Antibiotic residues

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Tue, 06/15/2021 - 16:00
Antibiotic bacterial residue is a unique hazardous waste, and its safe and effective disposal has always been a concern of pharmaceutical enterprises. This report presents the effective treatment of hazardous waste—antibiotic bacterial residue—by black soldier fly larvae (larvae), oxytetracycline bacterial residue (OBR), and soya meal with mass ratios of 0:1 (soya), 1:20 (OBRlow), and 1:2 (...
Sun, 06/13/2021 - 04:03
A new microfluidic approach using hybrid magnetoliposomes (h-MLs) containing hydrophobic magnetic nanoparticles (Fe3O4@AuNPs-C12SH) and encapsulated N-acetylcysteine has been developed in this research to determine aminoglycoside antibiotic (AAG) residues in food using o-phthalaldehyde. Four AAGs, kanamycin, streptomycin, gentamicin, and neomycin, have been used as model analytes. The h-MLs have...
Sat, 06/12/2021 - 06:28
Author(s): Qin Wu, Muhammad Abu Bakr Shabbir, Dapeng Peng, Zonghui Yuan, Yulian Wang This present study was designed to develop a novel microbiological inhibition-based method for the rapid screening and identification of antibiotic residues in milk, chicken egg and honey. Geobacillus stearothermophilus C953 was used as test bacterium in the detection system of this study. The optimization of...
Fri, 06/11/2021 - 02:03
Polychlorinated biphenyls (PCBs) are a group of highly toxic endocrine-disrupting chemicals comprising 209 homologs. PCBs are extensively found in the environment and can induce typical estrogenic and profound, long-lasting effects on animals. In this article, the introduction of PCB residues into the environment and the pathways of PCB enrichment in animals are described. PCBs are widely...
Wed, 06/09/2021 - 00:00
Hospital sewage constitutes an important point source for antibiotics and antibiotic-resistant bacteria due to the high antibiotic use. Antibiotic resistance can develop and cause problems in sewage systems within hospitals and municipal wastewater treatment plants, thus, interventions to treat hospital sewage on-site are important. Ozonation has proven effective in treating relatively clean...
Tue, 06/08/2021 - 02:02
A rapid, simple, and sensitive method of detecting veterinary drug residues in animal food sources, including poultry and pork, was developed and validated. The method was optimized for over 155 veterinary drugs of 21 different classes. Sample pretreatment included a simple solid-liquid extraction step with 0.2% formic acid-acetonitrile-water and a purification step with a PRiME HLB (hydrophile-...
Mon, 06/07/2021 - 06:10
Author(s): Delia Castilla-Fernández, David Moreno-González, Marcos Bouza, Andrea Saez-Gómez, Evaristo Ballesteros, Juan F. García-Reyes, Antonio Molina-Díaz A novel sample treatment approach based on a modified QuEChERS method was evaluated for the simultaneous determination of veterinary drug and pesticide residues in salmon in this work. To improve the QuEChERS performance, Enhanced Matrix...
Sun, 06/06/2021 - 02:02
A novel sensitive method for simultaneous determination of 19 antibiotics and 19 anthelmintics in edible fungi using QuEChERS-UHPLC-MS/MS method was established. For every 10.0 g sample, 20 mL of acetonitrile with 2% acetic acid and 1.2 g sodium acetate were used for extraction, followed by 6.0 g anhydrous MgSO4 for dehydration, and 50 mg anhydrous MgSO4+10 mg PSA for purification. The optimized...
Tue, 06/01/2021 - 06:25
Author(s): Guangyu Lu, Qi Chen, Yuping Li, Yuting Liu, Yuying Zhang, Yujia Huang, Lei Zhu Antibiotic residues (ARs) in food of animal origin are of worldwide concern, particularly in China, the world’s largest producer and consumer of antibiotics. Aiming to provide a reference for the use of antibiotics in dairy cows, for supervision and management departments in the detection of related...
