PLOS ONE

The Research Publications track research that is published across national and international peer-reviewed journals. The most recent articles are available ahead of print and searchable by Journal Title, Subject, USDA Grant Funding Agencies or FDA Grant Funding Agencies. The research publications are tracked across five subject areas: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, and Viruses.

Fri, 07/03/2020 - 08:01
by Feng Wu, Biao Chen, Sha Liu, Xiongjian Xia, Liuling Gao, Xiaoyong Zhang, Qing Pan The present study investigated the effects of four woody forages (Moringa oleifera Lam (MOL), fermented MOL, Folium mori (FM) and fermented FM) on biodiversity and bioactivity of aerobic culturable gut bacteria of tilapia (Oreochromis niloticus) by a traditional culture-dependent method. A total of 133 aerobic...
Fri, 07/03/2020 - 08:01
by Zhao Chen, Dai Kuang, Xuebin Xu, Narjol González-Escalona, David L. Erickson, Eric Brown, Jianghong Meng We sequenced 25 isolates of phenotypically multidrug-resistant Salmonella Indiana (n = 11), Typhimurium (n = 8), and Enteritidis (n = 6) using both MinION long-read [SQK-LSK109 and flow cell (R9.4.1)] and MiSeq short-read (Nextera XT and MiSeq Reagent Kit v2) sequencing technologies to...
Thu, 07/02/2020 - 08:02
by Csaba Varga, Patience John, Martin Cooke, Shannon E. Majowicz Nontyphoidal Salmonella enterica (NTS) causes a substantial health burden to human populations in Canada and worldwide. Exposure sources and demographic factors vary by location and can therefore have a major impact on salmonellosis clustering. We evaluated major NTS serotypes: S. Enteritidis (n = 620), S. Typhimurium (n = 150), S....
Thu, 07/02/2020 - 08:02
by Tâmara Natasha Gonzaga de Andrade Santos, Givalda Mendonça da Cruz Macieira, Bárbara Manuella Cardoso Sodré Alves, Thelma Onozato, Geovanna Cunha Cardoso, Mônica Thaís Ferreira Nascimento, Paulo Ricardo Saquete Martins-Filho, Divaldo Pereira de Lyra Jr., Alfredo Dias de Oliveira Filho Aims This review aims to determine the prevalence of clinically manifested drug-drug interactions (DDIs) in...
Thu, 07/02/2020 - 08:02
by Jiajun Li, Wanqiang Li, Zhenhua Wang, Abdul Khalique, Junrui Wang, Miao Yang, Xueqin Ni, Dong Zeng, Dongmei Zhang, Yan Zeng, Qihui Luo, Bo Jing, Kangcheng Pan To explore the molecular mechanism of the effect of Bacillus cereus PAS38 on the immunity of broilers, sixty 7-day-old broilers were divided into two groups with three replicates. The control group was fed with basal diet, and the...
Wed, 07/01/2020 - 08:02
by Michael G. Reuscher, Jeffrey G. Baguley, Paul A. Montagna The 2010 Deepwater Horizon blowout off the coast of Louisiana caused the largest marine oil spill on record. Samples were collected 2–3 months after the Macondo well was capped to assess damage to macrofauna and meiofauna communities. An earlier analysis of 58 stations demonstrated severe and moderate damage to an area of 148 km2. An...
Wed, 07/01/2020 - 08:02
by Yemane Weldu, Mulugeta Naizgi, Amanuel Hadgu, Abraham Aregay Desta, Amlsha Kahsay, Letemichael Negash, Genet Gebrehiwet Hailu, Araya Gebreyesus Wasihun Background Neonatal septicemia is a life threatening medical emergency that requires timely detection of pathogens with urgent rational antibiotics therapy. Methods A cross-sectional study was conducted between March 2017 to September 2018...
