Toxicology

Sat, 06/12/2021 - 06:15
Author(s): Ziwei Wang, Yanan Gao, Xin Huang, Shengnan Huang, Xue Yang, Jiaqi Wang, Nan Zheng
Wed, 06/09/2021 - 06:05
Author(s): Tengkai Wang, Fen Xu, Lijun Song, Juan Li, Qian Wang Previous studies have suggested that bisphenol A (BPA) has a toxic effect on bone development; however, its pathological mechanism has not been fully elucidated. In the present study, pregnant Wistar rats were intragastrically administered BPA (10 μg/kg per day) during gestational days 14–21. Then, bone tissues were obtained from...
Mon, 04/26/2021 - 06:05
Author(s): Haolei Li, Mengmeng Wang, Weili Kang, Ziman Lin, Fang Gan, Kehe Huang Ochratoxin A (OTA) and fumonisin B1 (FB1), two of the most toxicologically important mycotoxins, often coexist in a variety of foodstuff and feed in humans and animals. Because of the low content of FB1 in foodstuff and feed, alone harmfulness of FB1 is often ignored. However, it is unknown whether the lower dosage...
Thu, 04/22/2021 - 06:10
Author(s): Hao Wu, Shufang Zheng, Jinxi Zhang, Shiwen Xu, Zhiruo Miao Cadmium (Cd), an environmental pollutant, causes several adverse reactions in animals. High dose of Cd has serious cytotoxicities, including the induction of programmed cell necrosis, autophagy and apoptosis, which has aroused wide public concern. The balance of cytokine network is affected by Th1/Th2 balance which is closely...
Sun, 04/18/2021 - 06:05
Author(s): Frederick Adams Ekuban, Cai Zong, Madoka Takikawa, Kota Morikawa, Toshihiro Sakurai, Sahoko Ichihara, Ken Itoh, Masayuki Yamamoto, Seiichiroh Ohsako, Gaku Ichihara Acrylamide (ACR), a recognized neurotoxicant in humans and experimental animals, is widely used in industry and in food generated through Maillard reaction. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master...
Wed, 03/24/2021 - 06:05
Author(s): Chun-Fa Huang, Shing-Hwa Liu, Chin-Chuan Su, Kai-Min Fang, Cheng-Chieh Yen, Ching-Yao Yang, Feng-Cheng Tang, Jui-Ming Liu, Chin-Ching Wu, Kuan-I Lee, Ya-Wen Chen Bisphenol A (BPA) is recognized as a harmful pollutant in the worldwide. Growing studies have reported that BPA can cause adverse effects and diseases in human, and link to a potential risk factor for development of...
Thu, 03/18/2021 - 06:07
Author(s): Kan Shao, Zheng Zhou, Pengcheng Xun, Samuel M. Cohen Abundant epidemiological evidence has shown that there is a strong causal relationship between long-term exposure to inorganic arsenic (iAs) through drinking water and a few types of cancer (e.g., lung and bladder cancer). Traditionally, a linear low-dose extrapolation assumption was applied in risk assessment for iAs which resulted...
Wed, 03/03/2021 - 06:05
Author(s): Gopalapura J. Vishalakshi, Mahadevappa Hemshekhar, Vaddaragudisalu D. Sandesha, Kunthurumole S. Prashanth, Swamy Jagadish, Manoj Paul, Kempaiah Kemparaju, Kesturu S. Girish Bisphenol AF, an analogue of Bisphenol A, is an important raw material used in the production of plastic and rubber substances like plastic bottles and containers, toys, and medical supplies. Increased contamination...
Tue, 02/23/2021 - 06:08
Author(s): Xia Zhao, Shengchen Wang, Xiaojing Li, Honggui Liu, Shiwen Xu Cadmium (Cd) is one common environmental pollutant with systemic toxicity. Lipoxin A4 (LXA4) can regulate transforming growth factor-β (TGF-β) pathway and alleviate tissue injury via binding to formyl peptide receptor 2 (FPR2). The activation of nuclear factor-κB (NF-κB) pathway can promote the occurence of necroptosis....
Sun, 02/21/2021 - 06:06
Author(s): Ju Tang, Weixia Duan, Ping Deng, Huijuan Li, Cong Liu, Yu Duan, Min Feng, Shangcheng Xu Cadmium (Cd) is a ubiquitous environmental and occupational pollutant that is considered a high-risk factor for neurodegenerative diseases. However, the mechanism underlying Cd-induced neurotoxicity has not been fully elucidated. Abnormal mitochondrial distribution and excessive mitochondrial...
