Bacterial pathogens

Sat, 09/21/2019 - 03:33
Author(s): D. Fonseca e Silva, A. Silva-Dias, R. Gomes, I. Martins-Oliveira, M.H. Ramos, A.G. Rodrigues, R. Cantón, C. Pina-VazAbstractObjectivesThe accurate assessment of antimicrobial susceptibility of colistin is crucial with the increasing number of multi-drug resistant Gram-negative bacteria and simultaneous increasing of colistin resistance. Both EUCAST and CLSI recommend broth...
Sat, 09/21/2019 - 03:33
Author(s): Dishon Muloi, John Kiiru, Melissa J. Ward, James M. Hassell, Judy M. Bettridge, Timothy P. Robinson, Bram A.D. van Bunnik, Margo Chase-Topping, Gail Robertson, Amy B Pedersen, Eric M. Fèvre, Mark E.J. Woolhouse, Erastus K. Kang'ethe, Samuel KariukiAbstractThere are substantial limitations in our understanding of the distribution of antibiotic resistance (AMR) in humans and livestock in...
Sat, 09/21/2019 - 03:33
Author(s): Luís G.A. Longo, Viviane S. de Sousa, Gabriela B. Kraychete, Lívia H. Justo-da-Silva, Jaqueline A. Rocha, Silvana V. Superti, Raquel R. Bonelli, Ianick S. Martins, Beatriz M. MoreiraAbstractKlebsiella pneumoniae is an important human pathogen, able to accumulate and disseminate a variety of antimicrobial resistance genes. Resistance to colistin, one of the last therapeutic options for...
Sat, 09/21/2019 - 03:33
Author(s): Yu-Lin Lee, Min-Chi Lu, Pei-Lan Shao, Po-Liang Lu, Yen-Hsu Chen, Shu-Hsing Cheng, Wen-Chien Ko, Chi-Ying Lin, Ting-Shu Wu, Muh-Yong Yen, Lih-Shinn Wang, Chang-Pan Liu, Wen-Sen Lee, Zhi-Yuan Shi, Yao-Shen Chen, Fu-Der Wang, Shu-Hui Tseng, Chao-Nan Lin, Yu-Hui Chen, Wang-Huei ShengABSTRACTMulticentre surveillance of antimicrobial susceptibility of clinically important Gram-negative...
Sat, 09/21/2019 - 03:33
Author(s): Rafael Ortega-Huedo, Marina Cuesta, Andreas Hoefer, Bruno Gonzalez-ZornAbstractBackgroundInfectious pathogens harboring cephalosporin or fluoroquinolones resistance constitute a serious hazard to human health.ObjectivesThe aim of this study is to set up a methodology based on econometric analysis and largest European Union (EU) resistance database (EARS-Net) to model EU nosocomial...
Sat, 09/21/2019 - 03:33
Author(s): Olivier Barraud, Céline Ravry, Bruno François, Thomas Daix, Marie-Cécile Ploy, Philippe VignonAbstractIn sepsis, early and appropriate antibiotic therapy is key but frequently challenging due to increasing incidence of multidrug-resistant bacteria. Shotgun metagenomics (SM) feasibility has been scarcely assessed in urinary tract infections (UTI). We evaluated the feasibility of SM to...
Sat, 09/21/2019 - 03:33
Author(s): Lingyan Jiang, Xiaomin Li, Runxia Lv, Lu FengAbstractSalmonella enterica serovar Typhimurium uses virulence factors encoded by Salmonella pathogenicity island 1 (SPI-1) to invade the intestinal epithelium. The low oxygen-induced transcriptional regulator LoiA is established to be a positive regulator of SPI-1 genes and can also repress the expression of the ATP-dependent Lon protease,...
Sat, 09/21/2019 - 03:33
Author(s): Marie-Christine Etty, Sabato D'Auria, Carole Fraschini, Stephane Salmieri, Monique LacroixAbstractThis paper presents the effects of the composition of different media (i.e., Tryptic soy broth (TSB), Brain heart infusion (BHI), Listeria enrichment broth (LEB), Fraser broth (FB) and University of Vermont medium (UVM)) on the detection of a short peptide fragment PepD specific to the p60...
Sat, 09/21/2019 - 03:32
Author(s): Alisha Wehdnesday Bernardo Reyes, Lauren Togonon Arayan, Tran Xuan Ngoc Huy, Son Hai Vu, Chang Keun Kang, Wongi Min, Hu Jang Lee, John Hwa Lee, Suk KimAbstractWe investigated the involvement of chemokine receptor type 4 (CXCR4) signaling on the outcome of Brucella (B.) abortus 544 infection in murine macrophages and in a mouse model. CXCR4 manipulation were first evaluated for Brucella...
