PLoS One

The Research Publications track research that is published across national and international peer-reviewed journals. The most recent articles are available ahead of print and searchable by Journal Title, Subject, USDA Grant Funding Agencies or FDA Grant Funding Agencies. The research publications are tracked across five subject areas: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, and Viruses.

Sat, 02/15/2020 - 03:25
by Terence Lee, Stanley Pang, Marc Stegger, Shafi Sahibzada, Sam Abraham, Denise Daley, Geoffrey Coombs, on behalf of the Australian Group on Antimicrobial Resistance Background Over the last three decades, hospital adapted clonal complex (CC) 17 strains of Enterococcus faecium have acquired and exchanged antimicrobial resistance genes leading to the widespread resistance to clinically important...
Sat, 02/15/2020 - 03:25
by Magnus Wang, Thiemo Braasch, Christian Dietrich The statistical power of studies for the assessment of side effects of toxicants on honeybees conducted according to current guidelines is often limited. A new test design and modified field methods have therefore been developed to decrease uncertainty and variability and to be able to detect small effects. The new test design comprises a...
Fri, 02/14/2020 - 03:25
by Sergio Prada-Prada, Johanna Flórez-Castillo, Ana Farfán-García, Fanny Guzmán, Indira Hernández-Peñaranda The development of new antimicrobial peptides has become an attractive alternative to conventional antibiotics due to the increasing rates of microbial drug resistance. Ib-M corresponds to a family of cationic synthetic peptides, 20 amino acids in length, that have shown inhibitory effect...
Fri, 02/14/2020 - 03:25
by Agumas Shibabaw, Baye Gelaw, Wondwossen Gebreyes, Richard Robinson, Shu-Hua Wang, Belay Tessema Background The emergence of pre-extensively and extensively drug-resistant tuberculosis (Pre-XDR/XDR-TB) is the major hurdle for TB prevention and care programs especially in developing countries like Ethiopia. The less emphasis on universal access to laboratory techniques for the rapid diagnosis of...
Wed, 02/12/2020 - 03:24
by Eun Hee Kwon, Godefroid M. A. Musema, Jessica Boelter, Sydney Townsend, Désiré Tshala-Katumbay, Patrick K. Kayembe, John West, Charles Wood Background Complex mosaic structures of HIV-1 were found in the Democratic Republic of Congo (DRC). Currently, there is limited information on the circulating HIV-1 strains, the distribution of these strains and antiretroviral (ART) resistant viruses in...
Wed, 02/12/2020 - 03:24
by Amanda D. French, Katherine Shaw, Melanie Barnes, Jaclyn E. Cañas-Carrell, Warren C. Conway, David M. Klein Many studies have used grit (in the form of lead (Pb) pellets) presence in avian gizzards as an indicator of Pb shot exposure. However, due to nearly complete pellet absorption in gizzards or rapid passage of pellets, the absence of Pb shot presence in a gizzard does not confirm lack of...
Tue, 02/11/2020 - 03:25
by Chidozie Declan Iwu, Anthony Ifeanyi Okoh Listeria monocytogenes (L. monocytogenes) is a foodborne pathogen and the etiologic agent of listeriosis, which can be disseminated within the agricultural environment particularly soil and irrigation water, contaminate farm produce and cause high mortality and morbidity among vulnerable individuals. This study assessed the incidence and antibiogram of...
Tue, 02/11/2020 - 03:25
by Abdou Fatawou Modiyinji, Georges Marc Arthur Mveng Sanding, Marie Amougou Atsama, Chavely Gwladys Monamele, Moise Nola, Richard Njouom Background Hepatitis E virus (HEV) is a zoonotic pathogen of which pigs have been established as reservoirs. In the present study, we investigated the presence of HEV among pigs in the Center and Littoral regions of Cameroon and performed the molecular...
Sat, 02/08/2020 - 03:24
by Changjiao Sun, Manli Yu, Zhanghua Zeng, Frédéric Francis, Haixin Cui, François Verheggen Abamectin is a common biocide used to control agricultural insect pests. However, the water insolubility of abamectin may result in extra organic solvent introduced in the environment. To solve this issue, it is desirable to develop nanoformulations to encapsulate abamectin with environment-friendly...
Sat, 02/08/2020 - 03:24
by Eszter Kovács, Judit Sahin-Tóth, Adrienn Tóthpál, Mark van der Linden, Tamás Tirczka, Orsolya Dobay Background The nasopharynx can from time to time accommodate otherwise pathogenic bacteria. This phenomenon is called asymptomatic carriage. However, in case of decreased immunity, viral infection or any other enhancing factors, severe disease can develop. Our aim in this study was to survey the...
