Research Publications (Food Safety)

Occurrence of antibiotics in animal sourced foods not only affects economy but also poses potential health risks. The present study aimed to validate simultaneous detection of amoxicillin, penicillin – G and enrofloxacin in raw migratory goat milk (N=223) by HPLC-DAD and assess human health risks in Western Himalayan region, India.

Background Clenbuterol (CLB) is approved as a veterinary drug because of its tracheal smooth muscle and uterine relaxant effects. However, if improperly administered for the purpose of fattening livestock, CLB can remain in the organs, which may pose a health hazard to humans.

From farm to plate, food meets various challenges and pollution. Food detection is essential to ensure food safety. Although detection techniques have obtained great development, the accuracy, sensitivity and operating conditions still have room for improvement. Composed of dielectric media with different refractive indices to form a periodic structure, an optical material named photonic crystal (PC) can offer a breakthrough.

by Shary Tamara Schneider, Rudi Isbrandt, Heidrun Gehlen, Nina Langkabel, Diana Meemken The ‘positive list for equines’ (Regulation (EC) No 1950/2006) was implemented in the European Union in 2006. The drugs listed are approved for use in slaughter equines under certain conditions, although those drugs are not approved for use in livestock and are not listed in Table 1 of the annex to Regulation (EU) No 37/2010.

Abstract Fluoroquinolones are commonly used in poultry breeding. Few studies have evaluated the causes of serious drug residues in black‐boned silky fowl until enrofloxacin has been banned in black‐boned silky fowl breeding in the Chinese Veterinary Commission of Chinese Veterinary Pharmacopoeia (2020). However, similarly structured fluoroquinolones have not been studied in black‐boned silky fowl.

Lincomycin (LCM) is an antibiotic used to treat severe bacterial infections in livestock and companion animals. In this study, we aimed to investigate the oral bioavailability of LCM with PK data after IV and PO administration and to compare differences in drug residue patterns in eggs. To ensure food safety, an additional study on egg residue was conducted using three different commercial LCM drugs.

Abstract The marine finfish and crustaceans contribute immensely to human nutrition. Harvesting marine food‐fish to meet the global demand has become a challenge due to reduction of the fishery areas and food safety hazards associated with increased pre‐harvest and post‐harvest contaminations. The causes of low fish availability and contaminations were reviewed following the published literature from 2000 to 2023.

To get rid of the singularity of the detection of veterinary drug residues in liquid milk, a high-throughput determination was developed for 126 VDRs in 17 categories in liquid milk based on the one-step extraction coupled with LC-HRMS (UPLC-Q-Exactive-Orbitrap-MS).

Antibiotics are those drugs that can be extracted from some microorganisms and they are effective against other organisms, such as bacteria, by either inhibiting the growth of bacteria or by killing them. The present study was conducted to measure the amount of various antibiotics in the local and imported broiler chickens by using liquid chromatography-mass spectrometry (MS/Q-TOF).

Abstract Food quality and safety are crucial public health concerns with global significance. In recent years, a series of fluorescence detection technologies have been widely used in the detection/monitoring of food quality and safety. Due to the advantages of wide detection range, high sensitivity, convenient and fast detection, and strong specificity, quantum dot (QD)‐based fluorescent nanosensors have emerged as preferred candidates for food quality and safety analysis.

The development of different matrix adsorbents is a research focus in the multiresidue analysis of veterinary drugs in foods. In this study, a novel elastic matrix adsorbent based on a reduced graphene oxide-coated melamine sponge was prepared and applied in matrix purification for the simultaneous determination of 52 veterinary drugs in mutton by UPLC–MS/MS. Efficient and convenient matrix removal was achieved through simple soaking and squeezing.

Background AnticFast® Beta-Lactams Rapid Test Kit is a qualitative two-step (2 min + 5 min) rapid lateral flow assay to detect β-lactam (penicillins and cephalosporins) antibiotic residues in raw commingled cow’s milk.

A sensitive and accurate analytical method was developed and validated to detect bambermycin, a commonly used antibiotic in animal feed and livestock. The presence of bambermycin residues in food products can pose health risks to consumers, emphasizing the need for a sensitive and accurate analytical method.

