PLOS Pathogens

The Research Publications track research that is published across national and international peer-reviewed journals. The most recent articles are available ahead of print and searchable by Journal Title, Subject, USDA Grant Funding Agencies or FDA Grant Funding Agencies. The research publications are tracked across five subject areas: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, and Viruses.

Fri, 07/03/2020 - 08:01
by Eli J. Cohen, Daisuke Nakane, Yoshiki Kabata, David R. Hendrixson, Takayuki Nishizaka, Morgan Beeby Campylobacter jejuni rotates a flagellum at each pole to swim through the viscous mucosa of its hosts’ gastrointestinal tracts. Despite their importance for host colonization, however, how C. jejuni coordinates rotation of these two opposing flagella is unclear. As well as their polar placement...
Fri, 07/03/2020 - 08:01
by Chihong Song, Reiko Takai-Todaka, Motohiro Miki, Kei Haga, Akira Fujimoto, Ryoka Ishiyama, Kazuki Oikawa, Masaru Yokoyama, Naoyuki Miyazaki, Kenji Iwasaki, Kosuke Murakami, Kazuhiko Katayama, Kazuyoshi Murata Norovirus is the major cause of epidemic nonbacterial gastroenteritis worldwide. Lack of structural information on infection and replication mechanisms hampers the development of...
Fri, 06/12/2020 - 08:01
by Savannah J. Taylor, Sebastian E. Winter Infection with nontyphoidal Salmonella strains, such as Salmonella enterica serovar Typhimurium (S. Typhimurium) commonly causes foodborne bacterial gastroenteritis. Studies on the pathogenesis of S. Typhimurium infection often focus on bona fide virulence factors. S. Typhimurium produces two distinct type III secretion systems that allow for the...
Wed, 05/27/2020 - 03:34
by Rafael S. Aquino, Atsuko Hayashida, Pyong Woo Park Heparan sulfate proteoglycans (HSPGs) are at the forefront of host-microbe interactions. Molecular and cell-based studies suggest that HSPG-pathogen interactions promote pathogenesis by facilitating microbial attachment and invasion of host cells. However, the specific identity of HSPGs, precise mechanisms by which HSPGs promote pathogenesis,...
Wed, 05/27/2020 - 03:34
by Roberta M. O’Connor, Felix J. Nepveux V, Jaypee Abenoja, Gregory Bowden, Patricia Reis, Josiah Beaushaw, Rachel M. Bone Relat, Iwona Driskell, Fernanda Gimenez, Michael W. Riggs, Deborah A. Schaefer, Eric W. Schmidt, Zhenjian Lin, Daniel L. Distel, Jon Clardy, Timothy R. Ramadhar, David R. Allred, Heather M. Fritz, Pradipsinh Rathod, Laura Chery, John White Apicomplexan parasites cause severe...
Tue, 05/12/2020 - 03:32
by Lamyaa Shaban, Giang T. Nguyen, Benjamin D. Mecsas-Faxon, Kenneth D. Swanson, Shumin Tan, Joan Mecsas Yersinia suppress neutrophil responses by using a type 3 secretion system (T3SS) to inject 6–7 Yersinia effector proteins (Yops) effectors into their cytoplasm. YopH is a tyrosine phosphatase that causes dephosphorylation of the adaptor protein SKAP2, among other targets in neutrophils. SKAP2...
Tue, 05/05/2020 - 03:34
by Qinghe Li, Fei Wang, Qiao Wang, Na Zhang, Jumei Zheng, Maiqing Zheng, Ranran Liu, Huanxian Cui, Jie Wen, Guiping Zhao As a canonical adaptor for the Toll-like receptor (TLR) family, myeloid differentiation primary response protein 88 (MyD88) has crucial roles in host defense against infection by microbial pathogens, and its dysregulation might induce autoimmune diseases. Here, we demonstrate...
Tue, 05/05/2020 - 03:34
by Stefan A. Fattinger, Desirée Böck, Maria Letizia Di Martino, Sabrina Deuring, Pilar Samperio Ventayol, Viktor Ek, Markus Furter, Saskia Kreibich, Francesco Bosia, Anna A. Müller-Hauser, Bidong D. Nguyen, Manfred Rohde, Martin Pilhofer, Wolf-Dietrich Hardt, Mikael E. Sellin Salmonella enterica serovar Typhimurium (S.Tm) infections of cultured cell lines have given rise to the ruffle model for...