Thu, 02/06/2020 - 03:26
by Josep Darbà, Alicia Marsà More than 10% of the population will suffer from a depressive disorder during their lifetime, which represents a substantial economic and social burden for healthcare systems and societies. Nonetheless, studies suggest that an important percentage of patients receive inadequate treatment. This study aimed to evaluate the characteristics of patients with depressive...
Wed, 02/05/2020 - 03:26
by Fahmida Chowdhury, Abu Sadat Mohammad Sayeem Bin Shahid, Probir Kumar Ghosh, Mustafizur Rahman, Md. Zakiul Hassan, Zubair Akhtar, S. Mah-E- Muneer, Lubaba Shahrin, Tahmeed Ahmed, Mohammod Jobayer Chisti Background In Bangladesh, pneumonia has a higher mortality among malnourished children aged <5 years. Evaluating pneumonia etiology among malnourished children may help improve empiric...
Wed, 02/05/2020 - 03:26
by Franziska Nienhaus, Diana Meemken, Clara Schoneberg, Maria Hartmann, Thomas Kornhoff, Thomas May, Sabrina Heß, Lothar Kreienbrock, Anna Wendt There are growing demands to ensure animal health and, from a broader perspective, animal welfare, especially for farmed animals. In addition to the newly developed welfare assessment protocols, which provide a harmonised method to measure animal health...
Tue, 02/04/2020 - 03:42
by Rana Adnan Tahir, Afsheen Bashir, Muhammad Noaman Yousaf, Azka Ahmed, Yasmine Dali, Sanaullah Khan, Sheikh Arslan Sehgal Hypertension is considered as one of the most common diseases that affect human beings (both male and female) due to its high prevalence and also extending widely to both industrialize and developing countries. Angiotensin-converting enzyme (ACE) has a significant role in...
Sat, 02/01/2020 - 03:42
by Roger Pamphlett, Laveniya Satgunaseelan, Stephen Kum Jew, Philip A. Doble, David P. Bishop Objective Exposure to toxic metals such as mercury has been proposed to be a risk factor for the development of breast cancer since some metals can promote genetic mutations and epigenetic changes. We sought to find what toxic metals are present in normal breast tissue and in the tumours of women who had...
Sat, 02/01/2020 - 03:42
by Samantha Erwin, Derek M. Foster, Megan E. Jacob, Mark G. Papich, Cristina Lanzas Antimicrobial drugs administered systemically may cause the emergence and dissemination of antimicrobial resistance among enteric bacteria. To develop logical, research-based recommendations for food animal veterinarians, we must understand how to maximize antimicrobial drug efficacy while minimizing risk of...
Sat, 02/01/2020 - 03:42
by Maya E. Morales-McDevitt, Dawei Shi, Anthony H. Knap, Antonietta Quigg, Stephen T. Sweet, Jose L. Sericano, Terry L. Wade Concerns on the timing and processes associated with petroleum degradation were raised after the use of Corexit during the Deepwater Horizon oil spill. There is a lack of understanding of the removal of oil associated with flocculate materials to the sediment. Mesocosm...
Fri, 01/31/2020 - 03:24
by Chang-ye Hui, Yan Guo, Lisa Liu, Hao-qu Zheng, Chao-xian Gao, Wen Zhang The combination of a fluorescent reporter and enzymatic reporter provides a flexible and versatile way for the study of diverse biological processes, such as the detection of transcription and translation. Thus, there is an urgent need to develop this novel bifunctional reporter system. This study reports the design,...
Thu, 01/30/2020 - 03:25
by Jeremy R. Burt, Ali M. Agha, Basel Yacoub, Aryan Zahergivar, Julie Pepe Background Marijuana is the most popular drug of abuse in the United States. The association between its use and coronary artery disease has not yet been fully elucidated. This study aims to determine the frequency of coronary artery disease among young to middle aged adults presenting with chest pain who currently use...
Wed, 01/29/2020 - 03:43
by Daniel Herzberg, Pablo Strobel, Heine Müller, Constanza Meneses, Marianne Werner, Hedie Bustamante Chronic lameness affects bovine welfare and has a negative economic impact in dairy industry. Moreover, due to the translational gap between traditional pain models and new drugs development for treating chronic pain states, naturally occurring painful diseases could be a potential translational...