Wed, 07/01/2020 - 08:01
by Joelle K. Salazar, Vidya Natarajan, Diana Stewart, Megan Fay, Lauren J. Gonsalves, Tanvi Mhetras, Chinmyee Sule, Mary Lou Tortorello Refrigerated ready-to-eat (RTE) dips often have pH and water activity combinations conducive to the proliferation of foodborne pathogens, including Listeria monocytogenes. This study conducted product assessments of five refrigerated RTE dips: baba ghanoush,...
Sat, 06/27/2020 - 08:01
by Jiwon Seo, Dae-Young Kim, Iksung Cho, Geu-Ru Hong, Jong-Won Ha, Chi Young Shim This study aimed to investigate the prevalence and clinical significance of lead-related tricuspid regurgitation (TR) in patients with permanent pacemaker (PM). A total of 2,533 patients who underwent permanent PM implantation between January 2008 and December 2017 in a single center were retrospectively reviewed....
Sat, 06/27/2020 - 08:01
by Inusa J. Ajene, Fathiya M. Khamis, Barbara van Asch, Gerhard Pietersen, Brenda A. Rasowo, Fidelis L. Ombura, Anne W. Wairimu, Komivi S. Akutse, Mamoudou Sétamou, Samira Mohamed, Sunday Ekesi The Asian citrus psyllid (Diaphorina citri) is a key pest of Citrus spp. worldwide, as it acts as a vector for “Candidatus Liberibacter asiaticus (Las)”, the bacterial pathogen associated with the...
Fri, 06/26/2020 - 08:01
by Mohd W. Azam, Amit Kumar, Asad U. Khan Antimicrobial resistance is becoming a growing health problem, which has become a challenge for the physicians to control infection and also an economic burden on the healthcare. This increase in resistance to the present antimicrobial agents led the researchers to find some alternative and more efficient drugs which can fight with the resistant...
Tue, 06/23/2020 - 08:01
by Hansen Murcia, Gonzalo J. Diaz Aflatoxin B1 aldehyde reductase (AFAR) enzyme activity has been associated to a higher resistance to the aflatoxin B1 (AFB1) toxicity in ethoxyquin-fed rats. However, no studies about AFAR activity and its relationship with tolerance to AFB1 have been conducted in poultry. To determine the role of AFAR in poultry tolerance, the hepatic in vitro enzymatic activity...
Tue, 06/23/2020 - 08:01
by Elspeth Ready, Patrick Habecker, Roberto Abadie, Bilal Khan, Kirk Dombrowski We analyze a network of needle-sharing ties among 117 people who inject drugs (PWID) in rural Puerto Rico, using exponential random graph modeling to examine whether network members engage in partner restriction to lower their risk of contracting HIV or hepatitis C (HCV), or in informed altruism to prevent others from...
Tue, 06/23/2020 - 08:01
by Catherine E. Foster, Melissa Kok, Anthony R. Flores, Charles G. Minard, Ruth A. Luna, Linda B. Lamberth, Sheldon L. Kaplan, Kristina G. Hulten Background Microbial surface component recognizing adhesive matrix molecules (MSCRAMMs) facilitate Staphylococcus aureus adherence to host tissue. We hypothesized that S. aureus isolates from implant-associated infections (IAIs) would differ in MSCRAMM...
Tue, 06/23/2020 - 08:01
by Nicolas Simon, Nicolas Guichard, Pascal Odou, Bertrand Decaudin, Pascal Bonnabry, Sandrine Fleury-Souverain Background Residual contamination by intravenous conventional antineoplastic drugs (ICAD) is still a daily issue in hospital facilities. This study aimed to compare the efficiency (EffQ) of 4 different solutions to remove 23 widely used ICADs from surfaces. Method and findings A solution...
