Journal of Separation Science

Sat, 06/05/2021 - 22:06
Journal of Separation Science, Accepted Article. Endocrine disrupting chemicals are chemicals that interfere with any aspect of the endocrine system. Several natural and synthetic chemicals including pesticides have been identified as endocrine disruptors, which potentially inhibit the reproductive activity of the hormonal system. The pervasive occurrence with trace level concentrations and...
Tue, 05/25/2021 - 22:07
Journal of Separation Science, Accepted Article. Bubble-bursting flow microextraction combined with gas chromatography as a green and sustainable microextraction method is used to determine some organophosphorus pesticide residues in water samples. The extraction process occurs at the surface of liquid-gas contact, where the analytes interact with the gas molecules in the bubble. The analytes are...
Sat, 03/27/2021 - 22:06
Journal of Separation Science, Accepted Article. Pesticides and veterinary drugs are generally employed to control pests and insects in crop and livestock farming. However, remaining residues are considered potentially hazardous to human health and the environment. Therefore, regular monitoring is required for assessing and legislation of pesticides and veterinary drugs. Various approaches to...
Mon, 03/15/2021 - 22:06
Journal of Separation Science, Accepted Article. In this study, a new floating dispersive solid phase extraction method based on deep eutectic solvents has been developed in a home–made extraction device for the extraction of four tetracycline antibiotics from milk samples. In this approach, the sorbent (activated carbon) was dispersed in whole parts of solution with the aid of air stream and...
Wed, 03/03/2021 - 22:06
Journal of Separation Science, Accepted Article.The intensive application of pesticides to increase crop production has resulted in contamination of the agricultural products. Due to their occurrence at trace levels and the complexity of food samples, analysis of pesticide residues requires selective and efficient sample preparation methods. For this purpose, an extraction method based on...
Thu, 02/25/2021 - 22:06
Journal of Separation Science, Accepted Article. A moisture‐sensitive metal‐organic framework CoII(pybz)2·2DMF was synthesized and applied as the adsorbent of dispersive solid phase extraction. The structure changed after water treatment due to the fact that two chelate carboxylate groups on the skeleton were transformed to monodentate because of the coordination of water molecules. The material...
Fri, 02/19/2021 - 22:08
Journal of Separation Science, Accepted Article. In this paper, we propose a novel micro‐solid‐phase extraction and elution technique, which we called the thin‐layer solid‐phase extraction–liquid film elution technique. The thin‐layer solid‐phase extraction phase is an octadecylsilylated sol‐gel coated porous silica thin film prepared on the outer wall of a test tube, which has a larger surface...
Fri, 02/19/2021 - 22:08
Journal of Separation Science, Accepted Article. In this study, a lab‐made Parallel‐Single Drop Microextraction methodology using the magnetic ionic liquid trihexyltetradecylphosphonium tetrachloromanganate (II) as extraction solvent was developed to determine the pesticides tebuconazole, pendimethalin, dichlorodiphenyltrichloroethane, and dichlorodiphenyldichloroethylene in human urine samples....
Fri, 01/29/2021 - 22:07
A novel hexagonal boron nitride modified reduced graphene oxide material was synthesized and used as the adsorbent for the solid‐phase microextraction of seven polycyclic aromatic hydrocarbons from water and soil samples prior to their detection by gas chromatography‐flame ionization detector. Under optimal conditions, the linear response range of the analytes for water sample is 0.25‐50 ng mL−1...
Mon, 01/25/2021 - 22:09
A particle based stationary phase has been prepared for the separation of five synthetic peptides and a mixture containing tryptic digest of cytochrome C in liquid chromatography. Particles originating from silica monolith were differentially sedimented to obtained particles in 1 to 2 μm range. A stationary phase was achieved by the coating of Poly (styrene‐methacrylic acid‐N‐phenylacrylamide)...