Tue, 01/28/2020 - 03:26
by Sumaira Javaid, Syed Muhammad Saad, Humaira Zafar, Rizwana Malik, Khalid Mohammed Khan, M. Iqbal Choudhary, Atta-ur Rahman Over-expression of thymidine phosphorylase (TP) plays a key role in many pathological complications, including angiogenesis which leads to cancer cells proliferation. Thus in search of new anticancer agents, a series of 4-hydroxybenzohydrazides (1–29) was synthesized, and...
Tue, 01/28/2020 - 03:26
by Roksana Hoque, Syed Masud Ahmed, Nahitun Naher, Mohammad Aminul Islam, Emily K. Rousham, Bushra Zarin Islam, Shaikh Hassan Background Antimicrobial resistance (AMR) has become an emerging issue in the developing countries as well as in Bangladesh. AMR is aggravated by irrational use of antimicrobials in a largely unregulated pluralistic health system. This review presents a ‘snap shot’ of the...
Sat, 01/25/2020 - 03:23
by Jamie L. Burgess, Heather B. Case, R. Alan Burgess, Nicholas E. Dickenson Type three secretion systems (T3SS) are complex nano-machines that evolved to inject bacterial effector proteins directly into the cytoplasm of eukaryotic cells. Many high-priority human pathogens rely on one or more T3SSs to cause disease and evade host immune responses, underscoring the need to better understand the...
Sat, 01/25/2020 - 03:23
by Tania Henríquez, Juan Carlos Salazar, Massimiliano Marvasi, Ajit Shah, Gino Corsini, Cecilia S. Toro In recent years, multidrug resistance of Shigella strains associated with genetic elements like pathogenicity islands, have become a public health problem. The Shigella resistance locus pathogenicity island (SRL PAI) of S. flexneri 2a harbors a 16Kbp region that contributes to the multidrug...
Thu, 01/23/2020 - 03:24
by Andrea Dolfini, Ivana Angelini, Gilberto Artioli The paper discusses results of an interdisciplinary research project integrating lead isotope, chemical, and archaeological analysis of 20 early metal objects from central Italy. The aim of the research was to develop robust provenance hypotheses for 4th and 3rd millennia BC metals from an important, yet hitherto neglected, metallurgical...
Sat, 01/18/2020 - 03:23
by Bingqian Qu, Xue Li, Carol J. Cardona, Zheng Xing Human infections with avian influenza viruses including H5, H7 and H9 hemagglutinin subtypes occur at a low rate. Among human infections with H7 viruses, regional outbreaks with H7N2, H7N3, H7N7 and H7N9 have been documented. Early in 2018, a human infection with a novel H7N4 avian influenza virus was reported in Jiangsu, China. This study is...
Sat, 01/18/2020 - 03:23
by Mohamed Elhadidy, Mohamed Medhat Ali, Ayman El-Shibiny, William G. Miller, Walid F. Elkhatib, Nadine Botteldoorn, Katelijne Dierick The aim of this study is to characterize the antimicrobial resistance of Campylobacter jejuni recovered from diarrheal patients in Belgium, focusing on the genetic diversity of resistant strains and underlying molecular mechanisms of resistance among Campylobacter...
Sat, 01/18/2020 - 03:23
by Suzanne Rotheram, Jessie Cooper, Sara Ronzi, Benjamin Barr, Margaret Whitehead Background Gastrointestinal (GI) infections cause a significant public health burden worldwide and in the UK with evidence pointing to socio-economic inequalities, particularly among children. Qualitative studies can help us understand why inequalities occur and contribute to developing more effective interventions...
Wed, 01/15/2020 - 03:23
by Aviaja L. Hauptmann, Petronela Paulová, Lars Hestbjerg Hansen, Thomas Sicheritz-Pontén, Gert Mulvad, Dennis S. Nielsen The foods we eat contain microorganisms that we ingest alongside the food. Industrialized food systems offer great advantages from a safety point of view, but have also been accused of depleting the diversity of the human microbiota with negative implications for human health...
Wed, 01/15/2020 - 03:23
by Cristina V. Cardemil, Sean T. O’Leary, Brenda L. Beaty, Katy Ivey, Megan C. Lindley, Allison Kempe, Lori A. Crane, Laura P. Hurley, Michaela Brtnikova, Aron J. Hall Background Norovirus is a leading cause of acute gastroenteritis (AGE) across the age spectrum; candidate vaccines are in clinical trials. While norovirus diagnostic testing is increasingly available, stool testing may not be...