Tue, 06/01/2021 - 02:02
Biochar-immobilized microorganism technology is an effective way to remove antibiotic contamination in aqueous solutions. In this study, the effect and mechanism of immobilization of Bacillus subtilis by honeysuckle residue–derived biochar for the removal of chlortetracycline (CTC) were investigated using corn straw biochar as a comparison. The biochar’s structural characteristics and properties...
Sun, 05/30/2021 - 00:00
Infection-controlled release of antibacterial agents is of great importance, particularly for the control of peri-implant infections in the postoperative phase. Polymers containing antibiotics bound via enzymatically cleavable linkers could provide access to drug release systems that could accomplish this. Dispersions of nanogels were prepared by ionotropic gelation of alginate with poly-L-lysine...
Fri, 05/28/2021 - 14:05
A qualitative and quantitative liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the sensitive and exhaustive analysis of residues from triarylmethane dyes, triarylmethane-derivative dyes, phenothiazines, phenoxazines and xanthenes in aquaculture samples. For a wider and more robust detection of dye misuse on farms, other residue markers were also included the...
Sat, 05/22/2021 - 00:00
The constant use of synthetic antibiotics as growth promoters can cause bacterial resistance in chicks. Consequently, the use of these drugs has been restricted in different countries. In recent years, antimicrobial peptides have gained relevance due to their minimal capacity for bacterial resistance and does not generate toxic residues that harm the environment and human health. In this study, a...
Fri, 05/21/2021 - 16:00
This study introduces a valuable laccase, designated ThLacc-S, purified from white rot fungus Trametes hirsuta. ThLacc-S is a monomeric protein in nature with a molecular weight of 57.0 kDa and can efficiently metabolize endocrine disrupting chemicals. The enzyme was successfully purified to homogeneity via three consecutive steps consisting of salt precipitation and column chromatography,...
Fri, 05/21/2021 - 16:00
Animal manure is a reservoir of antibiotic resistance genes (ARGs), and direct application of the manure will lead to spread of ARGs in farmland. Here, we explored the impacts of chicken manure and heat-treated chicken manure on the patterns of soil resistome after 3 years’ application, with mushroom residues set as the plant-derived organic manure treatment. A total of 262 ARG subtypes were...
Wed, 05/19/2021 - 10:03
ABSTRACT The emergence of the plasmid-mediated high-level tigecycline resistance mechanism Tet(X) threatens the role of tigecycline as the "last-resort" antibiotic in the treatment of infections caused by carbapenem-resistant Gram-negative bacteria. Compared with that of the prototypical Tet(X), the enzymatic activities of Tet(X3) and Tet(X4) were significantly enhanced, correlating with high-...
Wed, 05/19/2021 - 10:02
The intestinal protozoan Cryptosporidium is a leading cause of diarrheal disease and mortality in young children. There is currently no fully effective treatment for cryptosporidiosis, which has stimulated interest in anticryptosporidial development over the last ~10 years, with numerous lead compounds identified, including several tRNA synthetase inhibitors. Here, we report the results of a...
Wed, 05/19/2021 - 08:03
by Sang Ho Park, Haley Siddiqi, Daniela V. Castro, Anna A. De Angelis, Aaron L. Oom, Charlotte A. Stoneham, Mary K. Lewinski, Alex E. Clark, Ben A. Croker, Aaron F. Carlin, John Guatelli, Stanley J. Opella SARS-CoV-2 is the novel coronavirus that is the causative agent of COVID-19, a sometimes-lethal respiratory infection responsible for a world-wide pandemic. The envelope (E) protein, one of...
Wed, 05/19/2021 - 04:07
Exploring novel p-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) inhibitors has become one of the most promising research directions in herbicide innovation. On the basis of our tremendous interest in exploiting more powerful HPPD inhibitors, we designed a family of benzyl-containing triketone-aminopyridines via a structure-based drug design (SBDD) strategy and then synthesized them....