Sat, 09/21/2019 - 03:32
Author(s): Kofi Britwum, Amalia YiannakaAbstractThe study examines the impact of gain and loss message framing and issue involvement elicitation on consumer willingness to pay (WTP) for two food safety enhancing technologies; cattle vaccines against E. coli and direct-fed microbials. A random sample of 1,842 US consumers completed a survey instrument that included six information treatments and a...
Sat, 09/21/2019 - 03:32
Author(s): Saber Esmaeili, Fahimeh Bagheri Amiri, Hamid Mokhayeri, Mohammad Hassan Kayedi, Max Maurin, Mahdi Rohani, Ehsan MostafaviAbstractMost zoonoses are occupational diseases. Q fever, brucellosis and tularemia are major zoonotic diseases for butchers and slaughterhouse workers. However, little information is available about these infectious diseases in such professional populations in...
Sat, 09/21/2019 - 03:32
Author(s): Maria Luisa Menandro, Giorgia Dotto, Alessandra Mondin, Marco Martini, Letizia Ceglie, Daniela PasottoAbstractThe aim of this study was to assess the prevalence, the genotypic diversity, the antimicrobial resistance traits of canine and feline clinical methicillin-resistant Staphylococcus pseudintermedius (MRSP) isolates in a diagnostic laboratory in Italy during 2015-2016.All isolates...
Sat, 09/21/2019 - 03:32
Author(s): Gamal A Elmowalid, Marwa I Abd El-Hamid, Ashraf M Abd El-Wahab, Mohammad Atta, Gamal Abd El-Naser, Adel M AttiaAbstractAdministration of antibiotics as feed additives in broilers resulted in prompting of some undesirable effects such as the rising emergence of multi-drug resistant (MDR) bacteria, so scrutinizing for new alternatives like herbs is the up to date task for global health....
Sat, 09/21/2019 - 03:32
Author(s): J. Filipe, V. Bronzo, G. Curone, B. Castiglioni, D. Vigo, B. Smith, V. Herrera, P. Roccabianca, P. Moroni, F. RivaAbstractIL-1R8 is a member of Interleukin-1 receptor family acting as a negative regulator of inflammation reliant on ILRs and TLRs activation. IL-1R8 role has never been evaluated in acute bacterial mastitis. We first investigated IL-1R8 sequence conservation among...
Sat, 09/21/2019 - 03:32
Author(s): Juliana Marzari Rossato, Terimar Ruoso Moresco, Juliano Uczay, João Batista Teixeira da RochaAbstractInvertebrates have been instrumental in understanding the mechanisms involved in infectious diseases, considering the idea to replace, reduce and refine the use of mammals as well as to understand the basic principles of immune response in insect. We evaluated the consequences of...
Sat, 09/21/2019 - 03:32
Author(s): Sobia Kanwal, Zobia Noreen, Vajeeha Aalam, Junaid Akhtar, Fariha Masood, Sundus Javed, Habib BokhariAbstractCampylobacter jejuni is a major cause of infectious diarrhea in humans. The bacterium can be transmitted through contaminated poultry meat and waste water. We report the presence of C. jejuni from potential transmission sources including egg shells, poultry waste, waste water and...
Sat, 09/21/2019 - 03:31
Author(s): Jung E. Park, Ejaz A. Shamim, Pattamon Panyakaew, Pawan Mathew, Camilo Toro, Jonathan Sackett, Barbara Karp, Codrin Lungu, Katharine Alter, Tianxia Wu, Omar F. Ahmad, Monica Villegas, Sungyoung Auh, Mark HallettAbstractBackgroundWriter's cramp (WC) is a form of focal hand dystonia, for which focal botulinum neurotoxin (BoNT) injections are the current best therapy. Past studies have...
Sat, 09/21/2019 - 03:31
Author(s): Aditi Gangopadhyay, Hirak Jyoti Chakraborty, Abhijit DattaAbstractCholera is a major global threat, affecting millions each year. The ADP ribosyltransferase activity of the active cholera toxin catalyses the massive loss of water and electrolytes during cholera infections. The active toxin heterodimer comprises the A1 subunit from Vibrio cholerae and ARF (ADP Ribosylation Factor) from...
Sat, 09/21/2019 - 03:30
We performed a literature search for English research papers, published between 2013 and 2018, reporting on plasmid‐mediated carbapenem resistance. A rise in both carbapenemase types and associated plasmid replicon groups was seen, with China, Canada, and the United States recording a higher increase than other countries. Most reported plasmids were conjugative but not present in multiple...
Sat, 09/21/2019 - 03:30
Brucellosis is a highly contagious zoonosis affecting humans and a wide range of domesticated and wild animal species. An important element for effective disease containment is to improve knowledge, attitudes and practices (KAP) of afflicted communities. This study aimed to assess the KAP related to brucellosis at the human–animal interface in an endemic area of Egypt and to identify the risk...