Microwave‐assisted extraction (MAE) is an important technique in analytical chemistry. It offers several advantages over traditional extraction methods, such as improved extraction efficiency, shorter extraction times, reduced solvent consumption, and enhanced analyte recovery.

Antibiotic residues in animal-derived food (egg) are threatening human health. Semiconductor heterojunction surface-enhanced Raman scattering (SERS) substrates can be used for ultra-sensitive detection of antibiotic residues in egg. Here, a TiO2/ZnO heterojunction was developed as a new SERS substrate based on an interface engineering strategy.

An optimized QuEChERS method for the simultaneous extraction of 26 antibiotics and 19 anthelmintics in whole cow milk was established, followed by UHPLC-MS/MS analysis. Briefly, 20 mL acetonitrile with 1 g disodium hydrogen citrate, 2 g sodium citrate, 4 g anhydrous MgSO4, and 1 g sodium chloride were added to 10 g milk for target chemical extraction, followed by 50 mg anhydrous MgSO4 for purification.

by Magdalena R. Raykova, Katie McGuire, William J. Peveler, Damion K. Corrigan, Fiona L. Henriquez, Andrew C. Ward Tetracycline antibiotics are used extensively in veterinary medicine, but the majority of the administrated dose is eliminated unmodified from the animal through various excretion routes including urine, faeces and milk. In dairy animals, limits on residues secreted in milk are strictly controlled by legislation.

The use of antimicrobial drugs and coccidiostats in poultry farming is widespread, with a significant proportion of these drugs being excreted and released into the environment. The residues of such drugs in poultry litter (PL) can result in the development of antibiotic-resistant bacteria.

Probiotics are live microorganisms with various health benefits when consumed in appropriate amounts. Fermented foods are a rich source of these beneficial organisms. This study aimed to investigate the probiotic potential of lactic acid bacteria (LAB) isolated from fermented papaya (Carica papaya L.) through in vitro methods. The LAB strains were thoroughly characterized, considering their morphological, physiological, fermentative, biochemical, and molecular properties.

There were few reports about antibiotic residues in egg-containing products. In the study, an effective method for the simultaneous determination of 24 sulfonamide antibiotics in two instant pastries based on a modified QuEChERS sample preparation technique coupled with ultra performance liquid chromatography-tandem mass spectrometry was developed.

Background Ivermectin is one of the first, safe, broad-spectrum avermectin class of antiparasitic agent, widely used to control parasitic growth in livestock. Ivermectin being highly lipophilic accumulates in fat tissues, causing its long-term existence in the body. Accordingly, ivermectin residues are observed in various animal products such as milk and meat presenting several health hazards.

Background Antibiotics are used in ethanol production to discourage undesirable bacteria growth. To determine if antibiotic residues remain in the distillers grain (DG) byproduct, which is used as an animal food ingredient, the U.S. Food and Drug Administration/Center for Veterinary Medicine previously developed an LC-MS/MS method to detect residues of erythromycin A, penicillin G, virginiamycin M1, and virginiamycin S1 in DG to enable regulatory decision-making.

A safe and effective method for eradicating poultry red mite (PRM; Dermanyssus gallinae) is urgently needed, as existing treatments show a low efficacy or hazardous effects on chickens. We evaluated the efficacy of a combined treatment with ivermectin and allicin (IA) against PRMs in chickens and drug residues in non-target samples. The efficiency of PRM eradication by IA was compared with those of natural acaricides in vitro.

Fish, like all other animals, are exposed to constant contact with microbes, both on their skin and on the surfaces of their respiratory and digestive systems. Fish have a system of non-specific immune responses that provides them with initial protection against infection and allows them to survive under normal conditions despite the presence of these potential invaders.

Bovine milk is a low cost, high nutritional value product commercialised worldwide. To maintain high standard levels and preserve consumer health, several tests could be used to identify antimicrobial drug residues, run voluntarily or officially planned and performed, according to European legislative requirements.