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Research Publications (Food Safety)

This page tracks research articles published in national and international peer-reviewed journals. Recent articles are available ahead of print and searchable by Journal, Article Title, and Category. Research publications are tracked across six categories: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, Produce Safety, and Viruses. Articles produced by USDA Grant Funding Agencies (requires login) and FDA Grant Funding Agencies (requires login) are also tracked in Scopus.

Displaying 126 - 150 of 615

  1. The type 3 secretion effector IpgD promotes S. flexneri dissemination

    • PLOS Pathogens
    • by Volkan K. Köseoğlu, Marieke K. Jones, Hervé Agaisse The bacterial pathogen Shigella flexneri causes 270 million cases of bacillary dysentery worldwide every year, resulting in more than 200,000 deaths. S. flexneri pathogenic properties rely on its ability to invade epithelial cells and spread from cell to cell within the colonic epithelium.

      • Bacterial pathogens
      • Shigella
  2. Gastrointestinal Autonomic Neuropathy Exacerbates Gut Microbiota Dysbiosis in Adult Patients With Type 2 Diabetes Mellitus

    • Frontiers in Cellular and Infection Microbiology
    • The diabetic autonomic neuropathy is one of the most common complications in type 2 diabetes mellitus (T2DM), especially gastrointestinal autonomic neuropathy (GAN), which occurs in up to 75% of patients.

      • Bacterial pathogens
      • Shigella
  3. The Chemical Structure Properties and Promoting Biofilm Activity of Exopolysaccharide Produced by Shigella flexneri

    • Frontiers in Microbiology
    • Shigella flexneri is a waterborne and foodborne pathogen that can damage human health. The exopolysaccharides (S-EPS) produced by S. flexneri CMCC51574 were found to promote biofilm formation and virulence. In this research, the crude S-EPS produced by S. flexneri CMCC51574 were separated into three main different fractions, S-EPS 1-1, S-EPS 2-1, and S-EPS 3-1. The structure of the S-ESP 2-1 was identified by FT-IR, ion chromatography analysis, methylation analysis, and NMR analysis.

      • Bacterial pathogens
      • Shigella
  4. An in silico hierarchal approach for drug candidate mining and validation of natural product inhibitors against pyrimidine biosynthesis enzyme in the antibiotic-resistant Shigella flexneri

    • Infection, Genetics and Evolution
    • Shigella flexneri is the main causative agent of the communicable diarrheal disease, shigellosis. It is estimated that about 80–165 million cases and > 1 million deaths occur every year due to this disease. S. flexneri causes dysentery mostly in young children, elderly and immunocompromised patients, all over the globe. Recently, due to the emergence of S.

      • Bacterial pathogens
      • Shigella
  5. The influence of food processing methods on serum parameters, apparent total-tract macronutrient digestibility, fecal microbiota and SCFA content in adult beagles

    • PLOS ONE
    • by Xuan Cai, Rongrong Liao, Guo Chen, Yonghong Lu, Yiqun Zhao, Yi Chen Food processing methods may influence the health of dogs. However, previous studies have mostly been based on a comparison of several commercial dog foods with different ingredients. In this study, eighteen adult beagles of the same age and health status (assessed by routine blood tests) were used in the experiments.

      • Bacterial pathogens
      • Shigella
  6. Efficient production of immunologically active Shigella invasion plasmid antigens IpaB and IpaH using a cell-free expression system

    • Applied Microbiology and Biotechnology
    • Abstract Shigella spp. invade the colonic epithelium and cause bacillary dysentery in humans. Individuals living in areas that lack access to clean water and sanitation are the most affected. Even though infection can be treated with antibiotics, Shigella antimicrobial drug resistance complicates clinical management. Despite decades of effort, there are no licensed vaccines to prevent shigellosis.

      • Bacterial pathogens
      • Shigella
  7. The type III secretion system effector network hypothesis

    • Trends in Microbiology
    • Type III secretion system (T3SS) effectors are key virulence factors that underpin the infection strategy of many clinically important Gram-negative pathogens, including Salmonella enterica, Shigella spp., enteropathogenic and enterohemorrhagic Escherichia coli and their murine equivalent, Citrobacter rodentium. The cellular processes or proteins targeted by the effectors can be common to multiple pathogens or pathogen-specific.

      • Bacterial pathogens
      • Salmonella
      • Shigella
  8. Effect of Lotus Seed Resistant Starch on Lactic Acid Conversion to Butyric Acid Fermented by Rat Fecal Microbiota

    • Journal of Agricultural and Food Chemistry
    • The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway. According to growth curves, the microbiota compositions at 10 and 36 h were further analyzed. The microbiota in the LRS group had higher richness and diversity compared to glucose (GLU) and high amylose maize starch (HAMS).