Mon, 02/15/2021 - 06:06
Author(s): Jingzeng Cai, Haoyue Guan, Xing Jiao, Jie Yang, Xiaoming Chen, Haoran Zhang, Yingying Zheng, Yue Zhu, Qi Liu, Ziwei Zhang Cadmium (Cd) chloride, as widely distributed toxic environmental pollutants by using in industry, severely imperils animal and human health. Pyroptosis is a Cas1-dependent pro-inflammatory programmed cell death and involves in various types of diseases. Nevertheless...
Sun, 01/31/2021 - 06:06
Author(s): Christelle Douillet, Jinglin Ji, Immaneni Lakshmi Meenakshi, Kun Lu, Fernando Pardo-Manuel de Villena, Rebecca C. Fry, Miroslav Stýblo Arsenic methyltransferase (AS3MT) is the key enzyme in the pathway for the methylation of inorganic arsenic (iAs), a potent human carcinogen and diabetogen. AS3MT converts iAs to mono- and dimethylated arsenic species (MAs, DMAs) that are excreted...
Sun, 01/24/2021 - 06:05
Author(s): Lu Yiming, Han Yanfei, Yin Hang, Cong Yimei, Shi Guangliang, Li Shu This study was aimed to explore the possible mechanism of environmental metal cadmium (Cd) inducing apoptosis of pig lymph nodes.
Thu, 01/21/2021 - 06:09
Author(s): Qipeng Zhang, Wenying Chen, Boyang Zhang, Chen Li, Xunyao Zhang, Qian Wang, Yan Wang, Qian Zhou, Xiaohong Li, Xiao Li Shen Ochratoxin A (OTA) is a nephrotoxic mycotoxin that is widely distributed in foodstuffs and feeds, meanwhile oleanolic acid (OA) is ubiquitous in various fruit skins, food materials, and medicinal herbs. Due to that OA has a nephroprotective effect, it has the...
Sat, 11/14/2020 - 06:16
Author(s): Jelena Kulas, Dina Tucovic, Milica Zeljkovic, Dusanka Popovic, Aleksandra Popov Aleksandrov, Mirela Ukropina, Maja Cakic Milosevic, Jasmina Glamoclija, Milena Kataranovski, Ivana Mirkov Cadmium (Cd) is one of the most toxic environmental heavy metals to which the general population is exposed mainly via the oral route. Owing to its immunomodulatory potential, orally acquired Cd affects...
Fri, 11/13/2020 - 06:09
Author(s): Masayo Hirao-Suzuki, Shuso Takeda, Genki Sakai, Michael P. Waalkes, Narumi Sugihara, Masufumi Takiguchi Cadmium (Cd) is recognized as a highly toxic heavy metal for humans in part because it is a multi-organ carcinogen. To clarify the mechanism of Cd carcinogenicity, we have established an experimental system using rat liver TRL1215 cells exposed to 2.5 μM Cd for 10 weeks and then...
Wed, 10/07/2020 - 06:09
Author(s): Jiaming Zheng, Liling Zhuo, Di Ran, Yonggang Ma, Tongwang Luo, Hongyan Zhao, Ruilong Song, Hui Zou, Jiaqiao Zhu, Jianhong Gu, Jianchun Bian, Yan Yuan, Zongping Liu Cadmium (Cd), a heavy metal produced by various industries, contaminates the environment and seriously damages the skeletal system of humans and animals. Recent studies have reported that Cd can affect the viability of cells...
Fri, 09/25/2020 - 06:09
Author(s): Fozia Ahmed, Assel Sarsenbayeva, Petros Katsogiannos, Céline Aguer, Maria J Pereira The environmental endocrine disruptors, bisphenol A (BPA) and bisphenol S (BPS) are associated with the development of type 2 diabetes. We aim to study the effects of BPA or BPS exposure on adipokine expression in human adipose tissue and on adipocyte glucose uptake.
