‐10 levels, and increased...
Fri, 12/27/2019 - 03:18
Quercetin at the dosages investigated substantially reversed the high blood glucose and glycosylation, enhanced glycogen and haemoglobin (Hb) contents as well as improved the pancreatic antioxidant status. Quercetin normalized reduction in organ body weight ratio of the pancreas and liver observed in type 2 diabetic rats via increased hepatic hexokinase and decreased glucose‐6‐phosphatase...
Tue, 12/24/2019 - 03:17
A detailed study on two Nepeta species. The essential oils of two Nepeta species might be used as Germacrene D source. The Nepeta heliotropifolia and N. congesta subsp. cryptantha flowers being rich in rosmarinic acid and having antioxidant potential, and their essential oils could be source for nutraceutical, food and drug industries. Abstract In the present study, the essential oil and aroma...
Tue, 11/05/2019 - 03:19
Maillard reaction is known to result in loss of nutrients, particularly that of essential amino acids; decrease in digestibility and safety issues due to the development of toxic compounds. Maillard reaction products are also known to cause oxidation of tissues and inflammation, thus increasing the risk of cardiovascular diseases and diabetes. The aim of this review is to present a detailed...
Tue, 10/22/2019 - 03:22
A previously unreported xylated glycosaminoglycan with a β‐D‐Xylop(1 → 3)‐(⋯ → 4)‐GlcpA(1 → 3)‐GlcpNAc(1 → ⋯) framework was isolated to homogeneity from marine buccinid gastropod Babylonia spirata, and was found to possess potential antioxidant and 5‐lipoxygenase attenuation activities. The isolated metabolite might be anticipated as potential naturally‐derived bioactive constituent in functional...
Thu, 10/17/2019 - 03:22
Interactions of the flavoring compounds hexyl acetate (HxAc), heptyl acetate (HpAc), linalyl formate (LiFo), linalyl acetate (LiAc), geraniol, linalool, limonene, and myrcene with soy protein isolate (SPI) were estimated in pH 3.0, 6.0, and 9.0 aqueous solutions using headspace solid‐phase microextraction gas chromatography–mass spectrometry (SPME–GC–MS). The binding capacity of HxAc, HpAc, LiFo...
Wed, 10/16/2019 - 03:21
The capsaicin in hot peppers is an important biological active substance that is widely used in food and medicine. Our current study shows that capsaicin derivatives have good antioxidant and antibacterial activities, and therefore, the present study of capsaicin derivatives with good activity provides a good foundation for future applications in natural food additives and medicine. Abstract The...
Sat, 10/05/2019 - 03:20
Pretreatment with beetroot‐based beverages for 8 weeks showed significantly higher levels of superoxide dismutase (25%–28%), catalase (21%–24%), and hepatic enzymes (15%–19%) alongside reduced lipid peroxidation (27%–32%) in liver tissues of hepatotoxicity‐induced rats. Hepatic injury was reduced by 19%–26% as indicated by concentrations of serum hepatic health biomarkers in hepatotoxicity‐...
Wed, 10/02/2019 - 03:22
The current study evaluated the immunomodulatory effects of Carica papaya pulp and seeds methanol (MeOH) extracts on mice infected with Listeria monocytogenes. Gas chromatography–mass spectrometry analysis identified 10 active constituents in C. papaya seed MeOH extract and 10 compounds in C. papaya pulp MeOH extract. The experimental animals were divided into negative control (G1) group,...
Mon, 09/23/2019 - 03:16
Ellagic acid reversibly and effectively inhibited tyrosinase in a mixed manner. Ellagic acid inhibited cell proliferation and induced apoptosis in B16 cells. Hydrogen bond and electrostatic force existed between ellagic acid and tyrosinase. Abstract The activities of ellagic acid in inhibiting mushroom tyrosinase and cell proliferation were evaluated in this research. The results of enzyme...
Mon, 09/23/2019 - 03:16
Sour rot, caused by Geotrichum citriaurantii (G. citri-aurantii.), is one of the most serious grapevine secondary infection diseases in China. We have determined that pterostilbene, the most important phytoalexin, effectively inhibits the activity of G. citri‐aurantii. To study the synthesis mechanism of pterostilbene against G. citri‐aurantii in grape, we initially detected the content of...
Mon, 09/23/2019 - 03:16
We evaluated the characteristic odor substances in Asian carp meat, which are prevalent in the Great Lakes, to provide a foundation for resource utilization and removing its fishy smell. Three Mono Trap RCC18 adsorbents were used to extract samples. Volatile components were analyzed by gas phase‐olfaction‐mass spectrometry. The main odor‐active substances were identified by aroma extraction...
Mon, 09/23/2019 - 03:16
Chia seeds (Salvia hispanica L.) are rich in omega fatty acids. The aim was to evaluate the effect of chia intake on acute dyslipidemia, on acute steatohepatitis, and on mixed damage in non‐obese rats. Chia seeds intake for 4 weeks partially or totally prevented steatohepatitis, and reduced dyslipidemia in groups. The hypolipidemic and hepatoprotective effects of chia may be correlated to its...
Mon, 09/23/2019 - 03:16
Purple rice extract (PRE) retarded the testosterone‐induced rat benign prostatic hyperplasia (BPH) and suppressed the growth of human prostate cancer (LNCaP). These effects might cause by the reduction of androgen receptor (AR) activation. Therefore, the genes responsible for AR‐DHT complex were down‐regulated such as prostate specific antigen (PSA). Abstract The preventive effects of purple rice...
Mon, 09/23/2019 - 03:16
The oligosaccharide Hep‐2 from cultured mycelium of Hericium erinaceus was isolated by the method of water extraction, alcohol precipitation, and column chromatography. Hep‐2 consists of galactose, and glucose with 1,080 Da molecular weight and it is an oligosaccharide mixture of 2–7 sugars by LC‐MSn and includes three types of sugar residues with no branches by methylation methods. Hep‐2 possess...
Mon, 09/23/2019 - 03:16
Diarrheagenic Escherichia coli O157 is an important reason for largest food borne inflectional outbreaks. E. coli O157 invades into the food chain through contaminated irrigation water and soil causing infectious diseases to humans. In our previous study, we have evaluated the persistence of E. coli O157 through plate count methods. However, conventional cultural procedures are less sensitive to...
Mon, 09/23/2019 - 03:16
A total of 40, male Wistar Albino, 2–3‐months‐old rats were used and divided into four groups. Control group received the vehicle alone, diosmin group received 100 mg/kg.bw diosmin, the cadmium group received 200 ppm cadmium, cadmium plus diosmin group received 200 ppm cadmium, and 100 mg/kg.bw diosmin for 30 days. Some biochemical parameters (aspartate aminotransferase, alanine aminotransferase...