Fri, 04/17/2020 - 03:24
by Julia María Coronas-Serna, Arthur Louche, María Rodríguez-Escudero, Morgane Roussin, Paul R. C. Imbert, Isabel Rodríguez-Escudero, Laurent Terradot, María Molina, Jean-Pierre Gorvel, Víctor J. Cid, Suzana P. Salcedo Brucella species are facultative intracellular Gram-negative bacteria relevant to animal and human health. Their ability to establish an intracellular niche and subvert host cell...
Thu, 04/16/2020 - 03:25
by Muhammad Fahim Raza, Yichen Wang, Zhaohui Cai, Shuai Bai, Zhichao Yao, Umar Anwar Awan, Zhenyu Zhang, Weiwei Zheng, Hongyu Zhang Gut symbiotic bacteria have a substantial impact on host physiology and ecology. However, the contribution of gut microbes to host fitness during long-term low-temperature stress is still unclear. This study examined the role of gut microbiota in host low-temperature...
Thu, 04/16/2020 - 03:25
by Leo Yi Yang Lee, Jie Zhou, Rebecca Frise, Daniel H. Goldhill, Paulina Koszalka, Edin J. Mifsud, Kaoru Baba, Takahiro Noda, Yoshinori Ando, Kenji Sato, Aoe-Ishikawa Yuki, Takao Shishido, Takeki Uehara, Steffen Wildum, Elke Zwanziger, Neil Collinson, Klaus Kuhlbusch, Barry Clinch, Aeron C. Hurt, Wendy S. Barclay Influenza viruses cause seasonal outbreaks and pose a continuous pandemic threat....
Tue, 04/14/2020 - 03:25
by Camille Rey, Yuen-Yan Chang, Patricia Latour-Lambert, Hugo Varet, Caroline Proux, Rachel Legendre, Jean-Yves Coppée, Jost Enninga Microfold (M) cell host-pathogen interaction studies would benefit from the visual analysis of dynamic cellular and microbial interplays. We adapted a human in vitro M cell model to physiological bacterial infections, expression of fluorescent localization reporters...
Tue, 04/14/2020 - 03:25
by Shauna M. Crowley, Xiao Han, Joannie M. Allaire, Martin Stahl, Isabella Rauch, Leigh A. Knodler, Bruce A. Vallance We investigated the role of the inflammasome effector caspases-1 and -11 during Salmonella enterica serovar Typhimurium infection of murine intestinal epithelial cells (IECs). Salmonella burdens were significantly greater in the intestines of caspase-1/11 deficient (Casp1/11−/−),...
Tue, 04/07/2020 - 03:42
by Vincent R. Graziano, Forrest C. Walker, Elizabeth A. Kennedy, Jin Wei, Khalil Ettayebi, Madison S. Strine, Renata B. Filler, Ebrahim Hassan, Leon L. Hsieh, Arthur S. Kim, Abimbola O. Kolawole, Christiane E. Wobus, Lisa C. Lindesmith, Ralph S. Baric, Mary K. Estes, Robert C. Orchard, Megan T. Baldridge, Craig B. Wilen Murine norovirus (MNoV) is an important model of human norovirus (HNoV) and...
Fri, 04/03/2020 - 03:23
by Raquel Tarancón, Jorge Domínguez-Andrés, Santiago Uranga, Anaísa V. Ferreira, Laszlo A. Groh, Mirian Domenech, Fernando González-Camacho, Niels P. Riksen, Nacho Aguilo, José Yuste, Carlos Martín, Mihai G. Netea Among infectious diseases, tuberculosis is the leading cause of death worldwide, and represents a serious threat, especially in developing countries. The protective effects of Bacillus...
Fri, 03/13/2020 - 03:23
by Yuxin Zhou, X. Edward Zhou, Yuanping Gong, Yuanye Zhu, Xiaoman Cao, Joseph S. Brunzelle, H. Eric Xu, Mingguo Zhou, Karsten Melcher, Feng Zhang Fusarium is a genus of filamentous fungi that includes species that cause devastating diseases in major staple crops, such as wheat, maize, rice, and barley, resulting in severe yield losses and mycotoxin contamination of infected grains. Phenamacril is...