Tue, 09/08/2020 - 06:13
Author(s): Tomoki Imaoka, Jade Yang, Lu Wang, Matthew G. McDonald, Zahra Afsharinejad, Theo K. Bammler, Kirk Van Ness, Catherine K. Yeung, Allan E. Rettie, Jonathan Himmelfarb, Edward J. Kelly Ochratoxin A (OTA) is one of the most abundant mycotoxin contaminants in food stuffs and possesses carcinogenic, nephrotoxic, teratogenic, and immunotoxic properties. Specifically, a major concern is severe...
Fri, 08/28/2020 - 06:07
Author(s): Balachander Rakesh, Bhavani Shankara Bagepally, Ravibabu Kalahasthi, Madhumitha Haridoss Present study aimed to systematically review and synthesise quantitative evidence on association between occupational Lead (Pb) exposure and male reproductive hormones (MRH) and sperm quality from the existing literature. Observational studies investigating the effects of Pb exposure on MRH, sperm-...
Fri, 08/14/2020 - 06:08
Author(s): Ashley E. Peppriell, Jakob T. Gunderson, Daria Vorojeikina, Matthew D. Rand Methylmercury (MeHg) is a ubiquitous environmental contaminant and developmental toxicant known to cause a variety of persistent motor and cognitive deficits. While previous research has focused predominantly on neurotoxic MeHg effects, emerging evidence points to a myotoxic role whereby MeHg induces defects in...
Wed, 08/12/2020 - 06:08
Author(s): Jonaina Fiorim, Maylla Ronacher Simões, Bruna Fernandes de Azevedo, Rogério Faustino Ribeiro, Leonardo dos Santos, Alessandra Simão Padilha, Dalton Valentim Vassallo Lead induces endothelial dysfunction and hypertension in humans and animals. Seven-day exposure to a low dose in rats reduces vasocontractile responses and increases nitric oxide (NO) bioavailability. We hypothesized that...
Mon, 07/20/2020 - 06:07
Author(s): Di Ran, Yonggang Ma, Wei Liu, Tongwang Luo, Jiaming Zheng, Dedong Wang, Ruilong Song, Hongyan Zhao, Hui Zou, Jianhong Gu, Yan Yuan, Jianchun Bian, Zongping Liu Cadmium (Cd) is one of worldwide environmental pollutants that causes bone homeostasis, which depends on the resorption of bones by osteoclasts and formation of bones by the osteoblasts (OB). However, the Cd toxicity on OB and...
Mon, 06/08/2020 - 06:06
Author(s): Wei Liu, Chung Chi Le, Dong Wang, Di Ran, Yi Wang, Hongyan Zhao, Jianhong Gu, Hui Zou, Yan Yuan, Jianchun Bian, Zongping Liu Environmental cadmium (Cd) pollution can ultimately lead to chronic toxicity via food consumption. Previous studies have demonstrated that long-term low-dose Cd exposure decreases bone mineral density and bone mineralization. Cd may increase receptor activator of...
Wed, 05/13/2020 - 03:31
Author(s): Faraz Ahmad, Shafiul Haque, Vijaya Ravinayagam, Aqeel Ahmad, Majid Rasool Kamli, George E. Barreto, Ghulam Md, Ashraf Neurotoxicity induced by exposure to heavy metal lead (Pb) is a concern of utmost importance particularly for countries with industrial-based economies. The developing brain is particularly sensitive to exposure to even minute quantities of Pb which can alter...
Sat, 05/02/2020 - 03:29
Author(s): Jamie B. Harris, Jessica H. Hartman, Anthony L. Luz, Joanna Y. Wilson, Audrey Dinyari, Joel N. Meyer Polycyclic aromatic hydrocarbons (PAHs) are environmental toxicants primarily produced during incomplete combustion; some are carcinogens. PAHs can be safely metabolized or, paradoxically, bioactivated via specific cytochrome P450 (CYP) enzymes to more reactive metabolites, some of...
Sun, 04/12/2020 - 03:21
Author(s): Yuchang Tao, Xiaozhuan Liu, Lingling Cui, Xinxin Liu, Yao Chen, Zhidong He, Mengmeng Ji, Zhan Gao, Ning Li, Zhongxiao Wan, Zengli Yu As a common birth defect, Cleft palate can be caused by the disturbance during the developmental process of the palatal shelves. The 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) is a well-known environmental teratogenic agent for cleft palate and Aryl...