      • Bacterial pathogens
      • Shigella
  9. Examination of Australian backyard poultry for Salmonella, Campylobacter and Shigella spp., and related risk factors

    • Zoonoses and Public Health
    • Zoonoses and Public Health, Volume 69, Issue 1, Page 13-22, February 2022. Worldwide, foodborne illness is a significant public health issue in both developed and developing countries. Salmonellosis, campylobacteriosis and shigellosis are common foodborne gastrointestinal illnesses caused by the bacteria Salmonella spp., Campylobacter spp. and Shigella spp. respectively.

      • Bacterial pathogens
      • Campylobacter
      • Salmonella
      • Shigella
  10. Development of a loop‐mediated isothermal amplification assay for molecular serotyping of Shigella flexneri Serotypes 2 and Xv

    • Journal of Applied Microbiology
    • Journal of Applied Microbiology, EarlyView. Aims This study developed and evaluated a loop-mediated isothermal amplification (LAMP) assay to simply, rapidly and accurately identify Shigella flexneri serotypes 2 and Xv. Methods and Results The LAMP assay based on the O-antigen synthesis and modification genes of Sflexneri including gtrIIgtrXopt and wzx&nbsp

      • Bacterial pathogens
      • Shigella
  11. Effect of Lotus Seed Resistant Starch on Lactic Acid Conversion to Butyric Acid Fermented by Rat Fecal Microbiota

    • Journal of Agricultural and Food Chemistry
    • The aim was to investigate the effect of lotus seed resistant starch (LRS) on lactic acid (LA) conversion to butyric acid (BA) fermented by rat fecal microbiota to construct an acetyl CoA pathway. According to growth curves, the microbiota compositions at 10 and 36 h were further analyzed. The microbiota in the LRS group had higher richness and diversity compared to glucose (GLU) and high amylose maize starch (HAMS).

      • Shigella
      • Bacterial pathogens
  12. Gut Microbiome Distinguishes Patients With Epilepsy From Healthy Individuals

    • Frontiers in Microbiology
    • Objective: The gut microecosystem is the largest microecosystem in the human body and has been proven to be linked to neurological diseases. The main objective of this study was to characterize the fecal microbiome, investigate the differences between epilepsy patients and healthy controls, and evaluate the potential efficacy of the fecal microbiome as a diagnostic tool for epilepsy.

      • Shigella
      • Bacterial pathogens
  13. Diallyl Disulfide (DADS) Ameliorates Intestinal Candida albicans Infection by Modulating the Gut microbiota and Metabolites and Providing Intestinal Protection in Mice

    • Frontiers in Cellular and Infection Microbiology
    • Diallyl disulfide (DADS), a garlic extract also known as allicin, has been reported to have numerous biological activities, including anticancer, antifungal, and inflammation-inhibiting activities, among others. Although many studies have assessed whether DADS can treat Candida albicans infection in vitro, its in vivo function and the underlying mechanism are still not clear. Accumulated evidence has implicated the gut microbiota as an important factor in the colonization and invasion of C.

      • Shigella
      • Bacterial pathogens
  14. A Novel Bacteriocin Against Shigella flexneri From Lactiplantibacillus plantarum Isolated From Tilapia Intestine: Purification, Antibacterial Properties and Antibiofilm Activity

    • Frontiers in Microbiology
    • Few bacteriocins with antibacterial activity against Shigella flexneri have been reported. Here, a novel bacteriocin (LFX01) produced by Lactiplantibacillus plantarum strain LF-8 from the intestine of tilapia was purified and extensively characterized. LFX01 possesses a molecular weight of 1049.56 Da and an amino acid sequence of I-T-G-G-P-A-V-V-H-Q-A. LFX01 significantly inhibited S. flexneri strain 14 (S. flexneri_14) growth.

      • Shigella
      • Bacterial pathogens
  15. Bacteroides Microbial Source Tracking Markers Perform Poorly in Predicting Enterobacteriaceae and Enteric Pathogen Contamination of Cow Milk Products and Milk-Containing Infant Food

    • Frontiers in Microbiology
    • Consumption of microbiologically contaminated food is one of the leading causes of diarrheal diseases. Understanding the source of enteric pathogens in food is important to guide effective interventions. Enterobacteriaceae bacterial assays typically used to assess food safety do not shed light on the source.

      • Bacterial pathogens
      • Salmonella
      • Shigella
  16. Efficient production of immunologically active Shigella invasion plasmid antigens IpaB and IpaH using a cell-free expression system

    • Applied Microbiology and Biotechnology
    • Abstract Shigella spp. invade the colonic epithelium and cause bacillary dysentery in humans. Individuals living in areas that lack access to clean water and sanitation are the most affected. Even though infection can be treated with antibiotics, Shigella antimicrobial drug resistance complicates clinical management. Despite decades of effort, there are no licensed vaccines to prevent shigellosis.