Tue, 03/10/2020 - 03:23
by Saori Oku, Toru Takeshita, Toshiko Futatsuki, Shinya Kageyama, Mikari Asakawa, Yasuo Mori, Toshihiro Miyamoto, Jun Hata, Toshiharu Ninomiya, Haruhiko Kashiwazaki, Yoshihisa Yamashita Disruption of the intestinal microbiota caused by intensive chemotherapy, irradiation and antibiotics can result in development of severe gut graft-versus-host disease and infectious complications, leading to...
Tue, 02/25/2020 - 03:27
by Michele Lunelli, Antje Kamprad, Jörg Bürger, Thorsten Mielke, Christian M. T. Spahn, Michael Kolbe The Type III Secretion Systems (T3SS) needle complex is a conserved syringe-shaped protein translocation nanomachine with a mass of about 3.5 MDa essential for the survival and virulence of many Gram-negative bacterial pathogens. This system is composed of a membrane-embedded basal body and an...
Tue, 02/25/2020 - 03:27
by Lenka Cernikova, Carmen Faso, Adrian B. Hehl Phosphorylated derivatives of phosphatidylinositol (PIPs), are key membrane lipid residues involved in clathrin-mediated endocytosis (CME). CME relies on PI(4,5)P2 to mark endocytic sites at the plasma membrane (PM) associated to clathrin-coated vesicle (CCV) formation. The highly diverged parasitic protist Giardia lamblia presents disordered and...
Sat, 02/22/2020 - 03:26
by Haili Zhang, Hongxin Li, Wenqiang Wang, Yujie Wang, Guan-Zhu Han, Hualan Chen, Xiaojun Wang Both the replication and transcription of the influenza virus are catalyzed by the viral polymerase complex. The polymerases of most avian influenza A viruses have poor performance in mammalian cells, which is considered to be one of the important species barriers. Pigs have been long considered as...
Wed, 02/19/2020 - 03:29
by Mona Alzheimer, Sarah L. Svensson, Fabian König, Matthias Schweinlin, Marco Metzger, Heike Walles, Cynthia M. Sharma The Gram-negative Epsilonproteobacterium Campylobacter jejuni is currently the most prevalent bacterial foodborne pathogen. Like for many other human pathogens, infection studies with C. jejuni mainly employ artificial animal or cell culture models that can be limited in their...
Wed, 02/19/2020 - 03:29
by Ainhoa Arbués, Dominique Brees, Salah-Dine Chibout, Todd Fox, Michael Kammüller, Damien Portevin TNF-α- as well as non-TNF-α-targeting biologics are prescribed to treat a variety of immune-mediated inflammatory disorders. The well-documented risk of tuberculosis progression associated with anti-TNF-α treatment highlighted the central role of TNF-α for the maintenance of protective immunity,...
Sat, 02/15/2020 - 03:25
by Samit Watve, Kelsey Barrasso, Sarah A. Jung, Kristen J. Davis, Lisa A. Hawver, Atul Khataokar, Ryan G. Palaganas, Matthew B. Neiditch, Lark J. Perez, Wai-Leung Ng Many bacteria use quorum sensing (QS) to regulate virulence factor production in response to changes in population density. QS is mediated through the production, secretion, and detection of signaling molecules called autoinducers (...
Fri, 02/07/2020 - 03:47
by Morgane Rolland, Sodsai Tovanabutra, Bethany Dearlove, Yifan Li, Christopher L. Owen, Eric Lewitus, Eric Sanders-Buell, Meera Bose, AnneMarie O’Sullivan, Raabya Rossenkhan, Jan Phillipus Lourens Labuschagne, Paul T. Edlefsen, Daniel B. Reeves, Gustavo Kijak, Shana Miller, Kultida Poltavee, Jenica Lee, Lydia Bonar, Elizabeth Harbolick, Bahar Ahani, Phuc Pham, Hannah Kibuuka, Lucas Maganga,...