Sat, 06/20/2020 - 08:01
by Stephan Wietkamp, Bernd Krock, Dave Clarke, Daniela Voß, Rafael Salas, Jane Kilcoyne, Urban Tillmann Representatives of the marine dinophyte family Amphidomataceae produce lipophilic phycotoxins called azaspiracids (AZA) which may cause azaspiracid shellfish poisoning (AZP) in humans after consumption of contaminated seafood. Three of the four known toxigenic species are observed frequently in...
Sat, 06/20/2020 - 08:01
by Emily E. Lynch, Helen C. S. Meier Environmental conditions that contribute to childhood lead exposure are spatially patterned. Socioeconomic and racial inequities in childhood lead exposure have been well documented, however childhood lead exposure in Milwaukee is understudied. As a segregated rustbelt metropolitan area with childhood lead exposure concerns, Milwaukee is uniquely positioned to...
Thu, 06/18/2020 - 08:01
by Akira Ito, Tianshu Wang, Ryo Nakahara, Hideki Kawai, Kohei Nishitani, Tomoki Aoyama, Hiroshi Kuroki Background Therapeutic ultrasound (US) is a promising physical therapy modality for peripheral nerve regeneration. However, it is necessary to identify the most effective US parameters and clarify the underlying mechanisms before its clinical application. The intensity of US is one of the most...
Wed, 06/17/2020 - 08:02
by Vijay Vinayak Chavan, Alpa Dalal, Sharath Nagaraja, Pruthu Thekkur, Homa Mansoor, Augusto Meneguim, Roma Paryani, Pramila Singh, Stobdan Kalon, Mrinalini Das, Gabriella Ferlazzo, Petros Isaakidis Background Imipenem, an intravenous antibiotic is recommended for use in drug resistant tuberculosis (DR-TB) when an effective regimen with combination of other second line drugs is not possible....
Tue, 06/16/2020 - 08:01
by Cesar Cabezas, Omar Trujillo, Ángel Gonzales-Vivanco, Carlos Manuel Benites Villafane, Johanna Balbuena, Alfredo Oswaldo Borda-Olivas, Magna Aurora Suarez-Jara, Flor de María Peceros, Max Carlos Ramírez-Soto Background Viral hepatitis (hepatitis A, B, C, D and E) remains a public health problem in Peru, with a high disease burden. There are limited data on the prevalence of viral hepatitis at...
Sat, 06/13/2020 - 08:01
by Tugce Olgun, Sydney E. Everhart, Troy Anderson, Judy Wu-Smart Managed honey bees (Apis mellifera L.) and wild bees provide critical ecological services that shape and sustain natural, agricultural, and urban landscapes. In recent years, declines in bee populations have highlighted the importance of the pollination services they provide and the need for more research into the reasons for global...
Sat, 06/13/2020 - 08:01
by Suraja J. Raj, Yuke Wang, Habib Yakubu, Katharine Robb, Casey Siesel, Jamie Green, Amy Kirby, Wolfgang Mairinger, James Michiel, Clair Null, Eddy Perez, Katherine Roguski, Christine L. Moe Inadequate sanitation can lead to exposure to fecal contamination through multiple environmental pathways and can result in adverse health outcomes. By understanding the relative importance of multiple...
Sat, 06/13/2020 - 08:01
by Vaithish Velazhahan, Przemyslaw Glaza, Alvaro I. Herrera, Om Prakash, Michal Zolkiewski, Brian V. Geisbrecht, Kathrin Schrick Flavonoids are plant-derived compounds that occur abundantly in fruits and vegetables and have been shown to possess potent anti-cancer, antioxidant, and anti-inflammatory properties. However, their direct targets and molecular mechanism of action are not well...
Fri, 06/12/2020 - 08:01
by Christopher A. Baker, Shinyoung Lee, Jaysankar De, Kwangcheol C. Jeong, Keith R. Schneider While the soil microbiome may influence pathogen survival, determining the major contributors that reduce pathogen survival is inconclusive. This research was performed to determine the survival of E. coli O157 in autoclaved and natural (unautoclaved) sandy soils. Soils were inoculated with three...