Mon, 05/17/2021 - 04:03
Bioglycosylation is an efficient strategy to improve biological activities and physicochemical properties of natural compounds to develop structural modifications of drugs. In this study, an N555 residue was identified as a candidate for site-directed mutagenesis through sequence alignment with GTF180ΔN. Caffeic acid phenethyl ester (CAPE) was used as an acceptor substrate. Two generated mutants...
Fri, 05/14/2021 - 08:03
by Shruti Koulgi, Vinod Jani, Mallikarjunachari Uppuladinne V. N., Uddhavesh Sonavane, Rajendra Joshi Drug repurposing studies targeting inhibition of RNA dependent RNA polymerase (RdRP) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have exhibited the potential effect of small molecules. In the present work a detailed interaction study between the phytochemicals from Indian...
Fri, 05/14/2021 - 02:04
Abstract Theileria and Babesia species are eukaryotic protozoan parasites classified under the order Piroplasmida of the phylum Apicomplexa. Tick vectors transmit these microorganisms in tropical and subtropical regions to a wide range of animals, including ruminants, causing fatal and life-threatening diseases such as bovine babesiosis and theileriosis. Resistance to commercially available drugs...
Wed, 05/12/2021 - 00:00
Scorpion venoms are rich resources of antimicrobial peptides (AMPs). While the short-chain noncysteine-containing AMPs have attracted much attention as templates for drug development, the antimicrobial potential of long-chain noncysteine-containing AMPs has been largely overlooked. Here, by using the online HeliQuest server, we designed and analyzed a series of 14-residue fragments of Smp43, a 43...
Fri, 05/07/2021 - 00:00
The extensive use of antibiotics leads to antibiotic residues in frequently consumed foods. Generally, the main use of antibiotics in animals is to treat and prevent diseases and growth promotion. However, the residues and their breakdown products have several side effects on the human body and, in a broader sense, on the environment. In relation to the human body, the frequency of mutations is...
Mon, 05/03/2021 - 22:11
Journal of Food Science, EarlyView. In this work, the occurrence of 34 common antibiotic (15 sulfonamides and 19 quinolones) residues were evaluated in 236 ready‐to‐eat duck eggs (salted and preserved duck eggs) marketed through e‐commerce stores by ultra‐performance liquid chromatography coupled to tandem mass spectrometry, and subsequent dietary risk assessments for Chinese consumers were...
Sun, 05/02/2021 - 02:02
This study was conducted to decipher the mechanism of emulsion-based food stabilization by fish-derived collagen hydrolysate. Collagen type I was isolated from seven fish processing by-products with yields ranging from 9.15 to 92.38%. The isolated samples had a mass of 110–120kDa and eluted at 30.44% NaCl in ion-exchange chromatography. The collagen samples were enzymatically digested to obtain...
Sun, 05/02/2021 - 00:00
The use of antibiotics in humans and animals results in a release of excess antibiotic residues into the environment through wastewaters and insufficient removal in wastewater treatment plants (WWTP), leading to increasing numbers of bacteria enriched in antibiotic resistance genes (ARG). However, the potential transfer of ARG and their host bacteria between different environments remains largely...
Thu, 04/29/2021 - 12:32
Candida albicans is an opportunistic pathogen accounting for the majority of cases of Candida infections. Currently, C. albicans are developing resistance towards different classes of antifungal drugs and this has become a global health burden that does not spare Lebanon. This study aims at determining point mutations in genes known to be involved in resistance acquisition and correlating...
Thu, 04/29/2021 - 12:11
Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis (M. tb). It is regarded as a major health threat all over the world, mainly because of its high mortality and drug-resistant nature. Toxin-antitoxin (TA) systems are modules ubiquitously found in prokaryotic organisms, and the well-studied MazEF systems (MazE means “what is it?” in Hebrew) are implicated in the...
Thu, 04/29/2021 - 12:11
Anaerobic digestion is one of the best ways to re-use animal manure and agricultural residues, through the production of combustible biogas and digestate. However, the use of antibiotics for preventing and treating animal diseases and, consequently, their residual concentrations in manure, could introduce them into anaerobic digesters. If the digestate is applied as a soil fertilizer, antibiotic...
