PLOS ONE

The Research Publications track research that is published across national and international peer-reviewed journals. The most recent articles are available ahead of print and searchable by Journal Title, Subject, USDA Grant Funding Agencies or FDA Grant Funding Agencies. The research publications are tracked across five subject areas: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, and Viruses.

Fri, 03/27/2020 - 03:40
by Mariana Cap, Celeste Cingolani, Carla Lires, Marina Mozgovoj, Trinidad Soteras, Adriana Sucari, Jimena Gentiluomo, Adriana Descalzo, Gabriela Grigioni, Marcelo Signorini, Celina Horak, Sergio Vaudagna, Gerardo Leotta The aim of this study was to assess the efficacy of lactic acid (LA), caprylic acid (CA), high- (HDI) and low- (LDI) dose gamma irradiation and LDI combined with LA or CA on the...
Wed, 03/25/2020 - 03:23
by Fatemeh Ashrafi Tafreshi, Zahra Fatahi, Seyedeh Fatemeh Ghasemi, Amirali Taherian, Neda Esfandiari Pesticides, widely used in modern agriculture, could potentially cause environmental pollution and affect human lives. Hence, the development of a highly sensitive sensing element to detect pesticide residues is crucial for food safety and ecosystem protection. Optical methods based on...
Tue, 03/24/2020 - 03:40
by Monika Słupecka-Ziemilska, Paulina Szczurek, Maria Boryczka, Małgorzata Gajewska, Piotr Wychowański, Atsukazu Kuwahara, Ikuo Kato, Żaneta Dzięgelewska, Jarosław Woliński A 23-amino acid peptide named obestatin is derived from the ghrelin gene. The aim of the experiment was to study the effects of enteral obestatin administration for a 6-day period on intestinal contractility in piglets fed...
Tue, 03/24/2020 - 03:40
by Anna Marta Banaś, Katarzyna Marta Bocian-Ostrzycka, Maciej Plichta, Stanisław Dunin-Horkawicz, Jan Ludwiczak, Jagoda Płaczkiewicz, Elżbieta Katarzyna Jagusztyn-Krynicka Posttranslational generation of disulfide bonds catalyzed by bacterial Dsb (disulfide bond) enzymes is essential for the oxidative folding of many proteins. Although we now have a good understanding of the Escherichia coli...
Thu, 03/19/2020 - 03:23
by Roberto Gnavi, Veronica Sciannameo, Francesca Baratta, Cecilia Scarinzi, Marco Parente, Massimo Mana, Mario Giaccone, Paolo Cavallo Perin, Giuseppe Costa, Teresa Spadea, Paola Brusa Background and aims Given the paucity of symptoms in the early stages of type 2 diabetes, its diagnosis is often made when complications have already arisen. Although systematic population-based screening is not...
Thu, 03/19/2020 - 03:23
by Chunxia Zhang, Jingli Gao, Yidan Guo, Aijun Xing, Pengpeng Ye, Yuntao Wu, Shouling Wu, Yang Luo Objective Atrial fibrillation (AF) is associated with adverse outcomes in the general population, but its impact on patients with chronic kidney disease (CKD) remains unclear. In this study, we assessed the association between AF and risks of all-cause mortality and stroke in Chinese adults with CKD...
Wed, 03/18/2020 - 03:23
by Ahmad R. Kirmani, Ahmed E. Mansour, Chen Yang, Rahim Munir, Ahmed M. El-Zohry, Omar F. Mohammed, Aram Amassian Halide vacancies and associated metallic lead (Pb°) observed at the surface and deep inside macroscopic organolead trihalide perovskite crystals is removed through a facile and noninvasive treatment. Indeed, Br2 vapor is shown to passivate Br-vacancies and associated Pb° in the bulk...
Tue, 03/17/2020 - 03:24
by Elena Gorokhova, Anne L. Soerensen, Nisha H. Motwani Methylmercury (MeHg) is a potent neurotoxin that biomagnifies in marine food webs. Inorganic mercury (Hg) methylation is conducted by heterotrophic bacteria inhabiting sediment or settling detritus, but endogenous methylation by the gut microbiome of animals in the lower food webs is another possible source. We examined the occurrence of the...
Tue, 03/17/2020 - 03:24
by Michael G. Jobling, Steven T. Poole, Fatima Rasulova-Lewis, Aisling O’Dowd, Annette L. McVeigh, Amit Balakrishnan, Stephanie A. Sincock, Michael G. Prouty, Randall K. Holmes, Stephen J. Savarino Surface-expressed colonization factors and their subunits are promising candidates for inclusion into a multivalent vaccine targeting enterotoxigenic Escherichia coli (ETEC), a leading cause of acute...