Wed, 02/05/2020 - 03:26
by Amanda L. Woerman, Smita Patel, Sabeen A. Kazmi, Abby Oehler, Jisoo Lee, Daniel A. Mordes, Steven H. Olson, Stanley B. Prusiner Multiple system atrophy (MSA), a progressive neurodegenerative disease characterized by autonomic dysfunction and motor impairment, is caused by the self-templated misfolding of the protein α-synuclein. With no treatment currently available, we sought to characterize...
Fri, 01/24/2020 - 03:23
by Sarah Ben Maamar, Adam J. Glawe, Taylor K. Brown, Nancy Hellgeth, Jinglin Hu, Ji-Ping Wang, Curtis Huttenhower, Erica M. Hartmann The decades-long global trend of urbanization has led to a population that spends increasing amounts of time indoors. Exposure to microbes in buildings, and specifically in dust, is thus also increasing, and has been linked to various health outcomes and to...
Wed, 01/22/2020 - 03:24
by Joseph T. Hicks, Dong-Hun Lee, Venkata R. Duvuuri, Mia Kim Torchetti, David E. Swayne, Justin Bahl The 2014–2015 highly pathogenic avian influenza (HPAI) H5NX outbreak represents the largest and most expensive HPAI outbreak in the United States to date. Despite extensive traditional and molecular epidemiological studies, factors associated with the spread of HPAI among midwestern poultry...
Sat, 01/18/2020 - 03:23
by Christian Twittenhoff, Ann Kathrin Heroven, Sabrina Mühlen, Petra Dersch, Franz Narberhaus Frequent transitions of bacterial pathogens between their warm-blooded host and external reservoirs are accompanied by abrupt temperature shifts. A temperature of 37°C serves as reliable signal for ingestion by a mammalian host, which induces a major reprogramming of bacterial gene expression and...
Sat, 01/18/2020 - 03:23
by Hongbin Wang, Carol Hoffman, Xinghong Yang, Beata Clapp, David W. Pascual Brucellosis remains the most common zoonotic disease globally. Currently no vaccines for humans exist, and conventional brucellosis vaccines for livestock fail to confer complete protection; hence, an improved vaccine is needed. Although Brucella infections primarily occur following a mucosal exposure, vaccines are...
Sat, 01/18/2020 - 03:23
by Louise H. Moncla, Trevor Bedford, Philippe Dussart, Srey Viseth Horm, Sareth Rith, Philippe Buchy, Erik A. Karlsson, Lifeng Li, Yongmei Liu, Huachen Zhu, Yi Guan, Thomas C. Friedrich, Paul F. Horwood Avian influenza viruses (AIVs) periodically cross species barriers and infect humans. The likelihood that an AIV will evolve mammalian transmissibility depends on acquiring and selecting mutations...
Tue, 01/07/2020 - 03:26
by Michèle Brocard, Valentina Iadevaia, Philipp Klein, Belinda Hall, Glenys Lewis, Jia Lu, James Burke, Margaret M. Willcocks, Roy Parker, Ian G. Goodfellow, Alessia Ruggieri, Nicolas Locker Viral infections impose major stress on the host cell. In response, stress pathways can rapidly deploy defence mechanisms by shutting off the protein synthesis machinery and triggering the accumulation of...
Fri, 12/27/2019 - 03:26
by Helen E. McNeil, Ilyas Alav, Ricardo Corona Torres, Amanda E. Rossiter, Eve Laycock, Simon Legood, Inderpreet Kaur, Matthew Davies, Matthew Wand, Mark A. Webber, Vassiliy N. Bavro, Jessica M. A. Blair Active efflux due to tripartite RND efflux pumps is an important mechanism of clinically relevant antibiotic resistance in Gram-negative bacteria. These pumps are also essential for Gram-negative...
Tue, 12/24/2019 - 03:24
by Dhritiman Samanta, Tatiana M. Clemente, Baleigh E. Schuler, Stacey D. Gilk Upon host cell infection, the obligate intracellular bacterium Coxiella burnetii resides and multiplies within the Coxiella–Containing Vacuole (CCV). The nascent CCV progresses through the endosomal maturation pathway into a phagolysosome, acquiring endosomal and lysosomal markers, as well as acidic pH and active...