Fri, 01/10/2020 - 03:23
by Shagnika Das, Andres Aria, Jing-O Cheng, Sami Souissi, Jiang-Shiou Hwang, Fung-Chi Ko Sediment profile and mud shrimp (Austinogebia edulis) from the coastal wetland of central Taiwan in 2017 and 2018 were analyzed for concentration, source, and composition of persistent organic pollutants (POPs) including polycyclic aromatic hydrocarbon (PAHs), polybrominated diphenyl ethers (PBDEs),...
Fri, 01/10/2020 - 03:23
by Soumendra Singh, Animesh Halder, Oindrila Sinha, Probir Kumar Sarkar, Priya Singh, Amrita Banerjee, Saleh A. Ahmed, Ahmed Alharbi, Rami J. Obaid, Sanjay K. Ghosh, Amitabha Mitra, Samir Kumar Pal Ultrasensitive detection of heavy metal ions in available water around us is a great challenge for scientists since long time. We developed an optical technique that combines Rayleigh scattering of UV...
Wed, 01/08/2020 - 03:27
by Markus Beutler, Sara Plesnik, Marina Mihalic, Laura Olbrich, Norbert Heinrich, Samuel Schumacher, Michael Lindner, Ina Koch, Wolfgang Grasse, Christoph Metzger-Boddien, Sabine Hofmann-Thiel, Harald Hoffmann Rapid diagnosis of tuberculosis (TB) and antibiotic resistances are imperative to initiate effective treatment and to stop transmission of the disease. A new generation of more sensitive,...
Wed, 01/08/2020 - 03:27
by Shih-Chao Lin, Brian D. Carey, Victoria Callahan, Ji-Hyun Lee, Nicole Bracci, Anurag Patnaik, Amy K. Smith, Aarthi Narayanan, Benjamin Lepene, Kylene Kehn-Hall Nanotrap® (NT) particles are hydrogel microspheres developed for target analyte separation and discovery applications. NT particles consist of cross-linked N-isopropylacrylamide (NIPAm) copolymers that are functionalized with a variety...
Wed, 01/08/2020 - 03:27
by Jilong Qin, Matthew Thomas Doyle, Elizabeth Ngoc Hoa Tran, Renato Morona Shigella species cause bacillary dysentery, especially among young individuals. Shigellae target the human colon for invasion; however, the initial adhesion mechanism is poorly understood. The Shigella surface protein IcsA, in addition to its role in actin-based motility, acts as a host cell adhesin through unknown...
Wed, 01/08/2020 - 03:27
by Soyoun Hwang, Justin J. Greenlee, Eric M. Nicholson Chronic wasting disease is a transmissible spongiform encephalopathy of cervids. This fatal neurodegenerative disease is caused by misfolding of the cellular prion protein (PrPC) to pathogenic conformers (PrPSc), and the pathogenic forms accumulate in the brain and other tissues. Real-time Quaking Induced Conversion (RT-QuIC) can be used for...
Wed, 01/08/2020 - 03:27
by Dirk Thielen, Karl-Ludwig Schuchmann, Paolo Ramoni-Perazzi, Marco Marquez, Wilmer Rojas, Jose Isrrael Quintero, Marinêz Isaac Marques Climate change poses a critical threat to the Pantanal, the largest wetland in the world. Models indicate an increase in the frequency of extreme precipitation events and extended periods of drought. These changes can amplify consequences for Pantanal’s...
Sat, 01/04/2020 - 03:25
by Tshering Dukpa, Nidup Dorji, Sangay Thinley, Wangchuk, Karma Tshering, Kinley Gyem, Diki Wangmo, Passang Lhamo Sherpa, Tshering Dorji, Antonio Montresor Soil Transmitted Helminth (STH) infections affect over 1.5 billion people worldwide. Although prevalent in all age groups, school aged children are a high-risk groups for STH infections. In Bhutan, epidemiological data on STH were collected...
Tue, 12/31/2019 - 03:44
This article was republished on December 18, 2019, to correct errors in the title that were introduced during the typesetting process. The publisher apologizes for this error. Please download this article again to view the correct version. The originally published, uncorrected article and the republished, corrected articles are provided here for reference.
Fri, 12/27/2019 - 03:26
by Elke J. Seppanen, Ruth B. Thornton, Karli J. Corscadden, Caitlyn M. Granland, Julie Hibbert, Angela Fuery, Selma P. Wiertsema, Shyan Vijayasekaran, Harvey L. Coates, Peter Jacoby, Andrew Currie, Peter C. Richmond, Lea-Ann S. Kirkham Recurrent and chronic otitis media (OM) are often refractory to antibiotics due to bacterial persistence in biofilm within the middle ear. In vitro and in vivo...