Thu, 04/29/2021 - 11:49
ABSTRACT Our current understanding of how low antibiotic concentrations shape the evolution of contemporary β-lactamases is limited. Using the widespread carbapenemase OXA-48, we tested the long-standing hypothesis that selective compartments with low antibiotic concentrations cause standing genetic diversity that could act as a gateway to developing clinical resistance. Here, we subjected...
Thu, 04/29/2021 - 11:44
Class D β-lactamases have risen to notoriety due to their wide spread in bacterial pathogens, propensity to inactivate clinically important β-lactam antibiotics, and ability to withstand inhibition by the majority of classical β-lactamase inhibitors. Understanding the catalytic mechanism of these enzymes is thus vitally important for the development of novel antibiotics and inhibitors active...
Thu, 04/22/2021 - 00:00
Multidrug resistant bacteria are a major therapeutic challenge. CTX-M-type enzymes are an important group of class A extended-spectrum β-lactamases (ESBLs). ESBLs are the enzymes that arm bacterial pathogens with drug resistance to an array of antibiotics, notably the advanced-generation cephalosporins. The current need for an effective CTX-M-inhibitor is high. Objective: The aim of the current...
Wed, 04/21/2021 - 16:00
The rapid spread of COVID-19, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a worldwide health emergency. Unfortunately, to date, a very small number of remedies have been to be found effective against SARS-CoV-2 infection. Therefore, further research is required to achieve a lasting solution against this deadly disease. Repurposing available drugs and...
Wed, 04/21/2021 - 04:03
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that is frequently found in the airways of cystic fibrosis (CF) patients due to the dehydrated mucus that collapses the underlying cilia and prevents mucociliary clearance. During this life-long chronic infection, P. aeruginosa cell accumulates mutations that lead to inactivation of the mucA gene that results in the constitutive...
Tue, 04/20/2021 - 10:02
AcrAB-TolC is a major tripartite multidrug efflux pump conferring resistance to a wide variety of compounds in Gram-negative pathogens. Many AcrB mutants have been constructed through site-directed mutagenesis to probe the mechanism of AcrB function in antibiotic resistance. However, much less is known about the actual drug resistance-related mutants that naturally occur in clinically isolated...
Sat, 04/17/2021 - 04:03
Currently, there are more than 1000 varieties of synthetic sulfonamides universally used as antibiotics causing severe results of potential carcinogenicity and drug resistance for human health due to excessive residue of animal-derived food. A facile and novel approach for untargeted screening of sulfonamides (SAs) and metabolites was proposed based on magnetic solid-phase extraction–ultrahigh-...
Sat, 04/17/2021 - 00:00
All infections are potentially curable as long as the etiological agents are susceptible to antimicrobials. The increased rate at which antimicrobials are becoming ineffective is a global health risk of increasing concern that threatens withdrawal of beneficial antimicrobials for disease control. The increased demand for food of animal origin, in particular eggs, meat and milk has led to...
Sat, 04/10/2021 - 00:00
Antibiotic resistant bacteria and antibiotic residues can enter the environment when using animal manure as fertilizer. Twenty-five mixed beef cattle farmyard manure samples and 9 mixed fattening calf slurry samples from different farms across Belgium were investigated for the presence of 69 antibiotic residues, antibiotic resistant Escherichia coli and Salmonella spp. Doxycycline,...
Fri, 04/09/2021 - 00:00
Residues of antimicrobials used in farm can exert selective pressure and accelerate the occurrence of multidrug resistant bacteria in litter. This study aimed to investigate the resistance profile of Escherichia coli isolated from poultry litter. A total of 101 E. coli strains was isolated from 229 litter samples collected and stored for two months in the laboratory at room temperature....
Sat, 03/27/2021 - 22:09
Journal of Separation Science, Accepted Article. Pesticides and veterinary drugs are generally employed to control pests and insects in crop and livestock farming. However, remaining residues are considered potentially hazardous to human health and the environment. Therefore, regular monitoring is required for assessing and legislation of pesticides and veterinary drugs. Various approaches to...