      • Bacterial pathogens
      • Shigella
  17. Yeast β-Glucan Altered Intestinal Microbiome and Metabolome in Older Hens

    • Frontiers in Microbiology
    • The prebiotics- and probiotics-mediated positive modulation of the gut microbiota composition is considered a useful approach to improve gut health and food safety in chickens. This study explored the effects of yeast β-glucan (YG) supplementation on intestinal microbiome and metabolites profiles as well as mucosal immunity in older hens. A total of 256 43-week-old hens were randomly assigned to two treatments, with 0 and 200 mg/kg of YG.

      • Bacterial pathogens
      • Shigella
  18. The evolutionary history of Shigella flexneri serotype 6 in Asia

    • Microbiology
    • serotype 6 is an understudied cause of diarrhoeal diseases in developing countries, and has been proposed as one of the major targets for vaccine development against shigellosis.

      • Shigella
      • Bacterial pathogens
  19. Cluster-specific gene markers enhance Shigella and enteroinvasive Escherichia coli in silico serotyping

    • Microbiology
    • and enteroinvasive (EIEC) cause human bacillary dysentery with similar invasion mechanisms and share similar physiological, biochemical an

      • Shigella
      • Bacterial pathogens
  20. Characteristics of Fecal Microbiota and Machine Learning Strategy for Fecal Invasive Biomarkers in Pediatric Inflammatory Bowel Disease

    • Frontiers in Cellular and Infection Microbiology
    • Background

      Early diagnosis and treatment of pediatric Inflammatory bowel disease (PIBD) is challenging due to the complexity of the disease and lack of disease specific biomarkers. The novel machine learning (ML) technique may be a useful tool to provide a new route for the identification of early biomarkers for the diagnosis of PIBD.

      Methods

      • Bacterial pathogens
      • Shigella
  21. ECTyper: in silico Escherichia coli serotype and species prediction from raw and assembled whole-genome sequence data

    • Microbiology
    • is a priority foodborne pathogen of public health concern and phenotypic serotyping provides critical information for surveillance and outbreak detection activities.

      • Shigella
      • Bacterial pathogens
  22. Development of a Loop‐Mediated Isothermal Amplification Assay for Molecular Serotyping of Shigella flexneri Serotypes 2 and Xv

    • Journal of Applied Microbiology
    • Journal of Applied Microbiology, Accepted Article. Aims
      This study developed and evaluated a loop-mediated isothermal amplification assay to simply, rapidly and accurately identify Shigella flexneri serotypes 2 and Xv.

      • Shigella
      • Bacterial pathogens
  23. A Predictive Model Based on the Gut Microbiota Improves the Diagnostic Effect in Patients With Cholangiocarcinoma

    • Frontiers in Cellular and Infection Microbiology
    • Cholangiocarcinoma (CCA) is a malignant hepatic tumor with a poor prognosis, which needs early diagnosis urgently. The gut microbiota has been shown to play a crucial role in the progression of liver cancer. Here, we explored a gut microbiota model covering genera Burkholderia-Caballeronia-Paraburkholderia, Faecalibacterium, and Ruminococcus_1 (B-F-R) for CCA early diagnosis. A case-control study was conducted to enroll 53 CCA patients, 47 cholelithiasis patients, and 40 healthy controls.

      • Bacterial pathogens
      • Shigella
  24. Propionic Acid and Sodium Benzoate Affected Biogenic Amine Formation, Microbial Community, and Quality of Oat Silage

    • Frontiers in Microbiology
    • Investigating the microbial communities and biogenic amine (BA) formation in silage is of vital for improving the quality and safety of oat silage. The present study evaluated the effects of propionic acid (P) and sodium benzoate (SB) on the quality properties, microbial communities, and BA formation in oat silage. Oat was harvested at boot stage and ensiled using P and SB as additives in mini silos, followed by 14 days of aerobic exposure.

      • Shigella
      • Bacterial pathogens
  25. Development of a Self-Adjuvanting, Cross-Protective, Stable Intranasal Recombinant Vaccine for Shigellosis

    • ACS Infectious Diseases
    • With the acquirement of antibiotic resistance, Shigella has resulted in multiple epidemics of shigellosis, an infectious diarrheal disease, causing thousands of deaths per year. Unfortunately, there are no licensed vaccines, primarily due to low or serotype-specific immunogenicity. Thus, conserved subunit vaccines utilizing recombinant invasion plasmid antigens (Ipa) have been explored as cross-protective vaccine candidates.

      • Shigella
      • Bacterial pathogens