Tue, 03/17/2020 - 03:24
by Wei Suo, Xiujin Shi, Sha Xu, Xiao Li, Yang Lin Single-nucleotide polymorphisms (SNPs) is associated with efficacy of specific drugs. Although there are several methods for SNP genotyping in clinical settings, alternative methods with lower cost, higher throughout and less complexity are still needed. In this study, we modified Kompetitive Allele Specific PCR to enable multiplex SNP genotyping...
Tue, 03/17/2020 - 03:24
by Yi-Jia Lin, Hsuan-Kai Lin, Ying-Hong Lin Banana (Musa sp.) is cultivated worldwide and is one of the most popular fruits. The soil-borne fungal disease Fusarium wilt of banana (FWB), commonly known as Panama disease, is caused by Fusarium oxysporum f. sp. cubense (Foc) and is a highly lethal vascular fungal disease in banana plants. Raman spectroscopy, an emerging laser-based technology based...
Thu, 03/12/2020 - 03:24
by Ashutosh Kumar, Tanvir Islam, Yoshihide Sekimoto, Chris Mattmann, Brian Wilson Nowcasting of precipitation is a difficult spatiotemporal task because of the non-uniform characterization of meteorological structures over time. Recently, convolutional LSTM has been shown to be successful in solving various complex spatiotemporal based problems. In this research, we propose a novel precipitation...
Thu, 03/12/2020 - 03:24
by Lene Bungenstock, Amir Abdulmawjood, Felix Reich With regards to the frequently reported findings of spoilage bacteria and pathogens in various foods there is a need to explore new ways to control hazards in food production and to improve consumer safety. Fermented sausages from traditional and industrial production in Germany were screened for lactic acid bacteria with antibacterial effects...
Tue, 03/10/2020 - 03:23
by Ana Pelerito, Alexandra Nunes, Maria Sofia Núncio, João Paulo Gomes Brucellosis is an important zoonotic disease that affects both humans and animals. To date, laboratory surveillance is still essentially based on the traditional MLVA-16 methodology and the associated epidemiological information is frequently scarce. Our goal was to contribute to the improvement of Brucella spp. surveillance...
Tue, 03/10/2020 - 03:23
by Pernille Nielsen, Bernd Krock, Per Juel Hansen, Bent Vismann Diarrheic Shellfish Poisoning toxins (DST) are a severe health risk to shellfish consumers and can be a major problem for the shellfish industry. Bivalve molluscs can accumulate DST via ingestion of toxic dinoflagellates like Dinophysis spp., which are the most prominent producers of DST. The effects of DST-containing dinoflagellate...
Sat, 03/07/2020 - 03:22
by Silvia Gil, Eduardo Solano, Francesc Martínez-Trucharte, Jordi Martínez-Esaín, Ana J. Pérez-Berná, José Javier Conesa, Christina Kamma-Lorger, Mercè Alsina, Manel Sabés The objective of this study was to regulate the cytotoxicity of cisplatin (cisPt) minimizing its adverse effects. For this purpose, the lowest cisPt concentration needed to obtain a significant positive response in cutaneous...
Sat, 03/07/2020 - 03:22
by Bengt B. Arnetz, Sukhesh Sudan, Judith E. Arnetz, Jolin B. Yamin, Mark A. Lumley, John S. Beck, Paul M. Stemmer, Paul Burghardt, Scott E. Counts, Hikmet Jamil Background Psychological war trauma among displaced refugees is an established risk factor for mental health disorders, especially post-traumatic stress disorder (PTSD). Persons with trauma-induced disorders have heightened neuroplastic...
Fri, 03/06/2020 - 03:42
by Jemal Beksisa, Tewodros Getinet, Sisay Tanie, Jilcha Diribi, Hamid Yimam Hassen Background Globally, the incidence of prostate cancer is increasing, particularly in low- and middle-income countries. It is the most common cancer among men worldwide, with higher mortality in low and middle-income countries. In Ethiopia, it is the second most common cause of cancer morbidity and mortality among...
Thu, 03/05/2020 - 03:25
by Dominick J. Lemas, Jasmine A. Mack, Jennifer J. Schoch, Nicole Cacho, Elizabeth Plasencia, Alice S. Rhoton-Vlasak, Josef Neu, Lindsay Thompson, Magda Francois, Keval Patel, William R. Hogan, Gloria P. Lipori, Matthew J. Gurka Background Delivery by cesarean section (C-section) is associated with adverse short-term and long-term infant outcomes. Given that antibiotics during early life are...