Thu, 06/11/2020 - 08:02
by Ruth Cabrera Orrego, Leonardo Alberto Ríos-Osorio, Yoav Keynan, Zulma Vanessa Rueda, Lina Andrea Gutiérrez Coxiella burnetii causes Q fever in humans and coxiellosis in animals. In humans, it causes acute febrile illnesses like influenza, pneumonia, hepatitis, and chronic illnesses such as endocarditis, vascular infection, and post-infectious fatigue syndrome. It is widely distributed...
Wed, 06/10/2020 - 08:01
by Callie M. Rogers, Erin M. Scott, Benjamin Sarawichitr, Carolyn Arnold, Jan S. Suchodolski The ocular surface microbiome of veterinary species has not been thoroughly characterized using molecular-based techniques, such as next generation sequencing (NGS), as the vast majority of studies have utilized traditional culture-based techniques. To date, there is one pilot study evaluating the ocular...
Wed, 06/10/2020 - 08:01
by Lauren Ali, Elisabeth Grey, Delezia Singh, Azad Mohammed, Vrijesh Tripathi, Judith Gobin, Indar Ramnarine There is a global lack of data concerning shark consumption trends, consumer attitudes, and public knowledge regarding sharks. This is the case in Trinidad and Tobago, where shark is a popular culinary delicacy. A Knowledge, Attitudes, and Practices (KAP) survey was conducted in Trinidad...
Sat, 06/06/2020 - 08:01
by Awwad Radwan, Gamal M. Mahrous Bacterial histidine kinases (HKs) are considered attractive drug targets because of their ability to govern adaptive responses coupled with their ubiquity. There are several classes of HK inhibitors; however, they suffer from drug resistance, poor bioavailability, and a lack of selectivity. The 3D structure of Staphylococcus aureus HK was not isolated in high-...
Fri, 06/05/2020 - 03:36
by Shuping Wang, Zhenguang Yan, Pengyuan Wang, Xin Zheng, Juntao Fan Qinhuangdao coastal area is an important mariculture area in North China. Microbial communities play an important role in driving biogeochemical cycle and energy flow. It is necessary to identify the microbial communities and their functions in the coastal mariculture area of Qinhuangdao. In this study, the microbial community...
Fri, 06/05/2020 - 03:36
by Benjamin W. Held, Christine E. Salomon, Robert A. Blanchette Mines and caves are unusual ecosystems containing unique fungi and are greatly understudied compared to other environments. The Soudan Mine in Tower, MN, an iron ore mine that closed in 1963 after operating for 80 years, was sampled to explore fungal diversity and to investigate taxa that tolerate heavy metals for potential...
Fri, 06/05/2020 - 03:36
by Alexandra M. Ward, Rola Yaman, Jon O. Ebbert Background Electronic nicotine delivery systems (ENDS; e-cigarettes), consisting of a battery, heating element and e-liquid, have evolved significantly with wide variation in design, components, operating powers, and chemical constituents. Generated aerosols have been reported to contain potentially toxic substances. We conducted a systematic review...
Fri, 06/05/2020 - 03:36
by Biruk Tesfaye Birhanu, Eon-Bee Lee, Seung-Chun Park Fluoroquinolone resistance in Salmonella Typhimurium is becoming a major concern. Hence, an intervention to limit the growth in resistance is inevitable. One way to combat this challenge is through combination therapy. The combination of antibiotics with phytochemicals has become an ideal means of preventing antimicrobial resistance. Recently...
Thu, 06/04/2020 - 03:36
by Saki Sultana, Jacklyn Stewart, Aarnoud C. van der Spoel The enzyme β-glucosidase 2 (GBA2) is clinically relevant because it is targeted by the drug miglustat (Zavesca®) and because it is involved in inherited diseases. Mutations in the GBA2 gene are associated with two neurological diseases on the ataxia-spasticity spectrum, hereditary spastic paraplegia 46 (SPG46) and Marinesco-Sjögren-like...
