Toxicon

Sun, 06/04/2017 - 08:55
Publication date: Available online 3 June 2017 Source: Author(s): Lisa C. Shriver-Lake, Dan Zabetakis, Ellen R. Goldman, George P. Anderson Botulinum neurotoxin (BoNT) is a highly potent and lethal toxin, which even in minute quantities can lead to death. BoNT occurs in seven well described serotypes, A-G, and it is critical to not only detect the presence of BoNT, but also to...
Thu, 05/18/2017 - 11:02
Publication date: Available online 17 May 2017 Source: Author(s): Mari Yotsu-Yamashita, Stefan W. Toennes, Dietrich Mebs Tetrodotoxin (TTX) and its analogues occur in a wide range of marine animals but also in terrestrial vertebrates such as frogs, toads and newts. Despite numerous studies on TTX in New World newts (Notophthalmus viridescens, Taricha spp.), few data only exist for Asian...
Thu, 05/04/2017 - 10:56
Publication date: Available online 3 May 2017 Source: Author(s): Marcela Preliasco, Dale Gardner, Jorge Moraes, Ana Celina González, Gonzalo Uriarte, Rodolfo Rivero The main objectives of this study were to determine the 1,2-dehydropyrrolizidine alkaloid (DHPA) content in Senecio grisebachii Baker (Compositae), to experimentally demonstrate its toxicity in calves and to describe...
Thu, 05/04/2017 - 10:56
Publication date: Available online 3 May 2017 Source: Author(s): Chenglei Fan, Xiao Chu, Lin Wang, Hao Shi, Tieshan Li Arthritis pain affects people's long-term health, and recent studies have demonstrated that transient receptor potential vanilloid type 1 (TRPV1) plays a crucial role in arthritis pain. In addition, Pre-clinical evidence indicated that botulinum toxin type A (BoNT/A...
Thu, 03/02/2017 - 20:26
Publication date: Available online 2 March 2017 Source: Author(s): Ryohei Tatsuno, Wei Gao, Kotaro Ibi, Tomoka Mine, Kogen Okita, Gregory Naoki Nishihara, Tomohiro Takatani, Osamu Arakawa Tetrodotoxin (TTX) was intramuscularly administered to nontoxic cultured specimens of the pufferfish Takifugu rubripes to investigate differences in the toxin transfer and accumulation...
Wed, 03/01/2017 - 20:26
Publication date: Available online 1 March 2017 Source: Author(s): Dongdong Wang, Yuhuan Yue, Guangmou Wu, Yuan Tian, Yuling Liu, Jia Yu, Yuangang Ji, Jinpeng Wang, Jian Li, Rongrong Pan, Hongyuan Ma, Guoli Zhang Alpha-toxin produced by Clostridium perfringens is an important virulence factor, causing food poisoning and gas gangrene in humans. As such, it is considered...
Wed, 02/22/2017 - 20:21
Publication date: Available online 22 February 2017 Source: Author(s): Winston E. Morris, Jorge Goldstein, Leandro M. Redondo, Adriana Cangelosi, Patricia Geoghegan, Marcela Brocco, Fabián C. Loidl, Mariano E. Fernandez-Miyakawa Clostridium perfringens epsilon toxin (ETX), the most potent toxin produced by this bacteria, plays a key role in the pathogenesis of enterotoxaemia...
Tue, 02/14/2017 - 20:03
Publication date: Available online 14 February 2017 Source: Author(s): Victor Ricardo Manuel Muñoz Lora, Juliana Trindade Clemente-Napimoga, Henrique Ballassini Abdalla, Cristina Gomes Macedo, Giancarlo de la Torre Canales, Celia Marissa Rizzatti Barbosa Objective This study aimed to investigate the antinociceptive effects of Botulinum toxin type A (BoNT-A) on persistent...
Tue, 01/17/2017 - 03:01
Publication date: Available online 16 January 2017 Source: Author(s): Lingchen Yang, Di Tu, Zhiyong Zhao, Jun Cui T-2 and HT-2 (T-2/HT-2) induced cytotoxicity and apoptosis in hepatocytes from broilers. In this study, hepatocytes treated with T-2/HT-2 were analyzed for cytotoxic effects and apoptosis and for the associated mechanisms. To assay cytotoxicity, we used the 3-(4, 5-...
Fri, 01/13/2017 - 02:40
Publication date: Available online 12 January 2017 Source: Author(s): Saeed Khalili, Abolfazl Jahangiri, Zahra Sadat Hashemi, Bahman Khalesi, Meysam Mardsoltani, Jafar Amani Epsilon toxin of the Clostridium perfringens garnered a lot of attention due to its potential for toxicity in humans, extreme potency for cytotoxicity in mice and lack of any approved therapeutics prescribed...