Sat, 09/21/2019 - 03:30
Clostridium difficile is considered the leading cause of antibiotic‐associated disease worldwide. In the past decade, a large number of studies have focused on identifying the main sources of contamination in order to elucidate the complete life cycle of the infection. Hospitals, animals and retail foods have been considered as potential vectors. However, the prevalence of C. difficile in these...
Sat, 09/21/2019 - 03:30
Leptospirosis is a bacterial disease that represents a major problem in animal and public health due to its high prevalence and widespread distribution. This zoonotic disease is most prevalent in tropical environments where conditions favour pathogen survival. The ecological preferences of Leptospira serovars are poorly understood, limiting our knowledge of where and when outbreaks can occur,...
Sat, 09/21/2019 - 03:30
The native Eurasian wild boar (Sus scrofa) is a reservoir of Mycobacterium bovis, the causative agent of animal tuberculosis (TB), a chronic disease in livestock, companion animals and wild mammals. Cases of M. bovis infection in wild boar or feral pig have been reported worldwide, making early detection a priority in the eradication of the disease. Point‐of‐care diagnostic tests, such as low...
Sat, 09/21/2019 - 03:30
Recent emergence of mcr‐1‐positive Escherichia coli (MCRPEC) is causing serious concern around the world. Due to poultry‐origin E. coli holding zoonotic potential, the improved understandings of MCRPEC population structure and antimicrobial resistance are critical to public health purposes. This study provided novel insights into the molecular epidemiology of avian‐origin MCRPEC. For the mcr...
Sat, 09/21/2019 - 03:30
The number of natural infections with Mycobacterium caprae in wildlife and in cattle in the Bavarian and Austrian alpine regions has increased over the last decade. Red deer (Cervus elaphus) have been recognized as maintenance reservoir, however, the transmission routes of M. caprae among and from naturally infected red deer are unknown. The unexpected high prevalence in some hot spot regions...
Sat, 09/21/2019 - 03:30
Despite of controls and preventive measures implemented along the food chain, infection with non‐typhoidal Salmonella (NTS) remains one of the major causes of foodborne disease worldwide. Poultry is considered one of the major sources of NTS. This has led to the implementation of monitoring and control programmes in many countries (including Spain) to ensure that in poultry flocks infection is...
Sat, 09/21/2019 - 03:30
Leptospirosis presents a complex and dynamic epidemiology. Bovine leptospirosis has been described as a major infectious disease impairing reproductive efficiency. Although infections by Leptospira interrogans, L. santarosai and L. borgpetersenii are frequently reported in cattle, the presence of L. noguchii in these animals should not be neglected. In this study, we describe serological (MAT)...
Sat, 09/21/2019 - 03:30
The occurrence of multidrug‐resistant zoonotic bacteria in animals has been increasing worldwide. Working in close contact with livestock increases the risk of carriage of these bacteria. We investigated the occurrence of extended‐spectrum beta‐lactamase (ESBL) and plasmidic AmpC beta‐lactamase producing Enterobacteriaceae (ESBL/pAmpC‐PE) and livestock‐associated methicillin‐resistant...
Sat, 09/21/2019 - 03:29
Fish‐eating birds prey and scavenge on catfish ponds with outbreaks of an emergent, atypical Aeromonas hydrophila (AAH) and may play a critical role in the pond‐to‐pond spread of AAH. The objectives of this study were to: (a) determine if great egrets that consumed AAH‐infected fish shed enough AAH in their feces to cause a disease outbreak and (b) determine the environmental factor(s) and animal...
Thu, 09/19/2019 - 14:29
Available online 13 September 2019 Author(s): Nan Ling, Jinling Shen, Jingjing Guo, Dexin Zeng, Jianluan Ren, Lixin Sun, Yuan Jiang, Feng Xue, Jianjun Dai, Baoguang LiAbstractVibrio parahaemolyticus is an important human pathogen causing a variety of life-threatening diseases and is widely distributed in marine and estuarine environments. The objective of this study was to develop a sensitive,...
Thu, 09/19/2019 - 14:29
Publication date: March 2020 , Volume 109Author(s): Quan Wang, MengYao Long, CaiYun Lv, SiPei Xin, XianGan Han, Wei JiangAbstractA simple, rapid, highly sensitive, and quantitative fluorescence-based immunochromatographic test (ICT) was successfully developed for the determination of Escherichia coli O157:H7 in food samples. Europium (III) chelated nanoparticles (EuNPs) conjugated to monoclonal...