Tue, 12/24/2019 - 03:24
by Warren Chanda, Mespa Manyepa, Ephraim Chikwanda, Victor Daka, Justin Chileshe, Mathias Tembo, Joseph Kasongo, Allen Chipipa, Ray Handema, John A. Mulemena Periodic monitoring of antibiotic susceptibility patterns in clinical settings is vital to ascertain the potency as well as re-establishing empirical therapy. This retrospective study aimed to evaluate the antibiotic susceptibility patterns...
Tue, 12/24/2019 - 03:24
by Rui Duarte, Angela Stainthorpe, James Mahon, Janette Greenhalgh, Marty Richardson, Sarah Nevitt, Eleanor Kotas, Angela Boland, Howard Thom, Tom Marshall, Mark Hall, Yemisi Takwoingi Background Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and is associated with increased risk of stroke and congestive heart failure. Lead-I electrocardiogram (ECG) devices are handheld...
Tue, 12/24/2019 - 03:24
by Jiajun Li, Wanqiang Li, Jianzhen Li, Zhenhua Wang, Dan Xiao, Yufei Wang, Xueqin Ni, Dong Zeng, Dongmei Zhang, Bo Jing, Lei Liu, Qihui Luo, Kangcheng Pan The aim of this study was to construct the spleen differential genes library of broilers fed with probiotic Bacillus cereus PAS38 by suppression subtractive hybridization (SSH) and screen the immune-related genes. Sixty seven-day-old broilers...
Sat, 12/21/2019 - 03:41
by Julia Maier, Salma Elmenofi, Alexander Taschauer, Martina Anton, Haider Sami, Manfred Ogris Tracking the activity of signalling pathways is a fundamental method for basic science, as well as in cancer- and pharmaceutical research. The developmental pathways Wnt, Hedgehog and Notch are frequently deregulated in cancers and represent a valuable target for the discovery of novel anticancer...
Fri, 12/20/2019 - 03:25
by Henrik Zetterberg, Elena Bozzetta, Alessandra Favole, Cristiano Corona, Maria Concetta Cavarretta, Francesco Ingravalle, Kaj Blennow, Maurizio Pocchiari, Daniela Meloni Scrapie is a fatal neurodegenerative disease of sheep and goats belonging to the group of Transmissible Spongiform Encephalopathy or prion diseases. The EU has adopted mandatory measures for scrapie surveillance to safeguard...
Thu, 12/19/2019 - 03:26
by Lydia Wuarin, Mohamed Abbas, Stephan Harbarth, Felix Waibel, Dominique Holy, Jan Burkhard, Ilker Uçkay Background Perioperative antibiotic prophylaxis in non-infected orthopedic surgery is evident, in contrast to prophylaxis during surgery for infection. Epidemiological data are lacking for this particular situation. Methods and findings It is a single-center cohort on iterative surgical site...
Wed, 12/18/2019 - 03:43
by Zhihong Du, Jiali Xing, Xiaohu Luo, Li Wang, Lihong Pan, Yulin Li, Ren Wang, Yuntao Liu, Xiaohong Li, Zhengxing Chen Electron-beam irradiation (EBI) is a cold sterilization technology used in the irradiation processing of food, including rice. Herein, the effects of EBI on the swelling power, color, pasting, and sensory properties of white rice after short-term storage were analyzed. Samples...
Sat, 12/14/2019 - 03:26
by David A. Groneberg, Stefan Rolle, Michael H. K. Bendels, Doris Klingelhöfer, Norman Schöffel, Jan Bauer, Dörthe Brüggmann Systematic reviews represent the core and backbone of evidence-based medicine (EBM) strategies in all fields of medicine. In order to depict a first global sketch of the international efforts in the Cochrane database systematic reviews (CDSR), we analyzed the systematic...
Sat, 12/14/2019 - 03:26
by Soraia Fonseca Marinho da Silva, Carlos Henrique de Souza Silva, Fernanda Carolina Ribeiro Dias, Eugenia Cordero-Schmidt, Juan Carlos Vargas-Mena, Ingrid Gracielle Martins da Silva, Sônia Nair Báo, Thaís Gomes de Carvalho, Raimundo Fernandes de Araújo Júnior, Carlos Eduardo Bezerra de Moura, Fabiana Cristina Silveira Alves de Melo, Sérgio Luis Pinto da Matta, Danielle Barbosa Morais Diphylla...

Pages