Parasite Immunology

Sun, 11/01/2020 - 22:09
Aim The anti‐leishmanial effect of the ‘carbohydrate fraction’ (designated as Ahf‐Car), isolated from an edible mushroom Astraeus hygrometricus, was evaluated against Leishmania donovani infection both in vitro and in vivo. Methods and Results Ahf‐Car induced the expression of inducible nitric oxide synthase 2 (iNOS2) and pro‐inflammatory cytokines like TNF‐α and IL‐12, with subsequent down‐...
Mon, 06/29/2020 - 22:07
Aims Giardia lamblia is a protozoan parasite that causes giardiasis, one of the most common worldwide gastrointestinal diseases. For rational development of a Giardia vaccine, increasing our understanding of the host‐Giardia interaction is crucial. In this study, we analyzed the immunogenicity and antigenicity of two G. lamblia strain variants [GS and GS‐5G8 (+)], which express different levels...
Tue, 05/19/2020 - 03:25
Aims Industrial growth has increased the exposure to endocrine disruptor compounds (EDCs) in all organisms. Bisphenol A (BPA), an EDC, has been demonstrated to be involved in the susceptibility to parasite infections. However, few studies have analyzed this connection in more depth. The aim of this study was to determine if early BPA exposure in female mice affects the systemic immune response...
Fri, 05/08/2020 - 03:26
Leishmania donovani (a causative agent of visceral leishmaniasis) poses a serious health threat to the human population is fatal if left untreated. The life cycle of Leishmania alternates between vertebrate host and Phlebotomine fly as intermediate ones. The difficulties linked to vector (sandfly) control and the lack of an effective vaccine, the control of leishmaniasis relies mostly on...