Fri, 04/10/2020 - 03:23
Author(s): Jing Xue, Li Zhang, Xuexue Xie, Yue Gao, Lei Jiang, Jun Wang, Yu Wang, Rong Gao, Jing Yu, Hang Xiao Bisphenol A (BPA) is a well-known endocrine disruptor used to manufacture polycarbonate plastics and epoxy resins. BPA exposure especially occupational perinatal exposure to has been linked to numerous adverse effects for the offspring. Available data have shown that perinatal exposure...
Sun, 03/22/2020 - 03:20
Author(s): Keqi Hu, Hang Yu, Zihuan Li, Guifang Jin, Hansi Jia, Meiqi Song, Yungang Liu Polychlorinated biphenyls (PCBs) are persistent organic pollutants with human carcinogenicity. Many lower chlorinated and non-dioxin-like PCBs have been observed to be mutagenic following activation by human CYP2E1, while activation of dioxin-like (DL-) PCBs by this enzyme has never been evidenced. In this...
Sat, 03/07/2020 - 03:20
Author(s): Fernanda Ivanski, Viviane Matoso de Oliveira, Isabela Medeiros de Oliveira, Anderson Tadeu de Araújo Ramos, Selma Thaisa de Oliveira Tonete, Gabriel de Oliveira Hykavei, Paula Bargi-Souza, Dalton Luiz Schiessel, Anderson Joel Martino-Andrade, Marco Aurelio Romano, Renata Marino Romano The increase in human infertility prevalence due to male reproductive disorders has been associated...
Sun, 02/16/2020 - 03:36
Author(s): Jie Liu, Sumedha Gunewardena, Julia Yue Cui, Curtis D. Klaassen, Brian N. Chorley, J. Christopher CortonAbstractArsenic is a known human carcinogen. Early-life exposure to inorganic arsenic induces tumors in humans and in C3H mice. We hypothesized that arsenic exposure in utero may induce epigenetic changes at the level of DNA methylation and miRNA alterations that could lead to...
Sun, 02/09/2020 - 03:21
Author(s): Mingjie Shi, Zeheng Lin, Lihe Ye, Xinlin Chen, Wenfeng Zhang, Zihan Zhang, Fei Luo, Yungang Liu, Ming ShiAbstractAs an alternative to bisphenol A (BPA), bisphenol F (BPF) has been increasingly used in manufacturing various consumer products. Exposured to BPF may lead to imbalanced immune homeostasis, yet the underlying mechanisms have not been fully elucidated. The present study was...
Wed, 02/05/2020 - 03:22
Author(s): Haibin Zhang, Zhouyu Wang, Lingxue Meng, Hongxuan Kuang, Jian Liu, Xuejing Lv, Qihua Pang, Ruifang FanAbstractHumans from fetal to adult stages are chronically and passively exposed to bisphenol A (BPA, an endocrine disruptor) due to its ubiquitous existence in daily life. To investigate the long-term neurotoxicity of maternal exposure to BPA for offspring, mice were used as the animal...
Sun, 02/02/2020 - 03:21
Author(s): Xin Sui, Jun Yang, Guangzhou Zhang, XiaoFeng Yuan, WanHua Li, JianHai Long, Yuan Luo, Yunfeng Li, Yongan WangAbstractAcrylamide (AA) constitutes an important industrial chemical agent and well-known neurotoxin. However, the mechanism underlying AA-mediated neurotoxicity is extremely complicated and controversial. In this study, we found that activation of the NLR family pyrin domain...
Fri, 01/24/2020 - 03:20
Author(s): Shoufei Yang, Wei Cheng, Xiaolan Li, Fan Liang, Ren Zhou, Hui Wang, Yan Feng, Yan WangAbstractBisphenol AF (BPAF) is a derivative of bisphenol A (BPA) that is widely used in fluorinated polymers, fluorinated rubber, electronic equipment, plastic optical fibers, etc. Studies have shown that BPAF exposure is associated with a number of diseases; however, little is known about the effects...
Sun, 12/29/2019 - 03:22
Author(s): Xiaozhuan Liu, Xue Li, Yuchang Tao, Ning Li, Mengmeng Ji, Xiuli Zhang, Yao Chen, Zhidong He, Kailun Yu, Zengli YuAbstractExposure to environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes cleft palate at high rates, but little is known about the underlying biological mechanisms. In the present study, we cultured osteoblasts from human fetal palate mesenchymal cells (...