Thu, 09/19/2019 - 14:29
Available online 16 September 2019 Author(s): Yawen Lin, Jeyamkondan Subbiah, Long Chen, Tushar Verma, Yanhong LiuAbstractThis study validated the radio frequency assisted traditional thermal processing (RF assisted-TTP) for pasteurization of low-moisture foods. Powdered infant formula milk (PIFM) with water activity of 0.22 ± 0.01 was selected as a low-moisture food model. The cold spot during...
Thu, 09/19/2019 - 11:00
Type VI secretion systems (T6SSs) are highly conserved and complex protein secretion systems that deliver effector proteins into eukaryotic hosts or other bacteria. T6SSs are regulated precisely by a variety of regulatory systems, which enables bacteria to adapt to varied environments. A T6SS within Salmonella pathogenicity island 6 (SPI-6) is activated during infection, and it contributes to the...
Thu, 09/19/2019 - 11:00
Infection with Coxiella burnetii, the causative agent of Q fever, can result in life-threatening persistent infection. Reactogenicity hinders worldwide implementation of the only licensed human Q fever vaccine. We previously demonstrated long-lived immunoreactivity in individuals with past symptomatic and asymptomatic Coxiella infection (convalescents) to promiscuous HLA class II C. burnetii...
Thu, 09/19/2019 - 11:00
In this study, a novel recombinant attenuated Yersinia pseudotuberculosis PB1+ strain (10069) engineered with yopK yopJ asd triple mutations was used to deliver a Y. pestis fusion protein, YopE amino acid 1 to 138-LcrV (YopENt138-LcrV), to Swiss Webster mice as a protective antigen against infections by yersiniae. 10069 bacteria harboring the pYA5199 plasmid constitutively synthesized the...
Thu, 09/19/2019 - 11:00
Enteropathogenic Escherichia coli (EPEC) is a leading cause of moderate to severe diarrhea among young children in developing countries, and EPEC isolates can be subdivided into two groups. Typical EPEC (tEPEC) bacteria are characterized by the presence of both the locus of enterocyte effacement (LEE) and the plasmid-encoded bundle-forming pilus (BFP), which are involved in adherence and...
Thu, 09/19/2019 - 11:00
To successfully colonize host tissues, bacteria must respond to and detoxify many different host-derived antimicrobial compounds, such as nitric oxide (NO). NO has direct antimicrobial activity through attack on iron-sulfur (Fe-S) cluster-containing proteins. NO detoxification plays an important role in promoting bacterial survival, but it remains unclear if repair of Fe-S clusters is also...
Thu, 09/19/2019 - 00:00
Toxins, Vol. 11, Pages 543: Genomic Analysis of Clostridium perfringens BEC/CPILE-Positive, Toxinotype D and E Strains Isolated from Healthy Children Toxins doi: 10.3390/toxins11090543 Authors: Raymond Kiu Kathleen Sim Alex Shaw Emma Cornwell Derek Pickard J. Simon Kroll Lindsay J. Hall Clostridium perfringens toxinotype D, toxinotype E, and gastroenteritis-linked BEC/CPILE-...
Wed, 09/18/2019 - 03:00
Journal of Food Protection, Volume 82, Issue 10, Page 1683-1687, October 2019.
Wed, 09/18/2019 - 01:03
Available online 16 September 2019 Author(s): Da-young Jeon, Su-jin Yum, Dong Woo Seo, Seung Min Kim, Hee Gon JeongAbstractPerilla (Perilla frutescens) is a commonly consumed herb with various health benefits in Asia. However, the risks of food-borne illness owing to the presence of pathogens on perilla leaves have not been evaluated. In this study, we evaluated the microbiota of perilla leaves...
Tue, 09/17/2019 - 20:00
Nitric oxide (NO) plays a major role in the regulation of mammalian biological functions. In recent years, NO has also been implicated in bacterial life cycles, including in the regulation of biofilm formation, and the metabolism of the bacterial second messenger signaling molecule cyclic-di-GMP. In a previous study, we reported the discovery of an NO-responsive quorum sensing (QS) circuit in...
Tue, 09/17/2019 - 20:00
Coxiella burnetii is the causative agent of the zoonotic disease Q fever. To date, the lipopolysaccharide (LPS) is the only defined and characterized virulence determinant of C. burnetii. In this study, proteome profiles of C. burnetii Nine Mile phase I (RSA 493, NMI) and its isogenic Nine Mile phase II (RSA 439 NMII) isolate with a deep rough LPS were compared on L-929 mouse fibroblasts and in...
Tue, 09/17/2019 - 17:00
Douglas Barker, Karen T. Gillum, Nancy A. Niemuth, Shantha Kodihalli Botulism neurotoxins are highly toxic and are potential agents for bioterrorism. The development of effective therapy is essential to counter the possible use of these toxins in military and bioterrorism scenarios, and to provide treatment in cases of natural intoxication. Guinea pigs were intoxicated with a lethal dose of...

Pages