Sat, 05/30/2020 - 03:38
by Rohana P. Dassanayake, Shollie M. Falkenberg, Judith A. Stasko, Adrienne L. Shircliff, John D. Lippolis, Robert E. Briggs Bacterial biofilms are organized sessile communities of bacteria enclosed in extracellular polymeric substances (EPS). To analyze organization of bacteria and EPS in high resolution and high magnification by scanning electron microscopy (SEM), it is important to preserve...
Sat, 05/30/2020 - 03:38
by Stephanie J. Wan, Sophia Ma, David J. Evans, Suzanne M. J. Fleiszig The healthy cornea is remarkably resistant to infection, quickly clearing deliberately inoculated bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus. Contrasting with the adjacent conjunctiva and other body surfaces, it also lacks a resident viable bacterial microbiome. Corneal resistance to microbes depends on...
Fri, 05/29/2020 - 03:35
by Kelsey Brown, Maina Mugoh, Douglas R. Call, Sylvia Omulo The use of veterinary antibiotics is largely unregulated in low-income countries. Consequently, food producers rarely observe drug withdrawal periods, contributing to drug residues in food products. Drug residues in milk can cause immunogenic reactions in people, and selectively favor antibiotic-resistant bacteria in unpasteurized...
Thu, 05/28/2020 - 03:37
by Viktor Sandblom, Johan Spetz, Emman Shubbar, Mikael Montelius, Ingun Ståhl, John Swanpalmer, Ola Nilsson, Eva Forssell-Aronsson Since patients with medullary thyroid cancer (MTC) often have metastatic disease at the time of diagnosis, the development of efficient systemic treatment options for MTC is important. Vandetanib and cabozantinib are two tyrosine kinase inhibitors (TKIs) that were...
Wed, 05/27/2020 - 03:34
by Beata Krawczyk, Magdalena Wysocka, Roman Kotłowski, Marek Bronk, Michał Michalik, Alfred Samet One of the most pressing problems of enterococci infections is occurring resistance to linezolid, which is an antibiotic used in the treatment of infections caused by vancomycin-resistant strains (VRE). The main objective of our research was to investigate the relationship of 19 linezolid-resistant E...
Thu, 05/21/2020 - 03:36
by Da-Hui Wang, Hui Xu, Yi-Hua Zheng, Dong-Sheng Gu, Ya-Jun Zhu, Ying Ren, Shi-Chang Wang, Lei Yang, Liang-Wen Xu Hearing loss is the second most common nonfatal problem affecting the Chinese population. Historical studies have suggested an association between exposure to heavy metals, such as cadmium and lead, and hearing loss. Few studies have investigated this relationship in the general...
Thu, 05/21/2020 - 03:36
by Beata Pepłońska, Beata Janasik, Valerie McCormack, Agnieszka Bukowska-Damska, Paweł Kałużny Introduction Cadmium (Cd) is a heavy metal, which is widespread in the environment and has been hypothesized to be a metalloestrogen and a breast cancer risk factor. Mammographic density (MD) reflects the composition of the breast and was proposed to be used as a surrogate marker for breast cancer. The...
Wed, 05/20/2020 - 03:33
by Christoph Strumann, Jost Steinhaeuser, Timo Emcke, Andreas Sönnichsen, Katja Goetz Background The treatment of upper respiratory tract infections (URTIs) accounts for the majority of antibiotic prescriptions in primary care, although an antibiotic therapy is rarely indicated. Non-clinical factors, such as time pressure and the perceived patient expectations are considered to be reasons for...
Wed, 05/20/2020 - 03:33
by Roger Pamphlett, Rachel Mak, Joonsup Lee, Michael E. Buckland, Antony J. Harding, Stephen Kum Jew, David J. Paterson, Michael W. M. Jones, Peter A. Lay Objective Damage to locus ceruleus neurons could play a part in the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis because of impairment of the blood-brain barrier and...