Sun, 12/15/2019 - 03:21
Author(s): Raphaël Cornu, Arnaud Béduneau, Hélène MartinAbstractDue to the increasing interest in nanotechnology in very large application fields, including biotechnology, electronics and food industries, humans are increasingly exposed to nanoparticles (NPs). Consequently, the question about the safety of these nanomaterials and their impact on human health is a legitimate concern. The liver is...
Wed, 12/04/2019 - 03:22
Author(s): Pritha Bhattacharjee, Somnath PaulAbstractBackgroundThe study of heritable epigenetic changes in arsenic exposure has intensified over the last decade. Groundwater arsenic contamination causes a great threat to humans and, to date, no accurate measure has been formulated for remediation. The fascinating possibilities of epi-therapeutics identify the need for an in-depth mechanistic...
Sat, 11/23/2019 - 03:22
Author(s): Qun Cheng, Shuzhen Jiang, Libo Huang, Yuxi Wang, Weiren Yang, Zaibin Yang, Jinshan GeAbstractZearalenone (ZEA) contamination of feed affects animal husbandry and the human health. Currently, the molecular mechanism underlying small intestine-related diseases caused by ZEA-induced oxidative stress is not well understood. In this study, we aimed to identify the mechanisms involved in ZEA...
Fri, 11/15/2019 - 03:21
Author(s): Yuting Chen, Yifan Wu, Weiwei Xiao, Hansi Jia, Hansruedi Glatt, Ming Shi, Yungang LiuAbstractPolychlorinated biphenyls (PCBs) are persistent organic pollutants and human carcinogens. It was reported that rat CYP1A1 and catfish CYP1A can hydroxylate 3,3',4,4',5-pentachlorobiphenyl (PCB 126) and 3,3',4,4'-tetrachlorobiphenyl (PCB 77), while potential roles of other CYP1 enzymes in the...
Sat, 11/02/2019 - 03:23
Author(s): Prerna Agarwal, Darshana Singh, S. Raisuddin, Raj KumarAbstractOchratoxin A (OTA) is known to induce nephro-toxicity via induction of cellular redox homeostasis perturbation, mitochondrial hyperpolarisation and depolarization, protein synthesis inhibition leading to apoptosis. In the present study protective efficacy of N-Acetyl-L-Tryptophan (NAT) against OTA induced toxicity was...
Sat, 10/19/2019 - 03:27
Author(s): Kailun Yu, Zengli YuAbstract2,3,7,8-Tetrachlorobenze-p-dioxin (TCDD), one of representive Endocrine Disrupting Chemicals (EDCs), has potential adverse effects on human health. Direct exposure to TCDD has been implicated in ovarian follicles development and functions deficits in adulthood. However, it is rarely reported whether indirect exposure to TCDD can cause similar negative impact...
Sat, 10/05/2019 - 03:24
Author(s): Xue Wang, Liping Jiang, Limin Shi, Kun Yao, Xiance Sun, Guang Yang, Lijie Jiang, Cong Zhang, Ningning Wang, Hongying Zhang, Yan Wang, Xiaofang LiuAbstractZearalenone (ZEA), one of the mycotoxins widely found in food and feed, can stimulate an inflammatory reaction. In the present study, we demonstrated that ZEA induced the activation of NLRP3 inflammasome even pyroptotic cell death in...
Tue, 10/01/2019 - 03:26
Author(s): Jasim Khan, Shikha Salhotra, Poonam Goswami, Juheb Akhtar, Shagufta Jahan, Sakshi Gupta, Shikha Sharma, Basu Dev Banerjee, Suhel Parvez, Sarika Gupta, Sheikh RaisuddinAbstractBisphenol A (BPA) is a ubiquitously distributed endocrine disrupting chemical (EDC). Its exposure in humans has been of concern due to its increased application in the products of day to day use. BPA has been...
Tue, 09/24/2019 - 03:24
Author(s): Melyssa Kmecick, Mariliza Cristine Vieira da Costa, Ciro Alberto de Oliveira Ribeiro, Claudia Feijó Ortolani-MachadoAbstractPerfluorooctanoic acid (PFOA) and cadmium (Cd) are persistent environmental pollutants, bioaccumulative, and capable of crossing the placental barrier. There is evidence of developmental toxicity induced by PFOA and Cd, but their effects on early development are...