Wed, 01/20/2021 - 22:07
Monitoring the residual toxicant concentrations in foods is the key step for minimizing potential hazards. The huge interest about food contamination and exposure to endocrine disruptors such as Bisphenol A has emerged the development of sensitive analytical methodologies to guarantee the safety and quality of foods. In this work, a green molecularly imprinted solid phase extraction protocol...
Wed, 01/20/2021 - 22:07
This study assesses the extraction of 11 pharmaceuticals, 5 pesticides, 5 perfluoroalkyl substances and 2 illicit drugs in haemolymph from (Mytilus Galloprovincialis). Four extraction procedures using Phree™ Phospholipid Removal cartridges were tested using different volumes of methanol (400 μl and 600 μl) and acetonitrile (300 μl and 450 μl). The pollutants were determined by HPLC‐MS/MS. The use...
Wed, 01/20/2021 - 22:07
A new extraction procedure based on combination of a solvent extraction and deep eutectic solvent‐based dispersive liquid–liquid microextraction has been introduced for the extraction of aflatoxin M1 from cheese samples. In this method, acetonitrile, deionized water, and n‐hexane are added onto the sample and vortexed. Owning to different affinities of the substances in cheese towards the...
Thu, 01/07/2021 - 22:07
In this study, several metal‐organic framework‐melamine foam columns were first developed and used as a laboratory‐made semi‐automatic solid phase extraction packed in syringe adsorber for the extraction of six triazine herbicides from vegetable oil samples coupled to high‐performance liquid chromatography‐tandem mass spectrometry. The metal‐organic framework‐foam columns were prepared using a...
Sun, 01/03/2021 - 22:08
This manuscript describes the development of an innovative method to determine cannabinoids (cannabidiol and tetrahydrocannabinol) in human plasma samples by pipette‐tip micro‐SPE and LC‐MS/MS. An octyl‐functionalized hybrid silica monolith, which had been synthesized and characterized, was used as a selective stationary phase. The octyl‐functionalized hybrid silica monoliths presented high...
Sat, 12/12/2020 - 22:05
Yanghe decoction is a traditional Chinese medicine prescription and has been used for breast cancer treatment for many years. However, the effective ingredients in the decoction have not been identified. The expression of poly (ADP‐ribose) polymerase‐1 is highly related to breast cancer. Using poly (ADP‐ribose) polymerase‐1 as a probe, we expressed the haloalkane dehalogenase‐tagged protein in E...
Sat, 12/12/2020 - 22:05
An LC–MS/MS method coupled with a stable isotope dilution assay was established for the simultaneous detection of 17 mycotoxins and their derivatives (aflatoxins B1, B2, G1, G2, M1, and M2; fumonisins B1 and B2; ochratoxin A; zearalenone; zearalanone; α‐zearalanol; α‐zearalenol; T‐2 toxin; deoxynivalenol; deepoxy‐deoxynivalenol; and sterigmatocystin) in milk and dairy products. The mycotoxins...
Sat, 12/12/2020 - 22:05
Excessive absorbtion of migrating substances from food contact materials can affect human health. Thus it is essential to analyze the migration of contaminant from food contact materials. However, comprehensive analysis has been challenged by low concentration of migrating substances, manifold and complex matrix interference of food contact materials. Therefore, appropriate sample pretreatment...
Wed, 12/02/2020 - 22:08
In a recent study conducted by Zhang et al. (2019), the adenosine monophosphate‐specific aptamer has been applied for the rapid extraction of ochratoxin A. Although several publications have already reported the selection of adenosine monophosphate, adenosine triphosphate, and adenosine, there is no report on the detection of ochratoxin A using this aptamer. The data of Zhang et al. is surprising...
Mon, 11/30/2020 - 22:10
Hydroxypropyl‐β‐cyclodextrin‐encapsulated stationary phase incorporated on silica monolith particles was prepared by physical embedding, providing a new method for the development of chiral stationary phase for enantioseparation in liquid chromatography. Ground silica monolith particles of about 2.0 μm were prepared via sol‐gel reaction followed by differential sedimentation. Initially, the...