Wed, 03/04/2020 - 03:41
by Christopher R. Ellis, Rebecca Racz, Naomi L. Kruhlak, Marlene T. Kim, Alexey V. Zakharov, Noel Southall, Edward G. Hawkins, Keith Burkhart, David G. Strauss, Lidiya Stavitskaya Kratom is a botanical substance that is marketed and promoted in the US for pharmaceutical opioid indications despite having no US Food and Drug Administration approved uses. Kratom contains over forty alkaloids...
Tue, 03/03/2020 - 03:33
by Farah Bokharaei-Salim, Maryam Esghaei, Khadijeh Khanaliha, Saeed Kalantari, Arezoo Marjani, Atousa Fakhim, Hossein Keyvani Background The presence of drug resistance mutations (DRMs) against antiretroviral agents is one of the main concerns in the clinical management of individuals with human immunodeficiency virus-1 (HIV-1) infection, especially in regions of the world where treatment options...
Sat, 02/29/2020 - 03:25
by Linda L. Jagodzinski, Mark M. Manak, Holly R. Hack, Ying Liu, Sheila A. Peel Management of Human Immunodeficiency Virus Type 2 (HIV-2) infections present unique challenges due to low viral titers, slow disease progression, and poor response to standard antiviral therapies. The need for a nucleic acid assay to detect and quantify HIV-2 virus has led to the development of a number of molecular-...
Sat, 02/29/2020 - 03:25
by Jaime Tejedor, Francisco J. Gutiérrez-Carmona Purpose To study the outcome of botulinum toxin (BTX) treatment (group 1) in partially accommodative esotropia with high accommodative convergence/accommodation (AC/A) ratio, in comparison with bilateral medial rectus muscles recessions and posterior fixation (group 2). Methods In a retrospective comparative study, children aged 3–8 years old...
Sat, 02/29/2020 - 03:25
by Kelly M. J. Simpson, Siobhan M. Mor, Michael P. Ward, Julie Collins, James Flint, Grant A. Hill-Cawthorne, Moataz Abd El Ghany Salmonella enterica serovar Wangata is an important pathogen in New South Wales (NSW), Australia. The incidence of S. Wangata is increasing and transmission is suspected to be via a non-food source. A recent outbreak investigation of sources of S. Wangata recovered...
Fri, 02/28/2020 - 03:25
by Angel A. Noda, Linda Grillová, Jean-Francois Mariet, Nadiezda B. Paiffer, Yanet C. Ruiz, Islay Rodríguez, Eduardo Echevarría, Ana Margarita Obregón, Reto Lienhard, Mathieu Picardeau Leptospirosis is a neglected disease causing severe infections in humans and animals. Due in part to misdiagnosis, this infectious disease results in nearly 60,000 deaths per year around the globe. This study...
Wed, 02/26/2020 - 03:24
by Jane Mingjie Lim, Minh Cam Duong, Li Yang Hsu, Clarence C. Tam Singapore’s Antimicrobial Resistance (AMR) national strategic action plan includes inappropriate use of antimicrobials in food-producing animals as a specific priority. Although the use of antibiotics and other drugs are monitored by regulatory bodies, food fish farmers are allowed to buy and administer antimicrobials without a...
Sat, 02/22/2020 - 03:26
by Min Hyung Kim, Haeyoung Jeong, Young Mi Sim, Soohyun Lee, Dongeun Yong, Choong-Min Ryu, Jun Yong Choi Acinetobacter baumannii is a highly potent nosocomial pathogen that is associated with increased in-hospital mortality. Here, we investigated the changes in molecular characteristics of carbapenem-resistant A. baumannii (CRAB) isolated from the blood samples of patients admitted to a tertiary...
Fri, 02/21/2020 - 03:48
by Ephantus J. Muturi, Gordon W. Selling, Kenneth M. Doll, William T. Hay, Jose L. Ramirez Synthetic pesticides are the cornerstone of vector-borne disease control, but alternatives are urgently needed to tackle the growing problem of insecticide resistance and concerns over environmental safety. Leptospermum scoparium J.R. Forst and G. Forst (manuka) essential oil and its four fractions were...
Fri, 02/21/2020 - 03:48
by Monica D. Hartanti, Roseanne Rosario, Katja Hummitzsch, Nicole A. Bastian, Nicholas Hatzirodos, Wendy M. Bonner, Rosemary A. Bayne, Helen F. Irving-Rodgers, Richard A. Anderson, Raymond J. Rodgers Polycystic ovary syndrome (PCOS) affects around 10% of young women, with adverse consequences on fertility and cardiometabolic outcomes. PCOS appears to result from a genetic predisposition...
