Molecular Nutrition & Food Research

Sat, 01/25/2020 - 03:17
Scope Urolithin A (UA) is a gut‐derived metabolite from ellagic acid found in pomegranates, berries and nuts can down‐regulate cell proliferation and migration. Cell proliferation and cell motility require actin reorganization which is under control of ras‐related C3 botulinum toxin substrate 1 (Rac1) and p21 protein‐activated kinase 1 (PAK1). The present study explored whether Urolithin A can...
Mon, 01/20/2020 - 03:20
: The influence of the intestinal microbiota, such as Lactobacillus, on the intestinal mucosa, particularly intestinal stem cells, remains incompletely understood. In this study, mice and intestinal organoids were used to explore the regulatory effect of Lactobacillus on the proliferation and differentiation of intestinal epithelial cells. Methods and results: This study demonstrated that S....
Sat, 01/11/2020 - 03:16
Fungi of the genus Alternaria are plant pathogens infecting agricultural foods. Alternaria isolates are cultivated in a chemically defined liquid medium and the extracts are analyzed by ultra‐high‐resolution mass spectrometry (FTICR‐MS) and LC‐MS/MS. The targeted and non‐targeted analysis of the fungal extracts uncovers differences in the mycotoxin and metabolic profile of the A. alternata and...
Thu, 12/19/2019 - 03:18
Reduced digestibility of foods containing oxidized proteins and the subsequent excessive accumulation of undigested components in the colon may cause changes in the intestinal flora composition. This study evaluates the characteristics of this change and the potential adverse effects on organisms. Methods and results Pork was cooked using sous‐vide or at high temperature and pressure (HTP), and...
Sat, 11/02/2019 - 03:18
High‐sodium and low‐potassium (HNaLK) intake increase the risk of cardiovascular disease (CVD) and metabolic syndrome. We investigated if the dietary minerals interact with the gut microbiota to alter circulating lipid profiles, implicated in CVD and metabolic syndrome. Methods and results Plasma samples from Wistar rats fed a control or HNaLK diet with or without antibiotic treatment (n = 7 each...
Fri, 10/11/2019 - 03:21
As a result of the obesity epidemic, the prevalence of non‐alcoholic steatohepatitis (NASH) is increasing. No drug is approved for the treatment of NASH. We have investigated the effect of a nutritional supplement, Mastiha or Chios mastic gum, on metabolic and histological parameters and on the gut microbiome in mice with NASH and fibrosis. Methods and results Advanced NASH was induced by feeding...
Sat, 10/05/2019 - 03:20
Several toxic secondary metabolites of filamentous fungi, so‐called mycotoxins, have the potential to modify immune responses. The results show that the food contaminant alternariol (AOH) alters the interleukin(IL)‐1β induced inflammatory response in non‐immune cells of the intestinal epithelium, most probably by targeting the NF‐κB (nuclear factor κB) pathway. Scope Alternariol (AOH), a toxic...
Mon, 09/23/2019 - 03:16
A high‐fat diet induces gut microbiome dysbiosis, including mucus‐foraging bacteria diminishing (e.g. Akkermansia muciniphila) and pathobionts enrichment (e.g. Enterobacteriaceae). This is in parallel with an expansion of firmly adherent mucus layer in the colon. A gradient of bacterial distribution in the gut is identified with a few bacteria residing in the firmly adherent mucus layer. Bilberry...