Tue, 05/19/2020 - 03:34
by Shoujing Zhu, Wenjuan Shi, Yucheng Jie, Qingming Zhou, Chenbo Song MYB-related transcription factors play important roles in plant development and response to various environmental stresses. In the present study, a novel MYB gene, designated as BnMYB2 (GenBank accession number: MF741319.1), was isolated from Boehmeria nivea using rapid amplification of cDNA ends (RACE) and RT-PCR on a sequence...
Tue, 05/19/2020 - 03:34
by Islam M. Ghazi, Wasim S. El Nekidy, Regan Asay, Paul Fingmori, Anthony Knarr, Mina Awad Imipenem/cilastatin/relebactam is a β-lactam/β-lactamase inhibitor that has been recently FDA approved for complicated intra-abdominal and urinary tract infections under the brand name Recarbrio®. It has activity against imipenem non-susceptible Pseudomonas species as well as KPC-producing...
Tue, 05/19/2020 - 03:34
by Armand Van Deun, Tom Decroo, Aung Kya Jai Maug, Mohamed Anwar Hossain, Murid Gumusboga, Wim Mulders, Nimer Ortuño-Gutiérrez, Lutgarde Lynen, Bouke C. de Jong, Hans L. Rieder Background Meta-analyses on impact of isoniazid-resistant tuberculosis informed the World Health Organization recommendation of a levofloxacin-strengthened rifampicin-based regimen.We estimated the effect of initial...
Sat, 05/16/2020 - 03:34
by Janine J. Wilden, Andre van Krüchten, Lutz Gieselmann, Eike R. Hrincius, Stefanie Deinhardt-Emmer, Karoline F. Haupt, Hannah F. Preugschas, Silke Niemann, Stephan Ludwig, Christina Ehrhardt Severe influenza virus (IV) infections still represent a major challenge to public health. To combat IV infections, vaccines and antiviral compounds are available. However, vaccine efficacies vary with very...
Sat, 05/16/2020 - 03:34
by Emily C. Moody, Elena Colicino, Robert O. Wright, Ezekiel Mupere, Ericka G. Jaramillo, Chitra Amarasiriwardena, Sarah E. Cusick Background Stunting is an indicator of poor linear growth in children and is an important public health problem in many countries. Both nutritional deficits and toxic exposures can contribute to lower height-for-age Z-score (HAZ) and stunting (HAZ < -2). Objectives...
Sat, 05/16/2020 - 03:34
by Yasemin Ceyhan, Manqi Zhang, Jingtao Guo, Carlos G. Sandoval, Jean Vacher, Elena M. Kaftanovskaya, Alexander I. Agoulnik, Irina U. Agoulnik Inositol polyphosphate-4-phosphatase type II (INPP4B) is a dual-specificity phosphatase that acts as a tumor suppressor in multiple cancers. INPP4B dephosphorylates phospholipids at the 4th position of the inositol ring and inhibits AKT and PKC signaling...
Sat, 05/16/2020 - 03:34
by Shuai Hao, Ayalew Kassahun, Yamine Bouzembrak, Hans Marvin The poultry meat supply chain is complex and therefore vulnerable to many potential contaminations that may occur. To ensure a safe product for the consumer, an efficient traceability system is required that enables a quick and efficient identification of the potential sources of contamination and proper implementation of mitigation...
Sat, 05/16/2020 - 03:34
by Graziela Ribeiro da Cunha, Maysa Pellizzaro, Camila Marinelli Martins, Suzana Maria Rocha, Ana Carolina Yamakawa, Evelyn Cristine da Silva, Andrea Pires dos Santos, Vivien Midori Morikawa, Hélio Langoni, Alexander Welker Biondo Despite vulnerability and unsanitary conditions of animal hoarding may predispose environmental contamination and spread of vectors and pathogens, no study to date has...

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