Sat, 02/15/2020 - 03:25
by Terence Lee, Stanley Pang, Marc Stegger, Shafi Sahibzada, Sam Abraham, Denise Daley, Geoffrey Coombs, on behalf of the Australian Group on Antimicrobial Resistance Background Over the last three decades, hospital adapted clonal complex (CC) 17 strains of Enterococcus faecium have acquired and exchanged antimicrobial resistance genes leading to the widespread resistance to clinically important...
Sat, 02/15/2020 - 03:25
by Magnus Wang, Thiemo Braasch, Christian Dietrich The statistical power of studies for the assessment of side effects of toxicants on honeybees conducted according to current guidelines is often limited. A new test design and modified field methods have therefore been developed to decrease uncertainty and variability and to be able to detect small effects. The new test design comprises a...
Fri, 02/14/2020 - 03:25
by Sergio Prada-Prada, Johanna Flórez-Castillo, Ana Farfán-García, Fanny Guzmán, Indira Hernández-Peñaranda The development of new antimicrobial peptides has become an attractive alternative to conventional antibiotics due to the increasing rates of microbial drug resistance. Ib-M corresponds to a family of cationic synthetic peptides, 20 amino acids in length, that have shown inhibitory effect...
Fri, 02/14/2020 - 03:25
by Agumas Shibabaw, Baye Gelaw, Wondwossen Gebreyes, Richard Robinson, Shu-Hua Wang, Belay Tessema Background The emergence of pre-extensively and extensively drug-resistant tuberculosis (Pre-XDR/XDR-TB) is the major hurdle for TB prevention and care programs especially in developing countries like Ethiopia. The less emphasis on universal access to laboratory techniques for the rapid diagnosis of...
Wed, 02/12/2020 - 03:24
by Eun Hee Kwon, Godefroid M. A. Musema, Jessica Boelter, Sydney Townsend, Désiré Tshala-Katumbay, Patrick K. Kayembe, John West, Charles Wood Background Complex mosaic structures of HIV-1 were found in the Democratic Republic of Congo (DRC). Currently, there is limited information on the circulating HIV-1 strains, the distribution of these strains and antiretroviral (ART) resistant viruses in...
Wed, 02/12/2020 - 03:24
by Amanda D. French, Katherine Shaw, Melanie Barnes, Jaclyn E. Cañas-Carrell, Warren C. Conway, David M. Klein Many studies have used grit (in the form of lead (Pb) pellets) presence in avian gizzards as an indicator of Pb shot exposure. However, due to nearly complete pellet absorption in gizzards or rapid passage of pellets, the absence of Pb shot presence in a gizzard does not confirm lack of...
Tue, 02/11/2020 - 03:25
by Chidozie Declan Iwu, Anthony Ifeanyi Okoh Listeria monocytogenes (L. monocytogenes) is a foodborne pathogen and the etiologic agent of listeriosis, which can be disseminated within the agricultural environment particularly soil and irrigation water, contaminate farm produce and cause high mortality and morbidity among vulnerable individuals. This study assessed the incidence and antibiogram of...
Tue, 02/11/2020 - 03:25
by Abdou Fatawou Modiyinji, Georges Marc Arthur Mveng Sanding, Marie Amougou Atsama, Chavely Gwladys Monamele, Moise Nola, Richard Njouom Background Hepatitis E virus (HEV) is a zoonotic pathogen of which pigs have been established as reservoirs. In the present study, we investigated the presence of HEV among pigs in the Center and Littoral regions of Cameroon and performed the molecular...
Sat, 02/08/2020 - 03:24
by Changjiao Sun, Manli Yu, Zhanghua Zeng, Frédéric Francis, Haixin Cui, François Verheggen Abamectin is a common biocide used to control agricultural insect pests. However, the water insolubility of abamectin may result in extra organic solvent introduced in the environment. To solve this issue, it is desirable to develop nanoformulations to encapsulate abamectin with environment-friendly...
Sat, 02/08/2020 - 03:24
by Eszter Kovács, Judit Sahin-Tóth, Adrienn Tóthpál, Mark van der Linden, Tamás Tirczka, Orsolya Dobay Background The nasopharynx can from time to time accommodate otherwise pathogenic bacteria. This phenomenon is called asymptomatic carriage. However, in case of decreased immunity, viral infection or any other enhancing factors, severe disease can develop. Our aim in this study was to survey the...