Fri, 11/20/2020 - 22:09
Polyethyleneimine‐modified magnetic multi‐walled carbon nanotubes were developed to extract 10 mycotoxins. Simple modification of polyethyleneimine was achieved on the magnetic substrate by using an epoxy‐containing silane agent as a linker. The resultant magnetic adsorbent was integrated with reverse phase and anion exchange interaction sites. Under optimal extraction conditions, only 20.0 mg...
Wed, 11/18/2020 - 22:08
The advent of a new pharmaceutical formulation evokes the need for examining the chemical stability of their constituents and establishing proper stability‐indicating methods. Herein, the stability of the newly co‐formulated Tamsulosin and Tadalafil were examined under different stress conditions. The acidic degradation of Tamsulosin yielded its sulfonated derivative, while Tadalafil was...
Tue, 11/17/2020 - 22:09
The aim of this study was to establish and validate an alternative high‐performance liquid chromatography (HPLC) method for simultaneous quantification of pyrazinamide, isoniazid, acetyl‐isoniazid and rifampicin in plasma of patients under treatment for tuberculosis. The performed method was lineal (r2>0.99) in the range of 2.00‐50.00 μg/mL for pyrazinamide, 0.50‐20.00 μg/mL for both acetyl‐...
Tue, 11/17/2020 - 22:09
A novel worm‐like nickel‐titanium oxide nanocomposites coating was directly grown on a nickel‐titanium alloy wire by low‐voltage electrochemical anodization in alkaline ethylene glycol and water solution. The in situ growth of nickel‐titanium oxide nanocomposites greatly depended on the volume ratio of ethylene glycol to water and temperature. Coupled to HPLC with UV detection by static...
Fri, 11/13/2020 - 22:10
Food can contain unwanted compounds and need to be analyzed for compounds like carcinogenic polycyclic aromatic hydrocarbons to ensure consumer safety. The analytes need to be extracted from the sample matrix and cleaned‐up to enable detection. However, established methods for clean‐up are labor‐intensive and have a high expenditure on organic solvents. Here we show a newly developed micro solid‐...
Thu, 11/05/2020 - 22:11
A solid phase extraction method combined with deep eutectic solvent‐based dispersive liquid‐liquid microextraction has been developed for the extraction of three antibiotics in honey samples prior to their determination by ion mobility spectrometry. In this method, firstly, a multi‐wall carbon nanotube/urea‐formaldehyde nanocomposite was synthesized using co‐precipitation polymerization method...
Tue, 10/27/2020 - 22:12
An open tubular capillary column (100 μm internal diameter and 120 cm length) was first fabricated with N‐phenylacrylamide and styrene copolymer layer on the inner surface by in situ one‐pot strategy, while ethylene dimethacrylate was used as the cross‐linker. The pretreated silica‐fused capillary was reacted with 3‐trimethoxysilyl propyl methacrylate to attach a double bond ligand onto the inner...
Fri, 10/02/2020 - 22:10
Bisphenol A is a synthetic compound widely used in industry, in the production of polycarbonate, epoxy resins and thermal paper, among others. Its annual production is estimated at millions of tons per year, demonstrating its importance. Despite its wide application in various everyday products, once in the environment (due to its disposal or leaching), it has high toxicity to humans and animal...
Fri, 10/02/2020 - 22:10
With metabolism being one of the main routes of drug elimination from the body (accounting for removal of around 75% of known drugs), it is crucial to understand and study metabolic stability of drug candidates. Metabolically unstable compounds are uncomfortable to administer (requiring repetitive dosage during therapy), while overly‐stable drugs increase risk of adverse drug reactions....
Thu, 10/01/2020 - 22:11
This work reports an HPLC method development able to simultaneously determine perampanel and stiripentol, two third‐generation antiepileptics whose therapeutic spectrum can potentially be extended, in several mouse matrices. A salting‐out assisted liquid‐liquid extraction optimized by a design of experiments approach was adopted for samples preparation. Isopropanol and magnesium sulfate were the...
