Microbes and Infection

Wed, 06/09/2021 - 06:07
Author(s): Wentao Song, Jin Guo, Xiansheng Ni, Jingwen Wu, Wen Xia, Fenglan He, Xi Wang, Guoyin Fan, Kun Zhou, Yuhang Wu, Shengen Chen, Haiying Chen We investigated fluctuations in the detection rates of avian influenza virus (AIV) subtypes H5, H7, and H9 in live bird markets (LBMs) in Nanchang city, Chinese province Jiangxi, before and after the Chinese nationwide AIV vaccination campaign...
Sat, 03/20/2021 - 06:10
Author(s): Jessica M. Jacob, Roy Curtiss The objective of this project was to conduct a feasibility study to determine whether the Brucella abortus S19 vaccine infects and persists in mice and determine whether S19 can be used as a challenge strain for vaccine trial studies. Groups of BALB/c mice were inoculated (intraperitoneally, subcutaneously, intranasally) and euthanized to determine...
Sat, 06/13/2020 - 06:10
Author(s): Mariana C. Ferrero, Iván M. Alonso Paiva, Florencia Muñoz González, Pablo C. Baldi Brucella infection is frequently acquired through the respiratory route. The pathogen disseminates systemically from the lungs to infect peripheral organs. In this review we summarize the existing data on the pathogenesis of inhalational Brucella infection, the pulmonary immune response to the pathogen,...
Mon, 09/30/2019 - 03:22
Author(s): Amanda L. Dragan, Daniel E. VothAbstractCoxiella burnetii is an intracellular bacterium that causes acute and chronic Q fever. This unique pathogen has been historically challenging to study due to obstacles in genetically manipulating the organism and the inability of small animal models to fully mimic human Q fever. Here, we review the current state of C. burnetii research,...
Sun, 09/22/2019 - 03:21
Author(s): Ayelén Ivana Pesce Viglietti, Guillermo Hernán Giambartolomei, María Victoria DelpinoAbstractOsteoarticular brucellosis is the most frequent complication of active disease. A large amount of cells in bone are osteocytes. Since bone remodeling process is regulated by hormones we sought to study the effect of cortisol and DHEA in Brucella abortus-infected osteocytes. Cortisol treatment...
Sun, 09/22/2019 - 03:21
Author(s): Rasheduzzaman Rashu, Taufiqur Rahman Bhuiyan, Mohammad Rubel Hoq, Lazina Hossain, Anik Paul, Ashraful Islam Khan, Fahima Chowdhury, Jason B. Harris, Edward T. Ryan, Stephen B. Calderwood, Ana A. Weil, Firdausi QadriAbstractVibrio cholerae O1 can cause life threatening diarrheal disease if left untreated. T cells can play critical roles in inducing B cell mediated immunity. As the...
Sun, 09/22/2019 - 03:21
Author(s): Priyadarshini Mukherjee, Vivek Mondal, Ushasi Bhaumik, Ritam Sinha, Sounak Sarkar, Soma Mitra, Debaki Ranjan Howlader, Suhrid Maiti, Asish Kumar Mukhopadhyay, Shanta Dutta, Hemanta KoleyAbstractMultiple diarrheagenic enteric bacterial infections cause global morbidity and mortality. A combination vaccine is needed to combat different diarrhea-causing organisms. In our present work, we...
Sun, 09/22/2019 - 03:21
Author(s): Sophia HäfnerAbstractArticle highlight based on “AIM2 senses Brucella abortus DNA in dendritic cells to induce IL-1β secretion, pyroptosis and resistance to bacterial infection in mice" by Miriam Maria Silva Costa Franco et al.
Sun, 09/22/2019 - 03:21
Author(s): Mina Rahmanpour, Fariba Keramat, Sanaz Jourghasemi, Golnaz Rashidi, Mohsen Abdolmaleki, Ghasem Solgi, Mehrdad HajilooiAbstractTh1 cells play a central role in immunity to brucellosis, while the exact role of Th17 cells has remained unknown. This study aimed to evaluate the peripheral distributions of Th1 and Th17 cells and serum levels of IFN-γ, IL-17A and IL-22 cytokines in...
Sun, 09/22/2019 - 03:21
Author(s): Paula Barrionuevo, Guillermo H. GiambartolomeiAbstractBrucella infection activates the immune system and favors the differentiation of CD4+ and CD8+ T cells. To persist during a long time inside macrophages evading immune surveillance of these T cells the pathogen must exploit different evasion strategies. We review the mechanisms whereby Brucella, through TLR signaling, inhibits MHC...
Thu, 12/06/2018 - 01:11
Publication date: Available online 22 September 2018Source: Author(s): Miriam Maria Silva Costa Franco, Fernanda Martins Marim, Juliana Alves-Silva, Daiane Cerqueira, M. Rungue, Isabela P. Tavares, Sergio C. OliveiraAbstractAbsent in melanoma 2 (AIM2) is a sensor of cytosolic dsDNA and is responsible for the activation of inflammatory and host immune responses to DNA viruses and intracellular...