Fri, 01/06/2017 - 03:35
Publication date: 25 December 2016 Source:, Volume 123, Supplement Author(s): Phillip H. Beske, Aaron B. Bradford, James B. Machamer, Patrick M. McNutt
Fri, 01/06/2017 - 03:35
Publication date: 25 December 2016 Source:, Volume 123, Supplement Author(s): Ronnie Berntsson, Lisheng Peng, Linda Henriksson, Min Dong, Pål Stenmark
Fri, 01/06/2017 - 03:35
Publication date: 25 December 2016 Source:, Volume 123, Supplement Author(s): Stephane Baudet, Valerie Bellingard, Dina Anderson, Catherine George, Jean-Paul Briffaux, Mikhail Kalinichev
Fri, 01/06/2017 - 03:35
Publication date: 25 December 2016 Source:, Volume 123, Supplement Author(s): Alexander Balbert, Victor Myakotnykh, Boris Bruk, Oksana Strizhakova, Ekaterina Moroshek, Elena Aronskind
Fri, 01/06/2017 - 03:35
Publication date: 25 December 2016 Source:, Volume 123, Supplement Author(s): Lyudmila Antipova, Elena Karanadze
Fri, 01/06/2017 - 03:35
Publication date: 25 December 2016 Source:, Volume 123, Supplement Author(s): Katharine Alter
Fri, 12/23/2016 - 03:18
Publication date: Available online 22 December 2016 Source: Author(s): Meihui Li, Geng Sun, Jiangbing Qiu, Aifeng Li Lipophilic shellfish toxins (LSTs) produced by diverse microalgae have become a potential threat to the marine aquaculture industry in coastal regions throughout the world. In this study, phytoplankton, scallop, and seawater samples were collected and monitored in the...
Sat, 12/10/2016 - 17:14
Publication date: January 2017 Source:, Volume 125 Author(s): Rebecca Coleman, Sharon W. Lemire, William Bragg, Alaine Garrett, Geovannie Ojeda-Torres, Elizabeth Hamelin, Rudolph C. Johnson, Jerry Thomas
Thu, 12/01/2016 - 02:48
Publication date: Available online 30 November 2016 Source: Author(s): Juan José Dorantes-Aranda, Katrina Campbell, Andrew Bradbury, Christopher T. Elliott, D. Tim Harwood, Shauna A. Murray, Sarah C. Ugalde, Katrina Wilson, Megan Burgoyne, Gustaaf M. Hallegraeff Blooms of the toxic dinoflagellate Alexandrium tamarense (Group 1) seriously impacted the Tasmanian shellfish...
Sat, 11/12/2016 - 11:12
Publication date: Available online 11 November 2016 Source: Author(s): Hina Satone, Shohei Nonaka, Jae Man Lee, Yohei Shimasaki, Takahiro Kusakabe, Shun-ichiro Kawabata, Yuji Oshima We investigated the ability of recombinant pufferfish saxitoxin and tetrodotoxin binding protein types 1 and 2 of Takifugu rubripes (rTrub.PSTBP1 and rTrub.PSTBP2) to bind to tetrodotoxin (TTX) and...
Thu, 11/10/2016 - 11:11
Publication date: Available online 9 November 2016 Source: Author(s): Tieshan Li, Lin Wang, Kaile Wang, Xiao Chu, Nana Shen, Chenglei Fan, Zhenyuan Niu, Xiaochen Zhang, Luoman Hu Currently, administration of Botulinum toxin Type A (BoNT/A) to treat arthritic pain has promising efficacy in clinical research. However, the mechanisms underlying anti-neurogenic inflammation...
Thu, 11/10/2016 - 11:11
Publication date: Available online 10 November 2016 Source: Author(s): Magdalena Gajęcka, Michał Tarasiuk, Łukasz Zielonka, Michał Dąbrowski, Jakub Nicpoń, Mirosław Baranowski, Maciej Tadeusz Gajęcki The aim of this study was to determine whether exposure to low doses of ZEN + DON induces changes in serum biochemical and hematological parameters in pre-pubertal gilts. In the...
Thu, 10/27/2016 - 17:51
Publication date: October 2016 Source:, Volume 121 Author(s): Olga I. Belykh, Irina V. Tikhonova, Anton V. Kuzmin, Ekaterina G. Sorokovikova, Galina A. Fedorova, Igor V. Khanaev, Tatyana A. Sherbakova, Oleg A. Timoshkin Cyanobacteria were screened from the surface of diseased sponges, stone and bedrock in Lake Baikal for the presence of saxitoxin using enzyme-linked...
Thu, 10/27/2016 - 17:51
Publication date: October 2016 Source:, Volume 121 Author(s): P. Caballero, M. Troncoso, S.I. Patterson, C. López Gómez, R. Fernandez, M.A. Sosa The type A of neurotoxin produced by Clostridium botulinum is the prevalent serotype in strains of Mendoza. The soil is the main reservoir for C.botulinum and is possibly one of the infection sources in infant botulism. In this study, we...

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