Sun, 09/27/2020 - 22:13
A facile method was introduced for preparing a biocharcoal aerogel, which was derived from pomelo peel as the only raw material. The inner spongy layer of pomelo peel was freeze‐dried for maintaining three‐dimensional structure, further carbonized under high temperature and oxygen‐limited conditions. The morphological structure and graphitization degree of biocharcoal aerogel were characterized...
Fri, 09/11/2020 - 22:11
Priority pollutants chlorophenols are broadly used chemicals that are persistent in the environment and causing serious human health hazards. The current study introduces a novel adsorbent for the extraction of chlorophenols from river water, surface water, and milk by headspace solid phase microextraction coupled with GC. The adsorbent composite was prepared by blending polycaprolactam (nylon‐6...
Thu, 09/10/2020 - 22:11
Variation in inter‐human attractiveness to mosquitoes, and the preference of mosquitoes to bite certain regions on the human host, are possible avenues for identifying lead compounds as potential mosquito attractants or repellents. We report a practical, non‐invasive method for the separation and detection of skin surface chemical compounds and comparison of skin chemical profiles between the...
Thu, 09/10/2020 - 22:11
In the last years, multidimensional liquid chromatography technique became very widespread for the complete separation of non‐volatile analytes in complex matrices. The main advantage of these techniques, especially when coupled with mass spectrometry, is the enhancement of separation power or peak capacity, due to an increase in selectivity and sensitivity of the two systems. With respect to...
Mon, 08/31/2020 - 22:11
An accurate and sensitive ultra‐high‐performance liquid chromatography coupled with triple quadrupole mass spectrometry method was established and validated for the determination of 9 bioactive compounds of Ligustri Lucidi Fructus in rat plasma. Separation was performed on Halo® C18 column with a mobile phase of acetonitrile and 0.1% formic acid in water. The eluate was detected by multiple‐...
Mon, 08/24/2020 - 21:28
A simple, fast, and sensitive analytical protocol using fabric‐phase sorptive extraction followed by high performance liquid chromatography with ultraviolet detection has been developed and validated for the extraction of five parabens including methylparaben, ethylparaben, propylparaben, butylparaben, and benzylparaben. In the present work, sol‐gel polyethylene glycol coated fabric‐phase...
Sat, 08/15/2020 - 22:12
Polycyclic aromatic hydrocarbons, ubiquitous compounds which result from incomplete combustion or pyrolysis of natural and man‐made combustion sources, can adversely affects human health due to their well‐known toxicity. This paper demonstrates the significant potential of graphene/chitosan composite aerogels as solid‐phase extraction sorbents for efficient polycyclic aromatic hydrocarbon...
Tue, 08/11/2020 - 22:11
A new analytical method based on capillary LC with diode array detection has been developed for the simultaneous quantification of seven neonicotinoid insecticides commercially available (imidacloprid, thiacloprid, clothianidin, thiamethoxam, acetamiprid, nitenpyram and dinotefuran) in honey samples. The separation was achieved in a Zorbax XDB‐C18 column (150 × 0.5 mm id, 5 μm), with a mobile...
Tue, 08/04/2020 - 22:10
This study ascertained the viability of a portable liquid chromatograph, operating at low μL/min flow, for the analysis of seized drugs at remote sites as well as in laboratory settings. Synthetic cathinones were screened using dual capillary columns in series, C8 and biphenyl, with on‐column ultraviolet detection at 255 nm and 275 nm. The relative retention times of the two columns in series and...
Thu, 07/30/2020 - 22:10
In this work, graphene oxide‐hybridized high internal emulsion polymers with crosslinking and open‐cell structure was prepared and applied for separation and enrichment of estrogens. The prepared graphene oxide‐hybridized high internal emulsion polymer monoliths had hydrophobicity, porosity and stability, which were just obtained by one step in‐situ emulsion polymerization of 2‐ethylhexyl...