Thu, 02/06/2020 - 03:26
by Josep Darbà, Alicia Marsà More than 10% of the population will suffer from a depressive disorder during their lifetime, which represents a substantial economic and social burden for healthcare systems and societies. Nonetheless, studies suggest that an important percentage of patients receive inadequate treatment. This study aimed to evaluate the characteristics of patients with depressive...
Wed, 02/05/2020 - 03:26
by Fahmida Chowdhury, Abu Sadat Mohammad Sayeem Bin Shahid, Probir Kumar Ghosh, Mustafizur Rahman, Md. Zakiul Hassan, Zubair Akhtar, S. Mah-E- Muneer, Lubaba Shahrin, Tahmeed Ahmed, Mohammod Jobayer Chisti Background In Bangladesh, pneumonia has a higher mortality among malnourished children aged <5 years. Evaluating pneumonia etiology among malnourished children may help improve empiric...
Wed, 02/05/2020 - 03:26
by Franziska Nienhaus, Diana Meemken, Clara Schoneberg, Maria Hartmann, Thomas Kornhoff, Thomas May, Sabrina Heß, Lothar Kreienbrock, Anna Wendt There are growing demands to ensure animal health and, from a broader perspective, animal welfare, especially for farmed animals. In addition to the newly developed welfare assessment protocols, which provide a harmonised method to measure animal health...
Tue, 02/04/2020 - 03:42
by Rana Adnan Tahir, Afsheen Bashir, Muhammad Noaman Yousaf, Azka Ahmed, Yasmine Dali, Sanaullah Khan, Sheikh Arslan Sehgal Hypertension is considered as one of the most common diseases that affect human beings (both male and female) due to its high prevalence and also extending widely to both industrialize and developing countries. Angiotensin-converting enzyme (ACE) has a significant role in...
Sat, 02/01/2020 - 03:42
by Roger Pamphlett, Laveniya Satgunaseelan, Stephen Kum Jew, Philip A. Doble, David P. Bishop Objective Exposure to toxic metals such as mercury has been proposed to be a risk factor for the development of breast cancer since some metals can promote genetic mutations and epigenetic changes. We sought to find what toxic metals are present in normal breast tissue and in the tumours of women who had...
Sat, 02/01/2020 - 03:42
by Samantha Erwin, Derek M. Foster, Megan E. Jacob, Mark G. Papich, Cristina Lanzas Antimicrobial drugs administered systemically may cause the emergence and dissemination of antimicrobial resistance among enteric bacteria. To develop logical, research-based recommendations for food animal veterinarians, we must understand how to maximize antimicrobial drug efficacy while minimizing risk of...
Sat, 02/01/2020 - 03:42
by Maya E. Morales-McDevitt, Dawei Shi, Anthony H. Knap, Antonietta Quigg, Stephen T. Sweet, Jose L. Sericano, Terry L. Wade Concerns on the timing and processes associated with petroleum degradation were raised after the use of Corexit during the Deepwater Horizon oil spill. There is a lack of understanding of the removal of oil associated with flocculate materials to the sediment. Mesocosm...
Fri, 01/31/2020 - 03:24
by Chang-ye Hui, Yan Guo, Lisa Liu, Hao-qu Zheng, Chao-xian Gao, Wen Zhang The combination of a fluorescent reporter and enzymatic reporter provides a flexible and versatile way for the study of diverse biological processes, such as the detection of transcription and translation. Thus, there is an urgent need to develop this novel bifunctional reporter system. This study reports the design,...
Thu, 01/30/2020 - 03:25
by Jeremy R. Burt, Ali M. Agha, Basel Yacoub, Aryan Zahergivar, Julie Pepe Background Marijuana is the most popular drug of abuse in the United States. The association between its use and coronary artery disease has not yet been fully elucidated. This study aims to determine the frequency of coronary artery disease among young to middle aged adults presenting with chest pain who currently use...
Wed, 01/29/2020 - 03:43
by Daniel Herzberg, Pablo Strobel, Heine Müller, Constanza Meneses, Marianne Werner, Hedie Bustamante Chronic lameness affects bovine welfare and has a negative economic impact in dairy industry. Moreover, due to the translational gap between traditional pain models and new drugs development for treating chronic pain states, naturally occurring painful diseases could be a potential translational...
Tue, 01/28/2020 - 03:26
by Sumaira Javaid, Syed Muhammad Saad, Humaira Zafar, Rizwana Malik, Khalid Mohammed Khan, M. Iqbal Choudhary, Atta-ur Rahman Over-expression of thymidine phosphorylase (TP) plays a key role in many pathological complications, including angiogenesis which leads to cancer cells proliferation. Thus in search of new anticancer agents, a series of 4-hydroxybenzohydrazides (1–29) was synthesized, and...

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