Tue, 12/24/2019 - 03:24
by Diana Hooker-Romero, Erin Mettert, Leah Schwiesow, David Balderas, Pablo A. Alvarez, Anadin Kicin, Azuah L. Gonzalez, Gregory V. Plano, Patricia J. Kiley, Victoria Auerbuch The enteropathogen Yersinia pseudotuberculosis and the related plague agent Y. pestis require the Ysc type III secretion system (T3SS) to subvert phagocyte defense mechanisms and cause disease. Yet type III secretion (T3S)...
Sat, 12/21/2019 - 03:41
by Zoltán Attila Nagy, Dávid Szakács, Eszter Boros, Dávid Héja, Eszter Vígh, Noémi Sándor, Mihály Józsi, Gábor Oroszlán, József Dobó, Péter Gál, Gábor Pál Ecotin is a serine protease inhibitor produced by hundreds of microbial species, including pathogens. Here we show, that ecotin orthologs from Escherichia coli, Yersinia pestis, Pseudomonas aeruginosa and Leishmania major are potent inhibitors...
Fri, 12/13/2019 - 03:27
by Vincenzo Torraca, Myrsini Kaforou, Jayne Watson, Gina M. Duggan, Hazel Guerrero-Gutierrez, Sina Krokowski, Michael Hollinshead, Thomas B. Clarke, Rafal J. Mostowy, Gillian S. Tomlinson, Vanessa Sancho-Shimizu, Abigail Clements, Serge Mostowy Shigella flexneri is historically regarded as the primary agent of bacillary dysentery, yet the closely-related Shigella sonnei is replacing S. flexneri,...
Thu, 12/05/2019 - 03:46
by Catalina Pardo-Roa, Geraldyne A. Salazar, Loreani Noguera, Francisco J. Salazar-Echegarai, Omar P. Vallejos, Isidora Suazo, Bárbara M. Schultz, Irenice Coronado-Arrazola, Alexis M. Kalergis, Susan M. Bueno Pathogenicity island excision is a phenomenon that occurs in several Salmonella enterica serovars and other members of the family Enterobacteriaceae. ROD21 is an excisable pathogenicity...
Tue, 11/19/2019 - 03:26
by Jennifer R. Linden, Claudia Flores, Eric F. Schmidt, Francisco A. Uzal, Adam O. Michel, Marissa Valenzuela, Sebastian Dobrow, Timothy K. Vartanian Clostridium perfringens epsilon toxin (ETX) is responsible for causing the economically devastating disease, enterotoxaemia, in livestock. It is well accepted that ETX causes blood brain barrier (BBB) permeability, however the mechanisms involved in...
Fri, 11/15/2019 - 03:24
by Brian C. Russo, Jeffrey K. Duncan, Alexandra L. Wiscovitch, Austin C. Hachey, Marcia B. Goldberg Type 3 secretion systems (T3SSs) are conserved bacterial nanomachines that inject virulence proteins (effectors) into eukaryotic cells during infection. Due to their ability to inject heterologous proteins into human cells, these systems are being developed as therapeutic delivery devices. The T3SS...
Tue, 10/08/2019 - 03:28
by Eric T. Sumrall, Yang Shen, Anja P. Keller, Jeanine Rismondo, Maria Pavlou, Marcel R. Eugster, Samy Boulos, Olivier Disson, Pierre Thouvenot, Samuel Kilcher, Bernd Wollscheid, Didier Cabanes, Marc Lecuit, Angelika Gründling, Martin J. Loessner The intracellular pathogen Listeria monocytogenes is distinguished by its ability to invade and replicate within mammalian cells. Remarkably, of the 15...
Fri, 10/04/2019 - 03:29
by Stephen F. Fitzgerald, Amy E. Beckett, Javier Palarea-Albaladejo, Sean McAteer, Sharif Shaaban, Jason Morgan, Nur Indah Ahmad, Rachel Young, Neil A. Mabbott, Liam Morrison, James L. Bono, David L. Gally, Tom N. McNeilly Specific Escherichia coli isolates lysogenised with prophages that express Shiga toxin (Stx) can be a threat to human health, with cattle being an important natural reservoir....
Sat, 09/28/2019 - 03:21
by Jana Van Dycke, Annelii Ny, Nádia Conceição-Neto, Jan Maes, Myra Hosmillo, Arno Cuvry, Ian Goodfellow, Tatiane C. Nogueira, Erik Verbeken, Jelle Matthijnssens, Peter de Witte, Johan Neyts, Joana Rocha-Pereira Human noroviruses (HuNoVs) are the most common cause of foodborne illness, with a societal cost of $60 billion and 219,000 deaths/year. The lack of robust small animal models has...