Thu, 07/30/2020 - 22:10
A method for separation and determination of 32 fentanyl‐related substances, including seven sets of isomeric fentanyl analogues, was developed using ultra‐high‐performance liquid chromatography coupled with quadrupole‐orbitrap high‐resolution mass spectrometry. The collision energy, chromatographic column and mobile phase were optimized. All compounds were efficiently flushed out of a universal...
Thu, 07/30/2020 - 22:10
An analytical method for the determination of 6 emerging derivatives or metabolites together with 25 common macrolides antibiotics in milk by ultra‐performance liquid chromatography quadrupole/electrostaticfield orbitrap mass spectrometry was established. The samples were purified with optimized Quick, Easy, Cheap, Effective, Rugged, Safe methods. The amounts of primary‐secondary amine, C18 and...
Wed, 07/29/2020 - 22:09
Peptide sequencing is critical to the quality control of peptide drugs and functional studies of active peptides. A combination of peptidase digestion and mass spectrometry technology is common for peptide sequencing. However, such methods often cannot obtain the complete sequence of a peptide due to insufficient amino acid sequence information. Here, we developed a method of generating full...
Fri, 07/24/2020 - 22:10
A magnetic covalent organic framework material was synthesized with a core‐shell structure using a simple solvothermal method. It was prepared with Fe3O4 as the magnetic core, covalent organic framework as the shell, which synthesized from 1,3,5‐triformylphloroglucinol and p‐phenylenediamine by Schiff base reaction. The transmission electron microscope, Fourier transform infrared spectroscopy,...
Thu, 07/23/2020 - 22:10
A sample pretreatment method based on the combination of a three‐phase solvent extraction system and deep eutectic solvent‐based dispersive liquid–liquid microextraction has been introduced for the extraction of four organochlorine pesticides in cocoa samples before their determination by gas chromatography–electron capture detection. A mixture of sodium chloride, acetonitrile, and potassium...
Tue, 07/21/2020 - 22:09
Although an efficient and stable fiber coating is essential for the development of solid‐phase microextraction technique, it remains a challenging prospect. Herein, an inorganic nanocomposite material Ag2S@ZnS was prepared and used as a coating for fibers to detect polycyclic aromatic hydrocarbons in water samples in combination with a GC with flame ionization detector. Compared with a single ZnS...
Tue, 07/14/2020 - 22:11
In order to enhance the extraction performance, a mesoporous silica was modified with ordered mesoporous carbon for solid‐phase microextraction. Three stainless steel wires coated with the mesoporous material were placed in a polyetheretherketone tube for getting an extraction tube. The tube was coupled to high performance liquid chromatography with diode array detector, and the online analysis...
Fri, 07/10/2020 - 22:10
Levetiracetam is an antiepileptic drug for the treatment of psychiatric patients. In this study, a selective, straightforward, and rapid online heart‐cutting LC method was developed for the therapeutic drug monitoring of levetiracetam. This method allows for the determination of levetiracetam in human plasma without complex sample preparation. The mobile phases consisted of 30 mM aq. ortho‐...
Fri, 07/10/2020 - 22:10
Drug resistance is one of the main problems of cancer treatment. For this reason, combination therapy is commonly used for years. The combination of a chemotherapeutic, carboplatin, and the epigenetic drug decitabine is a new approach to modulate drug resistance. Nanoparticulate systems can overcome the drawbacks associated with the drug combinations. An analytical method that can detect and...
Tue, 07/07/2020 - 22:09
Emerging drugs usually mimic the effects of traditional drugs, but are not always controlled due to the chemically altered structures. Positional isomers of emerging drugs are challenging to analyze because they challenge the separation and detection techniques commonly employed by forensic laboratories. The utility of silica hydride (SiH) stationary phases for the ultra high performance liquid...

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