Thu, 03/25/2021 - 06:16
Author(s): Véronique Dupouy, Jean-Yves Madec, Jessica Wucher, Nathalie Arpaillange, Véronique Métayer, Béatrice Roques, Alain Bousquet-Mélou, Marisa Haenni In the bovine sector, the spread of Enterobacterales producing extended-spectrum and AmpC β-lactamases (ESBL/AmpC) mostly concerns veal calves, and the use of waste milk containing antibiotic residues has been recurrently incriminated. In this...
Fri, 03/19/2021 - 02:02
Due to the inadequate removal rates of drug residues in wastewater treatment plants (WWTP), the transition of these compounds into the environment has become a serious environmental problem for ecosystems and public health. In this study, occurrence, fate, and removal of widely consumed two antibiotics, ciprofloxacin (CIP) and sulfamethoxazole (SMX), selected from fluoroquinolone and sulfonamide...
Thu, 03/18/2021 - 04:02
Burkholderia cepacia complex (Bcc) poses a serious health threat to people with cystic fibrosis or compromised immune systems. Infections often arise from Bcc strains, which are highly resistant to many classes of antibiotics, including β-lactams. β-Lactam resistance in Bcc is conferred largely via PenA-like β-lactamases. Avibactam was previously shown to be a potent inactivator of PenA1. Here,...
Tue, 03/16/2021 - 16:00
Different types of post-translational modifications are present in bacteria that play essential roles in bacterial metabolism modulation. Nevertheless, limited information is available on these types of modifications in actinobacteria, particularly on their effects on secondary metabolite biosynthesis. Recently, phosphorylation, acetylation, or phosphopantetheneylation of transcriptional factors...
Mon, 03/15/2021 - 22:09
Journal of Separation Science, Accepted Article. In this study, a new floating dispersive solid phase extraction method based on deep eutectic solvents has been developed in a home–made extraction device for the extraction of four tetracycline antibiotics from milk samples. In this approach, the sorbent (activated carbon) was dispersed in whole parts of solution with the aid of air stream and...
Sat, 03/13/2021 - 08:05
by Paula Priscila Correia Costa, Stefanie Bressan Waller, Gilvan Ribeiro dos Santos, Fladimir de Lima Gondim, Daniel Silveira Serra, Francisco Sales Ávila Cavalcante, Florêncio Sousa Gouveia Júnior, Valdir Ferreira de Paula Júnior, Eduardo Henrique Silva Sousa, Luiz Gonzaga de França Lopes, Wesley Lyeverton Correia Ribeiro, Helena Serra Azul Monteiro We aimed at evaluating the anti-asthmatic...
Wed, 03/10/2021 - 06:10
Author(s): Mogos Girmatsion, Abdu Mahmud, Bereket Abraha, Yunfei Xie, Yuliang Cheng, Hang Yu, Weirong Yao, Yahui Guo, He Qian The use of antibiotics as veterinary drugs is a significant practice to maintain the well-being of farmed animals. Meanwhile, ethical violations committed during the application of the drugs by animal producers have become a major reason for contamination of animal...
Tue, 03/09/2021 - 16:00
Edwardsiella tarda is a facultative intracellular pathogen in humans and animals. There is no effective way except vaccine candidates to eradicate intracellular E. tarda. In this study, four derivatives of marine peptide-N6NH2 were designed by an introduction of unnatural residues or substitution of natural ones, and their intracellular activities against E. tarda were evaluated in macrophages...
Sat, 03/06/2021 - 00:00
Macrolide–lincosamide–streptogramin B antibiotic resistance occurs through the action of erythromycin ribosome methylation (Erm) family proteins, causing problems due to their prevalence and high minimal inhibitory concentration, and feasibilities have been sought to develop inhibitors. Erms exhibit high conservation next to the N-terminal end region (NTER) as in ErmS, 64SQNF67. Side chains of...

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