Sat, 09/28/2019 - 03:21
by Rocío Canals, Roy R. Chaudhuri, Rebecca E. Steiner, Siân V. Owen, Natalia Quinones-Olvera, Melita A. Gordon, Michael Baym, Michael Ibba, Jay C. D. Hinton We have used a transposon insertion sequencing (TIS) approach to establish the fitness landscape of the African Salmonella enterica serovar Typhimurium ST313 strain D23580, to complement our previous comparative genomic and functional...
Thu, 09/19/2019 - 17:00
Jana Van Dycke, Annelii Ny, Nádia Conceição-Neto, Jan Maes, Myra Hosmillo, Arno Cuvry, Ian Goodfellow, Tatiane C. Nogueira, Erik Verbeken, Jelle Matthijnssens, Peter de Witte, Johan Neyts, Joana Rocha-Pereira Human noroviruses (HuNoVs) are the most common cause of foodborne illness, with a societal cost of $60 billion and 219,000 deaths/year. The lack of robust small animal models has...
Fri, 08/30/2019 - 17:00
Sergei Perov, Ofir Lidor, Nir Salinas, Nimrod Golan, Einav Tayeb- Fligelman, Maya Deshmukh, Dieter Willbold, Meytal Landau Curli amyloid fibrils secreted Enterobacteriaceae mediate host cell adhesion and contribute to biofilm formation, therepromoting bacterial resistance to environmental stressors. Here, we present crystal structures of amyloid-forming segments from the major curli subunit,...
Wed, 08/28/2019 - 17:00
Sandhya Ganesan, Craig R. Roy Most intracellular pathogens that reside in a vacuole prevent transit of their compartment to lysosomal organelles. Effector mechanisms induced the pro-inflammatory cytokine Interferon-gamma (IFNγ) can promote the delivery of pathogen-occupied vacuoles to lysosomes for proteolytic degradation and are therefore important for host defense against intracellular...
Thu, 08/22/2019 - 17:00
Tra-My Duong-Nu, Kwangjoon Jeong, Seol Hee Hong, Sao Puth, Soo Young Kim, Wenzhi Tan, Kwang Ho Lee, Shee Eun Lee, Joon Haeng Rhee The tad operons encode the machinery required for adhesive Flp (fimbrial low-molecular-weight protein) pili biogenesis. Vibrio vulnificus, an opportunistic pathogen, harbors three distinct tad loci. Among them, only tad1 locus was highly upregulated in in vivo growing...
Thu, 08/22/2019 - 17:00
Sivan Laviad-Shitrit, Ido Izhaki, Malka Halpern Vibrio cholerae is the causative agent of cholera, a life-threatening diarrheal disease. Cholera causes epidemics and pandemics, but the ways this disease spreads worldwide is still unclear. This review highlights a relatively new hypothesis regarding the way V. cholerae can be globally dispersed. Copepods and chironomids are natural reservoirs of...
Wed, 08/14/2019 - 17:00
Tae-Hwan Kim, Hyun-Cheol Lee, Jae-Hoon Kim, C. Y. Hewawaduge, Kiramage Chathuranga, W. A. Gayan Chathuranga, Pathum Ekanayaka, H. M. S. M. Wijerathne, Chul-Joong Kim, Eunhee Kim, Jong-Soo Lee Fas-associated factor 1 is a death-promoting protein that induces apoptosis interacting with the Fas receptor. Until now, FAF1 was reported to interact potentially with diverse proteins and to function as a...
Mon, 08/12/2019 - 17:00
Alyson R. Warr, Troy P. Hubbard, Diana Munera, Carlos J. Blondel, Pia Abel zur Wiesch, Sören Abel, Xiaoxue Wang, Brigid M. Davis, Matthew K. Waldor Enterohemorrhagic Escherichia coli O157:H7 (EHEC) is an important food-borne pathogen that colonizes the colon. Transposon-insertion sequencing (TIS) was used to identify genes required for EHEC and E. coli K-12 growth in vitro and for EHEC growth in...

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